LOCUS       NM_001001979            7514 bp    mRNA    linear   ROD 01-OCT-2024
DEFINITION  Mus musculus multiple EGF-like-domains 10 (Megf10), mRNA.
ACCESSION   NM_001001979 XM_140362
VERSION     NM_001001979.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 7514)
  AUTHORS   Kozlowski,C., Hadyniak,S.E. and Kay,J.N.
  TITLE     Retinal neurons establish mosaic patterning by excluding homotypic
            somata from their dendritic territories
  JOURNAL   Cell Rep 43 (8), 114615 (2024)
   PUBMED   39133615
REFERENCE   2  (bases 1 to 7514)
  AUTHORS   Juros,D., Avila,M.F., Hastings,R.L., Pendragon,A., Wilson,L.,
            Kay,J. and Valdez,G.
  TITLE     Cellular and molecular alterations to muscles and neuromuscular
            synapses in a mouse model of MEGF10-related myopathy
  JOURNAL   Skelet Muscle 14 (1), 10 (2024)
   PUBMED   38760872
  REMARK    GeneRIF: Cellular and molecular alterations to muscles and
            neuromuscular synapses in a mouse model of MEGF10-related myopathy.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 7514)
  AUTHORS   James,R.E., Hamilton,N.R., Huffman,L.N., Pasterkamp,J., Goff,L.A.
            and Kolodkin,A.L.
  TITLE     Semaphorin 6A in Retinal Ganglion Cells Regulates Functional
            Specialization of the Inner Retina
  JOURNAL   bioRxiv (2023)
   PUBMED   38014224
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 7514)
  AUTHORS   Zhuang,Y., Xu,X., Li,H., Niu,F., Yang,M., Ge,Q., Lu,S., Deng,Y.,
            Wu,H., Zhang,B. and Liu,B.
  TITLE     Megf10-related engulfment of excitatory postsynapses by astrocytes
            following severe brain injury
  JOURNAL   CNS Neurosci Ther 29 (10), 2873-2883 (2023)
   PUBMED   37081759
  REMARK    GeneRIF: Megf10-related engulfment of excitatory postsynapses by
            astrocytes following severe brain injury.
REFERENCE   5  (bases 1 to 7514)
  AUTHORS   Byun,Y.G., Kim,N.S., Kim,G., Jeon,Y.S., Choi,J.B., Park,C.W.,
            Kim,K., Jang,H., Kim,J., Kim,E., Han,Y.M., Yoon,K.J., Lee,S.H. and
            Chung,W.S.
  TITLE     Stress induces behavioral abnormalities by increasing expression of
            phagocytic receptor MERTK in astrocytes to promote synapse
            phagocytosis
  JOURNAL   Immunity 56 (9), 2105-2120 (2023)
   PUBMED   37527657
REFERENCE   6  (bases 1 to 7514)
  AUTHORS   Scheib,J.L., Sullivan,C.S. and Carter,B.D.
  TITLE     Jedi-1 and MEGF10 signal engulfment of apoptotic neurons through
            the tyrosine kinase Syk
  JOURNAL   J Neurosci 32 (38), 13022-13031 (2012)
   PUBMED   22993420
  REMARK    GeneRIF: These results indicated that both Jedi-1 and MEGF10 can
            mediate phagocytosis independently through the recruitment of Syk.
REFERENCE   7  (bases 1 to 7514)
  AUTHORS   Kay,J.N., Chu,M.W. and Sanes,J.R.
  TITLE     MEGF10 and MEGF11 mediate homotypic interactions required for
            mosaic spacing of retinal neurons
  JOURNAL   Nature 483 (7390), 465-469 (2012)
   PUBMED   22407321
  REMARK    GeneRIF: in mouse, two related transmembrane proteins, MEGF10 and
            MEGF11, have critical roles in the formation of mosaics by two
            retinal interneuron subtypes, starburst amacrine cells and
            horizontal cells
            Publication Status: Online-Only
REFERENCE   8  (bases 1 to 7514)
  AUTHORS   Wu,H.H., Bellmunt,E., Scheib,J.L., Venegas,V., Burkert,C.,
            Reichardt,L.F., Zhou,Z., Farinas,I. and Carter,B.D.
  TITLE     Glial precursors clear sensory neuron corpses during development
            via Jedi-1, an engulfment receptor
  JOURNAL   Nat Neurosci 12 (12), 1534-1541 (2009)
   PUBMED   19915564
REFERENCE   9  (bases 1 to 7514)
  AUTHORS   Holterman,C.E., Le Grand,F., Kuang,S., Seale,P. and Rudnicki,M.A.
  TITLE     Megf10 regulates the progression of the satellite cell myogenic
            program
  JOURNAL   J Cell Biol 179 (5), 911-922 (2007)
   PUBMED   18056409
  REMARK    GeneRIF: Megf10 represents a novel transmembrane protein that
            impinges on Notch signaling to regulate the satellite cell
            population balance between proliferation and differentiation.
REFERENCE   10 (bases 1 to 7514)
  AUTHORS   Suzuki,E. and Nakayama,M.
  TITLE     MEGF10 is a mammalian ortholog of CED-1 that interacts with
            clathrin assembly protein complex 2 medium chain and induces large
            vacuole formation
  JOURNAL   Exp Cell Res 313 (17), 3729-3742 (2007)
   PUBMED   17643423
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK147238.1, BC075647.1 and AK013855.1.
            
            On Feb 18, 2010 this sequence version replaced NM_001001979.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK147238.1, BC075647.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164132
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-385               AK147238.1         2-386
            386-6096            BC075647.1         1-5711
            6097-7513           BC075647.1         5714-7130
            7514-7514           AK013855.1         1585-1585
FEATURES             Location/Qualifiers
     source          1..7514
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 31.5 cM"
     gene            1..7514
                     /gene="Megf10"
                     /gene_synonym="3000002B06Rik; Gm331"
                     /note="multiple EGF-like-domains 10"
                     /db_xref="GeneID:70417"
                     /db_xref="MGI:MGI:2685177"
     exon            1..641
                     /gene="Megf10"
                     /gene_synonym="3000002B06Rik; Gm331"
                     /inference="alignment:Splign:2.1.0"
     exon            642..774
                     /gene="Megf10"
                     /gene_synonym="3000002B06Rik; Gm331"
                     /inference="alignment:Splign:2.1.0"
     CDS             659..4102
                     /gene="Megf10"
                     /gene_synonym="3000002B06Rik; Gm331"
                     /note="multiple epidermal growth factor-like domains
                     protein 10; multiple EGF-like domains protein 10"
                     /codon_start=1
                     /product="multiple epidermal growth factor-like domains
                     protein 10 precursor"
                     /protein_id="NP_001001979.1"
                     /db_xref="CCDS:CCDS29264.1"
                     /db_xref="GeneID:70417"
                     /db_xref="MGI:MGI:2685177"
                     /translation="MAISSSSCLGLICSLLCHWVGTASSLNLEDPNVCSHWESYSVTV
                     QESYPHPFDQIYYTSCTDILNWFKCTRHRISYRTAYRHGEKTMYRRKSQCCPGFYESR
                     DMCVPHCADKCVHGRCIAPNTCQCEPGWGGTNCSSACDGDHWGPHCSSRCQCKNRALC
                     NPITGACHCAAGYRGWRCEDRCEQGTYGNDCHQRCQCQNGATCDHITGECRCSPGYTG
                     AFCEDLCPPGKHGPHCEQRCPCQNGGVCHHVTGECSCPSGWMGTVCGQPCPEGRFGKN
                     CSQECQCHNGGTCDAATGQCHCSPGYTGERCQDECPVGSYGVRCAEACRCVNGGKCYH
                     VSGTCLCEAGFSGELCEARLCPEGLYGIKCDKRCPCHLDNTHSCHPMSGECGCKPGWS
                     GLYCNETCSPGFYGEACQQICSCQNGADCDSVTGRCACAPGFKGTDCSTPCPLGRYGI
                     NCSSRCGCKNDAVCSPVDGSCICKAGWHGVDCSIRCPSGTWGFGCNLTCQCLNGGACN
                     TLDGTCTCAPGWRGAKCEFPCQDGTYGLNCAERCDCSHADGCHPTTGHCRCLPGWSGV
                     HCDSVCAEGRWGPNCSLPCYCKNGASCSPDDGICECAPGFRGTTCQRICSPGFYGHRC
                     SQTCPQCVHSSGPCHHITGLCDCLPGFTGALCNEVCPSGRFGKNCAGVCTCTNNGTCN
                     PIDRSCQCYPGWIGSDCSQPCPPAHWGPNCIHTCNCHNGAFCSAYDGECKCTPGWTGL
                     YCTQRCPLGFYGKDCALICQCQNGADCDHISGQCTCRTGFMGRHCEQKCPAGTYGYGC
                     RQICDCLNNSTCDHITGTCYCSPGWKGARCDQAGVIIVGNLNSLSRTSTALPADSYQI
                     GAIAGIVVLVLVVLFLLALFIIYRHKQKRKESSMPAVTYTPAMRVINADYTIAETLPH
                     SNGGNANSHYFTNPSYHTLSQCATSPHVNNRDRMTIAKSKNNQLFVNLKNVNPGKRGT
                     LVDCTGTLPADWKQGGYLNELGAFGLDRSYMGKSLKDLGKNSEYNSSTCSLSSSENPY
                     ATIKDPPALLPKSSECGYVEMKSPARRDSPYAEINNSTPANRNVYEVEPTVSVVQGVF
                     SNSGHVTQDPYDLPKNSHIPCHYDLLPVRDSSSSPKREDGGGSNSTSSNSTSSSSSSS
                     E"
     exon            775..876
                     /gene="Megf10"
                     /gene_synonym="3000002B06Rik; Gm331"
                     /inference="alignment:Splign:2.1.0"
     exon            877..977
                     /gene="Megf10"
                     /gene_synonym="3000002B06Rik; Gm331"
                     /inference="alignment:Splign:2.1.0"
     exon            978..1070
                     /gene="Megf10"
                     /gene_synonym="3000002B06Rik; Gm331"
                     /inference="alignment:Splign:2.1.0"
     exon            1071..1317
                     /gene="Megf10"
                     /gene_synonym="3000002B06Rik; Gm331"
                     /inference="alignment:Splign:2.1.0"
     exon            1318..1438
                     /gene="Megf10"
                     /gene_synonym="3000002B06Rik; Gm331"
                     /inference="alignment:Splign:2.1.0"
     exon            1439..1575
                     /gene="Megf10"
                     /gene_synonym="3000002B06Rik; Gm331"
                     /inference="alignment:Splign:2.1.0"
     exon            1576..1788
                     /gene="Megf10"
                     /gene_synonym="3000002B06Rik; Gm331"
                     /inference="alignment:Splign:2.1.0"
     exon            1789..1963
                     /gene="Megf10"
                     /gene_synonym="3000002B06Rik; Gm331"
                     /inference="alignment:Splign:2.1.0"
     exon            1964..2084
                     /gene="Megf10"
                     /gene_synonym="3000002B06Rik; Gm331"
                     /inference="alignment:Splign:2.1.0"
     exon            2085..2248
                     /gene="Megf10"
                     /gene_synonym="3000002B06Rik; Gm331"
                     /inference="alignment:Splign:2.1.0"
     exon            2249..2351
                     /gene="Megf10"
                     /gene_synonym="3000002B06Rik; Gm331"
                     /inference="alignment:Splign:2.1.0"
     exon            2352..2498
                     /gene="Megf10"
                     /gene_synonym="3000002B06Rik; Gm331"
                     /inference="alignment:Splign:2.1.0"
     exon            2499..2633
                     /gene="Megf10"
                     /gene_synonym="3000002B06Rik; Gm331"
                     /inference="alignment:Splign:2.1.0"
     exon            2634..2762
                     /gene="Megf10"
                     /gene_synonym="3000002B06Rik; Gm331"
                     /inference="alignment:Splign:2.1.0"
     exon            2763..2891
                     /gene="Megf10"
                     /gene_synonym="3000002B06Rik; Gm331"
                     /inference="alignment:Splign:2.1.0"
     exon            2892..3020
                     /gene="Megf10"
                     /gene_synonym="3000002B06Rik; Gm331"
                     /inference="alignment:Splign:2.1.0"
     exon            3021..3149
                     /gene="Megf10"
                     /gene_synonym="3000002B06Rik; Gm331"
                     /inference="alignment:Splign:2.1.0"
     exon            3150..3386
                     /gene="Megf10"
                     /gene_synonym="3000002B06Rik; Gm331"
                     /inference="alignment:Splign:2.1.0"
     exon            3387..3514
                     /gene="Megf10"
                     /gene_synonym="3000002B06Rik; Gm331"
                     /inference="alignment:Splign:2.1.0"
     exon            3515..3638
                     /gene="Megf10"
                     /gene_synonym="3000002B06Rik; Gm331"
                     /inference="alignment:Splign:2.1.0"
     exon            3639..3683
                     /gene="Megf10"
                     /gene_synonym="3000002B06Rik; Gm331"
                     /inference="alignment:Splign:2.1.0"
     exon            3684..3890
                     /gene="Megf10"
                     /gene_synonym="3000002B06Rik; Gm331"
                     /inference="alignment:Splign:2.1.0"
     exon            3891..7514
                     /gene="Megf10"
                     /gene_synonym="3000002B06Rik; Gm331"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7428..7433
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Megf10"
                     /gene_synonym="3000002B06Rik; Gm331"
                     /note="hexamer: AATAAA"
     polyA_site      7448
                     /gene="Megf10"
                     /gene_synonym="3000002B06Rik; Gm331"
                     /note="major polyA site"
ORIGIN      
        1 gtcctgtccg cctggctgac gctggccctg tcccccaaat ccttgtagag ggcctagact
       61 cttctcctgg ggtactttga ggaggggtta gcactggcac tgtggggcac agcactactc
      121 tatcactctc tcaagccccc tggtgactcc aagtttgcca acttcttgac ccagtcactg
      181 acgggggtcc caggagtccg ggcccggaag gagcttgcag gtttggaggg atcgcgagtc
      241 agcaacatca cttcccctcc ccaaacctcc ccccccccgc ccccccaccg gccactgtcc
      301 tggaggcagc agctgcagca gcggcaactg ctcgcatccc agccgggctc gggttaccgc
      361 cttcttcttc tagcatctcc agccagacag ggaaaagctt gttcaagttt gcagcaggac
      421 tcggtccctg tgcgtgcgaa cctggggctc cgggacgggc ctgctccccg gcgtccccac
      481 ctccagtgtt taaacaagac ccgcaaacat tgctttctcc caggactctg cttggaaacc
      541 agcagccgct gttgggaaca gattttgaac agattttgct ggagtgggtg aagaccaggg
      601 gaaaacaggt tgcgctgcca atcacagcat ttcaggaccc gattgttctt cacagaaaat
      661 ggcgatttct tcaagttcgt gcctgggcct catctgctca ctgctctgtc actgggtggg
      721 gacagcatcc tccctgaacc tggaagaccc caacgtatgc agccactggg aaagctactc
      781 ggtgactgtg caggagtcgt atccacatcc cttcgatcag atctactaca caagctgcac
      841 cgacatcctg aactggttta aatgcacacg gcacagaatc agctaccgga cagcctaccg
      901 ccacggggag aaaaccatgt atagacgcaa atcccagtgt tgcccaggat tttatgaaag
      961 ccgagacatg tgtgtccctc actgtgctga taaatgtgtc catggtcgct gcattgctcc
     1021 aaacacctgt cagtgtgagc ctggctgggg tgggaccaac tgtagcagtg cttgtgatgg
     1081 tgatcactgg gggcctcact gcagcagccg atgccagtgc aaaaacagag ctttgtgtaa
     1141 ccccatcacc ggtgcttgcc actgcgctgc gggctaccgg ggatggcgct gcgaggaccg
     1201 ttgtgaacag ggcacgtacg gtaacgactg tcaccaaaga tgccagtgtc agaatggagc
     1261 gacctgtgac cacatcactg gggaatgccg ttgttcacct gggtacactg gagccttctg
     1321 tgaggatctt tgtcctcctg gcaaacatgg tccacattgt gagcagaggt gtccctgcca
     1381 aaatgggggt gtgtgccacc atgtcactgg agagtgctct tgcccttctg gttggatggg
     1441 cacagtgtgt ggtcagccct gccctgaggg tcgctttgga aagaactgtt cccaagaatg
     1501 ccagtgtcac aatggaggaa cgtgtgatgc tgccacaggc cagtgtcact gcagcccagg
     1561 atacacaggg gaacggtgtc aggacgaatg tcctgttggg agctatggag ttcgctgtgc
     1621 tgaggcctgc aggtgtgtca acggaggcaa gtgttaccac gtgagtggta catgcctgtg
     1681 cgaagcaggc ttttcgggtg aactttgcga ggcgcgcctg tgtcccgagg ggctttacgg
     1741 catcaaatgt gacaagcggt gcccctgcca cctggacaac actcacagct gtcatcccat
     1801 gtctggagag tgtggctgca agccgggttg gtcgggactg tactgtaatg aaacatgctc
     1861 ccctggattc tacggggagg cttgccaaca gatctgcagc tgccagaacg gggcggactg
     1921 cgacagtgtg actggaaggt gtgcctgcgc tccaggattc aaagggactg actgctctac
     1981 tccgtgtcct ctgggacgct acgggataaa ttgttcttct cgctgtggct gtaaaaatga
     2041 tgctgtctgt tctcctgtgg atggatcatg tatctgtaag gcaggctggc acggggtgga
     2101 ctgttccatc cgctgcccca gtggcacatg gggctttggc tgtaacctaa cgtgtcagtg
     2161 cctcaatggc ggtgcctgca acacgctgga tgggacctgc acctgtgcgc ccggatggcg
     2221 aggcgcgaag tgtgaatttc cctgccagga tggcacttat gggctgaact gtgccgagcg
     2281 ctgtgactgc agccatgcag atggctgtca ccccactaca ggccattgcc gctgcctccc
     2341 tggatggtca ggtgtgcact gtgacagtgt gtgcgctgag ggacgctggg gtcctaactg
     2401 ctcgctgccc tgctactgta aaaatggggc ttcgtgttct ccggatgatg gcatctgtga
     2461 gtgtgcaccc ggattccgag gcaccacttg ccagagaatc tgctcccccg gtttttatgg
     2521 acatcgctgt agccagacct gcccgcagtg tgtgcacagc agtgggccct gccaccacat
     2581 cacgggcctg tgtgactgct tacctggctt caccggtgcc ctgtgcaatg aagtgtgtcc
     2641 cagtggcaga tttgggaaaa actgtgcagg cgtttgtact tgcaccaaca atggcacctg
     2701 taaccccatc gacagatcct gccagtgtta cccaggctgg attggcagtg actgctccca
     2761 gccctgtcca cctgcgcact ggggtccgaa ctgcatccac acctgcaact gccacaacgg
     2821 agccttttgc agcgcctatg atggggaatg caaatgcact cctggctgga cggggctcta
     2881 ctgcactcag agatgccctc tgggcttcta tggtaaggac tgtgcactga tatgccaatg
     2941 tcaaaacgga gctgactgcg accatatctc ggggcagtgt acctgccgca cgggattcat
     3001 gggacggcac tgtgaacaga agtgccctgc gggaacatac ggctatggct gtcgccagat
     3061 ctgtgactgt ctgaacaact ccacctgtga ccacatcact ggcacgtgtt actgtagccc
     3121 aggatggaaa ggggcacgat gtgaccaagc tggggttatc atcgtgggca atctgaacag
     3181 cttaagccgg accagcaccg cccttcctgc cgattcctat cagatcgggg ccatcgcggg
     3241 catcgtggtc ctcgttcttg ttgtgctctt cctgctggcg ctgttcatca tctacagaca
     3301 caagcagaag aggaaggaat caagcatgcc ggccgtgacc tacacccccg ccatgagggt
     3361 catcaatgca gactatacca tcgcagaaac cctgcctcac agcaatggtg gaaatgccaa
     3421 cagccactac tttaccaatc ccagttatca cacacttagc cagtgtgcca catcccctca
     3481 tgtgaacaat agggacagga tgaccattgc aaagtcaaaa aacaatcagc tgtttgtgaa
     3541 tcttaaaaat gtgaatccag ggaagagagg gacattggtg gactgcactg ggacattgcc
     3601 agctgactgg aagcaaggag gctacctcaa tgagcttggt gctttcgggc tggacagaag
     3661 ctacatggga aagtccttaa aagatctggg gaagaactct gaatataatt caagcacttg
     3721 ctccttaagc agctctgaaa acccatatgc caccattaaa gacccgcctg cactcctgcc
     3781 taaaagctcc gagtgcggct acgtggagat gaagtcgccg gcgcggagag actccccata
     3841 tgcagagatc aacaactcaa ctccagccaa caggaatgtc tatgaagtcg aacctacagt
     3901 gagcgttgtg caaggagtat tcagcaacag cggtcacgtc acccaagacc catatgacct
     3961 tccaaagaac agtcacatcc cttgccatta tgacctgctg ccagtaaggg acagttcatc
     4021 ctccccaaag agagaggatg gtggtggcag caacagcacc agcagcaaca gcaccagcag
     4081 cagcagcagc agcagtgaat gacatcaaag gactactggg tgaccattgg tactctttcc
     4141 aagccttcag ttcatcttca gttggcactg cagatgaccg tgaaatactc taataagcag
     4201 ttgttggacg tgtaccagaa agccccaagc cgaggctgac acccatcgag gtgtgttgtg
     4261 aacacagggt ttggaaggag agagcttcat gagttctcat tgctgttagg ttaggaatgg
     4321 caccaatgac ttgttttaag atgttggctg atgaggtgaa cttcgcagaa cctttcggag
     4381 acacagactg gtggagacat tgtattgtca cctggaacac taaagtctat ttgttgtcct
     4441 tagcatcaca gagccactcc taggatcgtg caggtcacca tgtatttacc taagaaaagt
     4501 gaaaattgct aaatgtgtag gagacaggaa tatattcctg agtctttctt gcataatgtt
     4561 ttttttccgt ttggactcag gatcagaagc attctgtcag atggtaggac tggatagcaa
     4621 tgggagcaaa tctaaatata aaaactttat gtttgttttt agggcgagaa atgtacaatt
     4681 agaattattt tagatgtagt gtaattattg cagaaatcaa tacataaata tggtacttct
     4741 gtttgacctt tggcccatgt tagttagatt cacgacatca ttctaattgc tgtcccatca
     4801 tgcatattta ccacttgagg tacataactt atcagttatt cataatacaa agatgcaatc
     4861 gttttatttt ttttttgatt gagtgagtgt ctagtgagtg gcaaagggta aacattttac
     4921 atgtatgatg cttgggttag aggaaccatt agtaatactt gctgtaatat agacttagag
     4981 ggacgttttc cttaatattt ttccctacaa gtgactgaaa tatttttgaa aatatttggg
     5041 taaagggcac ttgtcttatt aactgttgat ttagagaaac tatgcttaag ctggcctttc
     5101 gcattgctaa tgtgacctgc actcattacc ttttagtttg cattttcatt aagccgtgta
     5161 ctctgttgtg tagtgtttgg attgttaatg cggaattatg atgtgtccat tgtttcctga
     5221 gtcattgcca ctcatcttct gctccataag aaggcatcat ttttcttttg gagggaggaa
     5281 atgaaaacat acaatttgat cctattaaaa ttggttgttg ctaaaatagt agccataggt
     5341 gggtagctga tcactggaat ggaactttct catagtccac agtggggctc ttttgggggg
     5401 tgttagttcc ttgagtcttg gttaaagtca ggaagaagga gcaatgagta ctaccggtgg
     5461 tttggctaaa gactttcatc ataatcatca ataactgagc atctaaacta ggacactttg
     5521 aatagtaaat gaggacatta ctaataatca tcaggcattg ggtttaaata tagactgttc
     5581 ccagcagacc agaacaaatg cttgcctggt ttacactatt gcagacacag ctttacccca
     5641 aggcttttgt ctcctaagaa taacaatatg atacaagaaa tcgttgttag gcagaggaga
     5701 ggaaaggctg tgagcacgtg caacatcaga gcagaatgaa atgaagaccc acatgacatt
     5761 ctcttggagc ctattaatag ctgaccacta cactcatcta ctaactgtag ctataaagtg
     5821 ttatcctagt ctacccctga ggtgaaatgt ctagtcattt tgcattttgc acctgtgcct
     5881 atcatgatgg gttaatttgg tcaggtgaat agttcagcaa atgtacttag ggcaattgtt
     5941 cttatattat ctggaatatt tagaaacaat cgatttttct cccagtaggg aggctctgcc
     6001 tgatccctag ggaataagca tcaaacagaa acatgggtta gcagctatag gcatccttcc
     6061 tactaagaga aggttcaata ccttcccttt ttttttctcc ttaaatatca tctcttttaa
     6121 gtatgctggt aagattgagg tccctgtgac actatagaga taggttttgt ttgtttgttt
     6181 gtttaagctg tctttcctca ttgtaccatt tggaaaaaaa atttatgtgc aacagtgaga
     6241 ggaacttaca ggaaacccac agagaagatt ccaaacagct gtactataaa gtgggaatga
     6301 cacgcccata agataccatg tggagtcctg ttgataccca tatcctaaca caagctgacc
     6361 ttcctgagcc tgtgtccgag gcagggttta cctagaaatt tcctcaagac tttgtcaaag
     6421 tcagaacact tcacttttca gacactgtaa aaatcccatg ttgtctttgg agacacagca
     6481 tcattttcta gatattttgc tgtaatttct ctctggtatc ctacagaagt gtgcactaga
     6541 tgagtttggc aatgccttgt atgggacatc catatgtgag ttgccttaga aattgatatt
     6601 ttaaaatttt tcaccattta ttgtctttgt acagcattat atcagaactt gccaagatga
     6661 taactcatat acttgctttt atcaggagaa tatgatattt gtggttaatt ctacaatatg
     6721 ggaatcttca taattactca gagtgttagg cagtcccttc ccatagagta ctagtaatgg
     6781 acagaattca atgtgtttag caatgttttt tgtgggtatt ggctgactac agaaaaactg
     6841 accttagaat tttacaacag agcagcatag ggtgtcatag ccaaatccat tagcacaata
     6901 cctcctgatc atgaaaaatt caggcaactt tatgaaaata tggttatctt gatgtcagtg
     6961 ggccataata gtggtcagtc ttagggaact tttcaaccaa atataactca aagtcaaaca
     7021 aaagcagcat aatagtatca acttgatatt aagtaagaca aaaatcatta aaatcaaatc
     7081 ttaggattat ggttttaaaa taatgaattt tccatctctg ggtaacatgt ccatattatt
     7141 ccaaggaaac atttaagggc tattttgatt ttaaaggctt actgccatgg gcatgtacag
     7201 aggctgggta gaatggttgc ttatgaagca ggggctacac acagcaaact gccccgtaga
     7261 gtcctggtca ccatttttgt ctcagctttg ttttgatatg accaaatggc agtatttctc
     7321 tctctatttt ttaaggagaa aaactcagaa tgcagtatga tttacttggt aattgcaagc
     7381 agaatgaatg ctttaagtgt tatgctcact ctctctttcc caaagacaat aaaccctcct
     7441 cagaattagt ctcgttgtca tttgtactgc caaatagtca atagatgaat gcaataaact
     7501 ttcccattaa gaac
//
