LOCUS       NM_001159568            4642 bp    mRNA    linear   ROD 18-MAR-2025
DEFINITION  Mus musculus Meis homeobox 2 (Meis2), transcript variant 4, mRNA.
ACCESSION   NM_001159568
VERSION     NM_001159568.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4642)
  AUTHORS   Lee,A.S., Arefin,T.M., Gubanova,A., Stephen,D.N., Liu,Y., Lao,Z.,
            Krishnamurthy,A., De Marco Garcia,N.V., Heck,D.H., Zhang,J.,
            Rajadhyaksha,A.M. and Joyner,A.L.
  TITLE     Cerebellar output neurons can impair non-motor behaviors by
            altering development of extracerebellar connectivity
  JOURNAL   Nat Commun 16 (1), 1858 (2025)
   PUBMED   39984491
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4642)
  AUTHORS   Hudacova,E., Abaffy,P., Kaplan,M.M., Krausova,M., Kubista,M. and
            Machon,O.
  TITLE     Single-cell transcriptomic resolution of osteogenesis during
            craniofacial morphogenesis
  JOURNAL   Bone 190, 117297 (2025)
   PUBMED   39461490
REFERENCE   3  (bases 1 to 4642)
  AUTHORS   Koo,H.Y., Oh,J.H., Duran Alonso,M.B., Hernandez,I.L.,
            Gonzalez-Vallinas,M., Alonso,M.T., Tena,J.J., Gil-Galvez,A.,
            Giraldez,F., Bok,J. and Schimmang,T.
  TITLE     Analysis of Meis2 knockout mice reveals Sonic hedgehog-mediated
            patterning of the cochlear duct
  JOURNAL   Dev Dyn (2024) In press
   PUBMED   39351969
  REMARK    Publication Status: Available-Online prior to print
REFERENCE   4  (bases 1 to 4642)
  AUTHORS   Krishnamurthy,A., Lee,A.S., Bayin,N.S., Stephen,D.N., Nasef,O.,
            Lao,Z. and Joyner,A.L.
  TITLE     Engrailed transcription factors direct excitatory cerebellar neuron
            diversity and survival
  JOURNAL   Development 151 (14) (2024)
   PUBMED   38912572
REFERENCE   5  (bases 1 to 4642)
  AUTHORS   Burglin,T.R. and Affolter,M.
  TITLE     Homeodomain proteins: an update
  JOURNAL   Chromosoma 125 (3), 497-521 (2016)
   PUBMED   26464018
  REMARK    Review article
REFERENCE   6  (bases 1 to 4642)
  AUTHORS   Cecconi,F., Proetzel,G., Alvarez-Bolado,G., Jay,D. and Gruss,P.
  TITLE     Expression of Meis2, a Knotted-related murine homeobox gene,
            indicates a role in the differentiation of the forebrain and the
            somitic mesoderm
  JOURNAL   Dev Dyn 210 (2), 184-190 (1997)
   PUBMED   9337138
REFERENCE   7  (bases 1 to 4642)
  AUTHORS   Oulad-Abdelghani,M., Chazaud,C., Bouillet,P., Sapin,V., Chambon,P.
            and Dolle,P.
  TITLE     Meis2, a novel mouse Pbx-related homeobox gene induced by retinoic
            acid during differentiation of P19 embryonal carcinoma cells
  JOURNAL   Dev Dyn 210 (2), 173-183 (1997)
   PUBMED   9337137
REFERENCE   8  (bases 1 to 4642)
  AUTHORS   Steelman,S., Moskow,J.J., Muzynski,K., North,C., Druck,T.,
            Montgomery,J.C., Huebner,K., Daar,I.O. and Buchberg,A.M.
  TITLE     Identification of a conserved family of Meis1-related homeobox
            genes
  JOURNAL   Genome Res 7 (2), 142-156 (1997)
   PUBMED   9049632
REFERENCE   9  (bases 1 to 4642)
  AUTHORS   Nakamura,T., Jenkins,N.A. and Copeland,N.G.
  TITLE     Identification of a new family of Pbx-related homeobox genes
  JOURNAL   Oncogene 13 (10), 2235-2242 (1996)
   PUBMED   8950991
REFERENCE   10 (bases 1 to 4642)
  AUTHORS   Bouillet,P., Oulad-Abdelghani,M., Vicaire,S., Garnier,J.M.,
            Schuhbaur,B., Dolle,P. and Chambon,P.
  TITLE     Efficient cloning of cDNAs of retinoic acid-responsive genes in P19
            embryonal carcinoma cells and characterization of a novel mouse
            gene, Stra1 (mouse LERK-2/Eplg2)
  JOURNAL   Dev Biol 170 (2), 420-433 (1995)
   PUBMED   7649373
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK146633.1, CX568764.1 and
            AL929037.3.
            
            Summary: This gene encodes a homeobox protein belonging to the TALE
            ('three amino acid loop extension') family of
            homeodomain-containing proteins. TALE homeobox proteins are highly
            conserved transcriptional regulators and several members have been
            shown to be essential contributors to developmental programs. In
            mice, a knock-out of this gene leads to lethality at embryonic day
            14, accompanied with hemorrhaging. Embryos lacking this gene show
            defects in tissues derived from the neural crest, suggesting a
            critical role of this gene during cranial and cardiac neural crest
            cell development. Alternative splicing results in multiple
            transcript variants. [provided by RefSeq, Sep 2016].
            
            Transcript Variant: This variant (4) differs in the 5' UTR, and has
            multiple differences in the coding region, compared to variant 9.
            The encoded isoform (4) is shorter and has a distinct N-terminus
            compared to isoform 9.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AJ000506.1, SRR1660815.15066.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164138
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1280              AK146633.1         1-1280
            1281-1393           CX568764.1         571-683
            1394-2837           AK146633.1         1468-2911
            2838-4642           AL929037.3         120395-122199       c
FEATURES             Location/Qualifiers
     source          1..4642
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 58.28 cM"
     gene            1..4642
                     /gene="Meis2"
                     /gene_synonym="A430109D20Rik; Mrg1; Stra10"
                     /note="Meis homeobox 2"
                     /db_xref="GeneID:17536"
                     /db_xref="MGI:MGI:108564"
     exon            1..257
                     /gene="Meis2"
                     /gene_synonym="A430109D20Rik; Mrg1; Stra10"
                     /inference="alignment:Splign:2.1.0"
     CDS             246..1679
                     /gene="Meis2"
                     /gene_synonym="A430109D20Rik; Mrg1; Stra10"
                     /note="isoform 4 is encoded by transcript variant 4;
                     homeobox protein Meis2; meis1-related protein 1;
                     Cbp/p300-interacting transactivator with Glu/Asp-rich
                     carboxy-terminal domain 2; myeloid ecotropic viral
                     integration site-related gene 1"
                     /codon_start=1
                     /product="homeobox protein Meis2 isoform 4"
                     /protein_id="NP_001153040.1"
                     /db_xref="CCDS:CCDS50667.1"
                     /db_xref="GeneID:17536"
                     /db_xref="MGI:MGI:108564"
                     /translation="MAQRYDELPHYGGMDGVGVPASMYGDPHAPRPIPPVHHLNHGPP
                     LHATQHYGAHAPHPNVMPASMGSAVNDALKRDKDAIYGHPLFPLLALVFEKCELATCT
                     PREPGVAGGDVCSSDSFNEDIAVFAKQVRAEKPLFSSNPELDNLMIQAIQVLRFHLLE
                     LEKVHELCDNFCHRYISCLKGKMPIDLVIDERDGSSKSDHEELSGSSTNLADHNPSSW
                     RDHDDATSTHSAGTPGPSSGGHASQSGDNSSEQGDGLDNSVASPGTGDDDDPDKDKKR
                     QKKRGIFPKVATNIMRAWLFQHLTHPYPSEEQKKQLAQDTGLTILQVNNWFINARRRI
                     VQPMIDQSNRAGFLLDPSVSQGAAYSPEGQPMGSFVLDGQQHMGIRPAGLQSMPGDYV
                     SQGGPMGMGMAQPSYTPPQMTPHPTQLRHGPPMHSYLPSHPHHPAMVMHGGPPTHPGM
                     TMSAQSPTMLNSVDPNVGGQVMDIHAQ"
     exon            258..490
                     /gene="Meis2"
                     /gene_synonym="A430109D20Rik; Mrg1; Stra10"
                     /inference="alignment:Splign:2.1.0"
     exon            491..632
                     /gene="Meis2"
                     /gene_synonym="A430109D20Rik; Mrg1; Stra10"
                     /inference="alignment:Splign:2.1.0"
     exon            633..683
                     /gene="Meis2"
                     /gene_synonym="A430109D20Rik; Mrg1; Stra10"
                     /inference="alignment:Splign:2.1.0"
     exon            684..734
                     /gene="Meis2"
                     /gene_synonym="A430109D20Rik; Mrg1; Stra10"
                     /inference="alignment:Splign:2.1.0"
     exon            735..884
                     /gene="Meis2"
                     /gene_synonym="A430109D20Rik; Mrg1; Stra10"
                     /inference="alignment:Splign:2.1.0"
     exon            885..999
                     /gene="Meis2"
                     /gene_synonym="A430109D20Rik; Mrg1; Stra10"
                     /inference="alignment:Splign:2.1.0"
     exon            1000..1145
                     /gene="Meis2"
                     /gene_synonym="A430109D20Rik; Mrg1; Stra10"
                     /inference="alignment:Splign:2.1.0"
     exon            1146..1222
                     /gene="Meis2"
                     /gene_synonym="A430109D20Rik; Mrg1; Stra10"
                     /inference="alignment:Splign:2.1.0"
     exon            1223..1281
                     /gene="Meis2"
                     /gene_synonym="A430109D20Rik; Mrg1; Stra10"
                     /inference="alignment:Splign:2.1.0"
     exon            1282..1392
                     /gene="Meis2"
                     /gene_synonym="A430109D20Rik; Mrg1; Stra10"
                     /inference="alignment:Splign:2.1.0"
     exon            1393..4642
                     /gene="Meis2"
                     /gene_synonym="A430109D20Rik; Mrg1; Stra10"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2813..2818
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Meis2"
                     /gene_synonym="A430109D20Rik; Mrg1; Stra10"
                     /note="hexamer: AATAAA"
     polyA_site      2832
                     /gene="Meis2"
                     /gene_synonym="A430109D20Rik; Mrg1; Stra10"
                     /note="major polyA site"
ORIGIN      
        1 ggaggaggag gaagatcagg aggaggagga agaagaggaa aaaagagaaa aagaagaaat
       61 atcactgaaa aaaattcttc gttttcttga ctgggctttc cccacccccc aaaaaataac
      121 attggaaaat tgggagaagt ctccttggtt tggaaaaaaa ggactcttca acctagctca
      181 ctttcttatc cggactggga tattaaatat acgacacatc caggagttta ttggagcgca
      241 gactgatggc gcaaaggtac gatgagctgc cccattacgg cgggatggac ggagtagggg
      301 ttcccgcttc catgtacgga gaccctcacg cgccgcggcc gatccccccg gttcaccacc
      361 taaaccacgg gccgccgctc cacgccacgc agcactacgg cgcgcacgcc ccgcacccca
      421 atgtcatgcc agccagcatg ggatctgctg tcaacgacgc cttgaaaaga gacaaggacg
      481 caatctatgg gcacccgttg tttcctctgt tagctctggt ttttgagaag tgcgagctgg
      541 cgacctgcac tccccgggaa cccggagtgg ccggcggaga cgtctgttcc tctgactcct
      601 tcaacgagga catcgcggtc ttcgccaagc aggttcgcgc cgaaaagcct cttttttcct
      661 caaacccaga gctggataat ttgatgatac aagcaattca agtactaagg tttcatcttc
      721 tggagttaga aaaggtccac gaactatgtg ataacttctg ccaccggtac attagctgtt
      781 tgaagggaaa aatgcccatt gacctcgtga ttgatgagag agatggaagc tccaagtcag
      841 atcatgaaga actttcaggc tcctccacaa atctcgccga ccacaaccct tcatcctggc
      901 gagaccacga tgacgcaacc tcaacgcact ccgcaggcac cccaggaccc tccagtgggg
      961 gccatgcttc ccagagtgga gacaacagca gtgagcaagg cgatgggtta gacaacagcg
     1021 tagcttcacc tggcacaggt gatgacgacg atccagacaa ggacaaaaaa cgccagaaga
     1081 aaagaggcat attccccaaa gtcgcgacaa atatcatgag agcgtggctc ttccagcatc
     1141 tcacacaccc gtacccttca gaagaacaga agaaacagtt agcgcaagac acgggactga
     1201 caattctgca agtgaacaac tggtttatca atgccagaag aagaatagtg cagcccatga
     1261 ttgaccagtc aaatcgagca ggttttcttc ttgatccttc agtgagccaa ggagcagcgt
     1321 atagtccaga gggtcagccc atggggagct ttgtgttgga tggtcagcaa cacatgggga
     1381 tccggcctgc aggtttgcag agcatgccag gggactacgt ttctcagggt ggtccaatgg
     1441 gaatgggtat ggcccagcca agttacactc ctccccagat gaccccacac cctactcagt
     1501 taagacatgg acccccaatg cattcatatt tgccaagcca tccccaccac ccagccatgg
     1561 tgatgcacgg aggaccccct acccaccctg gaatgactat gtcagcacag agccccacaa
     1621 tgttaaattc tgtagatccc aatgttggcg gacaggttat ggacattcat gcccaatagt
     1681 ataagggaac tcaaggaaga aggaaacaca cgcaaaaact attttaagac tctctgaact
     1741 ttgaccagat gtgacactta atatgaaact ccagacagct gtgattattt tttacttttt
     1801 gtcatttttc atcaagcaac agaggaccaa tgggacaaga acacaaatgt gaagcgacgg
     1861 gctcatcgag acaattttgt ccatgcaaag atcctctgga gaaagactcc gagagttata
     1921 actactgtag cataaacata gggactaagt taaacttgta catttctgtt gatcactccg
     1981 ttatgttgcc tcaaatagtt ttagaagaga aaaaaaaaat atatccttgt tttccacact
     2041 atgtgtgttg ttcccaaaag aatgactgtc ttggttcatc agtgaattca ctatccagaa
     2101 gagactgtgg tatattttaa acctgttggg ccaatgagaa aagaaccatg ctgcggagcg
     2161 agatggacac ttgtctgaac ctcatcacta actccagcgg ctagaatgtg ttttcatgcc
     2221 cggcctttgt tccccccgtc catgtgtcct ttagtttcaa acagatcttt atagtttgtg
     2281 cttcataagc caattcttat tatgattttg ggggactgtt cttcaaagag cttgccagtg
     2341 aagatctaga gacagagcga aggcttcttc aagttctgag ccttggctgt ggacaaaaca
     2401 atcttaagtt gggcagcttt cctcaacgca catacacaca cacacacaca caagttattc
     2461 atggtcgttg caccataagt aggattctat caggaactca aagcttgggg gataaaaagg
     2521 agcaagagaa tactgtaaca aacttcgtac agagttcggt cttttaattg tttcatgtta
     2581 gatattctat gtgtttacct caattgaaaa aaaaaaaaag aatgtttttg ctagtatcag
     2641 atctgctgtg gaattggtat tgtatgtcca tggggtcctc ttttctcagc acgtgttcct
     2701 cactagaaga aaatgctgtt acctttaagc tttgtcaaat ttacattaaa atacttgtat
     2761 gaggactgtg acgttatgtt aaaaaaaaag gtgttaagtc acaaaatgcg gtaataaata
     2821 tttcattttt gattttttgt taggctttgg tgttttttaa tggtttgaag gttgcaggag
     2881 gccagctcct gggcactgat gaaagtacct gatggtctcc caccaccccc ccccccaagg
     2941 aagttgagca tatttaagat gtaacttagc agcatctgta gcttttcatt gtgtgtttgg
     3001 actcttaggt ttcatcaaca gaaaacttcc aaaggtatga aattacttgt gttatatcca
     3061 gcttgagaga tcaccttcaa aaggcccagc ctatcttatt atagctgcat gatgttttta
     3121 aaagcagttg cagattaaac ttttgcctat gtacccacca gtagaataaa gggtttattc
     3181 catgttaatt ttatatcata agaagttatg tgtgtgctca aacatgattt atctgtactc
     3241 tatcttactc aaatactgtt gactctgtac attaaagctc atatatgatg tctatagata
     3301 agtaaacact ttctatggag ttgggaattc taagcttaaa agagtgctta agcattaata
     3361 tttagtacaa ataatacagt ggtatctttc taataaggtt gctttctcca tgtgcaggga
     3421 tgcaagtatg atagtctggt gcctcaaaaa tttttttttc ataaaaaaaa agaaaagaaa
     3481 aaaaaaagag atactttgat agcattttca aagctttact tggtaatcta gagccacaag
     3541 cttgttgatg ttgcagtgtc tactaaagtg tgcaaaatgt agccgcttaa gatagctgca
     3601 cactcaaaga gtttccaaat aaacacacag ctgaggcttt cctaactcct aaatgttgac
     3661 gcctccatct aaaggggagg ataaatagga gatggagaga tgatttgatt tggtagggaa
     3721 gagctcacta gtcatacaaa cttccacttg gaagcactcc atagtggcct ctcaggcaaa
     3781 cccttccctg tttccttgtt aggcagcctt aatggaagca ctacatatga atgagcaagg
     3841 atataaattg ctattgtttt cttttatatt gttaagtaaa atttttataa gtgcatttat
     3901 cactttaatt agtgcactgc tctttaaacc tagaaatagc agtgtttgac acaaacacac
     3961 tgatcttgta aaatacatag agcctccctc cctctcatta tccctgttcc atgctacatg
     4021 gaatctttct gtaaaattta aatatttgca tatgtttgct ttaaatgctc tgatgtaaac
     4081 tctgacaagt tcctcattta taaacttact ctcatatcag ttgaaagggg aaaaattata
     4141 ttggcagctt ttctctcatt gctctccata aggtaattgc tgaagggttt ccttggtcac
     4201 aagctcacgt ttataaaaag tattttatgg agttattact ccaggaaggg tacagccaga
     4261 gtggttgagc cttcgtttga attcacagac tcatcgtgag cttagtatct tggccaatct
     4321 gtatcctatc atgctaattt taaccttaga tatttggaga tgagtgataa ttgtggtaat
     4381 atctatgtat tttcttaccc cacccccacc ccattctatg acagagggat gatgaattta
     4441 tccagttttt atagtgcttt ttataccacc tcagaaggcg cttgctccta tctcgggttt
     4501 actatttagt ataaagagtt ccgatttggg tatatttaag aaagactcag ctgtcaaacg
     4561 caaagaaact gggaatggtg ttttgacaac catatagtgt taaaggaaat actgtagtct
     4621 gaataaaatt gcttatgttc tc
//
