LOCUS       NM_028897               3991 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus meiotic double-stranded break formation protein 1
            (Mei1), transcript variant 1, mRNA.
ACCESSION   NM_028897 XM_901649 XM_920920
VERSION     NM_028897.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3991)
  AUTHORS   Nguyen,N.M.P., Ge,Z.J., Reddy,R., Fahiminiya,S., Sauthier,P.,
            Bagga,R., Sahin,F.I., Mahadevan,S., Osmond,M., Breguet,M.,
            Rahimi,K., Lapensee,L., Hovanes,K., Srinivasan,R., Van den
            Veyver,I.B., Sahoo,T., Ao,A., Majewski,J., Taketo,T. and Slim,R.
  TITLE     Causative Mutations and Mechanism of Androgenetic Hydatidiform
            Moles
  JOURNAL   Am J Hum Genet 103 (5), 740-751 (2018)
   PUBMED   30388401
REFERENCE   2  (bases 1 to 3991)
  AUTHORS   Horiuchi,K., Perez-Cerezales,S., Papasaikas,P., Ramos-Ibeas,P.,
            Lopez-Cardona,A.P., Laguna-Barraza,R., Fonseca Balvis,N.,
            Pericuesta,E., Fernandez-Gonzalez,R., Planells,B., Viera,A.,
            Suja,J.A., Ross,P.J., Alen,F., Orio,L., Rodriguez de Fonseca,F.,
            Pintado,B., Valcarcel,J. and Gutierrez-Adan,A.
  TITLE     Impaired Spermatogenesis, Muscle, and Erythrocyte Function in U12
            Intron Splicing-Defective Zrsr1 Mutant Mice
  JOURNAL   Cell Rep 23 (1), 143-155 (2018)
   PUBMED   29617656
REFERENCE   3  (bases 1 to 3991)
  AUTHORS   Kumar,R., Ghyselinck,N., Ishiguro,K., Watanabe,Y., Kouznetsova,A.,
            Hoog,C., Strong,E., Schimenti,J., Daniel,K., Toth,A. and de
            Massy,B.
  TITLE     MEI4 - a central player in the regulation of meiotic DNA
            double-strand break formation in the mouse
  JOURNAL   J Cell Sci 128 (9), 1800-1811 (2015)
   PUBMED   25795304
REFERENCE   4  (bases 1 to 3991)
  AUTHORS   Boateng,K.A., Bellani,M.A., Gregoretti,I.V., Pratto,F. and
            Camerini-Otero,R.D.
  TITLE     Homologous pairing preceding SPO11-mediated double-strand breaks in
            mice
  JOURNAL   Dev Cell 24 (2), 196-205 (2013)
   PUBMED   23318132
REFERENCE   5  (bases 1 to 3991)
  AUTHORS   Li,X.C. and Schimenti,J.C.
  TITLE     Mouse pachytene checkpoint 2 (trip13) is required for completing
            meiotic recombination but not synapsis
  JOURNAL   PLoS Genet 3 (8), e130 (2007)
   PUBMED   17696610
  REMARK    Erratum:[PLoS Genet. 2007 Sep 7;3(9):e168. Li, Xin [corrected to
            Li, Xin Chenglin]]
REFERENCE   6  (bases 1 to 3991)
  AUTHORS   Reinholdt,L.G. and Schimenti,J.C.
  TITLE     Mei1 is epistatic to Dmc1 during mouse meiosis
  JOURNAL   Chromosoma 114 (2), 127-134 (2005)
   PUBMED   15928951
  REMARK    GeneRIF: Mei1 can be positioned upstream of Dmc1 in the genetic
            pathway that operates during mammalian meiosis.
REFERENCE   7  (bases 1 to 3991)
  AUTHORS   Libby,B.J., Reinholdt,L.G. and Schimenti,J.C.
  TITLE     Positional cloning and characterization of Mei1, a
            vertebrate-specific gene required for normal meiotic chromosome
            synapsis in mice
  JOURNAL   Proc Natl Acad Sci U S A 100 (26), 15706-15711 (2003)
   PUBMED   14668445
  REMARK    GeneRIF: Mei1 is required for vertebrate meiosis.
REFERENCE   8  (bases 1 to 3991)
  AUTHORS   Ward,J.O., Reinholdt,L.G., Hartford,S.A., Wilson,L.A., Munroe,R.J.,
            Schimenti,K.J., Libby,B.J., O'Brien,M., Pendola,J.K., Eppig,J. and
            Schimenti,J.C.
  TITLE     Toward the genetics of mammalian reproduction: induction and
            mapping of gametogenesis mutants in mice
  JOURNAL   Biol Reprod 69 (5), 1615-1625 (2003)
   PUBMED   12855593
REFERENCE   9  (bases 1 to 3991)
  AUTHORS   Libby,B.J., De La Fuente,R., O'Brien,M.J., Wigglesworth,K.,
            Cobb,J., Inselman,A., Eaker,S., Handel,M.A., Eppig,J.J. and
            Schimenti,J.C.
  TITLE     The mouse meiotic mutation mei1 disrupts chromosome synapsis with
            sexually dimorphic consequences for meiotic progression
  JOURNAL   Dev Biol 242 (2), 174-187 (2002)
   PUBMED   11820814
REFERENCE   10 (bases 1 to 3991)
  AUTHORS   Munroe,R.J., Bergstrom,R.A., Zheng,Q.Y., Libby,B., Smith,R.,
            John,S.W., Schimenti,K.J., Browning,V.L. and Schimenti,J.C.
  TITLE     Mouse mutants from chemically mutagenized embryonic stem cells
  JOURNAL   Nat Genet 24 (3), 318-321 (2000)
   PUBMED   10700192
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC102176.8, AK016514.1 and BY641487.1.
            
            On or before Aug 16, 2009 this sequence version replaced
            XM_920920.3, XM_901649.3, NM_028897.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN00849384,
                              SAMN01164132 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            RefSeq Select criteria    :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-188               AC102176.8         100600-100787
            189-312             AC102176.8         102365-102488
            313-363             AC102176.8         103322-103372
            364-437             AC102176.8         105601-105674
            438-543             AC102176.8         108083-108188
            544-747             AC102176.8         110408-110611
            748-878             AC102176.8         112380-112510
            879-993             AC102176.8         113557-113671
            994-1110            AC102176.8         115297-115413
            1111-3988           AK016514.1         316-3193
            3989-3991           BY641487.1         405-407
FEATURES             Location/Qualifiers
     source          1..3991
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 38.41 cM"
     gene            1..3991
                     /gene="Mei1"
                     /gene_synonym="4932408F18Rik"
                     /note="meiotic double-stranded break formation protein 1"
                     /db_xref="GeneID:74369"
                     /db_xref="MGI:MGI:3028590"
     exon            1..188
                     /gene="Mei1"
                     /gene_synonym="4932408F18Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             30..3836
                     /gene="Mei1"
                     /gene_synonym="4932408F18Rik"
                     /note="isoform 1 is encoded by transcript variant 1;
                     meiosis inhibitor protein 1; meiosis defective protein 1"
                     /codon_start=1
                     /product="meiosis inhibitor protein 1 isoform 1"
                     /protein_id="NP_083173.2"
                     /db_xref="CCDS:CCDS88810.1"
                     /db_xref="GeneID:74369"
                     /db_xref="MGI:MGI:3028590"
                     /translation="MTAADHPAFGRDEEAALLLERTHHRHDPRWLLPVSPHVCMACAL
                     ELLPEPGVSLVRKKHVVFCFQDALVRHTSLVAQLVAQDQRVCIHFVRVLFGLLNSVED
                     GSMADLCIEVLVQLTTQPNMEQTIRCLMNECHRELCNLRSMGGSLATTTLLGKLVDTI
                     PGLADELVMEHGNLMEHLLRGLVYPNEGVQASICYLYGKLYSSPTAAEMLSGHFREKL
                     CALFLSTLDSAQTKDLQINCLGLLRQLLKYDLFVSLIMNKSVPVEGAESVERPSRETS
                     LPLVLKKFLLSRDEILQVASSHCITAVLVHSPAKHAVAFIHADIPEFLFEHLSSSSEI
                     LVWSSYNCLILLAEEPLFFSKCHTVYGIEAVVRSLQGSQQMTNTELHTQGLLLFKEIL
                     TRQPEEIRLFTSSALCRDASRALQEAVSSPVLAVAAEALRAISAFLRKDHQSSLPVQY
                     RALRALLEAMLSRCMEFSQTPLNRRSLGHACSRNSEKATLRKGSFLLSTLEGFRNACR
                     LAVEFQGEPSAQENPFTAPSAEKEDTLEAFSEYLLSACDSQCIPMVMRYSEEATHPKL
                     MEVFLSILHSLFVIIPHMKVKFSRKLADSSFIRLTLELKARFCSGQSHSSLNQVCSSF
                     LYYMCLNLLSAPEKTEPLSQEELSAVSEFLQHGLPHISSRTPESLAFLSDRQYVEAAT
                     RQRQYCILLLFYLAHIHDDRFVPEAELFVAVQSFLLSLQDQGECPPPVVCKASMYLLA
                     VCGDKDSALAEAVISAIRKFLEGIPDLRGVYTHHPLLLRFFLAYPGLMSRFGHRVLEL
                     WFSWEESGYENLDDDSSPGRTVFPANLAALFRVLQSTPSILLILLDLVYSSPVDTARK
                     VLIVLRVFLWENEDVKVGGLIRGHFLLILQRLLVEYGASTSGGNLPLLLNLLSLVQMR
                     NESEQELDSMAMKLLHQVSMLCGKCSPAHVDILQPSFNFLYWSLHQTTPSSQKRAAAV
                     LLSSTALLELLEKMLALTWTETGSSPRTPLLSSAWLLTASFSAQQHNGNLQVHRTLSV
                     ELNQVLKALSFPKKMSALLSAAILRFLRTALQQSFSSALVVLVPSGDQPLSTPEDAVL
                     APLGKSQVLALLIGLQNLLVQKDPLLSQACIGCLEALLDYLHARSPDIALHVASQPWN
                     RFLLFTLLDAGENSFLRPEILRLMTLFVQYRSSCVLSREEVGLILQGAALVDLSALSN
                     DTLQALHGFLLQVQSMGLLNDQHMTQTLQSSLEGLCSRTFPAQPLFQDMLCLGGVSVS
                     QAHIRG"
     exon            189..312
                     /gene="Mei1"
                     /gene_synonym="4932408F18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            313..363
                     /gene="Mei1"
                     /gene_synonym="4932408F18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            364..437
                     /gene="Mei1"
                     /gene_synonym="4932408F18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            438..543
                     /gene="Mei1"
                     /gene_synonym="4932408F18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            544..747
                     /gene="Mei1"
                     /gene_synonym="4932408F18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            748..878
                     /gene="Mei1"
                     /gene_synonym="4932408F18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            879..993
                     /gene="Mei1"
                     /gene_synonym="4932408F18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            994..1110
                     /gene="Mei1"
                     /gene_synonym="4932408F18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1111..1210
                     /gene="Mei1"
                     /gene_synonym="4932408F18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1211..1345
                     /gene="Mei1"
                     /gene_synonym="4932408F18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1346..1460
                     /gene="Mei1"
                     /gene_synonym="4932408F18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1461..1552
                     /gene="Mei1"
                     /gene_synonym="4932408F18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1553..1694
                     /gene="Mei1"
                     /gene_synonym="4932408F18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1695..1806
                     /gene="Mei1"
                     /gene_synonym="4932408F18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1807..1867
                     /gene="Mei1"
                     /gene_synonym="4932408F18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1868..1965
                     /gene="Mei1"
                     /gene_synonym="4932408F18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1966..2134
                     /gene="Mei1"
                     /gene_synonym="4932408F18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2135..2282
                     /gene="Mei1"
                     /gene_synonym="4932408F18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2283..2558
                     /gene="Mei1"
                     /gene_synonym="4932408F18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2559..2724
                     /gene="Mei1"
                     /gene_synonym="4932408F18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2725..2823
                     /gene="Mei1"
                     /gene_synonym="4932408F18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2824..2934
                     /gene="Mei1"
                     /gene_synonym="4932408F18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2935..3098
                     /gene="Mei1"
                     /gene_synonym="4932408F18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3099..3180
                     /gene="Mei1"
                     /gene_synonym="4932408F18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3181..3356
                     /gene="Mei1"
                     /gene_synonym="4932408F18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3357..3438
                     /gene="Mei1"
                     /gene_synonym="4932408F18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3439..3545
                     /gene="Mei1"
                     /gene_synonym="4932408F18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3546..3677
                     /gene="Mei1"
                     /gene_synonym="4932408F18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3678..3790
                     /gene="Mei1"
                     /gene_synonym="4932408F18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3791..3991
                     /gene="Mei1"
                     /gene_synonym="4932408F18Rik"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggggaggcga ggaggtggct gcggggcaga tgacggctgc tgaccatccc gcgtttggga
       61 gagatgaaga agcggcgctg ctcctggaga ggacccatca ccggcacgat ccgcgctggc
      121 tgctgcccgt gtcccctcac gtctgcatgg cctgcgcgtt ggaactgctg ccggagcccg
      181 gagtgtcgct ggtgcgcaag aaacatgtgg tgttctgctt ccaagatgcc ctggtgaggc
      241 acacctcctt ggtcgctcag ctggtagctc aggaccagag agtctgcatc cattttgtac
      301 gcgtgctttt cggactgtta aacagtgtgg aagatgggag tatggcagac ctctgtattg
      361 aagtccttgt ccagctcact actcagccga atatggaaca gaccatccgt tgcctaatga
      421 atgagtgcca cagagagctg tgtaacctgc gctccatggg aggcagcctg gccaccacga
      481 ctctcctggg caagctggtg gacaccattc ctggtttggc ggacgagctt gtaatggagc
      541 acggcaactt gatggaacat ctgttgaggg gcttggttta ccccaatgag ggggtacagg
      601 cttccatctg ttacctctat gggaagctct actcctcgcc cacggccgct gagatgcttt
      661 ccggccattt ccgggagaag ctgtgtgccc tcttcctttc caccttggac agcgcccaga
      721 caaaggacct acagatcaac tgcttgggtt tactaaggca gctactgaag tacgatctct
      781 tcgtatcgct gatcatgaac aagtctgtgc cggtagaagg tgctgagagt gtcgagcggc
      841 catcgagaga gacctcacta cctttggtgc tcaaaaagtt tctcctgtcc agagatgaga
      901 tcctgcaggt ggccagctcc cactgtataa cggcagtgct ggtccattcc ccggcgaagc
      961 atgctgttgc cttcattcac gctgacatcc cagagttcct ctttgagcat ctttcgtcct
     1021 ccagcgaaat ccttgtctgg tccagctaca actgcctgat actcttggca gaagaaccgc
     1081 tcttcttttc aaagtgtcac acagtgtatg ggatcgaggc agtggtcagg agcctccagg
     1141 gcagccagca gatgaccaac acggaactgc atactcaggg actgctgctc ttcaaagaaa
     1201 ttctgactcg gcagccagag gagatcaggc tgttcacaag ctcagccctg tgcagagatg
     1261 ccagccgtgc cctccaggag gccgtgagca gccctgtgtt agctgtggcc gccgaagcac
     1321 tgagggccat ttcagctttt ctgaggaagg accatcagag ctctctgccc gtgcagtaca
     1381 gagcacttcg tgccttgctt gaagccatgc tgagccgatg tatggagttt tcccagaccc
     1441 ctctgaacag gaggtccctg ggccacgctt gcagtagaaa ctcggagaag gccactctga
     1501 gaaaggggag tttcctcctg agcactctgg aaggctttag aaatgcctgc aggctggctg
     1561 tggaattcca aggcgagcct tccgcccagg agaacccctt cacagctccc agtgcagaga
     1621 aggaagacac cttggaggcc ttctcagagt atcttctcag tgcctgtgac tcccagtgca
     1681 tcccgatggt gatgaggtac tcggaggagg ccacgcatcc aaagctgatg gaggttttcc
     1741 tctccattct acacagcctc tttgtcatca ttccccacat gaaggtgaag ttctccagga
     1801 agcttgctga ttcatcattc atacgactga ccctggagct gaaggccaga ttctgcagtg
     1861 gccagagtca ctcgtcccta aatcaggtgt gctccagttt cctctactac atgtgcctca
     1921 atctcctctc agctccagag aagacagaac cactttccca agaagaactc tctgcagtgt
     1981 ctgagttcct acagcatgga ctgccccaca taagcagcag gaccccagaa agccttgcct
     2041 tcctgtcaga tcggcagtat gtggaggcgg ccacgcgcca gagacagtac tgcatcctcc
     2101 tcctcttcta cctggctcac atccacgatg acaggtttgt ccctgaggcg gagctctttg
     2161 tggctgtgca gagcttcctt ttgtctctgc aggaccaggg tgagtgcccg ccaccagtgg
     2221 tctgcaaagc ctccatgtat ctgctggcag tgtgcgggga caaggacagt gcactggctg
     2281 aggccgtgat cagtgcaatc agaaagttcc tagagggcat cccagacctg cgtggggtct
     2341 acactcacca cccgctcctg ctcaggttct tcctggccta tccagggttg atgagcaggt
     2401 tcgggcaccg tgtcttggag ctttggttct cttgggaaga gagcggctac gagaacctag
     2461 atgatgactc ctctcctggg cgtacagtct ttcccgccaa cctcgcagcc ctgttccgtg
     2521 tgctccagag cacgcccagc atcctactca ttttgctgga cctggtctat tccagccccg
     2581 tggatacagc ccgaaaggtc ctgattgtcc tgagggtgtt cctttgggag aatgaggatg
     2641 tcaaggtggg tggcctcatc cgaggccact ttctgctcat cctgcagcgc ctcctggtgg
     2701 agtatggagc gtccacctca ggagggaacc tgccgctgct gctgaacctc ctgtccttgg
     2761 tgcagatgag gaatgagtcg gaacaagagc tggacagcat ggccatgaag ctgcttcatc
     2821 aagtgagcat gctgtgtggg aagtgcagcc ctgcacatgt ggatatcctg cagccctcct
     2881 tcaacttctt gtactggagt cttcatcaga ccacacccag tagccagaaa agagctgctg
     2941 ctgtcctgct gagcagcaca gccttgcttg agctcctgga gaagatgctg gccctcacct
     3001 ggacggaaac aggctcctcc cccaggacgc cactgctctc ctctgcctgg ctgctcactg
     3061 cctccttctc tgcccagcag cacaatggca atttgcaggt ccatcggaca ttatctgtgg
     3121 aactgaacca agtattgaag gctctcagct ttccaaagaa gatgtctgca ttgctgtcag
     3181 ctgccatcct acgattcctg cggacagcct tgcaacaaag cttttcctct gccttggtgg
     3241 tcttggtacc ctcaggggat caaccgctgt caactcctga ggacgctgtc ctagctccgc
     3301 taggaaagtc acaagtgcta gccctgttaa ttgggctcca gaacctcttg gtacagaaag
     3361 accctctgtt atctcaagcc tgtattggct gtctggaagc cttgctagat tacttgcatg
     3421 ccaggagccc agacattgcg ctccatgtgg cctcccagcc ctggaatcgg tttctgctgt
     3481 tcaccctctt ggatgctgga gagaattcct tcctcagacc tgagatactg agacttatga
     3541 ccttgtttgt gcagtaccgg agcagctgtg tcctctcacg tgaagaggtg ggtcttattt
     3601 tgcaaggtgc agctttggtt gacctgtcag ctctctcaaa cgatacactc caggccctgc
     3661 atggcttcct cctgcaggtc cagagcatgg gtctcctaaa tgaccaacac atgacccaga
     3721 ccttgcaatc atctttggaa ggcctttgct cccgcacctt cccagcccag ccactctttc
     3781 aagacatgct ctgcctcgga ggtgtgtctg tttcccaggc tcacatcaga ggctgagcct
     3841 caggacataa aggcccagaa acagaaaaca atgagacctg cagacaaatt ccgggcataa
     3901 tggttgaggg ggaaaacaat atcaagcctc tctctggagc tattttacac cacagtggaa
     3961 atggaattgg gaaataaaat aatgcattaa c
//
