LOCUS       NM_001355207             607 bp    mRNA    linear   ROD 05-JUN-2024
DEFINITION  Mus musculus meiosis expressed gene 1 (Meig1), transcript variant
            3, mRNA.
ACCESSION   NM_001355207 XM_006497307
VERSION     NM_001355207.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 607)
  AUTHORS   Yap,Y.T., Shi,L., Zhang,D., Huang,Q., Siddika,F., Wang,Z., Li,W.
            and Zhang,Z.
  TITLE     MEIG1 determines the manchette localization of IFT20 and IFT88, two
            intraflagellar transport components in male germ cells
  JOURNAL   Dev Biol 485, 50-60 (2022)
   PUBMED   35257720
  REMARK    GeneRIF: MEIG1 determines the manchette localization of IFT20 and
            IFT88, two intraflagellar transport components in male germ cells.
REFERENCE   2  (bases 1 to 607)
  AUTHORS   Li,W., Huang,Q., Zhang,L., Liu,H., Zhang,D., Yuan,S., Yap,Y.,
            Qu,W., Shiang,R., Song,S., Hess,R.A. and Zhang,Z.
  TITLE     A single amino acid mutation in the mouse MEIG1 protein disrupts a
            cargo transport system necessary for sperm formation
  JOURNAL   J Biol Chem 297 (5), 101312 (2021)
   PUBMED   34673028
  REMARK    GeneRIF: A single amino acid mutation in the mouse MEIG1 protein
            disrupts a cargo transport system necessary for sperm formation.
REFERENCE   3  (bases 1 to 607)
  AUTHORS   Manti,M., Pui,H.P., Edstrom,S., Risal,S., Lu,H., Lindgren,E.,
            Ohlsson,C., Jerlhag,E., Benrick,A., Deng,Q. and Stener-Victorin,E.
  TITLE     Excess of ovarian nerve growth factor impairs embryonic development
            and causes reproductive and metabolic dysfunction in adult female
            mice
  JOURNAL   FASEB J 34 (11), 14440-14457 (2020)
   PUBMED   32892421
REFERENCE   4  (bases 1 to 607)
  AUTHORS   Li,W., Miner,A.S., Zhang,L., Ratz,P.H. and Zhang,Z.
  TITLE     Mouse meiosis expressed gene 1 is not phosphorylated in vivo
  JOURNAL   Mol Reprod Dev 85 (4), 288-289 (2018)
   PUBMED   29393537
  REMARK    GeneRIF: Mouse meiosis expressed gene 1 is not phosphorylated in
            vivo.
REFERENCE   5  (bases 1 to 607)
  AUTHORS   Stauber,M., Weidemann,M., Dittrich-Breiholz,O., Lobschat,K.,
            Alten,L., Mai,M., Beckers,A., Kracht,M. and Gossler,A.
  TITLE     Identification of FOXJ1 effectors during ciliogenesis in the foetal
            respiratory epithelium and embryonic left-right organiser of the
            mouse
  JOURNAL   Dev Biol 423 (2), 170-188 (2017)
   PUBMED   27914912
REFERENCE   6  (bases 1 to 607)
  AUTHORS   Miyoshi,N., Wagatsuma,H., Wakana,S., Shiroishi,T., Nomura,M.,
            Aisaka,K., Kohda,T., Surani,M.A., Kaneko-Ishino,T. and Ishino,F.
  TITLE     Identification of an imprinted gene, Meg3/Gtl2 and its human
            homologue MEG3, first mapped on mouse distal chromosome 12 and
            human chromosome 14q
  JOURNAL   Genes Cells 5 (3), 211-220 (2000)
   PUBMED   10759892
REFERENCE   7  (bases 1 to 607)
  AUTHORS   Ever,L., Steiner,R., Shalom,S. and Don,J.
  TITLE     Two alternatively spliced Meig1 messenger RNA species are
            differentially expressed in the somatic and in the germ-cell
            compartments of the testis
  JOURNAL   Cell Growth Differ 10 (1), 19-26 (1999)
   PUBMED   9950214
REFERENCE   8  (bases 1 to 607)
  AUTHORS   Don,J., Winer,M.A. and Wolgemuth,D.J.
  TITLE     Developmentally regulated expression during gametogenesis of the
            murine gene meg1 suggests a role in meiosis
  JOURNAL   Mol Reprod Dev 38 (1), 16-23 (1994)
   PUBMED   8049060
REFERENCE   9  (bases 1 to 607)
  AUTHORS   Watanabe,D., Sawada,K., Koshimizu,U., Kagawa,T. and Nishimune,Y.
  TITLE     Characterization of male meiotic germ cell-specific antigen (Meg 1)
            by monoclonal antibody TRA 369 in mice
  JOURNAL   Mol Reprod Dev 33 (3), 307-312 (1992)
   PUBMED   1449797
REFERENCE   10 (bases 1 to 607)
  AUTHORS   Don,J. and Wolgemuth,D.J.
  TITLE     Identification and characterization of the regulated pattern of
            expression of a novel mouse gene, meg1, during the meiotic cell
            cycle
  JOURNAL   Cell Growth Differ 3 (8), 495-505 (1992)
   PUBMED   1390336
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL732620.14.
            
            On Sep 13, 2017 this sequence version replaced XM_006497307.3.
            
            Transcript Variant: This variant (3) differs in the 5' UTR compared
            to variant 1. All six transcripts encode the same protein.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BU937912.1, AI326529.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849384 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-159               AL732620.14        129773-129931       c
            160-326             AL732620.14        122647-122813       c
            327-607             AL732620.14        119845-120125       c
FEATURES             Location/Qualifiers
     source          1..607
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 1.92 cM"
     gene            1..607
                     /gene="Meig1"
                     /gene_synonym="Meg1; MLZ-278"
                     /note="meiosis expressed gene 1"
                     /db_xref="GeneID:104362"
                     /db_xref="MGI:MGI:1202878"
     exon            1..159
                     /gene="Meig1"
                     /gene_synonym="Meg1; MLZ-278"
                     /inference="alignment:Splign:2.1.0"
     exon            160..326
                     /gene="Meig1"
                     /gene_synonym="Meg1; MLZ-278"
                     /inference="alignment:Splign:2.1.0"
     CDS             189..455
                     /gene="Meig1"
                     /gene_synonym="Meg1; MLZ-278"
                     /note="protein expressed in male leptotene and zygotene
                     spermatocytes 278"
                     /codon_start=1
                     /product="meiosis-expressed gene 1 protein"
                     /protein_id="NP_001342136.1"
                     /db_xref="CCDS:CCDS38038.1"
                     /db_xref="GeneID:104362"
                     /db_xref="MGI:MGI:1202878"
                     /translation="MATSDVKPKSISRAKKWSEEIENLYRFQQAGYRDEIEYKQVKQV
                     AMVDRWPETGYVKKLQRRDNTFFYYNKERECEDKEVHKVKVYVY"
     exon            327..607
                     /gene="Meig1"
                     /gene_synonym="Meg1; MLZ-278"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      542
                     /gene="Meig1"
                     /gene_synonym="Meg1; MLZ-278"
                     /note="major polyA site"
     regulatory      581..586
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Meig1"
                     /gene_synonym="Meg1; MLZ-278"
                     /note="hexamer: CATAAA"
     polyA_site      607
                     /gene="Meig1"
                     /gene_synonym="Meg1; MLZ-278"
                     /note="major polyA site"
ORIGIN      
        1 ggctcgctca cgtggaccgg ccgagcggcg tcacggcgtt gctaggagac gcgccggtta
       61 caccggccgt aacagttggc ccctggctgt ctcagctcaa gatcccgagt agagaacacg
      121 aacaccgctg cgccctcctg cgaggccggc tgaacgagga aataattgct aataaggcct
      181 ctgtagccat ggctacttct gacgtgaaac caaaatcaat aagtcgtgcc aagaaatggt
      241 cagaggaaat agaaaatctg tacagatttc aacaagcagg atatcgggat gaaattgaat
      301 ataaacaagt gaaacaagtt gccatggtcg accgatggcc agagacaggg tacgtgaaga
      361 aacttcagcg gagggacaat actttcttct actacaacaa agagagggag tgcgaggaca
      421 aggaggtcca caaagtgaag gtttacgtct actgaccttt tcctttcttc ggcttggcaa
      481 tgctccttta agaattggtt gtttacattc ttccatcgtg taaatgtcat tttacaaaac
      541 aattcacaat tctgtcttta attcatggtg tcttacacaa cataaacacc caccttgaaa
      601 ccttgaa
//
