LOCUS       NM_001162977            6876 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus multiple EGF-like-domains 6 (Megf6), mRNA.
ACCESSION   NM_001162977 XM_620148 XM_909777
VERSION     NM_001162977.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6876)
  AUTHORS   Liang,H., Liu,G., Zeng,W., Fan,Q., Nie,Z., Hu,H., Zhang,R. and
            Xie,S.
  TITLE     MEGF6 prevents sepsis-induced acute lung injury in mice
  JOURNAL   Int Immunopharmacol 123, 110727 (2023)
   PUBMED   37597402
  REMARK    GeneRIF: MEGF6 prevents sepsis-induced acute lung injury in mice.
            Erratum:[Int Immunopharmacol. 2024 May 30;133:111787. doi:
            10.1016/j.intimp.2024.111787.. PMID: 38641473]
REFERENCE   2  (bases 1 to 6876)
  AUTHORS   Wang,Y., Song,H., Wang,W. and Zhang,Z.
  TITLE     Generation and characterization of Megf6 null and Cre knock-in
            alleles
  JOURNAL   Genesis 57 (2), e23262 (2019)
   PUBMED   30381865
REFERENCE   3  (bases 1 to 6876)
  AUTHORS   Hu,H., Wang,M., Wang,H., Liu,Z., Guan,X., Yang,R., Huang,R.,
            Tang,Q., Zou,C., Wang,G., Gao,X. and Wang,X.
  TITLE     MEGF6 Promotes the Epithelial-to-Mesenchymal Transition via the
            TGFbeta/SMAD Signaling Pathway in Colorectal Cancer Metastasis
  JOURNAL   Cell Physiol Biochem 46 (5), 1895-1906 (2018)
   PUBMED   29719292
  REMARK    GeneRIF: MEGF6 promoted Colorectal Cancer Metastasis metastasis in
            vitro and in vivo.
REFERENCE   4  (bases 1 to 6876)
  AUTHORS   Naba,A., Clauser,K.R., Mani,D.R., Carr,S.A. and Hynes,R.O.
  TITLE     Quantitative proteomic profiling of the extracellular matrix of
            pancreatic islets during the angiogenic switch and insulinoma
            progression
  JOURNAL   Sci Rep 7, 40495 (2017)
   PUBMED   28071719
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 6876)
  AUTHORS   Okazaki,N., F-Kikuno,R., Ohara,R., Inamoto,S., Koseki,H.,
            Hiraoka,S., Saga,Y., Seino,S., Nishimura,M., Kaisho,T., Hoshino,K.,
            Kitamura,H., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: IV. The complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 11 (3), 205-218 (2004)
   PUBMED   15368895
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL627123.13.
            
            On or before Jul 8, 2009 this sequence version replaced
            XM_909777.2, XM_620148.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR10223969.5199.1,
                                           SRR9219381.35117.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-430               AL627123.13        4351-4780
            431-565             AL627123.13        10677-10811
            566-675             AL627123.13        16296-16405
            676-798             AL627123.13        57739-57861
            799-921             AL627123.13        76040-76162
            922-1047            AL627123.13        83065-83190
            1048-1170           AL627123.13        84460-84582
            1171-1293           AL627123.13        85767-85889
            1294-1431           AL627123.13        86062-86199
            1432-1551           AL627123.13        86664-86783
            1552-1674           AL627123.13        87353-87475
            1675-1845           AL627123.13        87747-87917
            1846-1977           AL627123.13        88180-88311
            1978-2106           AL627123.13        89634-89762
            2107-2235           AL627123.13        91739-91867
            2236-2370           AL627123.13        92498-92632
            2371-2505           AL627123.13        92719-92853
            2506-2631           AL627123.13        96152-96277
            2632-2763           AL627123.13        96808-96939
            2764-2892           AL627123.13        97031-97159
            2893-3024           AL627123.13        97284-97415
            3025-3153           AL627123.13        98708-98836
            3154-3282           AL627123.13        98925-99053
            3283-3411           AL627123.13        99298-99426
            3412-3540           AL627123.13        99772-99900
            3541-3669           AL627123.13        100089-100217
            3670-3798           AL627123.13        100828-100956
            3799-3927           AL627123.13        101071-101199
            3928-4059           AL627123.13        101294-101425
            4060-4188           AL627123.13        101572-101700
            4189-4317           AL627123.13        102214-102342
            4318-4446           AL627123.13        103285-103413
            4447-4575           AL627123.13        103531-103659
            4576-4704           AL627123.13        104040-104168
            4705-4833           AL627123.13        104261-104389
            4834-4962           AL627123.13        105249-105377
            4963-6876           AL627123.13        107446-109359
FEATURES             Location/Qualifiers
     source          1..6876
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 83.89 cM"
     gene            1..6876
                     /gene="Megf6"
                     /gene_synonym="2600001P17Rik; Egfl3"
                     /note="multiple EGF-like-domains 6"
                     /db_xref="GeneID:230971"
                     /db_xref="MGI:MGI:1919351"
     exon            1..430
                     /gene="Megf6"
                     /gene_synonym="2600001P17Rik; Egfl3"
                     /inference="alignment:Splign:2.1.0"
     CDS             312..5030
                     /gene="Megf6"
                     /gene_synonym="2600001P17Rik; Egfl3"
                     /note="EGF-like-domain, multiple 3; multiple epidermal
                     growth factor-like domains protein 6; EGF-like protein 3;
                     multiple EGF-like domains protein 6; epidermal growth
                     factor-like protein 3"
                     /codon_start=1
                     /product="multiple epidermal growth factor-like domains
                     protein 6 precursor"
                     /protein_id="NP_001156449.1"
                     /db_xref="CCDS:CCDS51398.1"
                     /db_xref="GeneID:230971"
                     /db_xref="MGI:MGI:1919351"
                     /translation="MPVGVEARASWRVVALTLLLLPAVPAASQPLPPRPLQPSMPHVC
                     AEQKLTLVGHRQPCVQAFSRVVPVWRSGCGQQAWCVGQERRTVYYMSYRQVYATEART
                     VFRCCPGWSQKPGQEGCLSDVDECANANGGCEGPCCNTVGGFYCRCPPGYQLQGDGKT
                     CQDVDECRSHNGGCQHRCVNTPGSYLCECKPGFRLHTDGRTCLAISSCTLGNGGCQHQ
                     CVQLTVTQHRCQCRPQYQLQEDGRRCVRRSPCADGNGGCMHTCQELRGLAHCGCHPGY
                     QLAADRKACEDVDECALGLAQCAHGCLNTQGSFKCVCHAGYELGADGRQCYRIEMEIV
                     NSCEAGNGGCSHGCSHTSTGPLCTCPRGYELDEDQKTCIDIDDCANSPCCQQVCANTP
                     GGYECSCFAGYRLNTDGCGCEDVDECASGHSGCEHHCSNLAGSFQCFCEAGYRLDEDR
                     RGCTPLEESVVDLDGQLPFVRPLPHIAVLGDELPQLFQDDYGAEEEAVAELRGEHTLT
                     EKFVCLDHSFGHDCSLTCDDCRNGGTCFPGLDGCDCPEGWTGIICNETCPPDTFGKNC
                     SSPCICQNGGTCDPVSGACRCPPGVSGAHCEDGCPKGFYGKHCRKKCHCANRGRCHRL
                     YGACLCDPGLYGRFCHLACPPWAFGPGCSEDCLCEQSHTRSCNSKDGSCSCKAGFQGE
                     RCEAECEPGSFGPGCRNRCTCRPGVACDPVSGECRTQCPPGYQGEDCGQECPVGTFGV
                     NCSGSCSCVGAPCHRVTGECLCPPGKTGEDCGADCPEGRWGLGCQEICPACEHGASCD
                     PETGTCLCLPGFVGSRCQDACPAGWFGTGCQMRCACANDGHCHPATGRCSCAPGWTGL
                     SCQRACDSGHWGPDCIHPCNCSAGHGNCDAVSGLCLCEAGYEGPQCEQWCRQGYFGPG
                     CEQKCRCEHGATCDHVSGACTCPAGWRGSFCEHACPAGFFGLDCGSACNCSAGAPCDA
                     VTGSCICPAGRWGPHCAQTCPPLTFGLNCSQICTCFNGASCDPVLGQCHCAPGWMGPT
                     CLQACPAGLYGKNCQHSCLCRNGGNCDPILGQCTCPEGWTGLACENECLPGHHGAGCR
                     LNCSCLNGGTCDRLTGHCRCPTGWTGDKCQSPCVSGMFGVHCEEHCACRKGATCHHVT
                     GACLCPPGWRGSHCEQACPRGWFGEACAQRCHCPPGASCHHVSGECHCPPGFTGPGCE
                     QACQPGTFGKDCEHPCQCPGETWACHPASGACVCAAGYHGTDCQQRCPSGRYGPGCEQ
                     ICKCLNGGTCDPATGACYCPAGFLGADCSLACPQGRFGPSCAHVCTCGQGAACDPVSG
                     TCICPPGKTGGHCERGCPQDRFGKGCEHKCACRNGGLCHATNGSCSCPLGWMGPHCEH
                     ACPAGRYGAACLLECSCQNNGSCEPTSGACLCGPGFYGQACEDTCPAGFHGSGCQRVC
                     ECQQGAPCDPVSGRCLCPAGFHGQFCERGCKPGFFGDGCLQQCNCPTGVPCDPISGLC
                     LCPPGRAGTTCDLDCRRGRFGPGCALRCDCGGGADCDPISGQCHCVDSYTGPTCREVP
                     TQLSSIRPAPQHSSSKAMKH"
     exon            431..565
                     /gene="Megf6"
                     /gene_synonym="2600001P17Rik; Egfl3"
                     /inference="alignment:Splign:2.1.0"
     exon            566..675
                     /gene="Megf6"
                     /gene_synonym="2600001P17Rik; Egfl3"
                     /inference="alignment:Splign:2.1.0"
     exon            676..798
                     /gene="Megf6"
                     /gene_synonym="2600001P17Rik; Egfl3"
                     /inference="alignment:Splign:2.1.0"
     exon            799..921
                     /gene="Megf6"
                     /gene_synonym="2600001P17Rik; Egfl3"
                     /inference="alignment:Splign:2.1.0"
     exon            922..1047
                     /gene="Megf6"
                     /gene_synonym="2600001P17Rik; Egfl3"
                     /inference="alignment:Splign:2.1.0"
     exon            1048..1170
                     /gene="Megf6"
                     /gene_synonym="2600001P17Rik; Egfl3"
                     /inference="alignment:Splign:2.1.0"
     exon            1171..1293
                     /gene="Megf6"
                     /gene_synonym="2600001P17Rik; Egfl3"
                     /inference="alignment:Splign:2.1.0"
     exon            1294..1431
                     /gene="Megf6"
                     /gene_synonym="2600001P17Rik; Egfl3"
                     /inference="alignment:Splign:2.1.0"
     exon            1432..1551
                     /gene="Megf6"
                     /gene_synonym="2600001P17Rik; Egfl3"
                     /inference="alignment:Splign:2.1.0"
     exon            1552..1674
                     /gene="Megf6"
                     /gene_synonym="2600001P17Rik; Egfl3"
                     /inference="alignment:Splign:2.1.0"
     exon            1675..1845
                     /gene="Megf6"
                     /gene_synonym="2600001P17Rik; Egfl3"
                     /inference="alignment:Splign:2.1.0"
     exon            1846..1977
                     /gene="Megf6"
                     /gene_synonym="2600001P17Rik; Egfl3"
                     /inference="alignment:Splign:2.1.0"
     exon            1978..2106
                     /gene="Megf6"
                     /gene_synonym="2600001P17Rik; Egfl3"
                     /inference="alignment:Splign:2.1.0"
     exon            2107..2235
                     /gene="Megf6"
                     /gene_synonym="2600001P17Rik; Egfl3"
                     /inference="alignment:Splign:2.1.0"
     exon            2236..2370
                     /gene="Megf6"
                     /gene_synonym="2600001P17Rik; Egfl3"
                     /inference="alignment:Splign:2.1.0"
     exon            2371..2505
                     /gene="Megf6"
                     /gene_synonym="2600001P17Rik; Egfl3"
                     /inference="alignment:Splign:2.1.0"
     exon            2506..2631
                     /gene="Megf6"
                     /gene_synonym="2600001P17Rik; Egfl3"
                     /inference="alignment:Splign:2.1.0"
     exon            2632..2763
                     /gene="Megf6"
                     /gene_synonym="2600001P17Rik; Egfl3"
                     /inference="alignment:Splign:2.1.0"
     exon            2764..2892
                     /gene="Megf6"
                     /gene_synonym="2600001P17Rik; Egfl3"
                     /inference="alignment:Splign:2.1.0"
     exon            2893..3024
                     /gene="Megf6"
                     /gene_synonym="2600001P17Rik; Egfl3"
                     /inference="alignment:Splign:2.1.0"
     exon            3025..3153
                     /gene="Megf6"
                     /gene_synonym="2600001P17Rik; Egfl3"
                     /inference="alignment:Splign:2.1.0"
     exon            3154..3282
                     /gene="Megf6"
                     /gene_synonym="2600001P17Rik; Egfl3"
                     /inference="alignment:Splign:2.1.0"
     exon            3283..3411
                     /gene="Megf6"
                     /gene_synonym="2600001P17Rik; Egfl3"
                     /inference="alignment:Splign:2.1.0"
     exon            3412..3540
                     /gene="Megf6"
                     /gene_synonym="2600001P17Rik; Egfl3"
                     /inference="alignment:Splign:2.1.0"
     exon            3541..3669
                     /gene="Megf6"
                     /gene_synonym="2600001P17Rik; Egfl3"
                     /inference="alignment:Splign:2.1.0"
     exon            3670..3798
                     /gene="Megf6"
                     /gene_synonym="2600001P17Rik; Egfl3"
                     /inference="alignment:Splign:2.1.0"
     exon            3799..3927
                     /gene="Megf6"
                     /gene_synonym="2600001P17Rik; Egfl3"
                     /inference="alignment:Splign:2.1.0"
     exon            3928..4059
                     /gene="Megf6"
                     /gene_synonym="2600001P17Rik; Egfl3"
                     /inference="alignment:Splign:2.1.0"
     exon            4060..4188
                     /gene="Megf6"
                     /gene_synonym="2600001P17Rik; Egfl3"
                     /inference="alignment:Splign:2.1.0"
     exon            4189..4317
                     /gene="Megf6"
                     /gene_synonym="2600001P17Rik; Egfl3"
                     /inference="alignment:Splign:2.1.0"
     exon            4318..4446
                     /gene="Megf6"
                     /gene_synonym="2600001P17Rik; Egfl3"
                     /inference="alignment:Splign:2.1.0"
     exon            4447..4575
                     /gene="Megf6"
                     /gene_synonym="2600001P17Rik; Egfl3"
                     /inference="alignment:Splign:2.1.0"
     exon            4576..4704
                     /gene="Megf6"
                     /gene_synonym="2600001P17Rik; Egfl3"
                     /inference="alignment:Splign:2.1.0"
     exon            4705..4833
                     /gene="Megf6"
                     /gene_synonym="2600001P17Rik; Egfl3"
                     /inference="alignment:Splign:2.1.0"
     exon            4834..4962
                     /gene="Megf6"
                     /gene_synonym="2600001P17Rik; Egfl3"
                     /inference="alignment:Splign:2.1.0"
     exon            4963..6876
                     /gene="Megf6"
                     /gene_synonym="2600001P17Rik; Egfl3"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      5605
                     /gene="Megf6"
                     /gene_synonym="2600001P17Rik; Egfl3"
                     /note="major polyA site"
     polyA_site      5733
                     /gene="Megf6"
                     /gene_synonym="2600001P17Rik; Egfl3"
     regulatory      6310..6315
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Megf6"
                     /gene_synonym="2600001P17Rik; Egfl3"
                     /note="hexamer: AATATA"
     polyA_site      6339
                     /gene="Megf6"
                     /gene_synonym="2600001P17Rik; Egfl3"
     regulatory      6844..6849
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Megf6"
                     /gene_synonym="2600001P17Rik; Egfl3"
                     /note="hexamer: AATAAA"
     polyA_site      6875
                     /gene="Megf6"
                     /gene_synonym="2600001P17Rik; Egfl3"
ORIGIN      
        1 ggggctgggg tcgggccggg gggcgtgcgg cgggcgggcc tgacgtctgc tgcgtcccgc
       61 tccgagtttg ctctccatca ctcctggcaa gtgtctggcc gcgccgaacc gagcgcgaag
      121 gtctcggagg tccgggcaac tgtcccatct gcacctgcgg gaacctcgcg ccccgcacct
      181 ggcgcgactg ggttgtggtg ctccgctgtc ctctgggggt atggcgcccg tgaagacagc
      241 gtctactggc cgtaagggcc gcctgtgagt cgaagatccc aggaccgagt gggagcgcga
      301 ccgcgcgcac tatgcctgtc ggggtggagg cgagggcgtc ttggcgcgtg gtggccctga
      361 cgctgctgct gctccccgcc gtgcctgcag cctcccagcc gctacccccg cgcccgctgc
      421 agccgagcat gccccacgtg tgtgcagaac agaagctgac cctggtgggc caccgccagc
      481 cttgtgtgca agccttcagc cgcgtagtgc ctgtgtggag gtcgggctgc gggcagcagg
      541 catggtgtgt tggccaagag cgcaggactg tgtactatat gagctacagg caggtgtatg
      601 ccacagaggc tcgcactgtg ttcaggtgct gtcctggctg gagccagaag cctggccagg
      661 aaggctgcct ctcagatgtg gatgaatgtg ccaatgccaa cgggggctgt gagggcccgt
      721 gctgcaacac cgtgggtggc ttttactgtc gctgcccacc cggctaccag ctgcagggtg
      781 atggcaaaac gtgccaagat gtggatgaat gtcgatcaca caatggtggt tgtcaacaca
      841 ggtgtgtgaa tacccccggc tcttacctct gtgagtgcaa acccggcttc cggctccaca
      901 cagatggcag gacctgcctg gccatcagct cctgcactct gggaaatggt ggctgccagc
      961 atcagtgtgt acagctcacc gtgacacagc accgctgcca gtgccggccc cagtaccagc
     1021 tgcaggagga tggcaggcgc tgtgtccgga gaagcccctg tgcagacggc aatggtggct
     1081 gtatgcatac atgccaggaa ctccggggcc ttgcccactg tggctgccac ccaggttacc
     1141 agcttgctgc agaccgcaaa gcctgtgaag atgtggacga atgtgccttg ggtctggccc
     1201 agtgtgctca tggctgcctc aacactcagg ggtcctttaa gtgtgtgtgt cacgcaggct
     1261 atgagctggg tgctgatggc cggcagtgtt accggatcga gatggagatt gtgaacagct
     1321 gcgaggctgg caacggaggc tgctcacacg gctgtagtca cactagcaca gggcccctgt
     1381 gcacctgccc tcgtggttat gagctggatg aggaccagaa gacctgcatt gacatcgacg
     1441 actgcgccaa ctctccgtgc tgccagcagg tgtgtgccaa cacccccggt gggtatgagt
     1501 gtagctgctt cgccggctac agactcaaca cagacggctg tggctgtgag gatgttgacg
     1561 agtgtgcctc tggtcacagc ggctgcgaac accactgttc taatctggct ggctccttcc
     1621 agtgcttctg tgaggctggc taccggctgg atgaggaccg caggggctgc acgcccctag
     1681 aagaatccgt ggtggacctg gatggccagc tgccctttgt ccggcccctg ccccacattg
     1741 cggtgctggg ggatgagctt ccacaactct tccaagatga ctatggggct gaggaggagg
     1801 ctgtggcgga gctgcgggga gaacacactc tcactgagaa gtttgtctgc ttggatcact
     1861 ccttcggcca tgactgcagc ctaacctgcg atgactgcag gaatgggggg acctgcttcc
     1921 cgggcctgga tggctgtgac tgcccagagg gctggaccgg gatcatctgc aatgagactt
     1981 gtcctccaga cacttttggg aagaactgta gctctccctg catctgtcag aatggtggga
     2041 cctgtgaccc ggtgtcagga gcctgccgct gtcccccagg cgtcagtgga gcccactgtg
     2101 aggatggctg ccccaagggc ttctacggca aacactgtcg taagaaatgc cactgtgcta
     2161 accggggccg gtgccaccgc ctctatgggg cctgcctctg tgacccaggc ctctatggcc
     2221 gtttctgtca ccttgcttgc cctccctggg cctttggacc gggctgttct gaggactgcc
     2281 tttgtgagca gtcacacaca agatcttgta actcgaagga tggcagctgc tcctgcaagg
     2341 ccggcttcca gggcgagcgc tgcgaggcgg agtgcgagcc aggctccttt gggccaggct
     2401 gcagaaaccg ttgcacctgc cggccaggtg tggcctgtga ccctgtgagt ggcgagtgtc
     2461 ggacgcagtg tcctcctggc taccaggggg aggactgtgg ccaagagtgc ccagtgggga
     2521 catttggtgt gaactgctca ggttcctgct cctgcgtggg ggccccctgt caccgagtca
     2581 cgggggagtg tctgtgccca ccagggaaga ctggggagga ctgtggagcc gactgtcccg
     2641 agggccgttg ggggctcggc tgtcaagaga tctgccctgc atgtgagcat ggtgccagct
     2701 gcgaccctga gactggaacc tgcctgtgtc ttcctggttt tgttggtagc cgctgccagg
     2761 atgcttgccc agcaggctgg tttgggaccg gctgccagat gaggtgtgct tgtgccaatg
     2821 atgggcattg ccatccggcc actggacgct gtagctgtgc ccctgggtgg actggcctca
     2881 gctgccagag agcctgtgac agtggacact gggggcctga ctgcatccac ccctgcaact
     2941 gcagtgcagg ccatgggaac tgtgacgccg tcagtggcct ctgcctgtgt gaggctggct
     3001 acgaaggtcc gcagtgtgag cagtggtgtc gccaaggcta ctttgggccc ggctgcgagc
     3061 agaagtgcag gtgtgagcat ggggccacct gtgaccatgt cagtggggcc tgtacctgcc
     3121 cagctggctg gaggggaagc ttctgcgagc acgcctgtcc tgctggcttc tttgggttag
     3181 actgtggcag tgcctgcaac tgctccgccg gggccccctg tgatgctgtc actggctcgt
     3241 gcatctgccc agctggccgc tggggcccac actgtgccca gacttgccca cctctcacct
     3301 ttgggcttaa ctgcagccag atttgtacct gtttcaatgg ggcctcttgc gaccctgtcc
     3361 ttgggcagtg ccactgtgct cctggctgga tgggacccac ctgcctgcag gcctgccctg
     3421 ctggcctgta tggcaagaac tgtcagcatt cctgtctctg ccgaaatgga gggaactgtg
     3481 accccatctt gggccagtgc acgtgcccag agggttggac cggcttggcc tgtgagaacg
     3541 agtgccttcc tggacaccat ggggctggtt gccggctcaa ctgcagttgc cttaatgggg
     3601 gcacatgtga ccgtcttact ggccactgcc gctgcccaac tggctggact ggggacaagt
     3661 gtcagagccc ctgcgtcagt ggcatgtttg gggttcactg tgaggagcac tgtgcctgcc
     3721 ggaaaggtgc cacctgtcac catgtcacgg gggcctgcct ctgtccccca ggatggaggg
     3781 gctcacactg tgaacaggcc tgtccacgtg gctggtttgg agaggcctgt gctcagcgtt
     3841 gccactgccc gcctggtgcc tcctgccacc atgtctctgg agagtgccac tgtccacccg
     3901 gcttcactgg gcctggctgt gagcaggcct gccagcctgg cacctttggc aaggactgtg
     3961 agcacccgtg ccaatgtcct ggtgagacct gggcctgcca ccctgcttca ggggcctgcg
     4021 tatgtgctgc tggttaccat ggcaccgact gtcagcaacg atgcccatct gggcgctatg
     4081 ggccaggctg tgaacaaatt tgtaagtgtc tcaatggtgg gacctgcgat ccagccacgg
     4141 gagcctgcta ctgccctgct gggttccttg gggccgactg tagccttgcc tgtccacagg
     4201 gtcgcttcgg ccccagctgt gcccacgtgt gtacatgcgg gcaaggggcg gcatgtgacc
     4261 cagtgtcggg gacttgcatc tgtcctcccg ggaagacggg aggccattgt gagcgcggct
     4321 gtccccagga ccggtttggc aagggctgtg aacacaagtg tgcctgcagg aatgggggcc
     4381 tgtgtcatgc taccaatggc agctgctcct gccccctggg ctggatgggg ccacactgtg
     4441 agcacgcctg ccctgctggg cgctatggtg ctgcctgcct cctggagtgt tcctgtcaga
     4501 acaatggcag ctgtgagccc acctccggcg cttgcctctg tggccctggc ttctatggtc
     4561 aagcttgtga agacacctgc cctgccggct tccatggatc tggttgccag agagtttgcg
     4621 agtgtcaaca gggcgctccc tgtgaccctg tcagtggccg gtgcctctgc cctgctggct
     4681 tccatggcca gttctgcgag agggggtgca agccaggctt ttttggagat ggctgcctgc
     4741 agcagtgtaa ctgccccacg ggtgtgccct gtgatcccat cagcggcctc tgcctttgcc
     4801 caccagggcg tgcaggaacc acatgtgacc tagattgcag aagaggccgc tttgggccgg
     4861 gctgtgccct gcgctgtgat tgtgggggtg gggctgactg cgaccccatc agtgggcagt
     4921 gccactgtgt ggacagctac acgggaccca cttgccggga agtgcccaca cagctgtcct
     4981 ctatcagacc agcaccccag cactccagca gcaaggccat gaagcactaa ctcagaggaa
     5041 cgcccacaga ggcccactac tgtgttccag cccaagggac ccaggcctct gctggtgact
     5101 aagatagagg tggcactttt ggatccacac ctcttctgga aagccatgga ttgctgtgga
     5161 cagctatgga tagtcatata gccacacacc cgggctccat ggtcatgggg aagaaggcct
     5221 cctttggaca caaggaatcc aggaagtcgg ctgggcttcg ggccactgtt tacatgggga
     5281 ccctgcaggc tgtgctgtgg aatcctggcc ctcttcagcg acctgggatg ggaccaaggt
     5341 gggaatagac aaggccccac ctgcctgcca ggtccttctg gtgctaggcc atggactgct
     5401 gcagccagcc aactgtttac ctggaaatgt agtccagacc atatttatat aaggtattta
     5461 tgggcatctc cacctgccgt tatggtcctg ggtcagctgg aagctgcctg accccagaac
     5521 ttaggcagtg gcctgtgggg tctccagcaa gtgggatcaa gggttttgta aaacccagtg
     5581 agttaaaggc acagtggtgt ccccattgcc tgggtttctg tgctttctgt agactccgtg
     5641 ggtccttcca agagcaggtg gcctgagggt tcttgaatgg gaacctcctg tacccctctg
     5701 taatgacatg catgtaatgt aatgcttcag tcaccttagg gttcttcctg acttccagct
     5761 ctagggcatg aggcagtgcc tgtcaaggtg aattgttcca gagaacacat tgatgcctga
     5821 gacacctcca gagactacag aacaatgtcc cagagggagc agggcagggg tagtgtggaa
     5881 ggaaatccat gcttaaccaa gccagctgac cccctgcctc aacacagtga tggacaggca
     5941 gcatcacagg agccaggcct ctgctctcac tcaagcccct tgttttggat ctgggtggtg
     6001 gctgcctcct ccctctccca ctgcatccga ggcagctgaa acctccaggg acacttcaaa
     6061 ggccgcagtg gtgtggccag tagtggggag caagtcagtc ggccactgta tagagactta
     6121 ggttaaagca gagggatgga gcagagagtg gggtggagcg ttgtgtgaat gtgaagcagg
     6181 cagtatgggg acgaaggagg aattctaaag cacccagagg gaaaagggtt ttaagaatca
     6241 gactggccag aaactctaca agggaggggc tggcagccag gaaatggtgg tgatgtcaca
     6301 ggtattgaaa atatacaatt atatccagct aaactatcac catgcccaca ggttcaccca
     6361 tgtctaattt ggaaatattt ttgggaagag cctaagagac ctcacggcac acttcctaca
     6421 tggccatcat gaggagaact gaaattttcc ttctaaacca caggtcaacc ccaggctggg
     6481 taactgtggg gcagacacaa gggaagtcag agacagggca tcaccggtcc tgtgacaggc
     6541 agagaggcag cagctgtagc cagcagaggt aggagataga gaggcccact ttagcccacc
     6601 tgaggaccaa ggtccaccca gggacaggaa gggaaagaga aacagggatg gaaaaagcag
     6661 gctaacaggg cctgagcaga tagtgatcca gacttcacta agagtcatat gatcttggct
     6721 ggcaaggtgg ttcagggggt taaggccctt gctaccacgc ctgacaacct gacttagttt
     6781 cccctgtgat agaagattag tgacttccac gggttgtcct ctgacctcct catatatacc
     6841 cccaataaat attgtaatta ttttttttaa agcaag
//
