LOCUS       NM_029105               1433 bp    mRNA    linear   ROD 07-FEB-2024
DEFINITION  Mus musculus meiotic kinetochore factor (Meikin), mRNA.
ACCESSION   NM_029105 XM_484022 XM_911406
VERSION     NM_029105.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1433)
  AUTHORS   Maier,N.K., Ma,J., Lampson,M.A. and Cheeseman,I.M.
  TITLE     Separase cleaves the kinetochore protein Meikin at the meiosis I/II
            transition
  JOURNAL   Dev Cell 56 (15), 2192-2206 (2021)
   PUBMED   34331869
  REMARK    GeneRIF: Separase cleaves the kinetochore protein Meikin at the
            meiosis I/II transition.
REFERENCE   2  (bases 1 to 1433)
  AUTHORS   Horisawa-Takada,Y., Kodera,C., Takemoto,K., Sakashita,A.,
            Horisawa,K., Maeda,R., Shimada,R., Usuki,S., Fujimura,S., Tani,N.,
            Matsuura,K., Akiyama,T., Suzuki,A., Niwa,H., Tachibana,M., Ohba,T.,
            Katabuchi,H., Namekawa,S.H., Araki,K. and Ishiguro,K.I.
  TITLE     Meiosis-specific ZFP541 repressor complex promotes developmental
            progression of meiotic prophase towards completion during mouse
            spermatogenesis
  JOURNAL   Nat Commun 12 (1), 3184 (2021)
   PUBMED   34075040
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1433)
  AUTHORS   Ishiguro,K.I., Matsuura,K., Tani,N., Takeda,N., Usuki,S.,
            Yamane,M., Sugimoto,M., Fujimura,S., Hosokawa,M., Chuma,S.,
            Ko,M.S.H., Araki,K. and Niwa,H.
  TITLE     MEIOSIN Directs the Switch from Mitosis to Meiosis in Mammalian
            Germ Cells
  JOURNAL   Dev Cell 52 (4), 429-445 (2020)
   PUBMED   32032549
REFERENCE   4  (bases 1 to 1433)
  AUTHORS   Kim,J., Ishiguro,K., Nambu,A., Akiyoshi,B., Yokobayashi,S.,
            Kagami,A., Ishiguro,T., Pendas,A.M., Takeda,N., Sakakibara,Y.,
            Kitajima,T.S., Tanno,Y., Sakuno,T. and Watanabe,Y.
  TITLE     Meikin is a conserved regulator of meiosis-I-specific kinetochore
            function
  JOURNAL   Nature 517 (7535), 466-471 (2015)
   PUBMED   25533956
  REMARK    GeneRIF: integrative analysis indicates that the long-awaited key
            regulator of meiotic kinetochore function is Meikin, which is
            conserved from yeasts to humans
            Erratum:[Nature. 2018 Nov;563(7731):E23. PMID: 30275477]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK015073.1 and AB987828.1.
            
            [WARNING] On May 8, 2024 this sequence was replaced by NM_029105.3.
            
            On Jan 13, 2015 this sequence version replaced NM_029105.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK015073.1, AB987828.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849384 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-17                AK015073.1         2-18
            18-1322             AB987828.1         1-1305
            1323-1433           AK015073.1         1325-1435
FEATURES             Location/Qualifiers
     source          1..1433
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 32.13 cM"
     gene            1..1433
                     /gene="Meikin"
                     /gene_synonym="4930404A10Rik"
                     /note="meiotic kinetochore factor"
                     /db_xref="GeneID:74847"
                     /db_xref="MGI:MGI:1922097"
     exon            1..141
                     /gene="Meikin"
                     /gene_synonym="4930404A10Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             18..1322
                     /gene="Meikin"
                     /gene_synonym="4930404A10Rik"
                     /codon_start=1
                     /product="meiosis-specific kinetochore protein"
                     /protein_id="NP_083381.1"
                     /db_xref="CCDS:CCDS48798.1"
                     /db_xref="GeneID:74847"
                     /db_xref="MGI:MGI:1922097"
                     /translation="MDKIWHMGPRGDYTRKKRAGERLNLTPKPDLALPGRTEALPGLK
                     GKGKEQGLRKITEKKELSRLTGSSSQRPSLLSVTGGEHLQENSPGQETPEEKTPPCET
                     VTDTFEMDSLLSSTELVSGPAEQDDFSSCLPSCSNAELHTESTDERGSSFPSPELFRG
                     SDCLDWEHPKLEDYMFYKNSTLLDTSKAVVIEKAPQFANLSAVLSSSSKNYEKRHRKI
                     GMTLAAQHLSPEPKYASNLASVVDNAASEVVFAEKTGPPTTEKTQKKPENESEDSGPL
                     VQTKLSSGHPDNKALCSPLSSALESTAVRYTLLPQPLEPVLKKGCILPDKQSKALLTS
                     TPSSDIAEFVIDLSPVQNVSFEELFPNVSNYVNSSEVVPVSSLQESSSNEFSPNTSEI
                     CCIIRSSPGTRQMRRKDPAVKNRCSPPKDVPLDIIMKTNGRT"
     exon            142..235
                     /gene="Meikin"
                     /gene_synonym="4930404A10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            236..317
                     /gene="Meikin"
                     /gene_synonym="4930404A10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            318..378
                     /gene="Meikin"
                     /gene_synonym="4930404A10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            379..510
                     /gene="Meikin"
                     /gene_synonym="4930404A10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            511..630
                     /gene="Meikin"
                     /gene_synonym="4930404A10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            631..670
                     /gene="Meikin"
                     /gene_synonym="4930404A10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            671..735
                     /gene="Meikin"
                     /gene_synonym="4930404A10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            736..812
                     /gene="Meikin"
                     /gene_synonym="4930404A10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            813..968
                     /gene="Meikin"
                     /gene_synonym="4930404A10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            969..1049
                     /gene="Meikin"
                     /gene_synonym="4930404A10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1050..1169
                     /gene="Meikin"
                     /gene_synonym="4930404A10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1170..1290
                     /gene="Meikin"
                     /gene_synonym="4930404A10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1291..1433
                     /gene="Meikin"
                     /gene_synonym="4930404A10Rik"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 attacctcgg gaaggcaatg gacaagatat ggcatatggg gcccagaggg gactataccc
       61 gcaagaagag ggctggtgaa aggctcaacc tcaccccgaa gccagacctg gccctccctg
      121 ggaggacaga ggccctgcca ggtctgaagg gaaagggcaa agagcaggga ttgcggaaaa
      181 ttactgagaa gaaggaattg agcagactca caggtagcag ctcacagcgg ccaagtctgt
      241 taagtgttac aggaggggaa cacctgcaag aaaatagccc tggccaagag accccagagg
      301 aaaagacacc accatgtgaa acagtgactg atacctttga gatggacagc ttgttgtcga
      361 gtactgagct agtttcagga ccagccgagc aggatgactt ttccagctgt ctcccgagtt
      421 gttcaaatgc agagttacat acagagagca ccgatgagag aggaagtagc ttcccatcgc
      481 cagaactgtt cagagggtca gactgcctgg attgggagca tcccaagttg gaagattaca
      541 tgttctacaa gaattctact cttttagaca ccagtaaagc agtagttata gagaaagcgc
      601 cacagtttgc aaacctctct gcagttctga gttcctcttc aaaaaactat gagaaacgcc
      661 atagaaaaat agggatgaca ttagcagccc aacatctttc tccagaacca aagtatgctt
      721 caaatttagc atcagttgta gataatgcag cttctgaggt tgtatttgct gagaaaactg
      781 gccctccaac cactgaaaaa acacagaaaa agcctgaaaa tgaatctgaa gatagtggtc
      841 cgctcgttca aacaaagttg agctccggtc atccagacaa caaggctctg tgctcccctc
      901 taagttcagc tcttgaaagc actgcagtca ggtatactct gctgcctcag cccctggaac
      961 ctgtgctgaa aaaaggttgt attcttcctg ataaacaaag caaagccctg ctaacaagta
     1021 ccccatcttc agacatagct gagtttgtga ttgatttgtc tccagtgcaa aatgtgtctt
     1081 ttgaagaact atttccaaat gtcagcaatt atgttaactc aagtgaagtt gttcctgtgt
     1141 caagtttgca agaaagttca tcaaatgagt tttctccaaa cacatcagag atctgttgta
     1201 ttattaggtc atcaccagga accagacaga tgagaaggaa agaccctgct gtgaaaaaca
     1261 gatgttctcc tcctaaagat gttcctctag atattataat gaagacaaat ggcagaacat
     1321 aacatctgtg actgaatttt cactgctttg aagatgtgaa tgtaaatatg aaatccatag
     1381 aagcagaatg tctgcctgaa attatataaa attaaaattc tcttattgtt tgc
//
