LOCUS       NM_001346038            4913 bp    mRNA    linear   ROD 18-MAR-2025
DEFINITION  Mus musculus Meis homeobox 2 (Meis2), transcript variant 10, mRNA.
ACCESSION   NM_001346038
VERSION     NM_001346038.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4913)
  AUTHORS   Lee,A.S., Arefin,T.M., Gubanova,A., Stephen,D.N., Liu,Y., Lao,Z.,
            Krishnamurthy,A., De Marco Garcia,N.V., Heck,D.H., Zhang,J.,
            Rajadhyaksha,A.M. and Joyner,A.L.
  TITLE     Cerebellar output neurons can impair non-motor behaviors by
            altering development of extracerebellar connectivity
  JOURNAL   Nat Commun 16 (1), 1858 (2025)
   PUBMED   39984491
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4913)
  AUTHORS   Hudacova,E., Abaffy,P., Kaplan,M.M., Krausova,M., Kubista,M. and
            Machon,O.
  TITLE     Single-cell transcriptomic resolution of osteogenesis during
            craniofacial morphogenesis
  JOURNAL   Bone 190, 117297 (2025)
   PUBMED   39461490
REFERENCE   3  (bases 1 to 4913)
  AUTHORS   Koo,H.Y., Oh,J.H., Duran Alonso,M.B., Hernandez,I.L.,
            Gonzalez-Vallinas,M., Alonso,M.T., Tena,J.J., Gil-Galvez,A.,
            Giraldez,F., Bok,J. and Schimmang,T.
  TITLE     Analysis of Meis2 knockout mice reveals Sonic hedgehog-mediated
            patterning of the cochlear duct
  JOURNAL   Dev Dyn (2024) In press
   PUBMED   39351969
  REMARK    Publication Status: Available-Online prior to print
REFERENCE   4  (bases 1 to 4913)
  AUTHORS   Krishnamurthy,A., Lee,A.S., Bayin,N.S., Stephen,D.N., Nasef,O.,
            Lao,Z. and Joyner,A.L.
  TITLE     Engrailed transcription factors direct excitatory cerebellar neuron
            diversity and survival
  JOURNAL   Development 151 (14) (2024)
   PUBMED   38912572
REFERENCE   5  (bases 1 to 4913)
  AUTHORS   Burglin,T.R. and Affolter,M.
  TITLE     Homeodomain proteins: an update
  JOURNAL   Chromosoma 125 (3), 497-521 (2016)
   PUBMED   26464018
  REMARK    Review article
REFERENCE   6  (bases 1 to 4913)
  AUTHORS   Cecconi,F., Proetzel,G., Alvarez-Bolado,G., Jay,D. and Gruss,P.
  TITLE     Expression of Meis2, a Knotted-related murine homeobox gene,
            indicates a role in the differentiation of the forebrain and the
            somitic mesoderm
  JOURNAL   Dev Dyn 210 (2), 184-190 (1997)
   PUBMED   9337138
REFERENCE   7  (bases 1 to 4913)
  AUTHORS   Oulad-Abdelghani,M., Chazaud,C., Bouillet,P., Sapin,V., Chambon,P.
            and Dolle,P.
  TITLE     Meis2, a novel mouse Pbx-related homeobox gene induced by retinoic
            acid during differentiation of P19 embryonal carcinoma cells
  JOURNAL   Dev Dyn 210 (2), 173-183 (1997)
   PUBMED   9337137
REFERENCE   8  (bases 1 to 4913)
  AUTHORS   Steelman,S., Moskow,J.J., Muzynski,K., North,C., Druck,T.,
            Montgomery,J.C., Huebner,K., Daar,I.O. and Buchberg,A.M.
  TITLE     Identification of a conserved family of Meis1-related homeobox
            genes
  JOURNAL   Genome Res 7 (2), 142-156 (1997)
   PUBMED   9049632
REFERENCE   9  (bases 1 to 4913)
  AUTHORS   Nakamura,T., Jenkins,N.A. and Copeland,N.G.
  TITLE     Identification of a new family of Pbx-related homeobox genes
  JOURNAL   Oncogene 13 (10), 2235-2242 (1996)
   PUBMED   8950991
REFERENCE   10 (bases 1 to 4913)
  AUTHORS   Bouillet,P., Oulad-Abdelghani,M., Vicaire,S., Garnier,J.M.,
            Schuhbaur,B., Dolle,P. and Chambon,P.
  TITLE     Efficient cloning of cDNAs of retinoic acid-responsive genes in P19
            embryonal carcinoma cells and characterization of a novel mouse
            gene, Stra1 (mouse LERK-2/Eplg2)
  JOURNAL   Dev Biol 170 (2), 420-433 (1995)
   PUBMED   7649373
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK158839.1, AL772135.14,
            BB612458.1, AK146633.1, CX568764.1 and AL929037.3.
            
            Summary: This gene encodes a homeobox protein belonging to the TALE
            ('three amino acid loop extension') family of
            homeodomain-containing proteins. TALE homeobox proteins are highly
            conserved transcriptional regulators and several members have been
            shown to be essential contributors to developmental programs. In
            mice, a knock-out of this gene leads to lethality at embryonic day
            14, accompanied with hemorrhaging. Embryos lacking this gene show
            defects in tissues derived from the neural crest, suggesting a
            critical role of this gene during cranial and cardiac neural crest
            cell development. Alternative splicing results in multiple
            transcript variants. [provided by RefSeq, Sep 2016].
            
            Transcript Variant: This variant (10) lacks an alternate exon in
            the coding region, compared to variant 9. The encoded isoform (10)
            is shorter than isoform 9.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660821.85414.1,
                                           SRR6116558.67333.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164138
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-283               AK158839.1         3-285
            284-285             AL772135.14        168761-168762       c
            286-377             AK158839.1         286-377
            378-529             BB612458.1         1-152
            530-1270            AK146633.1         259-999
            1271-1551           AK146633.1         1000-1280
            1552-1664           CX568764.1         571-683
            1665-3108           AK146633.1         1468-2911
            3109-4913           AL929037.3         120395-122199       c
FEATURES             Location/Qualifiers
     source          1..4913
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 58.28 cM"
     gene            1..4913
                     /gene="Meis2"
                     /gene_synonym="A430109D20Rik; Mrg1; Stra10"
                     /note="Meis homeobox 2"
                     /db_xref="GeneID:17536"
                     /db_xref="MGI:MGI:108564"
     exon            1..528
                     /gene="Meis2"
                     /gene_synonym="A430109D20Rik; Mrg1; Stra10"
                     /inference="alignment:Splign:2.1.0"
     CDS             520..1950
                     /gene="Meis2"
                     /gene_synonym="A430109D20Rik; Mrg1; Stra10"
                     /note="isoform 10 is encoded by transcript variant 10;
                     homeobox protein Meis2; meis1-related protein 1;
                     Cbp/p300-interacting transactivator with Glu/Asp-rich
                     carboxy-terminal domain 2; myeloid ecotropic viral
                     integration site-related gene 1"
                     /codon_start=1
                     /product="homeobox protein Meis2 isoform 10"
                     /protein_id="NP_001332967.1"
                     /db_xref="GeneID:17536"
                     /db_xref="MGI:MGI:108564"
                     /translation="MFLYDELPHYGGMDGVGVPASMYGDPHAPRPIPPVHHLNHGPPL
                     HATQHYGAHAPHPNVMPASMGSAVNDALKRDKDAIYGHPLFPLLALVFEKCELATCTP
                     REPGVAGGDVCSSDSFNEDIAVFAKQVRAEKPLFSSNPELDNLMIQAIQVLRFHLLEL
                     EKVHELCDNFCHRYISCLKGKMPIDLVIDERDGSSKSDHEELSGSSTNLADHNPSSWR
                     DHDDATSTHSAGTPGPSSGGHASQSGDNSSEQGDGLDNSVASPGTGDDDDPDKDKKRQ
                     KKRGIFPKVATNIMRAWLFQHLTHPYPSEEQKKQLAQDTGLTILQVNNWFINARRRIV
                     QPMIDQSNRAGFLLDPSVSQGAAYSPEGQPMGSFVLDGQQHMGIRPAGLQSMPGDYVS
                     QGGPMGMGMAQPSYTPPQMTPHPTQLRHGPPMHSYLPSHPHHPAMVMHGGPPTHPGMT
                     MSAQSPTMLNSVDPNVGGQVMDIHAQ"
     exon            529..761
                     /gene="Meis2"
                     /gene_synonym="A430109D20Rik; Mrg1; Stra10"
                     /inference="alignment:Splign:2.1.0"
     exon            762..903
                     /gene="Meis2"
                     /gene_synonym="A430109D20Rik; Mrg1; Stra10"
                     /inference="alignment:Splign:2.1.0"
     exon            904..954
                     /gene="Meis2"
                     /gene_synonym="A430109D20Rik; Mrg1; Stra10"
                     /inference="alignment:Splign:2.1.0"
     exon            955..1005
                     /gene="Meis2"
                     /gene_synonym="A430109D20Rik; Mrg1; Stra10"
                     /inference="alignment:Splign:2.1.0"
     exon            1006..1155
                     /gene="Meis2"
                     /gene_synonym="A430109D20Rik; Mrg1; Stra10"
                     /inference="alignment:Splign:2.1.0"
     exon            1156..1270
                     /gene="Meis2"
                     /gene_synonym="A430109D20Rik; Mrg1; Stra10"
                     /inference="alignment:Splign:2.1.0"
     exon            1271..1416
                     /gene="Meis2"
                     /gene_synonym="A430109D20Rik; Mrg1; Stra10"
                     /inference="alignment:Splign:2.1.0"
     exon            1417..1493
                     /gene="Meis2"
                     /gene_synonym="A430109D20Rik; Mrg1; Stra10"
                     /inference="alignment:Splign:2.1.0"
     exon            1494..1552
                     /gene="Meis2"
                     /gene_synonym="A430109D20Rik; Mrg1; Stra10"
                     /inference="alignment:Splign:2.1.0"
     exon            1553..1663
                     /gene="Meis2"
                     /gene_synonym="A430109D20Rik; Mrg1; Stra10"
                     /inference="alignment:Splign:2.1.0"
     exon            1664..4913
                     /gene="Meis2"
                     /gene_synonym="A430109D20Rik; Mrg1; Stra10"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3084..3089
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Meis2"
                     /gene_synonym="A430109D20Rik; Mrg1; Stra10"
                     /note="hexamer: AATAAA"
     polyA_site      3103
                     /gene="Meis2"
                     /gene_synonym="A430109D20Rik; Mrg1; Stra10"
                     /note="major polyA site"
ORIGIN      
        1 gagagtgtgt gtgcgtgcgt gtgtgcgtgt ctggccgcgc gtgtcccagc gctgagcgag
       61 cgggcgggcg gcgagagcgt gtgagtggtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg
      121 tgtgtgtgtg tgtgtgtgtg tgtgtacttg tgtgcaattg ttacacgctt tcgcctcgct
      181 ccagctttta ccccggcagc gtgattcccc gggttctctg cgggcggcga gagcgtgtga
      241 gtggtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtacttg tgtgcaattg
      301 ttacacgctt tcgcctcgct ccagctttta ccccggcagc gtgattcccc gggttctcct
      361 gccgccgccg ctgcgcctct ttcgccgcta ctcgcgcggc tccgggcggg cgcgggctgc
      421 gtaggagccg ccggcgtggg gccgcgctgc ctagactagc cccggctgct tgttttgtct
      481 ctgaaattga caaggacgca gggaatccgc tgctaaataa tgtttctgta cgatgagctg
      541 ccccattacg gcgggatgga cggagtaggg gttcccgctt ccatgtacgg agaccctcac
      601 gcgccgcggc cgatcccccc ggttcaccac ctaaaccacg ggccgccgct ccacgccacg
      661 cagcactacg gcgcgcacgc cccgcacccc aatgtcatgc cagccagcat gggatctgct
      721 gtcaacgacg ccttgaaaag agacaaggac gcaatctatg ggcacccgtt gtttcctctg
      781 ttagctctgg tttttgagaa gtgcgagctg gcgacctgca ctccccggga acccggagtg
      841 gccggcggag acgtctgttc ctctgactcc ttcaacgagg acatcgcggt cttcgccaag
      901 caggttcgcg ccgaaaagcc tcttttttcc tcaaacccag agctggataa tttgatgata
      961 caagcaattc aagtactaag gtttcatctt ctggagttag aaaaggtcca cgaactatgt
     1021 gataacttct gccaccggta cattagctgt ttgaagggaa aaatgcccat tgacctcgtg
     1081 attgatgaga gagatggaag ctccaagtca gatcatgaag aactttcagg ctcctccaca
     1141 aatctcgccg accacaaccc ttcatcctgg cgagaccacg atgacgcaac ctcaacgcac
     1201 tccgcaggca ccccaggacc ctccagtggg ggccatgctt cccagagtgg agacaacagc
     1261 agtgagcaag gcgatgggtt agacaacagc gtagcttcac ctggcacagg tgatgacgac
     1321 gatccagaca aggacaaaaa acgccagaag aaaagaggca tattccccaa agtcgcgaca
     1381 aatatcatga gagcgtggct cttccagcat ctcacacacc cgtacccttc agaagaacag
     1441 aagaaacagt tagcgcaaga cacgggactg acaattctgc aagtgaacaa ctggtttatc
     1501 aatgccagaa gaagaatagt gcagcccatg attgaccagt caaatcgagc aggttttctt
     1561 cttgatcctt cagtgagcca aggagcagcg tatagtccag agggtcagcc catggggagc
     1621 tttgtgttgg atggtcagca acacatgggg atccggcctg caggtttgca gagcatgcca
     1681 ggggactacg tttctcaggg tggtccaatg ggaatgggta tggcccagcc aagttacact
     1741 cctccccaga tgaccccaca ccctactcag ttaagacatg gacccccaat gcattcatat
     1801 ttgccaagcc atccccacca cccagccatg gtgatgcacg gaggaccccc tacccaccct
     1861 ggaatgacta tgtcagcaca gagccccaca atgttaaatt ctgtagatcc caatgttggc
     1921 ggacaggtta tggacattca tgcccaatag tataagggaa ctcaaggaag aaggaaacac
     1981 acgcaaaaac tattttaaga ctctctgaac tttgaccaga tgtgacactt aatatgaaac
     2041 tccagacagc tgtgattatt ttttactttt tgtcattttt catcaagcaa cagaggacca
     2101 atgggacaag aacacaaatg tgaagcgacg ggctcatcga gacaattttg tccatgcaaa
     2161 gatcctctgg agaaagactc cgagagttat aactactgta gcataaacat agggactaag
     2221 ttaaacttgt acatttctgt tgatcactcc gttatgttgc ctcaaatagt tttagaagag
     2281 aaaaaaaaaa tatatccttg ttttccacac tatgtgtgtt gttcccaaaa gaatgactgt
     2341 cttggttcat cagtgaattc actatccaga agagactgtg gtatatttta aacctgttgg
     2401 gccaatgaga aaagaaccat gctgcggagc gagatggaca cttgtctgaa cctcatcact
     2461 aactccagcg gctagaatgt gttttcatgc ccggcctttg ttccccccgt ccatgtgtcc
     2521 tttagtttca aacagatctt tatagtttgt gcttcataag ccaattctta ttatgatttt
     2581 gggggactgt tcttcaaaga gcttgccagt gaagatctag agacagagcg aaggcttctt
     2641 caagttctga gccttggctg tggacaaaac aatcttaagt tgggcagctt tcctcaacgc
     2701 acatacacac acacacacac acaagttatt catggtcgtt gcaccataag taggattcta
     2761 tcaggaactc aaagcttggg ggataaaaag gagcaagaga atactgtaac aaacttcgta
     2821 cagagttcgg tcttttaatt gtttcatgtt agatattcta tgtgtttacc tcaattgaaa
     2881 aaaaaaaaaa gaatgttttt gctagtatca gatctgctgt ggaattggta ttgtatgtcc
     2941 atggggtcct cttttctcag cacgtgttcc tcactagaag aaaatgctgt tacctttaag
     3001 ctttgtcaaa tttacattaa aatacttgta tgaggactgt gacgttatgt taaaaaaaaa
     3061 ggtgttaagt cacaaaatgc ggtaataaat atttcatttt tgattttttg ttaggctttg
     3121 gtgtttttta atggtttgaa ggttgcagga ggccagctcc tgggcactga tgaaagtacc
     3181 tgatggtctc ccaccacccc cccccccaag gaagttgagc atatttaaga tgtaacttag
     3241 cagcatctgt agcttttcat tgtgtgtttg gactcttagg tttcatcaac agaaaacttc
     3301 caaaggtatg aaattacttg tgttatatcc agcttgagag atcaccttca aaaggcccag
     3361 cctatcttat tatagctgca tgatgttttt aaaagcagtt gcagattaaa cttttgccta
     3421 tgtacccacc agtagaataa agggtttatt ccatgttaat tttatatcat aagaagttat
     3481 gtgtgtgctc aaacatgatt tatctgtact ctatcttact caaatactgt tgactctgta
     3541 cattaaagct catatatgat gtctatagat aagtaaacac tttctatgga gttgggaatt
     3601 ctaagcttaa aagagtgctt aagcattaat atttagtaca aataatacag tggtatcttt
     3661 ctaataaggt tgctttctcc atgtgcaggg atgcaagtat gatagtctgg tgcctcaaaa
     3721 attttttttt cataaaaaaa aagaaaagaa aaaaaaaaga gatactttga tagcattttc
     3781 aaagctttac ttggtaatct agagccacaa gcttgttgat gttgcagtgt ctactaaagt
     3841 gtgcaaaatg tagccgctta agatagctgc acactcaaag agtttccaaa taaacacaca
     3901 gctgaggctt tcctaactcc taaatgttga cgcctccatc taaaggggag gataaatagg
     3961 agatggagag atgatttgat ttggtaggga agagctcact agtcatacaa acttccactt
     4021 ggaagcactc catagtggcc tctcaggcaa acccttccct gtttccttgt taggcagcct
     4081 taatggaagc actacatatg aatgagcaag gatataaatt gctattgttt tcttttatat
     4141 tgttaagtaa aatttttata agtgcattta tcactttaat tagtgcactg ctctttaaac
     4201 ctagaaatag cagtgtttga cacaaacaca ctgatcttgt aaaatacata gagcctccct
     4261 ccctctcatt atccctgttc catgctacat ggaatctttc tgtaaaattt aaatatttgc
     4321 atatgtttgc tttaaatgct ctgatgtaaa ctctgacaag ttcctcattt ataaacttac
     4381 tctcatatca gttgaaaggg gaaaaattat attggcagct tttctctcat tgctctccat
     4441 aaggtaattg ctgaagggtt tccttggtca caagctcacg tttataaaaa gtattttatg
     4501 gagttattac tccaggaagg gtacagccag agtggttgag ccttcgtttg aattcacaga
     4561 ctcatcgtga gcttagtatc ttggccaatc tgtatcctat catgctaatt ttaaccttag
     4621 atatttggag atgagtgata attgtggtaa tatctatgta ttttcttacc ccacccccac
     4681 cccattctat gacagaggga tgatgaattt atccagtttt tatagtgctt tttataccac
     4741 ctcagaaggc gcttgctcct atctcgggtt tactatttag tataaagagt tccgatttgg
     4801 gtatatttaa gaaagactca gctgtcaaac gcaaagaaac tgggaatggt gttttgacaa
     4861 ccatatagtg ttaaaggaaa tactgtagtc tgaataaaat tgcttatgtt ctc
//
