LOCUS       NM_001370811            2712 bp    mRNA    linear   ROD 09-JUN-2024
DEFINITION  Mus musculus meiosis initiator (Meiosin), transcript variant 1,
            mRNA.
ACCESSION   NM_001370811 XM_006540464
VERSION     NM_001370811.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2712)
  AUTHORS   Shimada,R., Kato,Y., Takeda,N., Fujimura,S., Yasunaga,K.I.,
            Usuki,S., Niwa,H., Araki,K. and Ishiguro,K.I.
  TITLE     STRA8-RB interaction is required for timely entry of meiosis in
            mouse female germ cells
  JOURNAL   Nat Commun 14 (1), 6443 (2023)
   PUBMED   37880249
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2712)
  AUTHORS   Ito,T., Ohta,M., Osada,A., Nishiyama,A., Ishiguro,K.I., Tamura,T.,
            Sekita,Y. and Kimura,T.
  TITLE     Switching defective/sucrose non-fermenting chromatin remodeling
            complex coordinates meiotic gene activation via promoter remodeling
            and Meiosin activation in female germline
  JOURNAL   Genes Cells 28 (1), 15-28 (2023)
   PUBMED   36371617
  REMARK    GeneRIF: Switching defective/sucrose non-fermenting chromatin
            remodeling complex coordinates meiotic gene activation via promoter
            remodeling and Meiosin activation in female germline.
REFERENCE   3  (bases 1 to 2712)
  AUTHORS   Ishiguro,K.I., Matsuura,K., Tani,N., Takeda,N., Usuki,S.,
            Yamane,M., Sugimoto,M., Fujimura,S., Hosokawa,M., Chuma,S.,
            Ko,M.S.H., Araki,K. and Niwa,H.
  TITLE     MEIOSIN Directs the Switch from Mitosis to Meiosis in Mammalian
            Germ Cells
  JOURNAL   Dev Cell 52 (4), 429-445 (2020)
   PUBMED   32032549
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC145199.3.
            
            On Jun 4, 2019 this sequence version replaced XM_006540464.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR10662773.2418473.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849379 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-167               AC145199.3         91518-91684
            168-238             AC145199.3         95381-95451
            239-329             AC145199.3         98090-98180
            330-441             AC145199.3         102817-102928
            442-567             AC145199.3         104016-104141
            568-804             AC145199.3         104862-105098
            805-898             AC145199.3         106079-106172
            899-1005            AC145199.3         106852-106958
            1006-1161           AC145199.3         107400-107555
            1162-1214           AC145199.3         107874-107926
            1215-1678           AC145199.3         108613-109076
            1679-1768           AC145199.3         109695-109784
            1769-2712           AC145199.3         110648-111591
FEATURES             Location/Qualifiers
     source          1..2712
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 9.46 cM"
     gene            1..2712
                     /gene="Meiosin"
                     /gene_synonym="9330180I18; Bhmg1; EG243866; Gm4969"
                     /note="meiosis initiator"
                     /db_xref="GeneID:243866"
                     /db_xref="MGI:MGI:3647482"
     exon            1..167
                     /gene="Meiosin"
                     /gene_synonym="9330180I18; Bhmg1; EG243866; Gm4969"
                     /inference="alignment:Splign:2.1.0"
     CDS             168..1937
                     /gene="Meiosin"
                     /gene_synonym="9330180I18; Bhmg1; EG243866; Gm4969"
                     /note="isoform 1 is encoded by transcript variant 1; basic
                     helix-loop-helix and HMG-box containing 1; basic
                     helix-loop-helix and HMG box domain-containing protein 1;
                     meiosis initiator protein"
                     /codon_start=1
                     /product="meiosis initiator protein isoform 1"
                     /protein_id="NP_001357740.1"
                     /db_xref="GeneID:243866"
                     /db_xref="MGI:MGI:3647482"
                     /translation="MLGSDKFSCFSDQHRARSPSPTDRKDKKNHTNKLRELALLIPVT
                     MKTRDKKYTKKEILLRVLHYIQYLQRNIDMTKALLKLHSSNGKGRFVGPGLNPSAGQT
                     QQQHSTPSSSQKPSLWSTSSKPRKKKFTRVSEHPSWPYNPRRSLALDQAENPNTIHPG
                     LKEENEECATYPGVLSPSTYPTTEPSVSEGDGQGAQLVFLDMAQNIFAYDILSDHAVE
                     VQGGEPNADIKVQRSFFLTRAQPCVSSCRQKLFLCTSSEADKEAPDSDPWLPVWTSED
                     SPNGSPLALGSSQINTWHVADYLNEILGVSSSLFSSPSKILPDHVLEDGTYFLTEGLL
                     ESSPATCEVESPQEKEVSSEGPTGPPNFQSSVSLDHCYLSLSENVKVLSNCGSSSEST
                     DTESLWGQEEVRGVATYPRRTGVFSLAQPSVLQQANPEGLQTSSDEDRDYTWTPTGQS
                     SGLPVASKKIKKVQASQGPVKPKDSRKACPGQVKKKCVNGFIMFCRMNRKQYIRACPG
                     TASTAATKDLAQLWRGMTLEEKKPYCTKARRFSRQNNRIVKQENSSSEDDDGETPKPF
                     YQLLAEKAQVSLGLTSLPTPNCQ"
     exon            168..238
                     /gene="Meiosin"
                     /gene_synonym="9330180I18; Bhmg1; EG243866; Gm4969"
                     /inference="alignment:Splign:2.1.0"
     exon            239..329
                     /gene="Meiosin"
                     /gene_synonym="9330180I18; Bhmg1; EG243866; Gm4969"
                     /inference="alignment:Splign:2.1.0"
     exon            330..441
                     /gene="Meiosin"
                     /gene_synonym="9330180I18; Bhmg1; EG243866; Gm4969"
                     /inference="alignment:Splign:2.1.0"
     exon            442..567
                     /gene="Meiosin"
                     /gene_synonym="9330180I18; Bhmg1; EG243866; Gm4969"
                     /inference="alignment:Splign:2.1.0"
     exon            568..804
                     /gene="Meiosin"
                     /gene_synonym="9330180I18; Bhmg1; EG243866; Gm4969"
                     /inference="alignment:Splign:2.1.0"
     exon            805..898
                     /gene="Meiosin"
                     /gene_synonym="9330180I18; Bhmg1; EG243866; Gm4969"
                     /inference="alignment:Splign:2.1.0"
     exon            899..1005
                     /gene="Meiosin"
                     /gene_synonym="9330180I18; Bhmg1; EG243866; Gm4969"
                     /inference="alignment:Splign:2.1.0"
     exon            1006..1161
                     /gene="Meiosin"
                     /gene_synonym="9330180I18; Bhmg1; EG243866; Gm4969"
                     /inference="alignment:Splign:2.1.0"
     exon            1162..1214
                     /gene="Meiosin"
                     /gene_synonym="9330180I18; Bhmg1; EG243866; Gm4969"
                     /inference="alignment:Splign:2.1.0"
     exon            1215..1678
                     /gene="Meiosin"
                     /gene_synonym="9330180I18; Bhmg1; EG243866; Gm4969"
                     /inference="alignment:Splign:2.1.0"
     exon            1679..1768
                     /gene="Meiosin"
                     /gene_synonym="9330180I18; Bhmg1; EG243866; Gm4969"
                     /inference="alignment:Splign:2.1.0"
     exon            1769..2712
                     /gene="Meiosin"
                     /gene_synonym="9330180I18; Bhmg1; EG243866; Gm4969"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2689..2694
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Meiosin"
                     /gene_synonym="9330180I18; Bhmg1; EG243866; Gm4969"
                     /note="hexamer: AATAAA"
     polyA_site      2712
                     /gene="Meiosin"
                     /gene_synonym="9330180I18; Bhmg1; EG243866; Gm4969"
                     /note="major polyA site"
ORIGIN      
        1 gccattcttc gctcggtctg cgcgtcggga ggcacgcggt ctgcatccct gggaccccgc
       61 gagccgcggg agccgcgcga gccgctgccg gagccttcag actgtcgaag cgtgagccca
      121 gtgccaaagc agaagtcgag gcttaacgcc atattgcaaa tcttgagatg ttgggttcag
      181 acaaattctc atgtttctct gatcagcaca gagctagatc tccaagtcct actgacagga
      241 aggataagaa aaaccacacg aacaagcttc gagagctggc tttgctgatc cctgtgacca
      301 tgaagaccag agacaagaag tacaccaaga aggagatcct gttgcgtgtc ctgcactaca
      361 tccagtacct ccagagaaac attgacatga ccaaggcctt gctcaagctc cacagcagca
      421 atggcaaagg tagatttgtg gggccaggtt tgaacccatc tgctggccag acacagcagc
      481 aacactccac tccctccagc tctcagaagc caagcctttg gagcacctct tcaaaacctc
      541 gaaagaagaa gtttacccga gtgtcagagc atccatcctg gccctataat cctcgacgct
      601 ctctagctct ggaccaggct gaaaatccta acaccataca tccaggccta aaggaagaaa
      661 atgaggaatg tgccacctat ccaggagtcc tcagccctag cacctacccc acaactgaac
      721 catctgtgtc tgaaggcgat ggacaagggg cccagttggt gttcttggac atggctcaga
      781 acatctttgc ctatgacatc ctaagtgatc atgctgtaga agtccagggt ggagagccca
      841 atgctgacat caaggttcag aggtcctttt tcctcaccag ggcacagccc tgtgtcagtt
      901 cttgcaggca gaagctattc ttgtgtactt ccagtgaggc agacaaagaa gccccagact
      961 ctgacccctg gcttcctgtt tggacctccg aggacagccc caatgggagc ccgctggctt
     1021 tggggtcttc ccagatcaat acttggcatg tggcagacta cctgaatgag atcttaggag
     1081 tcagctcttc cctcttcagc tccccaagca aaatcctgcc ggatcatgtc ctagaagatg
     1141 gcacctactt tctgactgaa ggtctcttgg agtcttcacc tgctacctgt gaagtggaga
     1201 gcccacaaga gaaggaagta tcctctgaag gccccacagg cccacctaac ttccagtcct
     1261 ctgtctcact ggaccactgc tacctgtcgc tgagtgagaa tgtcaaggtg ctgtctaact
     1321 gtggctccag ctcagagtcc acagacacag agtctctgtg gggacaggag gaggtgagag
     1381 gggtggccac ctacccaagg aggacagggg tcttctccct tgctcagcct tctgtcctgc
     1441 agcaggccaa ccctgaggga ttacagacct caagtgatga ggacagagac tacacatgga
     1501 cacctactgg ccagtcttct ggcctgccag tagccagcaa gaagatcaag aaggtccagg
     1561 caagccaggg ccccgtgaag cccaaagaca gcagaaaagc ctgccctggc caggtgaaga
     1621 aaaagtgtgt taatggcttc atcatgttct gcaggatgaa ccggaagcag tacatccgag
     1681 cctgtcctgg aactgcatcc acagctgcca ccaaggatct ggctcaactg tggcgaggga
     1741 tgactctgga ggaaaagaaa ccatactgca ctaaggcacg caggttcagc cgccagaaca
     1801 accgcattgt gaagcaggag aactccagca gtgaggacga cgatggggag acccccaagc
     1861 ccttctacca gctattagct gagaaggccc aagtgtcttt gggcctcacc tcactgccca
     1921 cccctaactg ccagtgagag gggcagtcct gctgggctct gccacctgct tagcatccag
     1981 gtcctctaac atttgtttcc cctgaacctc agacccactg ctgtgggtcc cctgcccagt
     2041 gccccagctt cagcaccaga gaggaaatgt atttactgat ccaaggcttt gtgttctgcc
     2101 ttgcacacag ccccgccctc tagcttgtcc tacatctgtt cttataggat gggcgcccta
     2161 gatgaaatgc agagcttccc tctgccccca gaaccacatg gtttcagccc caatctcact
     2221 gcatcctccc ctgttctatg tagaatgaaa ctcttttacc aacaggggga gaaggaatgt
     2281 tatgtccagg atctcttggc catgggtggg ctttccacgt atcaattcca taagcatttt
     2341 gcttctatac tttgacaccc gcccccgccc cccccccccc caagcctata ggtctgaact
     2401 caaacccttt acctcagaaa tccagtctta ggatgtagtt acccatgttt ataattccaa
     2461 cattcaggaa gctgaggcag aaagatggga tctgagacca gcctgggcta tataaaacat
     2521 gatccccatc tcacaaccca aacaagaaaa caagccacag cctctggctg ggctttgtcc
     2581 ccagttctct cttgggtggg ttgtctggca ggtaaccctt accctcaata gctctgttgt
     2641 ctgtttactt gactttaatt gaaatggagg cataacatat cctagaaaaa taaagattta
     2701 caatacaaac ta
//
