LOCUS       NM_001127576            4577 bp    mRNA    linear   ROD 21-AUG-2024
DEFINITION  Mus musculus meiosis specific with coiled-coil domain (Meioc),
            mRNA.
ACCESSION   NM_001127576 XM_001479295 XM_196054 XM_909116
VERSION     NM_001127576.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4577)
  AUTHORS   Pfaltzgraff,N.G., Liu,B., de Rooij,D.G., Page,D.C. and Mikedis,M.M.
  TITLE     Destabilization of mRNAs enhances competence to initiate meiosis in
            mouse spermatogenic cells
  JOURNAL   Development 151 (14) (2024)
   PUBMED   38884383
REFERENCE   2  (bases 1 to 4577)
  AUTHORS   Liu,H., Zhou,R., Li,S., Dong,J., Fang,Y., Luo,Y., Su,H., Lai,B.,
            Liang,L., Zhang,D., Zhang,Y., Shyy,J.Y., Zhou,B., Yuan,Z. and
            Wang,Y.
  TITLE     Epigenetic repression of Cend1 by lysine-specific demethylase 1 is
            essential for murine heart development
  JOURNAL   iScience 27 (1), 108722 (2023)
   PUBMED   38226173
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4577)
  AUTHORS   Qian,B., Li,Y., Yan,R., Han,S., Bu,Z., Gong,J., Zheng,B., Yuan,Z.,
            Ren,S., He,Q., Zhang,J., Xu,C., Wang,R., Sun,Z., Lin,M., Zhou,J.
            and Ye,L.
  TITLE     RNA binding protein RBM46 regulates mitotic-to-meiotic transition
            in spermatogenesis
  JOURNAL   Sci Adv 8 (34), eabq2945 (2022)
   PUBMED   36001654
REFERENCE   4  (bases 1 to 4577)
  AUTHORS   Li,L., Krasnykov,K., Homolka,D., Gos,P., Mendel,M., Fish,R.J.,
            Pandey,R.R. and Pillai,R.S.
  TITLE     The XRN1-regulated RNA helicase activity of YTHDC2 ensures mouse
            fertility independently of m6A recognition
  JOURNAL   Mol Cell 82 (9), 1678-1690 (2022)
   PUBMED   35305312
REFERENCE   5  (bases 1 to 4577)
  AUTHORS   Dahlet,T., Truss,M., Frede,U., Al Adhami,H., Bardet,A.F., Dumas,M.,
            Vallet,J., Chicher,J., Hammann,P., Kottnik,S., Hansen,P., Luz,U.,
            Alvarez,G., Auclair,G., Hecht,J., Robinson,P.N., Hagemeier,C. and
            Weber,M.
  TITLE     E2F6 initiates stable epigenetic silencing of germline genes during
            embryonic development
  JOURNAL   Nat Commun 12 (1), 3582 (2021)
   PUBMED   34117224
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4577)
  AUTHORS   Xia,X., Zhou,X., Quan,Y., Hu,Y., Xing,F., Li,Z., Xu,B., Xu,C. and
            Zhang,A.
  TITLE     Germline deletion of Cdyl causes teratozoospermia and progressive
            infertility in male mice
  JOURNAL   Cell Death Dis 10 (3), 229 (2019)
   PUBMED   30850578
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 4577)
  AUTHORS   Bailey,A.S., Batista,P.J., Gold,R.S., Chen,Y.G., de Rooij,D.G.,
            Chang,H.Y. and Fuller,M.T.
  TITLE     The conserved RNA helicase YTHDC2 regulates the transition from
            proliferation to differentiation in the germline
  JOURNAL   Elife 6, e26116 (2017)
   PUBMED   29087293
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 4577)
  AUTHORS   Wojtas,M.N., Pandey,R.R., Mendel,M., Homolka,D., Sachidanandam,R.
            and Pillai,R.S.
  TITLE     Regulation of m6A Transcripts by the 3'-->5' RNA Helicase YTHDC2 Is
            Essential for a Successful Meiotic Program in the Mammalian
            Germline
  JOURNAL   Mol Cell 68 (2), 374-387 (2017)
   PUBMED   29033321
REFERENCE   9  (bases 1 to 4577)
  AUTHORS   Soh,Y.Q.S., Mikedis,M.M., Kojima,M., Godfrey,A.K., de Rooij,D.G.
            and Page,D.C.
  TITLE     Meioc maintains an extended meiotic prophase I in mice
  JOURNAL   PLoS Genet 13 (4), e1006704 (2017)
   PUBMED   28380054
  REMARK    GeneRIF: We conclude that when the meiotic chromosomal program is
            initiated, Meioc is simultaneously induced so as to extend meiotic
            prophase. Specifically, MEIOC, together with YTHDC2, promotes a
            meiotic (as opposed to mitotic) cell cycle program via
            post-transcriptional control of their target transcripts.
            Publication Status: Online-Only
REFERENCE   10 (bases 1 to 4577)
  AUTHORS   Abby,E., Tourpin,S., Ribeiro,J., Daniel,K., Messiaen,S., Moison,D.,
            Guerquin,J., Gaillard,J.C., Armengaud,J., Langa,F., Toth,A.,
            Martini,E. and Livera,G.
  TITLE     Implementation of meiosis prophase I programme requires a conserved
            retinoid-independent stabilizer of meiotic transcripts
  JOURNAL   Nat Commun 7, 10324 (2016)
   PUBMED   26742488
  REMARK    GeneRIF: Meioc invalidation in mice induces early and pleiotropic
            meiotic defects in males and females. MEIOC prevents meiotic
            transcript degradation and interacts with an RNA helicase that
            binds numerous meiotic mRNAs.
            Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK163979.1, BB610289.1, AL672269.15, AK131737.1, CJ046726.1 and
            BG083749.2.
            
            On Jun 1, 2013 this sequence version replaced NM_001127576.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN00849384,
                              SAMN01164137 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            RefSeq Select criteria    :: based on conservation, expression,
                                         longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-496               AK163979.1         2-497
            497-716             BB610289.1         295-514
            717-717             AL672269.15        98904-98904
            718-1929            AK131737.1         516-1727
            1930-2239           AL672269.15        100117-100426
            2240-2666           CJ046726.1         1-427
            2667-2996           BG083749.2         97-426
            2997-4577           AL672269.15        105466-107046
FEATURES             Location/Qualifiers
     source          1..4577
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 66.48 cM"
     gene            1..4577
                     /gene="Meioc"
                     /gene_synonym="Gm1564; Gm663"
                     /note="meiosis specific with coiled-coil domain"
                     /db_xref="GeneID:268491"
                     /db_xref="MGI:MGI:2686410"
     exon            1..246
                     /gene="Meioc"
                     /gene_synonym="Gm1564; Gm663"
                     /inference="alignment:Splign:2.1.0"
     CDS             181..3078
                     /gene="Meioc"
                     /gene_synonym="Gm1564; Gm663"
                     /note="meiosis-specific with coiled-coil domain protein"
                     /codon_start=1
                     /product="meiosis-specific coiled-coil domain-containing
                     protein MEIOC"
                     /protein_id="NP_001121048.1"
                     /db_xref="CCDS:CCDS48945.1"
                     /db_xref="GeneID:268491"
                     /db_xref="MGI:MGI:2686410"
                     /translation="MEVSGGDTCRPRHPQGLREGPEPKVAAAAAAFRGSANRCWNLSV
                     DTSNRLSDVFNSMMLTGSAPFYDCYKSQNEDNVDLRQTCTPLSSSTEYASSIDSSLFY
                     APWSTYGDDIKQPPSSQISVKNRIQTERNDYGSETDLYGLVSNILEEQDKSQPYFAEG
                     TCSSNLKSVWPMNTSRFVDHHDLLTEPKRPVDTSISQQAFYSGESVSAVEKQYLHNSS
                     LTPQQKIDELYHGYTGLDLEEQWLYLSRSDHSNCYNSQANDTVKATFQEYPFVKNCFT
                     PQTGLSDIMKESGIDTYAYGREKICTKGLETPLQHKRAEIFLSQFNRYNENADYCRYP
                     EYAHPNKAKLNKCSNFSVQDGKKLANGTPETPTVEADAYTKLFQVKPANQKKMEETIP
                     DQQNFAFPKTTPHLTEKQFAKEAAFTADFGLKSEYGLKPHTACPTNNDFANVSEKQQF
                     AKPDPLNSEYFKSVNLFSNSATSSGGISLNRPTWMNVQTKNNLPIPYRNQGNLMKLNS
                     HLSAASKGSNHSSDFPQLSSTNLTSNSNLFQKYCQENPSAFSSFDFSYNGAERIQSVN
                     HMEGLTKTGEDNLFESVTEKKIKQPNGFCDSYSASQYGIIENVNKHNFQAKPQSGHYD
                     PEDIPKHFDGLPQNTYQDLLESQGHFNSHRQGSGDNNINSRVNRTQASCFSNNYMMGD
                     LRHNQGFQQLGSNGFPLRSTHPFGHSVVPLLDSYDLFSYDDLSHLYPYFNDMMYGDNS
                     FSGFVPTFGFQRPIKTRSGPASELHIRLEECYEQWRALEKERKKTELALAKNYPGKKV
                     SSTNNTPIPRLTSNPSRVDRLIVDELREQARVVTLLGKMERLRSSPLHANISTALDRH
                     LESIHIVQSRRKDEIVNASNRQRQGVPRCQDDRDVFALATAIKEMCVATRKARTTLWC
                     ALQMTLPKTASTAGQADMEKAFQDLVNCEEKVHESINSSNPMNQRGETSKH"
     exon            247..396
                     /gene="Meioc"
                     /gene_synonym="Gm1564; Gm663"
                     /inference="alignment:Splign:2.1.0"
     exon            397..554
                     /gene="Meioc"
                     /gene_synonym="Gm1564; Gm663"
                     /inference="alignment:Splign:2.1.0"
     exon            555..659
                     /gene="Meioc"
                     /gene_synonym="Gm1564; Gm663"
                     /inference="alignment:Splign:2.1.0"
     exon            660..2532
                     /gene="Meioc"
                     /gene_synonym="Gm1564; Gm663"
                     /inference="alignment:Splign:2.1.0"
     exon            2533..2667
                     /gene="Meioc"
                     /gene_synonym="Gm1564; Gm663"
                     /inference="alignment:Splign:2.1.0"
     exon            2668..2848
                     /gene="Meioc"
                     /gene_synonym="Gm1564; Gm663"
                     /inference="alignment:Splign:2.1.0"
     exon            2849..4577
                     /gene="Meioc"
                     /gene_synonym="Gm1564; Gm663"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctcttcgtcg caccgtctcg gctcggcccc ccacccacag agcggctcct ggcagcgccg
       61 acggcggctg cggcagcggt agcggtgggg tgcgggctga gggagctggg cctcgacgtc
      121 ctccctcacc cccgtacccc gggagctgtt aactagctca ggaggagctg gggggccccc
      181 atggaggtga gcggcggaga cacctgccgg ccccgtcacc cccaaggcct gagggaggga
      241 cctgagccga aggtggcggc ggccgcggcg gcgttccgtg gaagcgcgaa tcggtgctgg
      301 aacctcagcg tcgacaccag caatagatta tccgacgtct tcaacagcat gatgctgacc
      361 ggctcggcgc ccttctatga ttgctacaag tctcagaacg aagacaatgt agacctaagg
      421 cagacctgca ctccactctc ctcatcaaca gagtatgcaa gttctataga ctcctcactc
      481 ttctatgcac catggtctac ttacggagac gatattaaac aacctcccag ttctcagatc
      541 agtgtaaaga acaggattca gaccgaaaga aatgactatg gcagtgaaac agacttatat
      601 ggactcgtgt ctaacatttt ggaagaacag gataagtcgc agccatattt tgctgaaggg
      661 acctgctcct ccaacttaaa gtcagtttgg ccaatgaaca caagcagatt tgtagatcac
      721 catgacctct taacagaacc caaaaggcca gtagatacat ctatctctca gcaagcgttt
      781 tatagtggtg aatctgtgtc agcagtggaa aagcaatact tgcataatag ttctctcaca
      841 ccacagcaaa aaatagatga gctttatcat ggttatactg gtttagacct tgaagaacaa
      901 tggctgtacc tttcaagaag tgatcattct aactgttaca atagtcaggc taatgataca
      961 gttaaggcaa ctttccaaga atatccattt gtcaaaaact gttttacacc acagactggc
     1021 ctgtctgata tcatgaaaga atcaggaatt gatacttatg cctatggaag agagaaaata
     1081 tgtactaaag gtcttgaaac accattacag cataaaaggg cagagatatt tctttcccaa
     1141 tttaatagat ataatgaaaa tgcagattat tgtagatatc cagaatatgc tcatcctaat
     1201 aaggcaaagc ttaacaaatg ttcaaatttt agtgtccaag atggtaaaaa gttagccaat
     1261 ggcacacctg agacaccaac tgtggaagca gatgcctata cgaagttatt tcaagttaaa
     1321 ccagcaaatc agaaaaaaat ggaggagaca atacctgacc agcagaattt tgcatttcca
     1381 aaaacaacac cacatctgac agaaaaacag tttgcaaagg aagcagcatt cactgctgat
     1441 tttggcttaa aatcagaata tggactaaag cctcacacag cttgtccaac taataatgat
     1501 tttgctaatg tctctgaaaa gcaacagttt gctaagcctg accccctaaa ctctgaatat
     1561 tttaaatcag tgaatttatt ctcaaattca gcaacatctt caggaggtat cagtttaaac
     1621 agaccaactt ggatgaatgt tcaaacaaaa aataaccttc ctattcctta tcgaaatcaa
     1681 ggtaacttga tgaaattgaa tagtcattta agtgcagctt caaaaggttc taaccactct
     1741 tcagattttc cccaactttc atctacaaat ttaacttcaa atagcaactt atttcagaag
     1801 tattgccaag aaaacccttc agcattttct agttttgatt ttagttacaa cggtgcagaa
     1861 agaattcagt ctgtgaatca catggaagga ctaacaaaaa ccggagaaga caatctcttt
     1921 gaatcagtta cagagaaaaa aataaagcag ccaaatggat tttgtgatag ctattcagct
     1981 tcacagtatg ggataataga aaatgtaaac aaacataatt ttcaagccaa gccccagagt
     2041 ggacattatg atcctgagga cattccaaag cattttgatg gcttacctca aaatacatat
     2101 caagatctgt tagagtcaca gggtcatttt aatagccaca gacaaggaag tggagacaac
     2161 aatattaata gccgtgtgaa tcgcacacag gcctcatgct tttctaataa ttatatgatg
     2221 ggagatttac gacataatca gggttttcaa caacttggtt caaatgggtt tcccctaaga
     2281 tctacccacc catttggcca ttcagttgtt ccactgttgg attcctatga tttgttttct
     2341 tatgatgact taagccattt atatccttat tttaatgaca tgatgtatgg tgataattcc
     2401 ttttctggtt ttgtgccaac ttttggattt caaagaccaa ttaaaacccg tagtggacca
     2461 gctagtgagc ttcatattcg tctagaagag tgctatgaac aatggcgagc attggaaaag
     2521 gagagaaaaa agactgaatt agcccttgcc aagaattatc caggaaaaaa agtatccagt
     2581 actaataata ctccaattcc aagactgact tccaacccat ctagagttga tcggttaatt
     2641 gtggatgaac ttcgagaaca agccagagtt gtgactttac tgggcaaaat ggaacgtctt
     2701 cgaagctctc cccttcatgc taatatctct actgctcttg atagacactt ggagtcaatt
     2761 cacattgtac agtcacgtag aaaggatgaa attgttaatg cttcaaatcg gcaaagacaa
     2821 ggagtgccta ggtgccaaga tgacagagat gtgtttgccc ttgctacagc aattaaagag
     2881 atgtgtgtag ctactcgaaa agcacgcact accctatggt gtgcactgca gatgaccttg
     2941 cccaaaacag caagtacagc gggccaagct gacatggaaa aggctttcca agatctagta
     3001 aactgtgaag agaaagtcca tgaaagcata aatagtagca atccaatgaa ccagagaggt
     3061 gaaacaagta aacattaagg aaatgccagc agaaggaaga gtttaaaagc tgttaagtaa
     3121 atgtatcaag atgtgctaaa atttttaatg aacttgtcaa actttcagtc cattaatttt
     3181 ctttcagatt taaagttaat acttcaatga agtctaactt ctatttaaaa atctgcttgg
     3241 aatgaatcag atacagttta aagggaactc aaaggtaaag ttgattattc taggagttct
     3301 gagtagtcac aaagatagca agtttatttt ataaaatatc cccttacagc taaaaattgc
     3361 ttaaatccat tcttcagtgc aggtaaatgc aaatgtgaaa ttcttctagg agataagttt
     3421 catttagttc tgccttagta agtgtaattc caaataatga gtctaagtga ctgtaaccca
     3481 attatggcta cagtttagta accaagacaa gttttgattg tgatttaaaa gtattttcct
     3541 tacaaaactg gataatacct aggaaacaaa ggaaaacagg gataataaac ccaatattca
     3601 tgtaaaaatt taatatttaa aatactacca tatttataaa tttgaaatct tggtgcctaa
     3661 gtctatggag ggaaatgcat ctgcttctcc taaattagtg atgaaagtgc cagtgggaac
     3721 catgcgagtt gctggatata aagcctgttc aaatcattag tatatagtcc ttaaatttta
     3781 attatactat caattattaa atatttccaa ttttaaggta tttaaattga atcaaaataa
     3841 aacattcctt tatctggatc ttatagactt gatgcctagt aactaaaata atgactcttg
     3901 ttttaatacc cttagtttgc tgtcttaaat gagggtatca cgaagttcta aaatgtattt
     3961 ttaggttaat ctttaactag tttagtttct caattagtta gtgtatattt tgtgtagtta
     4021 tgttcatttt ttttgcttct gtattttttt taaaagagca cttgaaagct tggctttttc
     4081 tgttttcatc acttagtatc tttgtattag aacctgaata atccattaat atgaaatgtt
     4141 ggtattatgt gactcagaag atcttgggtt ttaaagtttc tagcatgagt taaactataa
     4201 tataatgtac tgatgaaatt taattgaaat atccttgact agaaacactg atgtttttga
     4261 tgttagtgtt ttttttctta gctttagaaa tcctggtatt aaaaagagtg taatcacacc
     4321 acataaattt cctttagatg atgtgcgggg aaactgattg ggagtgcagg agtgactgta
     4381 ggagggacgc tctgatcact gataagcttt agaactgtca aatgaatcac actgagggca
     4441 gtcacataag atagcccacc ccaccacagt cactgcatgc aaagtggtta agtttgacat
     4501 aaaacatgtt gaatgttatg aaaacaaata ttgtactgaa tttagtctct caggaaaaaa
     4561 taaattactt tgttgga
//
