LOCUS       NM_001410077            5920 bp    mRNA    linear   ROD 09-JUL-2024
DEFINITION  Mus musculus myocyte enhancer factor 2D (Mef2d), transcript variant
            4, mRNA.
ACCESSION   NM_001410077 XM_006501089
VERSION     NM_001410077.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5920)
  AUTHORS   Wang,X., Shen,H., Chen,Y., Zhang,Y., Wang,J., Liu,S., Xu,B.,
            Wang,H., Frangou,C. and Zhang,J.
  TITLE     MEF2D Functions as a Tumor Suppressor in Breast Cancer
  JOURNAL   Int J Mol Sci 25 (10), 5207 (2024)
   PUBMED   38791246
  REMARK    GeneRIF: MEF2D Functions as a Tumor Suppressor in Breast Cancer.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5920)
  AUTHORS   Novakova,K., Torok,M., Panajatovic,M., Bouitbir,J., Duong,F.H.T.,
            Handschin,C. and Krahenbuhl,S.
  TITLE     PGC-1alpha and MEF2 Regulate the Transcription of the Carnitine
            Transporter OCTN2 Gene in C2C12 Cells and in Mouse Skeletal Muscle
  JOURNAL   Int J Mol Sci 23 (20), 12304 (2022)
   PUBMED   36293168
  REMARK    GeneRIF: PGC-1alpha and MEF2 Regulate the Transcription of the
            Carnitine Transporter OCTN2 Gene in C2C12 Cells and in Mouse
            Skeletal Muscle.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5920)
  AUTHORS   Guan,X., Peng,Q. and Wang,J.
  TITLE     Sevoflurane activates MEF2D-mediated Wnt/beta-catenin signaling
            pathway via microRNA-374b-5p to affect renal ischemia/reperfusion
            injury
  JOURNAL   Immunopharmacol Immunotoxicol 44 (4), 603-612 (2022)
   PUBMED   35481398
  REMARK    GeneRIF: Sevoflurane activates MEF2D-mediated Wnt/beta-catenin
            signaling pathway via microRNA-374b-5p to affect renal
            ischemia/reperfusion injury.
REFERENCE   4  (bases 1 to 5920)
  AUTHORS   Velasco-Aviles,S., Patel,N., Casillas-Bajo,A., Frutos-Rincon,L.,
            Velasco,E., Gallar,J., Arthur-Farraj,P., Gomez-Sanchez,J.A. and
            Cabedo,H.
  TITLE     A genetic compensatory mechanism regulated by Jun and Mef2d
            modulates the expression of distinct class IIa Hdacs to ensure
            peripheral nerve myelination and repair
  JOURNAL   Elife 11, e72917 (2022)
   PUBMED   35076395
  REMARK    GeneRIF: A genetic compensatory mechanism regulated by Jun and
            Mef2d modulates the expression of distinct class IIa Hdacs to
            ensure peripheral nerve myelination and repair.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5920)
  AUTHORS   Di Giorgio,E., Wang,L., Xiong,Y., Christensen,L.M., Akimova,T.,
            Han,R., Samanta,A., Trevisanut,M., Brancolini,C., Beier,U.H. and
            Hancock,W.W.
  TITLE     A Biological Circuit Involving Mef2c, Mef2d, and Hdac9 Controls the
            Immunosuppressive Functions of CD4+Foxp3+ T-Regulatory Cells
  JOURNAL   Front Immunol 12, 703632 (2021)
   PUBMED   34290714
  REMARK    GeneRIF: A Biological Circuit Involving Mef2c, Mef2d, and Hdac9
            Controls the Immunosuppressive Functions of CD4+Foxp3+ T-Regulatory
            Cells.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5920)
  AUTHORS   Patapoutian,A., Yoon,J.K., Miner,J.H., Wang,S., Stark,K. and
            Wold,B.
  TITLE     Disruption of the mouse MRF4 gene identifies multiple waves of
            myogenesis in the myotome
  JOURNAL   Development 121 (10), 3347-3358 (1995)
   PUBMED   7588068
REFERENCE   7  (bases 1 to 5920)
  AUTHORS   Hidaka,K., Morisaki,T., Byun,S.H., Hashido,K., Toyama,K. and
            Mukai,T.
  TITLE     The MEF2B homologue differentially expressed in mouse embryonal
            carcinoma cells
  JOURNAL   Biochem Biophys Res Commun 213 (2), 555-560 (1995)
   PUBMED   7646512
REFERENCE   8  (bases 1 to 5920)
  AUTHORS   Lyons,G.E., Micales,B.K., Schwarz,J., Martin,J.F. and Olson,E.N.
  TITLE     Expression of mef2 genes in the mouse central nervous system
            suggests a role in neuronal maturation
  JOURNAL   J Neurosci 15 (8), 5727-5738 (1995)
   PUBMED   7643214
REFERENCE   9  (bases 1 to 5920)
  AUTHORS   Han,T.H. and Prywes,R.
  TITLE     Regulatory role of MEF2D in serum induction of the c-jun promoter
  JOURNAL   Mol Cell Biol 15 (6), 2907-2915 (1995)
   PUBMED   7760790
REFERENCE   10 (bases 1 to 5920)
  AUTHORS   Edmondson,D.G., Lyons,G.E., Martin,J.F. and Olson,E.N.
  TITLE     Mef2 gene expression marks the cardiac and skeletal muscle lineages
            during mouse embryogenesis
  JOURNAL   Development 120 (5), 1251-1263 (1994)
   PUBMED   8026334
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC137525.3.
            
            On Jul 27, 2022 this sequence version replaced XM_006501089.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR9219380.66681.1,
                                           SRR9219382.201128.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-796               AC137525.3         147336-148131
            797-981             AC137525.3         160310-160494
            982-1185            AC137525.3         160954-161157
            1186-1323           AC137525.3         162666-162803
            1324-1534           AC137525.3         163754-163964
            1535-1591           AC137525.3         164168-164224
            1592-1782           AC137525.3         165823-166013
            1783-1803           AC137525.3         166413-166433
            1804-1933           AC137525.3         167590-167719
            1934-2153           AC137525.3         172147-172366
            2154-2460           AC137525.3         172670-172976
            2461-5920           AC137525.3         173264-176723
FEATURES             Location/Qualifiers
     source          1..5920
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 38.78 cM"
     gene            1..5920
                     /gene="Mef2d"
                     /note="myocyte enhancer factor 2D"
                     /db_xref="GeneID:17261"
                     /db_xref="MGI:MGI:99533"
     exon            1..796
                     /gene="Mef2d"
                     /inference="alignment:Splign:2.1.0"
     exon            797..981
                     /gene="Mef2d"
                     /inference="alignment:Splign:2.1.0"
     CDS             928..2472
                     /gene="Mef2d"
                     /note="isoform 1 is encoded by transcript variant 4;
                     myocyte-specific enhancer factor 2D"
                     /codon_start=1
                     /product="myocyte-specific enhancer factor 2D isoform 1"
                     /protein_id="NP_001397006.1"
                     /db_xref="GeneID:17261"
                     /db_xref="MGI:MGI:99533"
                     /translation="MGRKKIQIQRITDERNRQVTFTKRKFGLMKKAYELSVLCDCEIA
                     LIIFNHSNKLFQYASTDMDKVLLKYTEYNEPHESRTNADIIETLRKKGFNGCDSPEPD
                     GEDSLEQSPLLEDKYRRASEELDGLFRRYGSSVPAPNFAMPVTVPVSNQSSMQFSNPS
                     SSLVTPSLVTSSLTDPRLLSPQQPALQRNSVSPGLPQRPASAGAMLGGDLNSANGACP
                     SPVGNGYVSARASPGLLPVANGNSLNKVIPAKSPPPPTHNTQLGAPSRKPDLRVITSQ
                     GGKGLMHHLTEDHLDLNNAQRLGVSQSTHSLTTPVVSVATPSLLSQGLPFSSMPTAYN
                     TDYQLPSAELSSLPAFSSPAGLALGNVTAWQQPQPPQQPQPPQPPQSQPQPPQPQPQQ
                     PPQQQPHLVPVSLSNLIPGSPLPHVGAALTVTTHPHISIKSEPVSPSRERSPAPPPPA
                     VFPAARPEPGEGLSSPAGGSYETGDRDDGRGDFGPTLGLLRPAPEPEAEGSAVKRMRL
                     DTWTLK"
     exon            982..1185
                     /gene="Mef2d"
                     /inference="alignment:Splign:2.1.0"
     exon            1186..1323
                     /gene="Mef2d"
                     /inference="alignment:Splign:2.1.0"
     exon            1324..1534
                     /gene="Mef2d"
                     /inference="alignment:Splign:2.1.0"
     exon            1535..1591
                     /gene="Mef2d"
                     /inference="alignment:Splign:2.1.0"
     exon            1592..1782
                     /gene="Mef2d"
                     /inference="alignment:Splign:2.1.0"
     exon            1783..1803
                     /gene="Mef2d"
                     /inference="alignment:Splign:2.1.0"
     exon            1804..1933
                     /gene="Mef2d"
                     /inference="alignment:Splign:2.1.0"
     exon            1934..2153
                     /gene="Mef2d"
                     /inference="alignment:Splign:2.1.0"
     exon            2154..2460
                     /gene="Mef2d"
                     /inference="alignment:Splign:2.1.0"
     exon            2461..5920
                     /gene="Mef2d"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3733..3738
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mef2d"
                     /note="hexamer: AATAAT"
     polyA_site      3760
                     /gene="Mef2d"
                     /note="major polyA site"
ORIGIN      
        1 agaacccctc ccccacgccg cgcggccggg ctcagggtgg tctggagcgc gaggggtgta
       61 cgggcgccct ggcacgagcg tcccggtccg ggcggggcga cggaggcagt gttggtgctg
      121 gggtgtctgc tgtgacagcc gcgcctggta cccgagcccc cgtcgcctcg cgccttggcg
      181 ggcgcaacgc acgtggctcc ggccgcgatt tcgcgcccgt gggggccccc ttggtcgggc
      241 gtgtcagcaa cgccggctgg agaacccctg gacagtagtt tgcagctgtt aacacctggc
      301 aggacctctc caggcctttc tcttggacgg tgcggtgcgg gccgagtcag tgcgagtggg
      361 gttcgagtgg tgaggctggc ccaagggact actgtgctcc cggcctccca cctcagagat
      421 ggggcaggga ggcctcccag agattccatc gagccctcgg ggttcccagt ggccctggac
      481 tacccagctt gtcctgagtg ccagttctgc ctacgactga ccggcacatt ggggccaggc
      541 taggggagta cagtgggtgg atcccgttcc ctcctgccct acccgtgtga gtttcctccg
      601 aggcctgttt ggctgtgtga gtggtggatc ttacccctcc ccctagccct cagtgggtct
      661 gagctgcctg actgtgggaa gtttgccgtc tgggacggtg accttgggct gctctggccg
      721 gatctcggag aggagcctac tgagtgcgct tggccttggg agctgtccac cttctgttcg
      781 tctccctgta tccgcggagg ctgtgcatag gtgttctgca gaccatgaac tgatcactag
      841 tccccagaca ttcatgagca cagtgtgagg ctcctgatca ccacccagca gccccttcct
      901 ctctggcact aaggaccccc ggagaagatg gggaggaaaa agattcagat ccagcgaatc
      961 actgatgaac ggaaccgcca ggtgaccttc accaagcgga agtttggact gatgaagaag
     1021 gcctacgagc tgagtgtgct gtgcgactgc gagatcgcgc tcatcatctt caaccactcc
     1081 aacaagctgt tccagtatgc cagcaccgac atggacaagg tgctgctcaa gtacaccgag
     1141 tacaacgagc cacacgagag ccgcaccaat gctgacatca tcgagaccct gaggaagaag
     1201 ggtttcaacg gctgtgacag cccagagccg gatggggagg actcactgga gcagagcccc
     1261 ctgctggagg acaagtaccg gcgggccagt gaggagctgg atgggctctt caggcgctat
     1321 gggtcatctg ttccggcccc caactttgcc atgcctgtca cagtgcccgt gtccaatcag
     1381 agctccatgc agttcagcaa tccaagtagc tctctggtca ctccttccct ggtgacatca
     1441 tcccttacgg acccacggct cctgtccccc cagcagccag cactacagag aaacagtgtt
     1501 tctccaggct tgccccagcg gcctgctagt gcaggagcca tgctgggtgg agacctcaac
     1561 agtgctaatg gagcctgccc cagccccgtt gggaatggct atgtcagtgc ccgagcttcc
     1621 cctggcctcc tccctgtggc caatggcaac agcctaaaca aagtcatccc tgccaagtct
     1681 ccgcccccac ccacccacaa cacccagctt ggagccccca gccgcaagcc tgatctgcgg
     1741 gtcatcactt cccagggagg caaagggtta atgcatcatt tgactgagga ccatttagat
     1801 ctgaacaatg cccagcgcct tggggtctcc cagtctaccc actcgctcac caccccagtg
     1861 gtttccgtgg caacaccaag tttactcagc cagggcctcc ccttctcctc catgcccact
     1921 gcctacaaca cagattacca gctgcccagt gcagagctat cctccttacc agccttcagt
     1981 tcacctgcag ggctggcact aggcaatgtc accgcctggc agcagcccca gccgccccag
     2041 cagccacaac cgccacaacc gccacagtca cagccacagc caccacagcc acagccacag
     2101 cagccacctc agcaacagcc ccacttggtc cccgtttctc tcagcaacct catccctggc
     2161 agccccttgc ctcacgtggg tgctgctctc acagtcacta cccaccccca catcagcatc
     2221 aagtcagaac cagtgtcccc aagtcgtgaa cgcagccctg cacctcctcc accagctgtg
     2281 ttcccagctg cccgccctga gcctggcgaa ggtctcagca gcccagctgg aggatcctat
     2341 gagaccgggg accgggatga tggacggggg gactttgggc ccacactagg cctgctgcgc
     2401 ccagccccag agcctgaggc tgagggctca gctgtgaaga ggatgcggct ggatacttgg
     2461 acattaaagt gatggttccc actccctcct ttcagcctcc ctgatgaaga gttgacaatc
     2521 tcaccgccca ccccctcctt atcctgggct cctcccgctc gaccccactt cctttcttct
     2581 gctccatgtc ctgttgatgg ttacatttgt gtataattat attattatta ttgttattat
     2641 tattattata tttttaaatt cgaattctcg ctttagagag agggatgctc ttgccccttt
     2701 cttgccccca ccattttcac tgatggggac tctctttatt gcgggaaagg ggggacactt
     2761 tgcacgttgt acacatatgc tgcaggaagg agggaggcgg taggccttgg agaaggacag
     2821 gtgccgagcc ctgcatgtgg agccctccca tcccattccc agatagacgt aaagaaccaa
     2881 aaactaccca acaacaaaac ccagatagtg gactgaaacc caaagctggc ttgacgatgg
     2941 gcttgtgtct caggggatag gaggaggcag tttctgcttc tgggctgttc acggctaata
     3001 cccatcctgg tccctccagc ttcctgcata cgtatcacac tctctgatcc tgtgtgttac
     3061 accccaagat ctgggtgata gaaaggctgc ctaggaatct gaggccaggg aaggggcttg
     3121 aggttggaat ctctagagat aacatggaga gagacagctg tagaaagagg gctgatgagg
     3181 acagaaggac tgggtgtggt gaattgggac cctaccccca gcttttcctt tgagatgtac
     3241 agtgcaatag ctccccgtcc tttagcctac cccaatccta aagaaagctg gccatgtact
     3301 gggagatttg ggagaggacc ttcattgaag tggctccagg atgggccaga gtcgtccttt
     3361 ggttccctgg ggcactgaga gcaggaggct tgtcaggggc agggtgagga gggcacctct
     3421 tggctttgtg cacctgtgtc cagaagagta cttactgggc acatggaggc tcctgtagat
     3481 gaggcccggg cccttcccca ggcctctgag ctcctgcccc tgacccacct cccagctctc
     3541 tgcgtgctcc ttgtctcgct acctcctgtc cctccacctc caggccacat cccaaacctg
     3601 ccctcttgct actgtaattg taaatagaga cctttcaaat gttagtggtg taaccgtcca
     3661 ggaaactgtt gtgtttgttg ttgttgtatt gatatgaaat gagattctat ttttgtcaaa
     3721 gtatattgta ataataatga ctcaaatggc ccgtactgta cagatgagat tcttctgctg
     3781 tgttcttgcc ttcctctcca gactaatgct ttgttgcctc ctcagtgggg ctgcagcaag
     3841 caccaggggc agtggaagaa gcattgggtc cttggacctc ttgctggatc tgaggtcaga
     3901 ctggagggaa tagtttgccc cctccccagc ctgctgtcac cacccctgcc cttcctctgc
     3961 ttccccacct ggggaaaggg gatgggagac agcacacact cccttggagt tcctcccagc
     4021 tggagggtag agttagacaa ggctcagtgt tgtagtacga tggtctttgc ccacctgtga
     4081 cccagccttt tgtagtattt tgacacttga tgcagggaag gagccagaag cagaggggtg
     4141 tgagcatgct cgtggaggcg tatctgggtt caccctgtat ttatgtgttt gtgtgcagct
     4201 gtgcggatgt acctttgagt gactcaagct ccaagggcct ctgtgtgagc tgggtgtgtt
     4261 tacaagggat cagcgccttc caactctgtg gcttcacccc ctccccgggc tgctctcagt
     4321 cccaaaacat tttactaaag tcatggggga cgggtgctag ttggccttcc tgtttctccc
     4381 cacagcctac ctccaccagg gcttcacatt tggagctctg cctccatatg gctgtccact
     4441 agccccaccc aggcatggtt catccctgga gttctgactt gtttatggag ccaactcaag
     4501 ttcttcttgc ccggagcttt gccttttgta aggcagggac cctcccttaa ccagagttta
     4561 ccccagtagc tgaccaagca tggggtgcta cccacatgcc tcaccttccc actcctcctc
     4621 acaagtcctg gagggagttt taagacttgc ttatggcctt gaaagaagcc agggttgtag
     4681 ccctgtgctc cccttgaagt agctggcaca ttgtaggccc tcagtaaatg ctgaatgggt
     4741 ggatgacagg tgctcaataa atgtggattc acggcctcat ctcaggccca tccttcaagg
     4801 ctgagcttgg ccaccattac agttgtgggt gaagccccta tagttcacag tgtgctactc
     4861 aacagtttgc catctgcttc ccgaaagcaa acctggcttg tgattgccat gtacggatgc
     4921 gtgcatgcac tgtgtgtgtg tgtgcgtgcg tgtgcgtgtc tgtgtctgca cacacacgta
     4981 tgagttcttg tgtgtctctg tccctgactg aaggggcagt ctgtgaatga gtatgtgaca
     5041 tttctgcagt ttagtatccc caggtttctc ctggggctat gcaggggctt ctggctggcc
     5101 aggtaaatgg atccctggga acctagacct caaatgggga cttattttct tcctctcaca
     5161 agccaaattt gcctactctc cactccctat acagaactgg gtatttgcca aagtagcctc
     5221 tggcgtcatc cagtgccctt cccacccagg ttcccctctg ctttcaggga tagtgggacc
     5281 gagggccacc cccacatgcc tcagtttagc acatttcctc catccccagc agtgcatcca
     5341 cccaccctcc ccaactccaa caggaaggaa gaaagaaatg caccttctct tgctcgttat
     5401 ttatttgttt ggagagacag aaatgatgga aaagtatcta aatctatctc tctctctatt
     5461 tttacctaac tctctggaac ccctgtgggg gaatgtaggc tctcctaaga ggctgggagc
     5521 tccttgttct accctgtctg cctctacata agcagaaggg gtgggatgta atggggcagg
     5581 agggctgaga ttcccaagga gaatctgaat tctctacccc cattcaagtc ccagaaagag
     5641 ggaagaaggg agggatgggc cagccaagag ctgacccgtc cccaaacttg acaatcaccc
     5701 acactcctgg ctcctgggtc tgggtgagtc caagtgtgtg gctgttggtt tgttttcatt
     5761 atttctttcc gtgctgtacg gtgatgcttt ctagtattct gcacattaag aaaagtcctc
     5821 gagattctta cgagtttggt ttgaaaactc tttcactata tttgttgtaa agaggtttac
     5881 tattaaaaga aaaaaaaaaa aacatgtttc tgatacctca
//
