LOCUS       NM_001159567            4737 bp    mRNA    linear   ROD 18-MAR-2025
DEFINITION  Mus musculus Meis homeobox 2 (Meis2), transcript variant 3, mRNA.
ACCESSION   NM_001159567
VERSION     NM_001159567.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4737)
  AUTHORS   Lee,A.S., Arefin,T.M., Gubanova,A., Stephen,D.N., Liu,Y., Lao,Z.,
            Krishnamurthy,A., De Marco Garcia,N.V., Heck,D.H., Zhang,J.,
            Rajadhyaksha,A.M. and Joyner,A.L.
  TITLE     Cerebellar output neurons can impair non-motor behaviors by
            altering development of extracerebellar connectivity
  JOURNAL   Nat Commun 16 (1), 1858 (2025)
   PUBMED   39984491
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4737)
  AUTHORS   Hudacova,E., Abaffy,P., Kaplan,M.M., Krausova,M., Kubista,M. and
            Machon,O.
  TITLE     Single-cell transcriptomic resolution of osteogenesis during
            craniofacial morphogenesis
  JOURNAL   Bone 190, 117297 (2025)
   PUBMED   39461490
REFERENCE   3  (bases 1 to 4737)
  AUTHORS   Koo,H.Y., Oh,J.H., Duran Alonso,M.B., Hernandez,I.L.,
            Gonzalez-Vallinas,M., Alonso,M.T., Tena,J.J., Gil-Galvez,A.,
            Giraldez,F., Bok,J. and Schimmang,T.
  TITLE     Analysis of Meis2 knockout mice reveals Sonic hedgehog-mediated
            patterning of the cochlear duct
  JOURNAL   Dev Dyn (2024) In press
   PUBMED   39351969
  REMARK    Publication Status: Available-Online prior to print
REFERENCE   4  (bases 1 to 4737)
  AUTHORS   Krishnamurthy,A., Lee,A.S., Bayin,N.S., Stephen,D.N., Nasef,O.,
            Lao,Z. and Joyner,A.L.
  TITLE     Engrailed transcription factors direct excitatory cerebellar neuron
            diversity and survival
  JOURNAL   Development 151 (14) (2024)
   PUBMED   38912572
REFERENCE   5  (bases 1 to 4737)
  AUTHORS   Burglin,T.R. and Affolter,M.
  TITLE     Homeodomain proteins: an update
  JOURNAL   Chromosoma 125 (3), 497-521 (2016)
   PUBMED   26464018
  REMARK    Review article
REFERENCE   6  (bases 1 to 4737)
  AUTHORS   Cecconi,F., Proetzel,G., Alvarez-Bolado,G., Jay,D. and Gruss,P.
  TITLE     Expression of Meis2, a Knotted-related murine homeobox gene,
            indicates a role in the differentiation of the forebrain and the
            somitic mesoderm
  JOURNAL   Dev Dyn 210 (2), 184-190 (1997)
   PUBMED   9337138
REFERENCE   7  (bases 1 to 4737)
  AUTHORS   Oulad-Abdelghani,M., Chazaud,C., Bouillet,P., Sapin,V., Chambon,P.
            and Dolle,P.
  TITLE     Meis2, a novel mouse Pbx-related homeobox gene induced by retinoic
            acid during differentiation of P19 embryonal carcinoma cells
  JOURNAL   Dev Dyn 210 (2), 173-183 (1997)
   PUBMED   9337137
REFERENCE   8  (bases 1 to 4737)
  AUTHORS   Steelman,S., Moskow,J.J., Muzynski,K., North,C., Druck,T.,
            Montgomery,J.C., Huebner,K., Daar,I.O. and Buchberg,A.M.
  TITLE     Identification of a conserved family of Meis1-related homeobox
            genes
  JOURNAL   Genome Res 7 (2), 142-156 (1997)
   PUBMED   9049632
REFERENCE   9  (bases 1 to 4737)
  AUTHORS   Nakamura,T., Jenkins,N.A. and Copeland,N.G.
  TITLE     Identification of a new family of Pbx-related homeobox genes
  JOURNAL   Oncogene 13 (10), 2235-2242 (1996)
   PUBMED   8950991
REFERENCE   10 (bases 1 to 4737)
  AUTHORS   Bouillet,P., Oulad-Abdelghani,M., Vicaire,S., Garnier,J.M.,
            Schuhbaur,B., Dolle,P. and Chambon,P.
  TITLE     Efficient cloning of cDNAs of retinoic acid-responsive genes in P19
            embryonal carcinoma cells and characterization of a novel mouse
            gene, Stra1 (mouse LERK-2/Eplg2)
  JOURNAL   Dev Biol 170 (2), 420-433 (1995)
   PUBMED   7649373
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK146633.1, AK158839.1 and
            AL929037.3.
            
            Summary: This gene encodes a homeobox protein belonging to the TALE
            ('three amino acid loop extension') family of
            homeodomain-containing proteins. TALE homeobox proteins are highly
            conserved transcriptional regulators and several members have been
            shown to be essential contributors to developmental programs. In
            mice, a knock-out of this gene leads to lethality at embryonic day
            14, accompanied with hemorrhaging. Embryos lacking this gene show
            defects in tissues derived from the neural crest, suggesting a
            critical role of this gene during cranial and cardiac neural crest
            cell development. Alternative splicing results in multiple
            transcript variants. [provided by RefSeq, Sep 2016].
            
            Transcript Variant: This variant (3) differs in the 5' and 3' UTRs
            and has multiple differences in the coding region, compared to
            variant 9. The encoded isoform (3) is shorter and has distinct N-
            and C-termini compared to isoform 9.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AJ000504.1, U57343.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164138
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1280              AK146633.1         1-1280
            1281-1393           AK158839.1         1553-1665
            1394-2932           AK146633.1         1373-2911
            2933-4737           AL929037.3         120395-122199       c
FEATURES             Location/Qualifiers
     source          1..4737
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 58.28 cM"
     gene            1..4737
                     /gene="Meis2"
                     /gene_synonym="A430109D20Rik; Mrg1; Stra10"
                     /note="Meis homeobox 2"
                     /db_xref="GeneID:17536"
                     /db_xref="MGI:MGI:108564"
     exon            1..257
                     /gene="Meis2"
                     /gene_synonym="A430109D20Rik; Mrg1; Stra10"
                     /inference="alignment:Splign:2.1.0"
     CDS             246..1451
                     /gene="Meis2"
                     /gene_synonym="A430109D20Rik; Mrg1; Stra10"
                     /note="isoform 3 is encoded by transcript variant 3;
                     homeobox protein Meis2; meis1-related protein 1;
                     Cbp/p300-interacting transactivator with Glu/Asp-rich
                     carboxy-terminal domain 2; myeloid ecotropic viral
                     integration site-related gene 1"
                     /codon_start=1
                     /product="homeobox protein Meis2 isoform 3"
                     /protein_id="NP_001153039.1"
                     /db_xref="CCDS:CCDS50668.1"
                     /db_xref="GeneID:17536"
                     /db_xref="MGI:MGI:108564"
                     /translation="MAQRYDELPHYGGMDGVGVPASMYGDPHAPRPIPPVHHLNHGPP
                     LHATQHYGAHAPHPNVMPASMGSAVNDALKRDKDAIYGHPLFPLLALVFEKCELATCT
                     PREPGVAGGDVCSSDSFNEDIAVFAKQVRAEKPLFSSNPELDNLMIQAIQVLRFHLLE
                     LEKVHELCDNFCHRYISCLKGKMPIDLVIDERDGSSKSDHEELSGSSTNLADHNPSSW
                     RDHDDATSTHSAGTPGPSSGGHASQSGDNSSEQGDGLDNSVASPGTGDDDDPDKDKKR
                     QKKRGIFPKVATNIMRAWLFQHLTHPYPSEEQKKQLAQDTGLTILQVNNWFINARRRI
                     VQPMIDQSNRAGFLLDPSVSQGAAYSPEGQPMGSFVLDGQQHMGIRPAGPMSGMGMNM
                     GMDGQWHYM"
     exon            258..490
                     /gene="Meis2"
                     /gene_synonym="A430109D20Rik; Mrg1; Stra10"
                     /inference="alignment:Splign:2.1.0"
     exon            491..632
                     /gene="Meis2"
                     /gene_synonym="A430109D20Rik; Mrg1; Stra10"
                     /inference="alignment:Splign:2.1.0"
     exon            633..683
                     /gene="Meis2"
                     /gene_synonym="A430109D20Rik; Mrg1; Stra10"
                     /inference="alignment:Splign:2.1.0"
     exon            684..734
                     /gene="Meis2"
                     /gene_synonym="A430109D20Rik; Mrg1; Stra10"
                     /inference="alignment:Splign:2.1.0"
     exon            735..884
                     /gene="Meis2"
                     /gene_synonym="A430109D20Rik; Mrg1; Stra10"
                     /inference="alignment:Splign:2.1.0"
     exon            885..999
                     /gene="Meis2"
                     /gene_synonym="A430109D20Rik; Mrg1; Stra10"
                     /inference="alignment:Splign:2.1.0"
     exon            1000..1145
                     /gene="Meis2"
                     /gene_synonym="A430109D20Rik; Mrg1; Stra10"
                     /inference="alignment:Splign:2.1.0"
     exon            1146..1222
                     /gene="Meis2"
                     /gene_synonym="A430109D20Rik; Mrg1; Stra10"
                     /inference="alignment:Splign:2.1.0"
     exon            1223..1281
                     /gene="Meis2"
                     /gene_synonym="A430109D20Rik; Mrg1; Stra10"
                     /inference="alignment:Splign:2.1.0"
     exon            1282..1392
                     /gene="Meis2"
                     /gene_synonym="A430109D20Rik; Mrg1; Stra10"
                     /inference="alignment:Splign:2.1.0"
     exon            1393..1487
                     /gene="Meis2"
                     /gene_synonym="A430109D20Rik; Mrg1; Stra10"
                     /inference="alignment:Splign:2.1.0"
     exon            1488..4737
                     /gene="Meis2"
                     /gene_synonym="A430109D20Rik; Mrg1; Stra10"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2908..2913
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Meis2"
                     /gene_synonym="A430109D20Rik; Mrg1; Stra10"
                     /note="hexamer: AATAAA"
     polyA_site      2927
                     /gene="Meis2"
                     /gene_synonym="A430109D20Rik; Mrg1; Stra10"
                     /note="major polyA site"
ORIGIN      
        1 ggaggaggag gaagatcagg aggaggagga agaagaggaa aaaagagaaa aagaagaaat
       61 atcactgaaa aaaattcttc gttttcttga ctgggctttc cccacccccc aaaaaataac
      121 attggaaaat tgggagaagt ctccttggtt tggaaaaaaa ggactcttca acctagctca
      181 ctttcttatc cggactggga tattaaatat acgacacatc caggagttta ttggagcgca
      241 gactgatggc gcaaaggtac gatgagctgc cccattacgg cgggatggac ggagtagggg
      301 ttcccgcttc catgtacgga gaccctcacg cgccgcggcc gatccccccg gttcaccacc
      361 taaaccacgg gccgccgctc cacgccacgc agcactacgg cgcgcacgcc ccgcacccca
      421 atgtcatgcc agccagcatg ggatctgctg tcaacgacgc cttgaaaaga gacaaggacg
      481 caatctatgg gcacccgttg tttcctctgt tagctctggt ttttgagaag tgcgagctgg
      541 cgacctgcac tccccgggaa cccggagtgg ccggcggaga cgtctgttcc tctgactcct
      601 tcaacgagga catcgcggtc ttcgccaagc aggttcgcgc cgaaaagcct cttttttcct
      661 caaacccaga gctggataat ttgatgatac aagcaattca agtactaagg tttcatcttc
      721 tggagttaga aaaggtccac gaactatgtg ataacttctg ccaccggtac attagctgtt
      781 tgaagggaaa aatgcccatt gacctcgtga ttgatgagag agatggaagc tccaagtcag
      841 atcatgaaga actttcaggc tcctccacaa atctcgccga ccacaaccct tcatcctggc
      901 gagaccacga tgacgcaacc tcaacgcact ccgcaggcac cccaggaccc tccagtgggg
      961 gccatgcttc ccagagtgga gacaacagca gtgagcaagg cgatgggtta gacaacagcg
     1021 tagcttcacc tggcacaggt gatgacgacg atccagacaa ggacaaaaaa cgccagaaga
     1081 aaagaggcat attccccaaa gtcgcgacaa atatcatgag agcgtggctc ttccagcatc
     1141 tcacacaccc gtacccttca gaagaacaga agaaacagtt agcgcaagac acgggactga
     1201 caattctgca agtgaacaac tggtttatca atgccagaag aagaatagtg cagcccatga
     1261 ttgaccagtc aaatcgagca ggttttcttc ttgatccttc agtgagccaa ggagcagcgt
     1321 atagtccaga gggtcagccc atggggagct ttgtgttgga tggtcagcaa cacatgggga
     1381 tccggcctgc aggacccatg agtggaatgg gcatgaatat gggcatggat gggcagtggc
     1441 actatatgta accttcgcca tgtaaagcaa tctcaaggca aggggaagtt tgcagagcat
     1501 gccaggggac tacgtttctc agggtggtcc aatgggaatg ggtatggccc agccaagtta
     1561 cactcctccc cagatgaccc cacaccctac tcagttaaga catggacccc caatgcattc
     1621 atatttgcca agccatcccc accacccagc catggtgatg cacggaggac cccctaccca
     1681 ccctggaatg actatgtcag cacagagccc cacaatgtta aattctgtag atcccaatgt
     1741 tggcggacag gttatggaca ttcatgccca atagtataag ggaactcaag gaagaaggaa
     1801 acacacgcaa aaactatttt aagactctct gaactttgac cagatgtgac acttaatatg
     1861 aaactccaga cagctgtgat tattttttac tttttgtcat ttttcatcaa gcaacagagg
     1921 accaatggga caagaacaca aatgtgaagc gacgggctca tcgagacaat tttgtccatg
     1981 caaagatcct ctggagaaag actccgagag ttataactac tgtagcataa acatagggac
     2041 taagttaaac ttgtacattt ctgttgatca ctccgttatg ttgcctcaaa tagttttaga
     2101 agagaaaaaa aaaatatatc cttgttttcc acactatgtg tgttgttccc aaaagaatga
     2161 ctgtcttggt tcatcagtga attcactatc cagaagagac tgtggtatat tttaaacctg
     2221 ttgggccaat gagaaaagaa ccatgctgcg gagcgagatg gacacttgtc tgaacctcat
     2281 cactaactcc agcggctaga atgtgttttc atgcccggcc tttgttcccc ccgtccatgt
     2341 gtcctttagt ttcaaacaga tctttatagt ttgtgcttca taagccaatt cttattatga
     2401 ttttggggga ctgttcttca aagagcttgc cagtgaagat ctagagacag agcgaaggct
     2461 tcttcaagtt ctgagccttg gctgtggaca aaacaatctt aagttgggca gctttcctca
     2521 acgcacatac acacacacac acacacaagt tattcatggt cgttgcacca taagtaggat
     2581 tctatcagga actcaaagct tgggggataa aaaggagcaa gagaatactg taacaaactt
     2641 cgtacagagt tcggtctttt aattgtttca tgttagatat tctatgtgtt tacctcaatt
     2701 gaaaaaaaaa aaaagaatgt ttttgctagt atcagatctg ctgtggaatt ggtattgtat
     2761 gtccatgggg tcctcttttc tcagcacgtg ttcctcacta gaagaaaatg ctgttacctt
     2821 taagctttgt caaatttaca ttaaaatact tgtatgagga ctgtgacgtt atgttaaaaa
     2881 aaaaggtgtt aagtcacaaa atgcggtaat aaatatttca tttttgattt tttgttaggc
     2941 tttggtgttt tttaatggtt tgaaggttgc aggaggccag ctcctgggca ctgatgaaag
     3001 tacctgatgg tctcccacca cccccccccc caaggaagtt gagcatattt aagatgtaac
     3061 ttagcagcat ctgtagcttt tcattgtgtg tttggactct taggtttcat caacagaaaa
     3121 cttccaaagg tatgaaatta cttgtgttat atccagcttg agagatcacc ttcaaaaggc
     3181 ccagcctatc ttattatagc tgcatgatgt ttttaaaagc agttgcagat taaacttttg
     3241 cctatgtacc caccagtaga ataaagggtt tattccatgt taattttata tcataagaag
     3301 ttatgtgtgt gctcaaacat gatttatctg tactctatct tactcaaata ctgttgactc
     3361 tgtacattaa agctcatata tgatgtctat agataagtaa acactttcta tggagttggg
     3421 aattctaagc ttaaaagagt gcttaagcat taatatttag tacaaataat acagtggtat
     3481 ctttctaata aggttgcttt ctccatgtgc agggatgcaa gtatgatagt ctggtgcctc
     3541 aaaaattttt ttttcataaa aaaaaagaaa agaaaaaaaa aagagatact ttgatagcat
     3601 tttcaaagct ttacttggta atctagagcc acaagcttgt tgatgttgca gtgtctacta
     3661 aagtgtgcaa aatgtagccg cttaagatag ctgcacactc aaagagtttc caaataaaca
     3721 cacagctgag gctttcctaa ctcctaaatg ttgacgcctc catctaaagg ggaggataaa
     3781 taggagatgg agagatgatt tgatttggta gggaagagct cactagtcat acaaacttcc
     3841 acttggaagc actccatagt ggcctctcag gcaaaccctt ccctgtttcc ttgttaggca
     3901 gccttaatgg aagcactaca tatgaatgag caaggatata aattgctatt gttttctttt
     3961 atattgttaa gtaaaatttt tataagtgca tttatcactt taattagtgc actgctcttt
     4021 aaacctagaa atagcagtgt ttgacacaaa cacactgatc ttgtaaaata catagagcct
     4081 ccctccctct cattatccct gttccatgct acatggaatc tttctgtaaa atttaaatat
     4141 ttgcatatgt ttgctttaaa tgctctgatg taaactctga caagttcctc atttataaac
     4201 ttactctcat atcagttgaa aggggaaaaa ttatattggc agcttttctc tcattgctct
     4261 ccataaggta attgctgaag ggtttccttg gtcacaagct cacgtttata aaaagtattt
     4321 tatggagtta ttactccagg aagggtacag ccagagtggt tgagccttcg tttgaattca
     4381 cagactcatc gtgagcttag tatcttggcc aatctgtatc ctatcatgct aattttaacc
     4441 ttagatattt ggagatgagt gataattgtg gtaatatcta tgtattttct taccccaccc
     4501 ccaccccatt ctatgacaga gggatgatga atttatccag tttttatagt gctttttata
     4561 ccacctcaga aggcgcttgc tcctatctcg ggtttactat ttagtataaa gagttccgat
     4621 ttgggtatat ttaagaaaga ctcagctgtc aaacgcaaag aaactgggaa tggtgttttg
     4681 acaaccatat agtgttaaag gaaatactgt agtctgaata aaattgctta tgttctc
//
