LOCUS       NM_001408630            6284 bp    mRNA    linear   ROD 13-JUN-2024
DEFINITION  Mus musculus multiple EGF-like-domains 11 (Megf11), transcript
            variant 21, mRNA.
ACCESSION   NM_001408630
VERSION     NM_001408630.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6284)
  AUTHORS   Huang,C.P., Tsai,Y.F., Lin,Y.S., Liu,C.Y., Huang,T.T., Huang,C.C.,
            Chiu,J.H. and Tseng,L.M.
  TITLE     Overexpression of multiple epidermal growth factor like domains 11
            rescues anoikis survival through tumor cells-platelet interaction
            in triple negative breast Cancer cells
  JOURNAL   Life Sci 299, 120541 (2022)
   PUBMED   35398017
  REMARK    GeneRIF: Overexpression of multiple epidermal growth factor like
            domains 11 rescues anoikis survival through tumor cells-platelet
            interaction in triple negative breast Cancer cells.
REFERENCE   2  (bases 1 to 6284)
  AUTHORS   Peng,Y.R., James,R.E., Yan,W., Kay,J.N., Kolodkin,A.L. and
            Sanes,J.R.
  TITLE     Binary Fate Choice between Closely Related Interneuronal Types Is
            Determined by a Fezf1-Dependent Postmitotic Transcriptional Switch
  JOURNAL   Neuron 105 (3), 464-474 (2020)
   PUBMED   31812516
REFERENCE   3  (bases 1 to 6284)
  AUTHORS   Hanley,O., Zewdu,R., Cohen,L.J., Jung,H., Lacombe,J.,
            Philippidou,P., Lee,D.H., Selleri,L. and Dasen,J.S.
  TITLE     Parallel Pbx-Dependent Pathways Govern the Coalescence and Fate of
            Motor Columns
  JOURNAL   Neuron 91 (5), 1005-1020 (2016)
   PUBMED   27568519
REFERENCE   4  (bases 1 to 6284)
  AUTHORS   Kay,J.N., Chu,M.W. and Sanes,J.R.
  TITLE     MEGF10 and MEGF11 mediate homotypic interactions required for
            mosaic spacing of retinal neurons
  JOURNAL   Nature 483 (7390), 465-469 (2012)
   PUBMED   22407321
  REMARK    GeneRIF: in mouse, two related transmembrane proteins, MEGF10 and
            MEGF11, have critical roles in the formation of mosaics by two
            retinal interneuron subtypes, starburst amacrine cells and
            horizontal cells
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 6284)
  AUTHORS   Wu,H.H., Bellmunt,E., Scheib,J.L., Venegas,V., Burkert,C.,
            Reichardt,L.F., Zhou,Z., Farinas,I. and Carter,B.D.
  TITLE     Glial precursors clear sensory neuron corpses during development
            via Jedi-1, an engulfment receptor
  JOURNAL   Nat Neurosci 12 (12), 1534-1541 (2009)
   PUBMED   19915564
REFERENCE   6  (bases 1 to 6284)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Aizawa,H., Yuasa,S.,
            Nakajima,D., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: II. The complete nucleotide sequences of 400 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 10 (1), 35-48 (2003)
   PUBMED   12693553
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC135358.3, AC162917.3 and AC147560.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR9219381.303752.1,
                                           SRR9219382.231056.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164132
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-146               AC135358.3         121891-122036
            147-247             AC162917.3         51248-51348         c
            248-349             AC162917.3         46742-46843         c
            350-450             AC162917.3         44063-44163         c
            451-543             AC162917.3         8185-8277           c
            544-790             AC147560.3         46412-46658
            791-911             AC147560.3         48191-48311
            912-1048            AC147560.3         55992-56128
            1049-1261           AC147560.3         61247-61459
            1262-1436           AC147560.3         68517-68691
            1437-1557           AC147560.3         87356-87476
            1558-1721           AC147560.3         88411-88574
            1722-1824           AC147560.3         89567-89669
            1825-1971           AC147560.3         94057-94203
            1972-2100           AC147560.3         99972-100100
            2101-2229           AC147560.3         100532-100660
            2230-2466           AC147560.3         101938-102174
            2467-2585           AC147560.3         103541-103659
            2586-2652           AC147560.3         105484-105550
            2653-2754           AC147560.3         105984-106085
            2755-2811           AC147560.3         108274-108330
            2812-6284           AC147560.3         113904-117376
FEATURES             Location/Qualifiers
     source          1..6284
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 34.67 cM"
     gene            1..6284
                     /gene="Megf11"
                     /gene_synonym="2410080H04Rik; D130061K05"
                     /note="multiple EGF-like-domains 11"
                     /db_xref="GeneID:214058"
                     /db_xref="MGI:MGI:1920951"
     exon            1..146
                     /gene="Megf11"
                     /gene_synonym="2410080H04Rik; D130061K05"
                     /inference="alignment:Splign:2.1.0"
     exon            147..247
                     /gene="Megf11"
                     /gene_synonym="2410080H04Rik; D130061K05"
                     /inference="alignment:Splign:2.1.0"
     CDS             153..3035
                     /gene="Megf11"
                     /gene_synonym="2410080H04Rik; D130061K05"
                     /note="isoform 21 precursor is encoded by transcript
                     variant 21; multiple epidermal growth factor-like domains
                     protein 11; multiple EGF-like domains protein 11"
                     /codon_start=1
                     /product="multiple epidermal growth factor-like domains
                     protein 11 isoform 21 precursor"
                     /protein_id="NP_001395559.1"
                     /db_xref="GeneID:214058"
                     /db_xref="MGI:MGI:1920951"
                     /translation="MAPSAVGLLVFLLQAALALNPEDPNVCSHWESYAVTVQESYAHP
                     FDQIYYTRCADILNWFKCTRHRISYKTAYRRGLRTMYRRRSQCCPGYYENGDFCIPLC
                     TEECMHGRCVSPDTCHCEPGWGGPDCSSGCDSEHWGPHCSNRCQCQNGALCNPITGAC
                     VCAPGFRGWRCEELCAPGTHGKGCQLLCQCHHGASCDPRTGECLCAPGYTGVYCEELC
                     PPGSHGAHCELRCPCQNGGTCHHITGECACPPGWTGAVCAQPCPPGTFGQNCSQDCPC
                     HHGGQCDHVTGQCHCTAGYMGDRCQEECPFGTFGFLCSQRCDCHNGGQCSPATGACEC
                     EPGYKGPSCQERLCPEGLHGPGCTLPCPCDTENTISCHPVTGACTCQPGWSGHYCNES
                     CPAGYYGNGCQLPCTCQNGADCHSITGSCTCAPGFMGEVCAVPCAAGTYGPNCSSVCS
                     CSNGGTCSPVDGSCTCREGWQGLDCSLPCPSGTWGLNCNETCICANGAACSPFDGSCA
                     CTPGWLGDSCELPCPDGTFGLNCSEHCDCSHADGCDPVTGHCCCLAGWTGIRCDSTCP
                     PGRWGPNCSVSCSCENGGSCSPEDGSCECAPGFRGPLCQRSCPSAFFGKDCGHICQCQ
                     NGASCDHITGKCTCRTGFSGRHCEQRCAPGTFGYGCQQLCECMNNATCDHVTGTCYCS
                     PGFKGIRCDQAALMMDELNPYTKISPALGAERHSVGAVTGIVLLLFLVVVLLGLFAWR
                     RRRQKEKGRDLAPRVSYTPAMRMTSTDYSLSDLSQSSSHAQCFSNASYHTLACGGPAT
                     SQASTLDRNSPTKLSNKSLDRDTAGWTPYSYVNVLDSHFQISALEARYPPEDFYIELR
                     HLSRHAEPHSPGTCGMDRRQNTYIMDKGFKDYMKESVCSSSTCSLNSSENPYATIKDP
                     PILTCKLPESSYVEMKSPVHLGSPYTDVPSLSTSNKNIYEVGRCLT"
     exon            248..349
                     /gene="Megf11"
                     /gene_synonym="2410080H04Rik; D130061K05"
                     /inference="alignment:Splign:2.1.0"
     exon            350..450
                     /gene="Megf11"
                     /gene_synonym="2410080H04Rik; D130061K05"
                     /inference="alignment:Splign:2.1.0"
     exon            451..543
                     /gene="Megf11"
                     /gene_synonym="2410080H04Rik; D130061K05"
                     /inference="alignment:Splign:2.1.0"
     exon            544..790
                     /gene="Megf11"
                     /gene_synonym="2410080H04Rik; D130061K05"
                     /inference="alignment:Splign:2.1.0"
     exon            791..911
                     /gene="Megf11"
                     /gene_synonym="2410080H04Rik; D130061K05"
                     /inference="alignment:Splign:2.1.0"
     exon            912..1048
                     /gene="Megf11"
                     /gene_synonym="2410080H04Rik; D130061K05"
                     /inference="alignment:Splign:2.1.0"
     exon            1049..1261
                     /gene="Megf11"
                     /gene_synonym="2410080H04Rik; D130061K05"
                     /inference="alignment:Splign:2.1.0"
     exon            1262..1436
                     /gene="Megf11"
                     /gene_synonym="2410080H04Rik; D130061K05"
                     /inference="alignment:Splign:2.1.0"
     exon            1437..1557
                     /gene="Megf11"
                     /gene_synonym="2410080H04Rik; D130061K05"
                     /inference="alignment:Splign:2.1.0"
     exon            1558..1721
                     /gene="Megf11"
                     /gene_synonym="2410080H04Rik; D130061K05"
                     /inference="alignment:Splign:2.1.0"
     exon            1722..1824
                     /gene="Megf11"
                     /gene_synonym="2410080H04Rik; D130061K05"
                     /inference="alignment:Splign:2.1.0"
     exon            1825..1971
                     /gene="Megf11"
                     /gene_synonym="2410080H04Rik; D130061K05"
                     /inference="alignment:Splign:2.1.0"
     exon            1972..2100
                     /gene="Megf11"
                     /gene_synonym="2410080H04Rik; D130061K05"
                     /inference="alignment:Splign:2.1.0"
     exon            2101..2229
                     /gene="Megf11"
                     /gene_synonym="2410080H04Rik; D130061K05"
                     /inference="alignment:Splign:2.1.0"
     exon            2230..2466
                     /gene="Megf11"
                     /gene_synonym="2410080H04Rik; D130061K05"
                     /inference="alignment:Splign:2.1.0"
     exon            2467..2585
                     /gene="Megf11"
                     /gene_synonym="2410080H04Rik; D130061K05"
                     /inference="alignment:Splign:2.1.0"
     exon            2586..2652
                     /gene="Megf11"
                     /gene_synonym="2410080H04Rik; D130061K05"
                     /inference="alignment:Splign:2.1.0"
     exon            2653..2754
                     /gene="Megf11"
                     /gene_synonym="2410080H04Rik; D130061K05"
                     /inference="alignment:Splign:2.1.0"
     exon            2755..2811
                     /gene="Megf11"
                     /gene_synonym="2410080H04Rik; D130061K05"
                     /inference="alignment:Splign:2.1.0"
     exon            2812..6284
                     /gene="Megf11"
                     /gene_synonym="2410080H04Rik; D130061K05"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6262..6267
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Megf11"
                     /gene_synonym="2410080H04Rik; D130061K05"
                     /note="hexamer: AATAAA"
     polyA_site      6284
                     /gene="Megf11"
                     /gene_synonym="2410080H04Rik; D130061K05"
                     /note="major polyA site"
ORIGIN      
        1 actcgttctc agtgcccgga gccggctgcc cggctcgggg cggttcgcag ctccctctcc
       61 tgcctgggga cctgaagccg ctccggctcc ggggtatagg accgcgcgac tggctggccc
      121 aagcccgggg cgcgccacgg aagcaggccc cgatggcgcc gtctgcggtg ggcctccttg
      181 tcttccttct gcaagctgct cttgctctga accctgaaga ccccaatgtg tgtagccact
      241 gggagagcta tgccgtgact gtgcaggagt cttatgcaca cccctttgat cagatctact
      301 acacacgatg tgcagacatc ctcaactggt tcaagtgtac ccggcaccgg atcagctata
      361 agaccgcgta taggcgcggc ctccggacca tgtaccggcg gaggtcccaa tgctgccctg
      421 gctactatga gaacggagac ttctgcattc ctctgtgtac cgaggagtgc atgcacggcc
      481 gctgtgtctc tcccgatacc tgccactgtg agcctggatg gggaggccct gactgctcca
      541 gcggctgtga cagcgagcac tggggtcccc actgcagcaa ccggtgtcag tgtcagaacg
      601 gcgccctgtg caaccctatc accggcgcct gcgtgtgcgc cccgggcttc cgaggctggc
      661 gctgtgagga actctgcgct cctggtactc acggcaaggg ctgccagctg ctctgtcagt
      721 gccaccatgg cgccagctgt gacccgcgca ctggcgagtg cctctgcgct cctggctaca
      781 caggcgttta ctgtgaggag ctgtgccccc ctgggagcca tggagctcac tgtgagctgc
      841 gctgcccctg ccagaatgga ggcacctgcc accacatcac tggcgaatgt gcctgccctc
      901 caggctggac gggagcagtg tgtgcccagc cctgccctcc agggaccttt ggccagaact
      961 gtagccagga ctgtccctgc caccatggag gccagtgtga ccatgtgact ggacaatgcc
     1021 actgtacagc tggatacatg ggggacaggt gtcaagaaga atgtcccttt ggaacgttcg
     1081 gtttcctgtg ctctcaacgc tgtgactgcc acaatggagg tcaatgttca ccagccacag
     1141 gggcctgtga gtgtgagcct ggctacaagg gccctagctg ccaggagcgg ctatgccctg
     1201 agggcctgca tggcccaggc tgcaccttgc cctgcccctg tgacaccgag aacactatca
     1261 gctgccatcc agttactgga gcttgtacct gccaaccagg ctggtctggc cactactgca
     1321 atgagtcctg ccccgccggc tactatggca acggttgcca gctaccctgc acctgccaga
     1381 acggtgctga ctgccacagt atcaccggga gctgcacttg tgctccaggc ttcatgggag
     1441 aggtgtgtgc cgtcccctgt gctgcaggga cctatggtcc caactgttca tctgtatgta
     1501 gctgtagcaa cggcggcacc tgttccccag tggatggctc ctgcacctgc cgagagggat
     1561 ggcagggcct ggactgctcc ctgccttgtc ccagtgggac ctggggcctg aactgcaatg
     1621 agacttgcat ctgtgccaat ggagctgcct gcagcccctt tgatgggtcc tgtgcctgca
     1681 ccccaggctg gctgggggac tcctgtgaac tgccctgccc ggacggcact tttgggctga
     1741 actgcagtga gcattgcgac tgcagccatg ctgatggctg tgaccctgtc acaggccact
     1801 gctgctgcct ggcaggatgg acaggcatcc gctgtgatag cacgtgtcct ccaggtcgct
     1861 ggggccccaa ctgttcagtg tcctgcagct gtgagaacgg aggttcctgc tccccggagg
     1921 acgggagctg cgagtgtgcc cctggctttc gaggaccctt atgtcagaga agttgccctt
     1981 cagcattttt tgggaaggac tgtgggcaca tatgccagtg tcagaatgga gccagctgtg
     2041 accacatcac tgggaaatgc acctgtcgaa caggcttctc tggccgccac tgtgaacaga
     2101 gatgtgcccc tggaaccttt ggatatgggt gtcagcagct atgtgagtgc atgaacaatg
     2161 ccacttgtga ccacgtcact ggtacctgtt actgtagccc gggattcaaa ggaatcaggt
     2221 gtgaccaagc tgccctcatg atggatgagc tgaatcccta caccaagatc agtccagctc
     2281 tgggagcaga gcggcactca gtgggtgctg tcaccggcat cgttctcctg ttgttcctgg
     2341 tggtggtgct gctgggcctg tttgcctggc gacggaggcg gcagaaagag aaaggccgtg
     2401 acctggctcc ccgagtctcc tacaccccag ccatgaggat gaccagcaca gactactctc
     2461 tctcagattt gtctcaaagt agcagccatg cccagtgctt ttccaatgcc agctaccaca
     2521 cactggcgtg tggggggcct gccaccagcc aggccagcac tctggacagg aacagcccca
     2581 ccaagctcag taacaagtcc cttgacagag acacagcagg ctggaccccc tacagctatg
     2641 tgaacgtgtt agactcccat ttccagatca gtgccctgga ggccaggtac ccgcccgagg
     2701 acttctacat tgaacttaga cacctcagcc gccatgctga gccacactca ccaggcactt
     2761 gtggaatgga cagacgtcag aacacataca ttatggacaa aggcttcaaa gattacatga
     2821 aagaatctgt gtgcagttct agcacttgct ccttgaacag cagtgaaaac ccttacgcca
     2881 caattaagga cccacccatc ctcacctgca agcttccaga aagcagttat gtagaaatga
     2941 agtcacctgt gcacttgggg tctccgtaca cagatgtgcc atccttgtcg acatctaata
     3001 aaaatatata tgaagttggt aggtgtctca cataacttag caaaaccagg gcaacagtgc
     3061 agcatctcaa gtgaaaacaa gccctcctcc acacactcta tctccatacc acatccttct
     3121 gtttggttgc atttgaagga acctgaggag aaactttgtc tcagggttgc ccttccctct
     3181 aatgcaggaa accagaatct tgtgccacct tgcttacaaa tcacaactga taaaagtaga
     3241 aactgtgagg gtggagagcc agtatacaac acttcgacta ctgttaatac aaatccaaag
     3301 cggaaaacga aaacaatcag aatggccgtt tacaagtttc taaatcactt cttaaacctc
     3361 ccccagtaag acccacacct ctaggatgtc ttgaatctct tgttgttgag caaactagga
     3421 ttctggcagt acactgtctt aggtttttcc ctctcttaag caagcctcca tcctaatcct
     3481 cctggatttg tcagatgtat acatataccc acagtttttc tccccaacaa gttaaataga
     3541 actttcttcc ctcccaccaa ggcaacaatg ctaatctatt ctctgaactc atttttcact
     3601 atattcctta gagcccacag tcagtgtggt ccaagaaggc cgaggtcata actccagcta
     3661 tatccagaat ccatacgacc tacctaagaa cagccatatt cctggtcact atgacctcct
     3721 cccagtaaga cagagccctg cccatgggcc cttccaggaa aagcagtaag agggataagc
     3781 gtctctctta gtgtgctctg ctgactattt tctgactctg aaagaagaca atccatgact
     3841 tgaaatatca gtacagaatg ccttgagctg tgtgttatta gttccttcac ctggattgaa
     3901 agaaacactt ccaaacggga ctggggtaac tgttcaagaa agtctgttca caaaggcaaa
     3961 tcctatcaac ctttcagctc taaatgtcct ggatatgatt tttcagaaca ttaaagatac
     4021 cacttttcat cagcatcagc taaaagctat gtatttaata ttctgaaaca tcgcttaaga
     4081 agcatgtagc ttaggttcct caagccttcc aagaaggaaa aggaaactgg gaggggaggg
     4141 ggcacttaaa gtgcctgaaa tgtgtatgtg ctgttgattg ttgttatcct caacatctgt
     4201 ttcagtatct aagggaattg gtatgtgggc atgaactgtt ctaatattaa tcttggtctc
     4261 tgttcatttg gtatgcccca gcaaattata acagccacaa tcagagttta aaatataacc
     4321 taattcttta atcaagacag gttcactttc ttctgcccta tcagtaatag taggcaaaac
     4381 agaaaggggg aaaagagcag cagtttcact cactctagaa tgatttctat gccagcctta
     4441 ccaaattttg ccaagtcaaa gttcaagaat aacgaatgcc aatcctggcc tggctgcatt
     4501 gcattggttc acccaatact tgagtcattc tgtgtgcacc agagaactaa gatgctgttt
     4561 taagaaaatg gtcacagggc tgggaatgta gcttagtggt agatgttctt gcctactgag
     4621 caaggacctg ggatagatca gcagcatcat ataaaaggca taggcttata atgaagtttc
     4681 cccaacaaca taattagatc actcaagtta cttagtcgga gttccttgac ttgtttatgg
     4741 gcagttcttc atagatggtg cttgatgtag tatggaacct taaggtgtag aaaatattac
     4801 acaaatgtgg gcatggcaca cttatgttgc ttagcataca ttatgttttt gatgcaacta
     4861 aatgaaataa atgtaaaaca aaacaaaaac aaaaaaacat aaaagcccac cgcctgaagt
     4921 gggcaaatat gtattccatt agttggtgct tttaatctcc tgtccagaga agtccataac
     4981 ttccactgca caggtaacaa taggtaaacg gaggcttgga caactctgaa tggttaatcc
     5041 ccaaattctt cacaagaatt aagaacagaa gggacaagtt ggaagttaat ggtcaccttt
     5101 gtgccatccc atgttcttaa gaggattaag agtctagagt gagtaaaaat tacctagaag
     5161 gggtttacag aagagggact agaagactgt aaagctagat actgctacag gaagtaggga
     5221 tgataacctt agtttgagta gtaatcagca aaagagagaa aataaatatg taagcaaatc
     5281 tctgctcgtt tcactccagg cataagccag tatgacatta gaggaacaca tacatgaatg
     5341 ctgcatgtgt gcatggaagc gagccatcag caatagtgaa cgctcccaaa agccttataa
     5401 aatagaaaca gtaggaaata ttggtagacc taagttaata tttctcatac atgtataaag
     5461 aaacgtagtg aagagactca cctcagtgtt tcagggccac aagtgctctg ttatctttgt
     5521 gaagcaagga tgaagaagca tggcgaagtc caaccagcaa gcagaaatgg cgtctcaatc
     5581 ccaggcttta tcttcttccc ctaccctgca tgtacaataa ctgctacctg gcaaactgca
     5641 atcatgcaaa ttccaaacct cacttctctc ttgccaacta cactctgcac aaagtaccca
     5701 gcaagaggtg ggatggctag agcagcaagt caagagaagt tggcaccact cttgttgagt
     5761 cacttgccct cttcgggctc ctttattacc cacacatgaa agaagagaga cacagagtgg
     5821 gagcagagct ctaacaactc tccaagtgta gcactctaca acatttcaag taacatagtt
     5881 cagtcaggct atacagagaa gggaaagggc aaagatgtga ttaagtatgg tgacagcagc
     5941 agccttcaca tagctaagag ttagcactag gacatttcga tcatgcagag caactgttag
     6001 gaacttctgt ctaacaatca caaacaggtt tgcggtcagc ctcaacatgt gcgctgtgca
     6061 ttctatagtc aatttggaaa gatctgctca attatttttc aaaacaaaaa tttcaatcca
     6121 gtaaattaat atgtatacaa gtcagacaaa gaaaacacag atactgtaca atagtgtgag
     6181 agactatgaa atggcaatac ttttttaaac cacagatttg taatatattt gttcactgtg
     6241 cagaggatgt accttataca aaataaaatg gattctcaaa ctaa
//
