LOCUS       NM_010789               3346 bp    mRNA    linear   ROD 18-MAR-2025
DEFINITION  Mus musculus Meis homeobox 1 (Meis1), transcript variant A, mRNA.
ACCESSION   NM_010789
VERSION     NM_010789.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3346)
  AUTHORS   Thiruppathy,M., Teubner,L., Roberts,R.R., Lasser,M.C.,
            Moscatello,A., Chen,Y.W., Hochstim,C., Ruffins,S., Sarkar,A.,
            Tassey,J., Evseenko,D., Lozito,T.P., Willsey,H.R., Gillis,J.A. and
            Crump,J.G.
  TITLE     Repurposing of a gill gene regulatory program for outer-ear
            evolution
  JOURNAL   Nature (2025) In press
   PUBMED   39788155
  REMARK    Publication Status: Available-Online prior to print
REFERENCE   2  (bases 1 to 3346)
  AUTHORS   Bai,M., Xu,S., Jiang,M., Guo,Y., Hu,D., He,J., Wang,T., Zhang,Y.,
            Guo,Y., Zhang,Y., Huang,S., Jia,Z. and Zhang,A.
  TITLE     Meis1 Targets Protein Tyrosine Phosphatase Receptor J in Fibroblast
            to Retard Chronic Kidney Disease Progression
  JOURNAL   Adv Sci (Weinh) 11 (39), e2309754 (2024)
   PUBMED   39162106
  REMARK    GeneRIF: Meis1 Targets Protein Tyrosine Phosphatase Receptor J in
            Fibroblast to Retard Chronic Kidney Disease Progression.
REFERENCE   3  (bases 1 to 3346)
  AUTHORS   Leu,C.L., Lam,D.D., Salminen,A.V., Wefers,B., Becker,L.,
            Garrett,L., Rozman,J., Wurst,W., Hrabe de Angelis,M., Holter,S.M.,
            Winkelmann,J. and Williams,R.H.
  TITLE     A patient-enriched MEIS1 coding variant causes a restless legs
            syndrome-like phenotype in mice
  JOURNAL   Sleep 47 (5) (2024)
   PUBMED   38314840
  REMARK    GeneRIF: A patient-enriched MEIS1 coding variant causes a restless
            legs syndrome-like phenotype in mice.
REFERENCE   4  (bases 1 to 3346)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   5  (bases 1 to 3346)
  AUTHORS   Langner,E., Cheng,T., Kefaloyianni,E., Gluck,C., Wang,B. and
            Mahjoub,M.R.
  TITLE     Cep120 is essential for kidney stromal progenitor cell growth and
            differentiation
  JOURNAL   EMBO Rep 25 (1), 428-454 (2024)
   PUBMED   38177914
REFERENCE   6  (bases 1 to 3346)
  AUTHORS   Chang,C.P., Jacobs,Y., Nakamura,T., Jenkins,N.A., Copeland,N.G. and
            Cleary,M.L.
  TITLE     Meis proteins are major in vivo DNA binding partners for wild-type
            but not chimeric Pbx proteins
  JOURNAL   Mol Cell Biol 17 (10), 5679-5687 (1997)
   PUBMED   9315626
REFERENCE   7  (bases 1 to 3346)
  AUTHORS   Steelman,S., Moskow,J.J., Muzynski,K., North,C., Druck,T.,
            Montgomery,J.C., Huebner,K., Daar,I.O. and Buchberg,A.M.
  TITLE     Identification of a conserved family of Meis1-related homeobox
            genes
  JOURNAL   Genome Res 7 (2), 142-156 (1997)
   PUBMED   9049632
REFERENCE   8  (bases 1 to 3346)
  AUTHORS   Nakamura,T., Jenkins,N.A. and Copeland,N.G.
  TITLE     Identification of a new family of Pbx-related homeobox genes
  JOURNAL   Oncogene 13 (10), 2235-2242 (1996)
   PUBMED   8950991
REFERENCE   9  (bases 1 to 3346)
  AUTHORS   Nakamura,T., Largaespada,D.A., Shaughnessy,J.D. Jr., Jenkins,N.A.
            and Copeland,N.G.
  TITLE     Cooperative activation of Hoxa and Pbx1-related genes in murine
            myeloid leukaemias
  JOURNAL   Nat Genet 12 (2), 149-153 (1996)
   PUBMED   8563752
REFERENCE   10 (bases 1 to 3346)
  AUTHORS   Moskow,J.J., Bullrich,F., Huebner,K., Daar,I.O. and Buchberg,A.M.
  TITLE     Meis1, a PBX1-related homeobox gene involved in myeloid leukemia in
            BXH-2 mice
  JOURNAL   Mol Cell Biol 15 (10), 5434-5443 (1995)
   PUBMED   7565694
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL603984.7 and AL645570.13.
            
            On Jul 17, 2010 this sequence version replaced NM_010789.2.
            
            Transcript Variant: This variant (A) encodes the longer isoform
            (A).
            
            Sequence Note: This RefSeq record was created from genomic sequence
            data to make the sequence consistent with the reference genome
            assembly. The genomic coordinates used for the transcript record
            were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U33630.1, AB221660.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-749               AL603984.7         199106-199854
            750-976             AL603984.7         201716-201942
            977-1118            AL603984.7         203684-203825
            1119-1169           AL603984.7         204393-204443
            1170-1220           AL603984.7         205215-205265
            1221-1367           AL603984.7         206687-206833
            1368-1479           AL645570.13        182994-183105       c
            1480-1625           AL645570.13        136385-136530       c
            1626-1702           AL645570.13        100415-100491       c
            1703-1761           AL645570.13        80319-80377         c
            1762-1851           AL645570.13        79113-79202         c
            1852-3346           AL645570.13        75154-76648         c
FEATURES             Location/Qualifiers
     source          1..3346
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 11.11 cM"
     gene            1..3346
                     /gene="Meis1"
                     /gene_synonym="C530044H18Rik; Evi8"
                     /note="Meis homeobox 1"
                     /db_xref="GeneID:17268"
                     /db_xref="MGI:MGI:104717"
     exon            1..749
                     /gene="Meis1"
                     /gene_synonym="C530044H18Rik; Evi8"
                     /inference="alignment:Splign:2.1.0"
     CDS             738..2135
                     /gene="Meis1"
                     /gene_synonym="C530044H18Rik; Evi8"
                     /note="isoform A is encoded by transcript variant A;
                     homeobox protein Meis1; myeloid ecotropic viral
                     integration site 1"
                     /codon_start=1
                     /product="homeobox protein Meis1 isoform A"
                     /protein_id="NP_034919.1"
                     /db_xref="CCDS:CCDS24453.1"
                     /db_xref="GeneID:17268"
                     /db_xref="MGI:MGI:104717"
                     /translation="MAQRYDDLPHYGGMDGVGIPSTMYGDPHAARSMQPVHHLNHGPP
                     LHSHQYPHTAHTNAMAPSMGSSVNDALKRDKDAIYGHPLFPLLALIFEKCELATCTPR
                     EPGVAGGDVCSSESFNEDIAVFAKQIRAEKPLFSSNPELDNLMIQAIQVLRFHLLELE
                     KVHELCDNFCHRYISCLKGKMPIDLVIDDREGGSKSDSEDVTRSANLTDQPSWNRDHD
                     DTASTRSGGTPGPSSGGHTSHSGDNSSEQGDGLDNSVASPSTGDDDDPDKDKKRHKKR
                     GIFPKVATNIMRAWLFQHLTHPYPSEEQKKQLAQDTGLTILQVNNWFINARRRIVQPM
                     IDQSNRAVSQGTPYNPDGQPMGGFVMDGQQHMGIRAPGLQSMPGEYVARGGPMGVSMG
                     QPSYTQAQMPPHPAQLRHGPPMHTYIPGHPHHPAVMMHGGQPHPGMPMSASSPSVLNT
                     GDPTMSAQVMDIHAQ"
     exon            750..976
                     /gene="Meis1"
                     /gene_synonym="C530044H18Rik; Evi8"
                     /inference="alignment:Splign:2.1.0"
     exon            977..1118
                     /gene="Meis1"
                     /gene_synonym="C530044H18Rik; Evi8"
                     /inference="alignment:Splign:2.1.0"
     exon            1119..1169
                     /gene="Meis1"
                     /gene_synonym="C530044H18Rik; Evi8"
                     /inference="alignment:Splign:2.1.0"
     exon            1170..1220
                     /gene="Meis1"
                     /gene_synonym="C530044H18Rik; Evi8"
                     /inference="alignment:Splign:2.1.0"
     exon            1221..1367
                     /gene="Meis1"
                     /gene_synonym="C530044H18Rik; Evi8"
                     /inference="alignment:Splign:2.1.0"
     exon            1368..1479
                     /gene="Meis1"
                     /gene_synonym="C530044H18Rik; Evi8"
                     /inference="alignment:Splign:2.1.0"
     exon            1480..1625
                     /gene="Meis1"
                     /gene_synonym="C530044H18Rik; Evi8"
                     /inference="alignment:Splign:2.1.0"
     exon            1626..1702
                     /gene="Meis1"
                     /gene_synonym="C530044H18Rik; Evi8"
                     /inference="alignment:Splign:2.1.0"
     exon            1703..1761
                     /gene="Meis1"
                     /gene_synonym="C530044H18Rik; Evi8"
                     /inference="alignment:Splign:2.1.0"
     exon            1762..1851
                     /gene="Meis1"
                     /gene_synonym="C530044H18Rik; Evi8"
                     /inference="alignment:Splign:2.1.0"
     exon            1852..3346
                     /gene="Meis1"
                     /gene_synonym="C530044H18Rik; Evi8"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3078..3083
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Meis1"
                     /gene_synonym="C530044H18Rik; Evi8"
                     /note="hexamer: AATAAA"
     polyA_site      3106
                     /gene="Meis1"
                     /gene_synonym="C530044H18Rik; Evi8"
                     /note="major polyA site"
ORIGIN      
        1 agcattctgg tcggaatcca cctctccgcc tgtgcaacac acactttaca cacgcacggc
       61 gactgcaagc gggcagcatc gatcgtggct cctttaagac aaactcagac agacattttt
      121 ttaaccctcc tctctaatct cccttcagtg cagcagttgc aaagagggag agagaaagag
      181 aaagagagcg agagaagaga gaaactgatt aggaattagg actgattcaa ggaaagcggg
      241 cgctagggct ttgtgcattt gaatattaac atttgaggtg ttctgaccag aagaagacag
      301 aacggacgat cattcattca ccacgttgac aacctcgcct gtgattgaca gctggagtgg
      361 cagaaagcca tgagatttgg tagttgggtc tgaggggcgc tctttttttt ttttcttttt
      421 cttttctttt ctttcttttt ttttaaactg atttttttgg gggggagaga agatctgctt
      481 tttttttccc ctcccactgc tgtcttggtg gaaccagagc gcttttatgc tcagcgacgc
      541 gggcgccttg cttcaggtcc ggtagaccga agatctggga ccagtaattc acactgctgg
      601 agacgcaaag ggattttttt ttgttattgt tgtgctttat ttttttttcc gggggagttt
      661 gcatatttgt ttcttttcac actggcctta aagaggatat attagaagtt gaagtaggaa
      721 gggagccaga gaggccgatg gcgcaaaggt acgacgacct accccattat gggggtatgg
      781 atggagtagg catcccctcc acgatgtatg gggacccgca tgcagccagg tccatgcaac
      841 cggtccacca cctgaaccac gggcctcctc tgcactcgca tcagtacccg cacacagctc
      901 acaccaacgc catggccccc agcatgggtt cctcggtcaa tgacgcttta aagagagata
      961 aagatgccat ttatggacac cccctcttcc ctctcttagc actgattttt gagaaatgtg
     1021 aattagctac ttgtaccccc cgcgagccgg gggtggcggg cggggacgtc tgctcgtcag
     1081 agtcattcaa tgaagatata gcggtgttcg ccaaacagat tcgcgcagaa aaacctctat
     1141 tctcttctaa tccagaactg gataacttga tgattcaagc catacaagtg ttaaggtttc
     1201 atctgttgga attagagaag gtacacgaat tatgtgacaa tttctgccac cggtatatta
     1261 gctgtttgaa agggaaaatg cctatcgatt tggtgataga tgatagagaa ggaggatcaa
     1321 aatcagacag tgaagatgta acaagatcag caaatctaac tgaccagccc tcttggaata
     1381 gagaccatga tgacacggca tccactcgtt caggaggaac cccgggccct tccagcggtg
     1441 gccatacttc acacagtggg gataacagca gtgagcaagg tgatggcttg gacaacagtg
     1501 tagcttcccc cagcacaggt gacgatgatg accctgataa ggacaaaaag cgtcacaaaa
     1561 agcgtggcat ctttcccaaa gtagccacca atatcatgag ggcgtggctg ttccagcatc
     1621 taacacaccc ttacccttct gaagaacaga aaaagcagtt ggcacaagat acaggactta
     1681 ccatccttca agtgaacaat tggtttatta atgcccggag aagaatagtg cagcccatga
     1741 tagaccagtc caaccgagca gtcagccaag ggacacctta taaccctgat ggacagccaa
     1801 tgggaggttt tgtaatggac ggtcagcagc acatgggcat cagagcgcca gggctgcaaa
     1861 gtatgccagg ggagtatgta gcccggggtg gcccaatggg tgtgagtatg ggacagccga
     1921 gttataccca agcccagatg cccccccatc ctgctcagct gcgtcatggg ccccccatgc
     1981 atacgtacat tcctggacac cctcaccacc ccgcagtgat gatgcatgga ggacagcccc
     2041 accctggaat gccaatgtca gcctcaagcc cctcggttct taacacagga gacccgacaa
     2101 tgagtgcaca agtcatggac attcacgctc agtagcttaa gggaatatgc gttgtctaca
     2161 atggtgactg atctcgaatc aggtcttttc ctgcaaggac tatggagttc cattcttgac
     2221 atctactttg gaccaaggag catccctagt tcttcatagg gactcttaaa atgcaggaga
     2281 accatccgaa gtcaactcgg gggacatgca aaaataacta tataagacat taaaagaaca
     2341 aagagtgaaa tattgtaaat gctattatac tgttatccat attacgttgt ttcttataga
     2401 ttttttaaaa aaaatgtgaa atttttccac actatgtgtg ttgtttccat agctgttcac
     2461 ttcctccaga agcctcctta cattaaaaag ccttacagtt atcctgcaag ggacaggaag
     2521 gtctgatttg caggattttt agagcattaa aataactatc aggcagaaga atctttcttc
     2581 ttgcctagga tttcagccat gtgcgtgcgc tctctctctc tctctctctc tctctctctc
     2641 tctctctctc tctctctctc tctctcttct cctccctctc cctctttcta gcctggggct
     2701 tgaatttgca tgtctaattc atttactcac catatttgaa ttggcctgaa cagatgtaaa
     2761 tcgggaagga tgggaaaaac tgcagtcacc aacaatgatt aatcagctgt tgcaggcagt
     2821 gtcttaagga gactggtagg aggaggcatg gaaacccaaa ggccgtgtgt gtttagaagc
     2881 ctaactgtca catcaagcat catcgtcccc atgcaacaac aaccatcacc ttatacatca
     2941 cttcctgttt tatgcagctc aaaaaacata gactgaagat ttatttttta atatgttgac
     3001 tttgtttctc agcaaagcat tggtcatgtg tgtatttttc catagtccca ccttggagca
     3061 tttatgtaga cattgtaaat aaattttgtg caaaaaggac tggaaagatg aactgtatta
     3121 ttgcatttat tttgtttttt tttttgtgaa agtagcagat tagtgcaagg tggcatgcat
     3181 ataaggttaa ctgagtgggg tacgctaatt atactttttg ttgtggataa aaaatgcttg
     3241 tcaatagcct ttttctatca agaaaacaag gagctaatta ttaataacag tcatggcaca
     3301 ctgtgtccta tcttagcatt taaaagtatg caaactccag gtccag
//
