LOCUS       NM_001136072            4716 bp    mRNA    linear   ROD 18-MAR-2025
DEFINITION  Mus musculus Meis homeobox 2 (Meis2), transcript variant 1, mRNA.
ACCESSION   NM_001136072
VERSION     NM_001136072.2
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4716)
  AUTHORS   Lee,A.S., Arefin,T.M., Gubanova,A., Stephen,D.N., Liu,Y., Lao,Z.,
            Krishnamurthy,A., De Marco Garcia,N.V., Heck,D.H., Zhang,J.,
            Rajadhyaksha,A.M. and Joyner,A.L.
  TITLE     Cerebellar output neurons can impair non-motor behaviors by
            altering development of extracerebellar connectivity
  JOURNAL   Nat Commun 16 (1), 1858 (2025)
   PUBMED   39984491
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4716)
  AUTHORS   Hudacova,E., Abaffy,P., Kaplan,M.M., Krausova,M., Kubista,M. and
            Machon,O.
  TITLE     Single-cell transcriptomic resolution of osteogenesis during
            craniofacial morphogenesis
  JOURNAL   Bone 190, 117297 (2025)
   PUBMED   39461490
REFERENCE   3  (bases 1 to 4716)
  AUTHORS   Koo,H.Y., Oh,J.H., Duran Alonso,M.B., Hernandez,I.L.,
            Gonzalez-Vallinas,M., Alonso,M.T., Tena,J.J., Gil-Galvez,A.,
            Giraldez,F., Bok,J. and Schimmang,T.
  TITLE     Analysis of Meis2 knockout mice reveals Sonic hedgehog-mediated
            patterning of the cochlear duct
  JOURNAL   Dev Dyn (2024) In press
   PUBMED   39351969
  REMARK    Publication Status: Available-Online prior to print
REFERENCE   4  (bases 1 to 4716)
  AUTHORS   Krishnamurthy,A., Lee,A.S., Bayin,N.S., Stephen,D.N., Nasef,O.,
            Lao,Z. and Joyner,A.L.
  TITLE     Engrailed transcription factors direct excitatory cerebellar neuron
            diversity and survival
  JOURNAL   Development 151 (14) (2024)
   PUBMED   38912572
REFERENCE   5  (bases 1 to 4716)
  AUTHORS   Burglin,T.R. and Affolter,M.
  TITLE     Homeodomain proteins: an update
  JOURNAL   Chromosoma 125 (3), 497-521 (2016)
   PUBMED   26464018
  REMARK    Review article
REFERENCE   6  (bases 1 to 4716)
  AUTHORS   Cecconi,F., Proetzel,G., Alvarez-Bolado,G., Jay,D. and Gruss,P.
  TITLE     Expression of Meis2, a Knotted-related murine homeobox gene,
            indicates a role in the differentiation of the forebrain and the
            somitic mesoderm
  JOURNAL   Dev Dyn 210 (2), 184-190 (1997)
   PUBMED   9337138
REFERENCE   7  (bases 1 to 4716)
  AUTHORS   Oulad-Abdelghani,M., Chazaud,C., Bouillet,P., Sapin,V., Chambon,P.
            and Dolle,P.
  TITLE     Meis2, a novel mouse Pbx-related homeobox gene induced by retinoic
            acid during differentiation of P19 embryonal carcinoma cells
  JOURNAL   Dev Dyn 210 (2), 173-183 (1997)
   PUBMED   9337137
REFERENCE   8  (bases 1 to 4716)
  AUTHORS   Steelman,S., Moskow,J.J., Muzynski,K., North,C., Druck,T.,
            Montgomery,J.C., Huebner,K., Daar,I.O. and Buchberg,A.M.
  TITLE     Identification of a conserved family of Meis1-related homeobox
            genes
  JOURNAL   Genome Res 7 (2), 142-156 (1997)
   PUBMED   9049632
REFERENCE   9  (bases 1 to 4716)
  AUTHORS   Nakamura,T., Jenkins,N.A. and Copeland,N.G.
  TITLE     Identification of a new family of Pbx-related homeobox genes
  JOURNAL   Oncogene 13 (10), 2235-2242 (1996)
   PUBMED   8950991
REFERENCE   10 (bases 1 to 4716)
  AUTHORS   Bouillet,P., Oulad-Abdelghani,M., Vicaire,S., Garnier,J.M.,
            Schuhbaur,B., Dolle,P. and Chambon,P.
  TITLE     Efficient cloning of cDNAs of retinoic acid-responsive genes in P19
            embryonal carcinoma cells and characterization of a novel mouse
            gene, Stra1 (mouse LERK-2/Eplg2)
  JOURNAL   Dev Biol 170 (2), 420-433 (1995)
   PUBMED   7649373
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK146633.1 and AL929037.3.
            
            On Apr 22, 2009 this sequence version replaced NM_001136072.1.
            
            Summary: This gene encodes a homeobox protein belonging to the TALE
            ('three amino acid loop extension') family of
            homeodomain-containing proteins. TALE homeobox proteins are highly
            conserved transcriptional regulators and several members have been
            shown to be essential contributors to developmental programs. In
            mice, a knock-out of this gene leads to lethality at embryonic day
            14, accompanied with hemorrhaging. Embryos lacking this gene show
            defects in tissues derived from the neural crest, suggesting a
            critical role of this gene during cranial and cardiac neural crest
            cell development. Alternative splicing results in multiple
            transcript variants. [provided by RefSeq, Sep 2016].
            
            Transcript Variant: This variant (1) differs in the 5' and 3' UTRs
            and has multiple differences in the coding region, compared to
            variant 9. The encoded isoform (1) is shorter and has distinct N-
            and C-termini compared to isoform 9.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK146633.1, AJ000505.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164138
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2911              AK146633.1         1-2911
            2912-4716           AL929037.3         120395-122199       c
FEATURES             Location/Qualifiers
     source          1..4716
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 58.28 cM"
     gene            1..4716
                     /gene="Meis2"
                     /gene_synonym="A430109D20Rik; Mrg1; Stra10"
                     /note="Meis homeobox 2"
                     /db_xref="GeneID:17536"
                     /db_xref="MGI:MGI:108564"
     exon            1..257
                     /gene="Meis2"
                     /gene_synonym="A430109D20Rik; Mrg1; Stra10"
                     /inference="alignment:Splign:2.1.0"
     CDS             246..1430
                     /gene="Meis2"
                     /gene_synonym="A430109D20Rik; Mrg1; Stra10"
                     /note="isoform 1 is encoded by transcript variant 1;
                     homeobox protein Meis2; meis1-related protein 1;
                     Cbp/p300-interacting transactivator with Glu/Asp-rich
                     carboxy-terminal domain 2; myeloid ecotropic viral
                     integration site-related gene 1"
                     /codon_start=1
                     /product="homeobox protein Meis2 isoform 1"
                     /protein_id="NP_001129544.1"
                     /db_xref="CCDS:CCDS50666.1"
                     /db_xref="GeneID:17536"
                     /db_xref="MGI:MGI:108564"
                     /translation="MAQRYDELPHYGGMDGVGVPASMYGDPHAPRPIPPVHHLNHGPP
                     LHATQHYGAHAPHPNVMPASMGSAVNDALKRDKDAIYGHPLFPLLALVFEKCELATCT
                     PREPGVAGGDVCSSDSFNEDIAVFAKQVRAEKPLFSSNPELDNLMIQAIQVLRFHLLE
                     LEKVHELCDNFCHRYISCLKGKMPIDLVIDERDGSSKSDHEELSGSSTNLADHNPSSW
                     RDHDDATSTHSAGTPGPSSGGHASQSGDNSSEQGDGLDNSVASPGTGDDDDPDKDKKR
                     QKKRGIFPKVATNIMRAWLFQHLTHPYPSEEQKKQLAQDTGLTILQVNNWFINARRRI
                     VQPMIDQSNRAVSQGAAYSPEGQPMGSFVLDGQQHMGIRPAGPMSGMGMNMGMDGQWH
                     YM"
     exon            258..490
                     /gene="Meis2"
                     /gene_synonym="A430109D20Rik; Mrg1; Stra10"
                     /inference="alignment:Splign:2.1.0"
     exon            491..632
                     /gene="Meis2"
                     /gene_synonym="A430109D20Rik; Mrg1; Stra10"
                     /inference="alignment:Splign:2.1.0"
     exon            633..683
                     /gene="Meis2"
                     /gene_synonym="A430109D20Rik; Mrg1; Stra10"
                     /inference="alignment:Splign:2.1.0"
     exon            684..734
                     /gene="Meis2"
                     /gene_synonym="A430109D20Rik; Mrg1; Stra10"
                     /inference="alignment:Splign:2.1.0"
     exon            735..884
                     /gene="Meis2"
                     /gene_synonym="A430109D20Rik; Mrg1; Stra10"
                     /inference="alignment:Splign:2.1.0"
     exon            885..999
                     /gene="Meis2"
                     /gene_synonym="A430109D20Rik; Mrg1; Stra10"
                     /inference="alignment:Splign:2.1.0"
     exon            1000..1145
                     /gene="Meis2"
                     /gene_synonym="A430109D20Rik; Mrg1; Stra10"
                     /inference="alignment:Splign:2.1.0"
     exon            1146..1222
                     /gene="Meis2"
                     /gene_synonym="A430109D20Rik; Mrg1; Stra10"
                     /inference="alignment:Splign:2.1.0"
     exon            1223..1281
                     /gene="Meis2"
                     /gene_synonym="A430109D20Rik; Mrg1; Stra10"
                     /inference="alignment:Splign:2.1.0"
     exon            1282..1371
                     /gene="Meis2"
                     /gene_synonym="A430109D20Rik; Mrg1; Stra10"
                     /inference="alignment:Splign:2.1.0"
     exon            1372..1466
                     /gene="Meis2"
                     /gene_synonym="A430109D20Rik; Mrg1; Stra10"
                     /inference="alignment:Splign:2.1.0"
     exon            1467..4716
                     /gene="Meis2"
                     /gene_synonym="A430109D20Rik; Mrg1; Stra10"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2887..2892
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Meis2"
                     /gene_synonym="A430109D20Rik; Mrg1; Stra10"
                     /note="hexamer: AATAAA"
     polyA_site      2906
                     /gene="Meis2"
                     /gene_synonym="A430109D20Rik; Mrg1; Stra10"
                     /note="major polyA site"
ORIGIN      
        1 ggaggaggag gaagatcagg aggaggagga agaagaggaa aaaagagaaa aagaagaaat
       61 atcactgaaa aaaattcttc gttttcttga ctgggctttc cccacccccc aaaaaataac
      121 attggaaaat tgggagaagt ctccttggtt tggaaaaaaa ggactcttca acctagctca
      181 ctttcttatc cggactggga tattaaatat acgacacatc caggagttta ttggagcgca
      241 gactgatggc gcaaaggtac gatgagctgc cccattacgg cgggatggac ggagtagggg
      301 ttcccgcttc catgtacgga gaccctcacg cgccgcggcc gatccccccg gttcaccacc
      361 taaaccacgg gccgccgctc cacgccacgc agcactacgg cgcgcacgcc ccgcacccca
      421 atgtcatgcc agccagcatg ggatctgctg tcaacgacgc cttgaaaaga gacaaggacg
      481 caatctatgg gcacccgttg tttcctctgt tagctctggt ttttgagaag tgcgagctgg
      541 cgacctgcac tccccgggaa cccggagtgg ccggcggaga cgtctgttcc tctgactcct
      601 tcaacgagga catcgcggtc ttcgccaagc aggttcgcgc cgaaaagcct cttttttcct
      661 caaacccaga gctggataat ttgatgatac aagcaattca agtactaagg tttcatcttc
      721 tggagttaga aaaggtccac gaactatgtg ataacttctg ccaccggtac attagctgtt
      781 tgaagggaaa aatgcccatt gacctcgtga ttgatgagag agatggaagc tccaagtcag
      841 atcatgaaga actttcaggc tcctccacaa atctcgccga ccacaaccct tcatcctggc
      901 gagaccacga tgacgcaacc tcaacgcact ccgcaggcac cccaggaccc tccagtgggg
      961 gccatgcttc ccagagtgga gacaacagca gtgagcaagg cgatgggtta gacaacagcg
     1021 tagcttcacc tggcacaggt gatgacgacg atccagacaa ggacaaaaaa cgccagaaga
     1081 aaagaggcat attccccaaa gtcgcgacaa atatcatgag agcgtggctc ttccagcatc
     1141 tcacacaccc gtacccttca gaagaacaga agaaacagtt agcgcaagac acgggactga
     1201 caattctgca agtgaacaac tggtttatca atgccagaag aagaatagtg cagcccatga
     1261 ttgaccagtc aaatcgagca gtgagccaag gagcagcgta tagtccagag ggtcagccca
     1321 tggggagctt tgtgttggat ggtcagcaac acatggggat ccggcctgca ggacccatga
     1381 gtggaatggg catgaatatg ggcatggatg ggcagtggca ctatatgtaa ccttcgccat
     1441 gtaaagcaat ctcaaggcaa ggggaagttt gcagagcatg ccaggggact acgtttctca
     1501 gggtggtcca atgggaatgg gtatggccca gccaagttac actcctcccc agatgacccc
     1561 acaccctact cagttaagac atggaccccc aatgcattca tatttgccaa gccatcccca
     1621 ccacccagcc atggtgatgc acggaggacc ccctacccac cctggaatga ctatgtcagc
     1681 acagagcccc acaatgttaa attctgtaga tcccaatgtt ggcggacagg ttatggacat
     1741 tcatgcccaa tagtataagg gaactcaagg aagaaggaaa cacacgcaaa aactatttta
     1801 agactctctg aactttgacc agatgtgaca cttaatatga aactccagac agctgtgatt
     1861 attttttact ttttgtcatt tttcatcaag caacagagga ccaatgggac aagaacacaa
     1921 atgtgaagcg acgggctcat cgagacaatt ttgtccatgc aaagatcctc tggagaaaga
     1981 ctccgagagt tataactact gtagcataaa catagggact aagttaaact tgtacatttc
     2041 tgttgatcac tccgttatgt tgcctcaaat agttttagaa gagaaaaaaa aaatatatcc
     2101 ttgttttcca cactatgtgt gttgttccca aaagaatgac tgtcttggtt catcagtgaa
     2161 ttcactatcc agaagagact gtggtatatt ttaaacctgt tgggccaatg agaaaagaac
     2221 catgctgcgg agcgagatgg acacttgtct gaacctcatc actaactcca gcggctagaa
     2281 tgtgttttca tgcccggcct ttgttccccc cgtccatgtg tcctttagtt tcaaacagat
     2341 ctttatagtt tgtgcttcat aagccaattc ttattatgat tttgggggac tgttcttcaa
     2401 agagcttgcc agtgaagatc tagagacaga gcgaaggctt cttcaagttc tgagccttgg
     2461 ctgtggacaa aacaatctta agttgggcag ctttcctcaa cgcacataca cacacacaca
     2521 cacacaagtt attcatggtc gttgcaccat aagtaggatt ctatcaggaa ctcaaagctt
     2581 gggggataaa aaggagcaag agaatactgt aacaaacttc gtacagagtt cggtctttta
     2641 attgtttcat gttagatatt ctatgtgttt acctcaattg aaaaaaaaaa aaagaatgtt
     2701 tttgctagta tcagatctgc tgtggaattg gtattgtatg tccatggggt cctcttttct
     2761 cagcacgtgt tcctcactag aagaaaatgc tgttaccttt aagctttgtc aaatttacat
     2821 taaaatactt gtatgaggac tgtgacgtta tgttaaaaaa aaaggtgtta agtcacaaaa
     2881 tgcggtaata aatatttcat ttttgatttt ttgttaggct ttggtgtttt ttaatggttt
     2941 gaaggttgca ggaggccagc tcctgggcac tgatgaaagt acctgatggt ctcccaccac
     3001 cccccccccc aaggaagttg agcatattta agatgtaact tagcagcatc tgtagctttt
     3061 cattgtgtgt ttggactctt aggtttcatc aacagaaaac ttccaaaggt atgaaattac
     3121 ttgtgttata tccagcttga gagatcacct tcaaaaggcc cagcctatct tattatagct
     3181 gcatgatgtt tttaaaagca gttgcagatt aaacttttgc ctatgtaccc accagtagaa
     3241 taaagggttt attccatgtt aattttatat cataagaagt tatgtgtgtg ctcaaacatg
     3301 atttatctgt actctatctt actcaaatac tgttgactct gtacattaaa gctcatatat
     3361 gatgtctata gataagtaaa cactttctat ggagttggga attctaagct taaaagagtg
     3421 cttaagcatt aatatttagt acaaataata cagtggtatc tttctaataa ggttgctttc
     3481 tccatgtgca gggatgcaag tatgatagtc tggtgcctca aaaatttttt tttcataaaa
     3541 aaaaagaaaa gaaaaaaaaa agagatactt tgatagcatt ttcaaagctt tacttggtaa
     3601 tctagagcca caagcttgtt gatgttgcag tgtctactaa agtgtgcaaa atgtagccgc
     3661 ttaagatagc tgcacactca aagagtttcc aaataaacac acagctgagg ctttcctaac
     3721 tcctaaatgt tgacgcctcc atctaaaggg gaggataaat aggagatgga gagatgattt
     3781 gatttggtag ggaagagctc actagtcata caaacttcca cttggaagca ctccatagtg
     3841 gcctctcagg caaacccttc cctgtttcct tgttaggcag ccttaatgga agcactacat
     3901 atgaatgagc aaggatataa attgctattg ttttctttta tattgttaag taaaattttt
     3961 ataagtgcat ttatcacttt aattagtgca ctgctcttta aacctagaaa tagcagtgtt
     4021 tgacacaaac acactgatct tgtaaaatac atagagcctc cctccctctc attatccctg
     4081 ttccatgcta catggaatct ttctgtaaaa tttaaatatt tgcatatgtt tgctttaaat
     4141 gctctgatgt aaactctgac aagttcctca tttataaact tactctcata tcagttgaaa
     4201 ggggaaaaat tatattggca gcttttctct cattgctctc cataaggtaa ttgctgaagg
     4261 gtttccttgg tcacaagctc acgtttataa aaagtatttt atggagttat tactccagga
     4321 agggtacagc cagagtggtt gagccttcgt ttgaattcac agactcatcg tgagcttagt
     4381 atcttggcca atctgtatcc tatcatgcta attttaacct tagatatttg gagatgagtg
     4441 ataattgtgg taatatctat gtattttctt accccacccc caccccattc tatgacagag
     4501 ggatgatgaa tttatccagt ttttatagtg ctttttatac cacctcagaa ggcgcttgct
     4561 cctatctcgg gtttactatt tagtataaag agttccgatt tgggtatatt taagaaagac
     4621 tcagctgtca aacgcaaaga aactgggaat ggtgttttga caaccatata gtgttaaagg
     4681 aaatactgta gtctgaataa aattgcttat gttctc
//
