LOCUS       NM_001346036            5102 bp    mRNA    linear   ROD 18-MAR-2025
DEFINITION  Mus musculus Meis homeobox 2 (Meis2), transcript variant 9, mRNA.
ACCESSION   NM_001346036
VERSION     NM_001346036.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5102)
  AUTHORS   Lee,A.S., Arefin,T.M., Gubanova,A., Stephen,D.N., Liu,Y., Lao,Z.,
            Krishnamurthy,A., De Marco Garcia,N.V., Heck,D.H., Zhang,J.,
            Rajadhyaksha,A.M. and Joyner,A.L.
  TITLE     Cerebellar output neurons can impair non-motor behaviors by
            altering development of extracerebellar connectivity
  JOURNAL   Nat Commun 16 (1), 1858 (2025)
   PUBMED   39984491
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5102)
  AUTHORS   Hudacova,E., Abaffy,P., Kaplan,M.M., Krausova,M., Kubista,M. and
            Machon,O.
  TITLE     Single-cell transcriptomic resolution of osteogenesis during
            craniofacial morphogenesis
  JOURNAL   Bone 190, 117297 (2025)
   PUBMED   39461490
REFERENCE   3  (bases 1 to 5102)
  AUTHORS   Koo,H.Y., Oh,J.H., Duran Alonso,M.B., Hernandez,I.L.,
            Gonzalez-Vallinas,M., Alonso,M.T., Tena,J.J., Gil-Galvez,A.,
            Giraldez,F., Bok,J. and Schimmang,T.
  TITLE     Analysis of Meis2 knockout mice reveals Sonic hedgehog-mediated
            patterning of the cochlear duct
  JOURNAL   Dev Dyn (2024) In press
   PUBMED   39351969
  REMARK    Publication Status: Available-Online prior to print
REFERENCE   4  (bases 1 to 5102)
  AUTHORS   Krishnamurthy,A., Lee,A.S., Bayin,N.S., Stephen,D.N., Nasef,O.,
            Lao,Z. and Joyner,A.L.
  TITLE     Engrailed transcription factors direct excitatory cerebellar neuron
            diversity and survival
  JOURNAL   Development 151 (14) (2024)
   PUBMED   38912572
REFERENCE   5  (bases 1 to 5102)
  AUTHORS   Burglin,T.R. and Affolter,M.
  TITLE     Homeodomain proteins: an update
  JOURNAL   Chromosoma 125 (3), 497-521 (2016)
   PUBMED   26464018
  REMARK    Review article
REFERENCE   6  (bases 1 to 5102)
  AUTHORS   Cecconi,F., Proetzel,G., Alvarez-Bolado,G., Jay,D. and Gruss,P.
  TITLE     Expression of Meis2, a Knotted-related murine homeobox gene,
            indicates a role in the differentiation of the forebrain and the
            somitic mesoderm
  JOURNAL   Dev Dyn 210 (2), 184-190 (1997)
   PUBMED   9337138
REFERENCE   7  (bases 1 to 5102)
  AUTHORS   Oulad-Abdelghani,M., Chazaud,C., Bouillet,P., Sapin,V., Chambon,P.
            and Dolle,P.
  TITLE     Meis2, a novel mouse Pbx-related homeobox gene induced by retinoic
            acid during differentiation of P19 embryonal carcinoma cells
  JOURNAL   Dev Dyn 210 (2), 173-183 (1997)
   PUBMED   9337137
REFERENCE   8  (bases 1 to 5102)
  AUTHORS   Steelman,S., Moskow,J.J., Muzynski,K., North,C., Druck,T.,
            Montgomery,J.C., Huebner,K., Daar,I.O. and Buchberg,A.M.
  TITLE     Identification of a conserved family of Meis1-related homeobox
            genes
  JOURNAL   Genome Res 7 (2), 142-156 (1997)
   PUBMED   9049632
REFERENCE   9  (bases 1 to 5102)
  AUTHORS   Nakamura,T., Jenkins,N.A. and Copeland,N.G.
  TITLE     Identification of a new family of Pbx-related homeobox genes
  JOURNAL   Oncogene 13 (10), 2235-2242 (1996)
   PUBMED   8950991
REFERENCE   10 (bases 1 to 5102)
  AUTHORS   Bouillet,P., Oulad-Abdelghani,M., Vicaire,S., Garnier,J.M.,
            Schuhbaur,B., Dolle,P. and Chambon,P.
  TITLE     Efficient cloning of cDNAs of retinoic acid-responsive genes in P19
            embryonal carcinoma cells and characterization of a novel mouse
            gene, Stra1 (mouse LERK-2/Eplg2)
  JOURNAL   Dev Biol 170 (2), 420-433 (1995)
   PUBMED   7649373
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK158839.1, AL772135.14,
            BB612458.1, AK146633.1, BQ572308.1, CX568764.1 and AL929037.3.
            
            Summary: This gene encodes a homeobox protein belonging to the TALE
            ('three amino acid loop extension') family of
            homeodomain-containing proteins. TALE homeobox proteins are highly
            conserved transcriptional regulators and several members have been
            shown to be essential contributors to developmental programs. In
            mice, a knock-out of this gene leads to lethality at embryonic day
            14, accompanied with hemorrhaging. Embryos lacking this gene show
            defects in tissues derived from the neural crest, suggesting a
            critical role of this gene during cranial and cardiac neural crest
            cell development. Alternative splicing results in multiple
            transcript variants. [provided by RefSeq, Sep 2016].
            
            Transcript Variant: This variant (9) encodes the longest isoform
            (9).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660811.87376.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164138
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-283               AK158839.1         3-285
            284-285             AL772135.14        168761-168762       c
            286-377             AK158839.1         286-377
            378-529             BB612458.1         1-152
            530-1270            AK146633.1         259-999
            1271-1351           AL772135.14        146473-146553       c
            1352-1460           BQ572308.1         1-109
            1461-1740           AK146633.1         1001-1280
            1741-1853           CX568764.1         571-683
            1854-3297           AK146633.1         1468-2911
            3298-5102           AL929037.3         120395-122199       c
FEATURES             Location/Qualifiers
     source          1..5102
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 58.28 cM"
     gene            1..5102
                     /gene="Meis2"
                     /gene_synonym="A430109D20Rik; Mrg1; Stra10"
                     /note="Meis homeobox 2"
                     /db_xref="GeneID:17536"
                     /db_xref="MGI:MGI:108564"
     exon            1..528
                     /gene="Meis2"
                     /gene_synonym="A430109D20Rik; Mrg1; Stra10"
                     /inference="alignment:Splign:2.1.0"
     CDS             520..2139
                     /gene="Meis2"
                     /gene_synonym="A430109D20Rik; Mrg1; Stra10"
                     /note="isoform 9 is encoded by transcript variant 9;
                     homeobox protein Meis2; meis1-related protein 1;
                     Cbp/p300-interacting transactivator with Glu/Asp-rich
                     carboxy-terminal domain 2; myeloid ecotropic viral
                     integration site-related gene 1"
                     /codon_start=1
                     /product="homeobox protein Meis2 isoform 9"
                     /protein_id="NP_001332965.1"
                     /db_xref="GeneID:17536"
                     /db_xref="MGI:MGI:108564"
                     /translation="MFLYDELPHYGGMDGVGVPASMYGDPHAPRPIPPVHHLNHGPPL
                     HATQHYGAHAPHPNVMPASMGSAVNDALKRDKDAIYGHPLFPLLALVFEKCELATCTP
                     REPGVAGGDVCSSDSFNEDIAVFAKQVRAEKPLFSSNPELDNLMIQAIQVLRFHLLEL
                     EKVHELCDNFCHRYISCLKGKMPIDLVIDERDGSSKSDHEELSGSSTNLADHNPSSWR
                     DHDDATSTHSAGTPGPSSGGHASQSGDNSSEQGASETEADHLLLWKPMTDRTGCVSVQ
                     MSREDREESREGKHSPQPLENIIIPCQPPFRGESEAGGDGLDNSVASPGTGDDDDPDK
                     DKKRQKKRGIFPKVATNIMRAWLFQHLTHPYPSEEQKKQLAQDTGLTILQVNNWFINA
                     RRRIVQPMIDQSNRAGFLLDPSVSQGAAYSPEGQPMGSFVLDGQQHMGIRPAGLQSMP
                     GDYVSQGGPMGMGMAQPSYTPPQMTPHPTQLRHGPPMHSYLPSHPHHPAMVMHGGPPT
                     HPGMTMSAQSPTMLNSVDPNVGGQVMDIHAQ"
     exon            529..761
                     /gene="Meis2"
                     /gene_synonym="A430109D20Rik; Mrg1; Stra10"
                     /inference="alignment:Splign:2.1.0"
     exon            762..903
                     /gene="Meis2"
                     /gene_synonym="A430109D20Rik; Mrg1; Stra10"
                     /inference="alignment:Splign:2.1.0"
     exon            904..954
                     /gene="Meis2"
                     /gene_synonym="A430109D20Rik; Mrg1; Stra10"
                     /inference="alignment:Splign:2.1.0"
     exon            955..1005
                     /gene="Meis2"
                     /gene_synonym="A430109D20Rik; Mrg1; Stra10"
                     /inference="alignment:Splign:2.1.0"
     exon            1006..1155
                     /gene="Meis2"
                     /gene_synonym="A430109D20Rik; Mrg1; Stra10"
                     /inference="alignment:Splign:2.1.0"
     exon            1156..1270
                     /gene="Meis2"
                     /gene_synonym="A430109D20Rik; Mrg1; Stra10"
                     /inference="alignment:Splign:2.1.0"
     exon            1271..1459
                     /gene="Meis2"
                     /gene_synonym="A430109D20Rik; Mrg1; Stra10"
                     /inference="alignment:Splign:2.1.0"
     exon            1460..1605
                     /gene="Meis2"
                     /gene_synonym="A430109D20Rik; Mrg1; Stra10"
                     /inference="alignment:Splign:2.1.0"
     exon            1606..1682
                     /gene="Meis2"
                     /gene_synonym="A430109D20Rik; Mrg1; Stra10"
                     /inference="alignment:Splign:2.1.0"
     exon            1683..1741
                     /gene="Meis2"
                     /gene_synonym="A430109D20Rik; Mrg1; Stra10"
                     /inference="alignment:Splign:2.1.0"
     exon            1742..1852
                     /gene="Meis2"
                     /gene_synonym="A430109D20Rik; Mrg1; Stra10"
                     /inference="alignment:Splign:2.1.0"
     exon            1853..5102
                     /gene="Meis2"
                     /gene_synonym="A430109D20Rik; Mrg1; Stra10"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3273..3278
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Meis2"
                     /gene_synonym="A430109D20Rik; Mrg1; Stra10"
                     /note="hexamer: AATAAA"
     polyA_site      3292
                     /gene="Meis2"
                     /gene_synonym="A430109D20Rik; Mrg1; Stra10"
                     /note="major polyA site"
ORIGIN      
        1 gagagtgtgt gtgcgtgcgt gtgtgcgtgt ctggccgcgc gtgtcccagc gctgagcgag
       61 cgggcgggcg gcgagagcgt gtgagtggtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg
      121 tgtgtgtgtg tgtgtgtgtg tgtgtacttg tgtgcaattg ttacacgctt tcgcctcgct
      181 ccagctttta ccccggcagc gtgattcccc gggttctctg cgggcggcga gagcgtgtga
      241 gtggtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtacttg tgtgcaattg
      301 ttacacgctt tcgcctcgct ccagctttta ccccggcagc gtgattcccc gggttctcct
      361 gccgccgccg ctgcgcctct ttcgccgcta ctcgcgcggc tccgggcggg cgcgggctgc
      421 gtaggagccg ccggcgtggg gccgcgctgc ctagactagc cccggctgct tgttttgtct
      481 ctgaaattga caaggacgca gggaatccgc tgctaaataa tgtttctgta cgatgagctg
      541 ccccattacg gcgggatgga cggagtaggg gttcccgctt ccatgtacgg agaccctcac
      601 gcgccgcggc cgatcccccc ggttcaccac ctaaaccacg ggccgccgct ccacgccacg
      661 cagcactacg gcgcgcacgc cccgcacccc aatgtcatgc cagccagcat gggatctgct
      721 gtcaacgacg ccttgaaaag agacaaggac gcaatctatg ggcacccgtt gtttcctctg
      781 ttagctctgg tttttgagaa gtgcgagctg gcgacctgca ctccccggga acccggagtg
      841 gccggcggag acgtctgttc ctctgactcc ttcaacgagg acatcgcggt cttcgccaag
      901 caggttcgcg ccgaaaagcc tcttttttcc tcaaacccag agctggataa tttgatgata
      961 caagcaattc aagtactaag gtttcatctt ctggagttag aaaaggtcca cgaactatgt
     1021 gataacttct gccaccggta cattagctgt ttgaagggaa aaatgcccat tgacctcgtg
     1081 attgatgaga gagatggaag ctccaagtca gatcatgaag aactttcagg ctcctccaca
     1141 aatctcgccg accacaaccc ttcatcctgg cgagaccacg atgacgcaac ctcaacgcac
     1201 tccgcaggca ccccaggacc ctccagtggg ggccatgctt cccagagtgg agacaacagc
     1261 agtgagcaag gcgcttcgga gactgaggct gaccatttac tattgtggaa gcccatgact
     1321 gatcgcacag gatgcgtttc agtgcaaatg tcaagagaag atagagaaga aagcagagag
     1381 ggaaaacact ctccacaacc acttgaaaac atcatcattc cctgtcagcc gccctttcgt
     1441 ggggaaagcg aagctggagg cgatgggtta gacaacagcg tagcttcacc tggcacaggt
     1501 gatgacgacg atccagacaa ggacaaaaaa cgccagaaga aaagaggcat attccccaaa
     1561 gtcgcgacaa atatcatgag agcgtggctc ttccagcatc tcacacaccc gtacccttca
     1621 gaagaacaga agaaacagtt agcgcaagac acgggactga caattctgca agtgaacaac
     1681 tggtttatca atgccagaag aagaatagtg cagcccatga ttgaccagtc aaatcgagca
     1741 ggttttcttc ttgatccttc agtgagccaa ggagcagcgt atagtccaga gggtcagccc
     1801 atggggagct ttgtgttgga tggtcagcaa cacatgggga tccggcctgc aggtttgcag
     1861 agcatgccag gggactacgt ttctcagggt ggtccaatgg gaatgggtat ggcccagcca
     1921 agttacactc ctccccagat gaccccacac cctactcagt taagacatgg acccccaatg
     1981 cattcatatt tgccaagcca tccccaccac ccagccatgg tgatgcacgg aggaccccct
     2041 acccaccctg gaatgactat gtcagcacag agccccacaa tgttaaattc tgtagatccc
     2101 aatgttggcg gacaggttat ggacattcat gcccaatagt ataagggaac tcaaggaaga
     2161 aggaaacaca cgcaaaaact attttaagac tctctgaact ttgaccagat gtgacactta
     2221 atatgaaact ccagacagct gtgattattt tttacttttt gtcatttttc atcaagcaac
     2281 agaggaccaa tgggacaaga acacaaatgt gaagcgacgg gctcatcgag acaattttgt
     2341 ccatgcaaag atcctctgga gaaagactcc gagagttata actactgtag cataaacata
     2401 gggactaagt taaacttgta catttctgtt gatcactccg ttatgttgcc tcaaatagtt
     2461 ttagaagaga aaaaaaaaat atatccttgt tttccacact atgtgtgttg ttcccaaaag
     2521 aatgactgtc ttggttcatc agtgaattca ctatccagaa gagactgtgg tatattttaa
     2581 acctgttggg ccaatgagaa aagaaccatg ctgcggagcg agatggacac ttgtctgaac
     2641 ctcatcacta actccagcgg ctagaatgtg ttttcatgcc cggcctttgt tccccccgtc
     2701 catgtgtcct ttagtttcaa acagatcttt atagtttgtg cttcataagc caattcttat
     2761 tatgattttg ggggactgtt cttcaaagag cttgccagtg aagatctaga gacagagcga
     2821 aggcttcttc aagttctgag ccttggctgt ggacaaaaca atcttaagtt gggcagcttt
     2881 cctcaacgca catacacaca cacacacaca caagttattc atggtcgttg caccataagt
     2941 aggattctat caggaactca aagcttgggg gataaaaagg agcaagagaa tactgtaaca
     3001 aacttcgtac agagttcggt cttttaattg tttcatgtta gatattctat gtgtttacct
     3061 caattgaaaa aaaaaaaaag aatgtttttg ctagtatcag atctgctgtg gaattggtat
     3121 tgtatgtcca tggggtcctc ttttctcagc acgtgttcct cactagaaga aaatgctgtt
     3181 acctttaagc tttgtcaaat ttacattaaa atacttgtat gaggactgtg acgttatgtt
     3241 aaaaaaaaag gtgttaagtc acaaaatgcg gtaataaata tttcattttt gattttttgt
     3301 taggctttgg tgttttttaa tggtttgaag gttgcaggag gccagctcct gggcactgat
     3361 gaaagtacct gatggtctcc caccaccccc ccccccaagg aagttgagca tatttaagat
     3421 gtaacttagc agcatctgta gcttttcatt gtgtgtttgg actcttaggt ttcatcaaca
     3481 gaaaacttcc aaaggtatga aattacttgt gttatatcca gcttgagaga tcaccttcaa
     3541 aaggcccagc ctatcttatt atagctgcat gatgttttta aaagcagttg cagattaaac
     3601 ttttgcctat gtacccacca gtagaataaa gggtttattc catgttaatt ttatatcata
     3661 agaagttatg tgtgtgctca aacatgattt atctgtactc tatcttactc aaatactgtt
     3721 gactctgtac attaaagctc atatatgatg tctatagata agtaaacact ttctatggag
     3781 ttgggaattc taagcttaaa agagtgctta agcattaata tttagtacaa ataatacagt
     3841 ggtatctttc taataaggtt gctttctcca tgtgcaggga tgcaagtatg atagtctggt
     3901 gcctcaaaaa tttttttttc ataaaaaaaa agaaaagaaa aaaaaaagag atactttgat
     3961 agcattttca aagctttact tggtaatcta gagccacaag cttgttgatg ttgcagtgtc
     4021 tactaaagtg tgcaaaatgt agccgcttaa gatagctgca cactcaaaga gtttccaaat
     4081 aaacacacag ctgaggcttt cctaactcct aaatgttgac gcctccatct aaaggggagg
     4141 ataaatagga gatggagaga tgatttgatt tggtagggaa gagctcacta gtcatacaaa
     4201 cttccacttg gaagcactcc atagtggcct ctcaggcaaa cccttccctg tttccttgtt
     4261 aggcagcctt aatggaagca ctacatatga atgagcaagg atataaattg ctattgtttt
     4321 cttttatatt gttaagtaaa atttttataa gtgcatttat cactttaatt agtgcactgc
     4381 tctttaaacc tagaaatagc agtgtttgac acaaacacac tgatcttgta aaatacatag
     4441 agcctccctc cctctcatta tccctgttcc atgctacatg gaatctttct gtaaaattta
     4501 aatatttgca tatgtttgct ttaaatgctc tgatgtaaac tctgacaagt tcctcattta
     4561 taaacttact ctcatatcag ttgaaagggg aaaaattata ttggcagctt ttctctcatt
     4621 gctctccata aggtaattgc tgaagggttt ccttggtcac aagctcacgt ttataaaaag
     4681 tattttatgg agttattact ccaggaaggg tacagccaga gtggttgagc cttcgtttga
     4741 attcacagac tcatcgtgag cttagtatct tggccaatct gtatcctatc atgctaattt
     4801 taaccttaga tatttggaga tgagtgataa ttgtggtaat atctatgtat tttcttaccc
     4861 cacccccacc ccattctatg acagagggat gatgaattta tccagttttt atagtgcttt
     4921 ttataccacc tcagaaggcg cttgctccta tctcgggttt actatttagt ataaagagtt
     4981 ccgatttggg tatatttaag aaagactcag ctgtcaaacg caaagaaact gggaatggtg
     5041 ttttgacaac catatagtgt taaaggaaat actgtagtct gaataaaatt gcttatgttc
     5101 tc
//
