LOCUS       NP_083173               1268 aa            linear   ROD 04-JUN-2024
DEFINITION  meiosis inhibitor protein 1 isoform 1 [Mus musculus].
ACCESSION   NP_083173 XP_906742 XP_926013
VERSION     NP_083173.2
DBSOURCE    REFSEQ: accession NM_028897.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 1268)
  AUTHORS   Nguyen,N.M.P., Ge,Z.J., Reddy,R., Fahiminiya,S., Sauthier,P.,
            Bagga,R., Sahin,F.I., Mahadevan,S., Osmond,M., Breguet,M.,
            Rahimi,K., Lapensee,L., Hovanes,K., Srinivasan,R., Van den
            Veyver,I.B., Sahoo,T., Ao,A., Majewski,J., Taketo,T. and Slim,R.
  TITLE     Causative Mutations and Mechanism of Androgenetic Hydatidiform
            Moles
  JOURNAL   Am J Hum Genet 103 (5), 740-751 (2018)
   PUBMED   30388401
REFERENCE   2  (residues 1 to 1268)
  AUTHORS   Horiuchi,K., Perez-Cerezales,S., Papasaikas,P., Ramos-Ibeas,P.,
            Lopez-Cardona,A.P., Laguna-Barraza,R., Fonseca Balvis,N.,
            Pericuesta,E., Fernandez-Gonzalez,R., Planells,B., Viera,A.,
            Suja,J.A., Ross,P.J., Alen,F., Orio,L., Rodriguez de Fonseca,F.,
            Pintado,B., Valcarcel,J. and Gutierrez-Adan,A.
  TITLE     Impaired Spermatogenesis, Muscle, and Erythrocyte Function in U12
            Intron Splicing-Defective Zrsr1 Mutant Mice
  JOURNAL   Cell Rep 23 (1), 143-155 (2018)
   PUBMED   29617656
REFERENCE   3  (residues 1 to 1268)
  AUTHORS   Kumar,R., Ghyselinck,N., Ishiguro,K., Watanabe,Y., Kouznetsova,A.,
            Hoog,C., Strong,E., Schimenti,J., Daniel,K., Toth,A. and de
            Massy,B.
  TITLE     MEI4 - a central player in the regulation of meiotic DNA
            double-strand break formation in the mouse
  JOURNAL   J Cell Sci 128 (9), 1800-1811 (2015)
   PUBMED   25795304
REFERENCE   4  (residues 1 to 1268)
  AUTHORS   Boateng,K.A., Bellani,M.A., Gregoretti,I.V., Pratto,F. and
            Camerini-Otero,R.D.
  TITLE     Homologous pairing preceding SPO11-mediated double-strand breaks in
            mice
  JOURNAL   Dev Cell 24 (2), 196-205 (2013)
   PUBMED   23318132
REFERENCE   5  (residues 1 to 1268)
  AUTHORS   Li,X.C. and Schimenti,J.C.
  TITLE     Mouse pachytene checkpoint 2 (trip13) is required for completing
            meiotic recombination but not synapsis
  JOURNAL   PLoS Genet 3 (8), e130 (2007)
   PUBMED   17696610
  REMARK    Erratum:[PLoS Genet. 2007 Sep 7;3(9):e168. Li, Xin [corrected to
            Li, Xin Chenglin]]
REFERENCE   6  (residues 1 to 1268)
  AUTHORS   Reinholdt,L.G. and Schimenti,J.C.
  TITLE     Mei1 is epistatic to Dmc1 during mouse meiosis
  JOURNAL   Chromosoma 114 (2), 127-134 (2005)
   PUBMED   15928951
  REMARK    GeneRIF: Mei1 can be positioned upstream of Dmc1 in the genetic
            pathway that operates during mammalian meiosis.
REFERENCE   7  (residues 1 to 1268)
  AUTHORS   Libby,B.J., Reinholdt,L.G. and Schimenti,J.C.
  TITLE     Positional cloning and characterization of Mei1, a
            vertebrate-specific gene required for normal meiotic chromosome
            synapsis in mice
  JOURNAL   Proc Natl Acad Sci U S A 100 (26), 15706-15711 (2003)
   PUBMED   14668445
  REMARK    GeneRIF: Mei1 is required for vertebrate meiosis.
REFERENCE   8  (residues 1 to 1268)
  AUTHORS   Ward,J.O., Reinholdt,L.G., Hartford,S.A., Wilson,L.A., Munroe,R.J.,
            Schimenti,K.J., Libby,B.J., O'Brien,M., Pendola,J.K., Eppig,J. and
            Schimenti,J.C.
  TITLE     Toward the genetics of mammalian reproduction: induction and
            mapping of gametogenesis mutants in mice
  JOURNAL   Biol Reprod 69 (5), 1615-1625 (2003)
   PUBMED   12855593
REFERENCE   9  (residues 1 to 1268)
  AUTHORS   Libby,B.J., De La Fuente,R., O'Brien,M.J., Wigglesworth,K.,
            Cobb,J., Inselman,A., Eaker,S., Handel,M.A., Eppig,J.J. and
            Schimenti,J.C.
  TITLE     The mouse meiotic mutation mei1 disrupts chromosome synapsis with
            sexually dimorphic consequences for meiotic progression
  JOURNAL   Dev Biol 242 (2), 174-187 (2002)
   PUBMED   11820814
REFERENCE   10 (residues 1 to 1268)
  AUTHORS   Munroe,R.J., Bergstrom,R.A., Zheng,Q.Y., Libby,B., Smith,R.,
            John,S.W., Schimenti,K.J., Browning,V.L. and Schimenti,J.C.
  TITLE     Mouse mutants from chemically mutagenized embryonic stem cells
  JOURNAL   Nat Genet 24 (3), 318-321 (2000)
   PUBMED   10700192
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC102176.8, AK016514.1 and BY641487.1.
            
            On or before Aug 16, 2009 this sequence version replaced
            XP_926013.2, XP_906742.2, NP_083173.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN00849384,
                              SAMN01164132 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            RefSeq Select criteria    :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1268
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 38.41 cM"
     Protein         1..1268
                     /product="meiosis inhibitor protein 1 isoform 1"
                     /note="meiosis inhibitor protein 1; meiosis defective
                     protein 1"
                     /calculated_mol_wt=140744
     CDS             1..1268
                     /gene="Mei1"
                     /gene_synonym="4932408F18Rik"
                     /coded_by="NM_028897.3:30..3836"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS88810.1"
                     /db_xref="GeneID:74369"
                     /db_xref="MGI:MGI:3028590"
ORIGIN      
        1 mtaadhpafg rdeeaallle rthhrhdprw llpvsphvcm acalellpep gvslvrkkhv
       61 vfcfqdalvr htslvaqlva qdqrvcihfv rvlfgllnsv edgsmadlci evlvqlttqp
      121 nmeqtirclm nechrelcnl rsmggslatt tllgklvdti pgladelvme hgnlmehllr
      181 glvypnegvq asicylygkl yssptaaeml sghfreklca lflstldsaq tkdlqinclg
      241 llrqllkydl fvslimnksv pvegaesver psretslplv lkkfllsrde ilqvasshci
      301 tavlvhspak havafihadi peflfehlss sseilvwssy nclillaeep lffskchtvy
      361 gieavvrslq gsqqmtntel htqglllfke iltrqpeeir lftssalcrd asralqeavs
      421 spvlavaaea lraisaflrk dhqsslpvqy ralralleam lsrcmefsqt plnrrslgha
      481 csrnsekatl rkgsfllstl egfrnacrla vefqgepsaq enpftapsae kedtleafse
      541 yllsacdsqc ipmvmrysee athpklmevf lsilhslfvi iphmkvkfsr kladssfirl
      601 tlelkarfcs gqshsslnqv cssflyymcl nllsapekte plsqeelsav seflqhglph
      661 issrtpesla flsdrqyvea atrqrqycil llfylahihd drfvpeaelf vavqsfllsl
      721 qdqgecpppv vckasmylla vcgdkdsala eavisairkf legipdlrgv ythhplllrf
      781 flaypglmsr fghrvlelwf sweesgyenl dddsspgrtv fpanlaalfr vlqstpsill
      841 illdlvyssp vdtarkvliv lrvflwened vkvgglirgh fllilqrllv eygastsggn
      901 lplllnllsl vqmrneseqe ldsmamkllh qvsmlcgkcs pahvdilqps fnflywslhq
      961 ttpssqkraa avllsstall ellekmlalt wtetgssprt pllssawllt asfsaqqhng
     1021 nlqvhrtlsv elnqvlkals fpkkmsalls aailrflrta lqqsfssalv vlvpsgdqpl
     1081 stpedavlap lgksqvlall iglqnllvqk dpllsqacig clealldylh arspdialhv
     1141 asqpwnrfll ftlldagens flrpeilrlm tlfvqyrssc vlsreevgli lqgaalvdls
     1201 alsndtlqal hgfllqvqsm gllndqhmtq tlqssleglc srtfpaqplf qdmlclggvs
     1261 vsqahirg
//
