LOCUS       NM_001347564            6316 bp    mRNA    linear   ROD 18-MAR-2025
DEFINITION  Mus musculus myocyte enhancer factor 2C (Mef2c), transcript variant
            3, mRNA.
ACCESSION   NM_001347564 XM_006517122
VERSION     NM_001347564.2
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6316)
  AUTHORS   Fan,W., Li,Z., He,X., Wang,X., Sun,M. and Yang,Z.
  TITLE     SLC25A1 regulates placental development to ensure embryonic heart
            morphogenesis
  JOURNAL   Development 151 (22) (2024)
   PUBMED   39591637
REFERENCE   2  (bases 1 to 6316)
  AUTHORS   Hong,Y., Hu,J., Zhang,S., Liu,J., Yan,F., Yang,H. and Hu,H.
  TITLE     Integrative analysis identifies region- and sex-specific gene
            networks and Mef2c as a mediator of anxiety-like behavior
  JOURNAL   Cell Rep 43 (7), 114455 (2024)
   PUBMED   38990717
  REMARK    GeneRIF: Integrative analysis identifies region- and sex-specific
            gene networks and Mef2c as a mediator of anxiety-like behavior.
REFERENCE   3  (bases 1 to 6316)
  AUTHORS   Chen,C., Wang,J., Kang,M., Wu,P., Zhu,L., Fang,Y. and Xue,Y.
  TITLE     Identification of a novel MEF2C::SS18L1 fusion in childhood acute
            B-lymphoblastic leukemia
  JOURNAL   J Cancer Res Clin Oncol 150 (6), 314 (2024)
   PUBMED   38907739
  REMARK    GeneRIF: Identification of a novel MEF2C::SS18L1 fusion in
            childhood acute B-lymphoblastic leukemia.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 6316)
  AUTHORS   Li,Y., Ma,K., Dong,Z., Gao,S., Zhang,J., Huang,S., Yang,J.,
            Fang,G., Li,Y., Li,X., Welch,C., Griffin,E.L., Ramaswamy,P.,
            Valivullah,Z., Liu,X., Dong,J., Wang,D.W., Du,J., Chung,W.K. and
            Li,Y.
  TITLE     Frameshift variants in C10orf71 cause dilated cardiomyopathy in
            human, mouse, and organoid models
  JOURNAL   J Clin Invest 134 (12), e177172 (2024)
   PUBMED   38950288
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 6316)
  AUTHORS   Fukushima,T., Hasegawa,Y., Kuse,S., Fujioka,T., Nikawa,T.,
            Masubuchi,S. and Sakakibara,I.
  TITLE     PHF2 regulates sarcomeric gene transcription in myogenesis
  JOURNAL   PLoS One 19 (5), e0301690 (2024)
   PUBMED   38701072
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 6316)
  AUTHORS   Sato,H., Tsukada,T., Nagayoshi,M., Ikawa,Y., Aizawa,S. and
            Kato,M.V.
  TITLE     Repression of p53-dependent sequence-specific transactivation by
            MEF2c
  JOURNAL   Biochem Biophys Res Commun 214 (2), 468-474 (1995)
   PUBMED   7677753
REFERENCE   7  (bases 1 to 6316)
  AUTHORS   Hidaka,K., Morisaki,T., Byun,S.H., Hashido,K., Toyama,K. and
            Mukai,T.
  TITLE     The MEF2B homologue differentially expressed in mouse embryonal
            carcinoma cells
  JOURNAL   Biochem Biophys Res Commun 213 (2), 555-560 (1995)
   PUBMED   7646512
REFERENCE   8  (bases 1 to 6316)
  AUTHORS   Lyons,G.E., Micales,B.K., Schwarz,J., Martin,J.F. and Olson,E.N.
  TITLE     Expression of mef2 genes in the mouse central nervous system
            suggests a role in neuronal maturation
  JOURNAL   J Neurosci 15 (8), 5727-5738 (1995)
   PUBMED   7643214
REFERENCE   9  (bases 1 to 6316)
  AUTHORS   Lyons,I., Parsons,L.M., Hartley,L., Li,R., Andrews,J.E., Robb,L.
            and Harvey,R.P.
  TITLE     Myogenic and morphogenetic defects in the heart tubes of murine
            embryos lacking the homeo box gene Nkx2-5
  JOURNAL   Genes Dev 9 (13), 1654-1666 (1995)
   PUBMED   7628699
REFERENCE   10 (bases 1 to 6316)
  AUTHORS   Han,T.H. and Prywes,R.
  TITLE     Regulatory role of MEF2D in serum induction of the c-jun promoter
  JOURNAL   Mol Cell Biol 15 (6), 2907-2915 (1995)
   PUBMED   7760790
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC107750.9, CT025631.2 and CU074400.3.
            
            On Jan 7, 2022 this sequence version replaced NM_001347564.1.
            
            Transcript Variant: This variant (3) represents the longest
            transcript and encodes the longest isoform (3). Variants 3, 4 and 5
            all encode isoform 3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR6116558.51897.1,
                                           SRR1660811.153552.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164132, SAMN01164138
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-209               AC107750.9         20221-20429         c
            210-305             AC107750.9         4117-4212           c
            306-498             CT025631.2         70556-70748
            499-702             CT025631.2         87796-87999
            703-846             CT025631.2         120283-120426
            847-1033            CT025631.2         128073-128259
            1034-1081           CT025631.2         130440-130487
            1082-1254           CT025631.2         147832-148004
            1255-1278           CT025631.2         149616-149639
            1279-1408           CT025631.2         150525-150654
            1409-1544           CT025631.2         151235-151370
            1545-4540           CT025631.2         157325-160320
            4541-6316           CU074400.3         2001-3776
FEATURES             Location/Qualifiers
     source          1..6316
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 43.68 cM"
     gene            1..6316
                     /gene="Mef2c"
                     /gene_synonym="5430401D19Rik; 9930028G15Rik; Mef2"
                     /note="myocyte enhancer factor 2C"
                     /db_xref="GeneID:17260"
                     /db_xref="MGI:MGI:99458"
     exon            1..209
                     /gene="Mef2c"
                     /gene_synonym="5430401D19Rik; 9930028G15Rik; Mef2"
                     /inference="alignment:Splign:2.1.0"
     exon            210..305
                     /gene="Mef2c"
                     /gene_synonym="5430401D19Rik; 9930028G15Rik; Mef2"
                     /inference="alignment:Splign:2.1.0"
     exon            306..498
                     /gene="Mef2c"
                     /gene_synonym="5430401D19Rik; 9930028G15Rik; Mef2"
                     /inference="alignment:Splign:2.1.0"
     CDS             445..1869
                     /gene="Mef2c"
                     /gene_synonym="5430401D19Rik; 9930028G15Rik; Mef2"
                     /note="isoform 3 is encoded by transcript variant 3;
                     myocyte-specific enhancer factor 2C"
                     /codon_start=1
                     /product="myocyte-specific enhancer factor 2C isoform 3"
                     /protein_id="NP_001334493.1"
                     /db_xref="CCDS:CCDS84042.1"
                     /db_xref="GeneID:17260"
                     /db_xref="MGI:MGI:99458"
                     /translation="MGRKKIQITRIMDERNRQVTFTKRKFGLMKKAYELSVLCDCEIA
                     LIIFNSTNKLFQYASTDMDKVLLKYTEYNEPHESRTNSDIVETLRKKGLNGCDSPDPD
                     ADDSVGHSPESEDKYRKINEDIDLMISRQRLCAVPPPSFEMPVTIPVSSHNSLVYSNP
                     VSTLGNPNLLPLAHPSLQRNSMSPGVTHRPPSAGNTGGLMGGDLTSGAGTSAGNGYGN
                     PRNSPGLLVSPGNLNKNIQAKSPPPMNLGMNNRKPDLRVLIPPGSKNTMPSVSEDVDL
                     LLNQRINNSQSAQSLATPVVSVATPTLPGQGMGGYPSAISTTYGTEYSLSSADLSSLS
                     GFNTASALHLGSVTGWQQQHLHNMPPSALSQLGACTSTHLSQSSNLSLPSTQSLSIKS
                     EPVSPPRDRTTTPSRYPQHTTRHEAGRSPVDSLSSCSSSYDGSDREDHRNEFHSPIGL
                     TRPSPDERESPSVKRMRLSEGWAT"
     exon            499..702
                     /gene="Mef2c"
                     /gene_synonym="5430401D19Rik; 9930028G15Rik; Mef2"
                     /inference="alignment:Splign:2.1.0"
     exon            703..846
                     /gene="Mef2c"
                     /gene_synonym="5430401D19Rik; 9930028G15Rik; Mef2"
                     /inference="alignment:Splign:2.1.0"
     exon            847..1033
                     /gene="Mef2c"
                     /gene_synonym="5430401D19Rik; 9930028G15Rik; Mef2"
                     /inference="alignment:Splign:2.1.0"
     exon            1034..1081
                     /gene="Mef2c"
                     /gene_synonym="5430401D19Rik; 9930028G15Rik; Mef2"
                     /inference="alignment:Splign:2.1.0"
     exon            1082..1254
                     /gene="Mef2c"
                     /gene_synonym="5430401D19Rik; 9930028G15Rik; Mef2"
                     /inference="alignment:Splign:2.1.0"
     exon            1255..1278
                     /gene="Mef2c"
                     /gene_synonym="5430401D19Rik; 9930028G15Rik; Mef2"
                     /inference="alignment:Splign:2.1.0"
     exon            1279..1408
                     /gene="Mef2c"
                     /gene_synonym="5430401D19Rik; 9930028G15Rik; Mef2"
                     /inference="alignment:Splign:2.1.0"
     exon            1409..1544
                     /gene="Mef2c"
                     /gene_synonym="5430401D19Rik; 9930028G15Rik; Mef2"
                     /inference="alignment:Splign:2.1.0"
     exon            1545..6316
                     /gene="Mef2c"
                     /gene_synonym="5430401D19Rik; 9930028G15Rik; Mef2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6291..6296
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mef2c"
                     /gene_synonym="5430401D19Rik; 9930028G15Rik; Mef2"
                     /note="hexamer: AGTAAA"
     polyA_site      6316
                     /gene="Mef2c"
                     /gene_synonym="5430401D19Rik; 9930028G15Rik; Mef2"
                     /note="major polyA site"
ORIGIN      
        1 atctcaccgc ttgacgatca agggggcaaa gcttcggtgt tcatagaaaa ggagaggagg
       61 cgagcgcagc ccaaactggg gggtttctct tcaaagccag ctggtctggc tttattctac
      121 aggaattttt ttacctgtca gagtttggac aacaaagccc tcagcaggtg ctgacgggaa
      181 caacttcctg gagaagcaga aaggcactgg tgccaacaaa agcattgaaa actgtgaagt
      241 aacctctgga gagatgaagt gaagcgtgga aggccaatgg ctgtggcagt gaagaagtgc
      301 agagggaacg aatgcaggga tttgggaact gagctgtgcg cgtgctgaag aaggaaacgt
      361 gtttgaagga aacaggaaag agaaagaaaa ggaaggaaaa aatacataat ttcagggacg
      421 agagagagaa gaaacacggg gactatgggg agaaaaaaga ttcagattac gaggataatg
      481 gatgagcgta acagacaggt gacttttacg aagaggaaat ttggattgat gaagaaggct
      541 tatgagctga gcgtgctgtg cgactgtgag attgcactga tcatcttcaa cagcaccaac
      601 aagctgttcc agtacgccag cactgacatg gataaggtgt tgctcaagta caccgagtac
      661 aacgagccgc acgagagccg gacaaactca gacattgtgg agacattgag aaagaagggc
      721 ctcaatggct gtgacagccc agatcccgat gcagacgatt cagtaggtca cagccctgag
      781 tctgaggaca agtacaggaa aattaacgaa gatattgatc taatgatcag caggcaaaga
      841 ttgtgtgctg ttccacctcc cagctttgag atgccagtta ccatcccagt gtccagccat
      901 aacagtttgg tgtacagcaa tcctgtcagc acactgggaa accccaatct tctgccactg
      961 gcccacccgt ctctgcagag gaatagtatg tctcctggtg taacacatag acctccaagt
     1021 gcaggtaaca caggcggtct gatgggcgga gatctgacat ccggtgcagg caccagcgca
     1081 gggaatggat acggcaaccc ccggaactca ccaggcctgc tggtctcacc tggtaacctg
     1141 aacaagaata tacaagccaa atctcctccc cctatgaatc taggaatgaa taatcgtaag
     1201 ccagatctcc gcgttcttat cccacctggc agcaagaaca cgatgccatc agtgtctgag
     1261 gatgtggatc tgctgttgaa tcaaaggata aataactccc agtcggctca gtcattggct
     1321 accccggtgg tttccgtagc aactcctact ttaccaggac aaggaatggg aggatatcca
     1381 tcagccattt caacaacata tggtactgag tactctctga gtagcgcaga tctgtcatct
     1441 ctgtctggct tcaacactgc cagtgcgctc cacctcggct ctgtaactgg ctggcagcag
     1501 cagcacctac ataacatgcc gccatctgcc ctcagtcagt tgggagcttg cactagcact
     1561 catttatctc agagttcaaa tctctccctg ccttctactc aaagcctcag catcaagtca
     1621 gaacctgttt ctcctcctag agaccgtacc accacccctt cgagataccc acaacacacc
     1681 acgcgccacg aggcggggag gtctcctgtt gacagcttga gcagctgtag cagttcctac
     1741 gatgggagcg accgagagga tcaccggaac gaattccact cccccattgg actcaccaga
     1801 ccttcgccgg acgaaaggga aagtccttca gtcaagcgca tgcgactctc tgaaggatgg
     1861 gcaacatgat cacattatta cttaatagtt tttttttttc ttgcagtgtg tgtgtgtgct
     1921 ataccttaat ggggaagggg gggtcgatat gcattatatg tgccgtgtgt ggaaaaaaaa
     1981 aaaaaagtca ggtactctgt tttgtaaaag tacttttaaa ttgcctcagt gatacagtat
     2041 aaagataaac agaaatgctg agatacgctt agcacttgag ttgtacaaca gaacacttgt
     2101 acaaaataga ttttaaggct aacttctttt cactgttgtg accctttgca aaatgtatgt
     2161 tacaatagat agtgtcatgt tgcaggttca acgttattta catgtaaata gacaaaagga
     2221 aacatttgcc aaaagcggca gatctttact gaaagagaga gcagctgtta tgcaacatat
     2281 agaaaaatgt atagaggttt ggacagaccc ggcaagtggt gactaccggt aattgtagga
     2341 acacgcctgt cacctaacat ccaagcacgc tcacaaacct gcaggcatat cattggcgta
     2401 tggcactcat tcaaaaggat cagaaaccat tcagagagga ccatacctac cttaaaagaa
     2461 aagagaagaa aggaaaggaa aggaaaggga aaaaaaagtg tggcgtttga gagctaacat
     2521 atttaattaa ataaataaat ctgggtctgc atctcttatt aaataaaaat ataaaaatat
     2581 gtacattaca ttttgcttat tttcatataa aaggtaagaa agagtttgca aagcatttgt
     2641 ggctttttgt agtttactta agccaaaatg tgtttttccc tcaatagctt cgctaatatt
     2701 ttaaacagtc ctgtaaaaac ccaccaagga ctttttgtat agaaagcact accctaagcc
     2761 atgaggatct ccatgctttg ctaaccaaga taactgtttt ctctttgtag aagttttgtt
     2821 tttgaaatgt gtatttctaa ttatataaaa tattaagaat cttttaaaaa tctgtgaaat
     2881 taacatgctt gtgtatagct ttctaatata tataatatta tggtaatggc agaagttttg
     2941 ttttcttaat agcgggaggg gggtatattt gtgcagttgc acatttgagt aactattttc
     3001 tttctgattt cttttactct gcatacattt tataagttca aggtcagctg tcaaaaggat
     3061 aagctgtggg gttagaacat attacattgc aacatcctaa attgttttta aaacgtcagc
     3121 aaactattgg gtcaactgac atccattgta tatactaatt ggtttctttc aaactatttt
     3181 tttttttggt ttggttttga attgttggtt tcttttcatt ttatcaaaag cagggcccct
     3241 ttcagatctc tcttcatttc accatacatc ttggaattct gtaagtttgt atcctaactt
     3301 gcccatattc taaatttaca tagtttattt tcagccttga gttggatgtt ttttagaaat
     3361 atgcccagag taagaagctg tgttggagcc taagtcctgc aagctgggtc ctgggggcga
     3421 ccgacctgct ttacttgatg gataagttac agagttctgg aggagaacaa ggtgaaagcc
     3481 tgggtgctgg agaggaagga aacagttaaa gggtagttac ttggtatcca ccttcatgat
     3541 tttaactgac ccataacaat gttgtcagca gtataggact gttgaacagc ctggtgtgtc
     3601 aggaccccca aatgtcactt ctgcctaaag catgtatgtc acctattttt ttcttcaata
     3661 aagaaattta acagccattt caagaaatcc cactttaaaa aaaaaaaaaa acaaaccttt
     3721 ctctatgtcc cccccccttt tttttaattt tcaagataat ttaactcttg tctaatattc
     3781 ttgtgtaagg gattaatttt cagacccctt taaaagtgag tgccataaag agtcaatata
     3841 tagtgttgaa gtggtatttc aggctaggaa ttattccctt ctcttggaat gtgaagatct
     3901 gtcgattcat cctgtcatta atcctgacat acagaacaaa gaatgcagta acattagccc
     3961 tgccaggtca cgtgtaggac gtgcttatcc agttttttcc ccctttacct gcatagttgc
     4021 tacatacatg tttctcactg taaaaggctg ccgctgggtg gcagaagcca aaagacctta
     4081 ttaacgaggc tatatttttc ttaacttgat ctgcaatcca gaattagacc acaatgcacc
     4141 tttggtggta tccatatagg atgctagcct gccttgtagt aatgttttat atgttaaaaa
     4201 caaaataaag acatcaacca tttcacatat attctactac taaaggtatc aatggaacat
     4261 gaagacgagt atttaggcag aagcaaaaca ggaaaccatc cttacaaaca tgcttacctg
     4321 cacatctgtt tgcatggtca tgtgtacatt caaacatgca cataaagtga acaagaaagt
     4381 cagccattat ttcacgccag acttgattcc atcctgagaa ttcatgttta taattaaatg
     4441 tgtgttaaat atgcaagcat atcacaaatg ttccttgtcc tttcaaagtg catttgttca
     4501 tcaagatcaa tagaatctta ccagtgggta ggaaaggatc atataaaata tgaagaaata
     4561 gccatattaa attttttgct gtcatttgcc tccgcaacaa agcgagtgta agtgtctaat
     4621 gctgaagcta gagtgaactc atgtgccagc agaggcctcc tctctttata gcaattctga
     4681 caataggttt gtttgtttgt ttgtttgttt ttacaaactc aagaaaaaca gactcacttg
     4741 aaaaaatgga tgccagtcac ctggttccca ctactgtcgt agcagatagc gaagggacaa
     4801 tctgagactt gtagagatga tttaatgaga agcacaattt ttattgtgac cagtcacgtt
     4861 ctatcaccag gcactgtctt gtctttgccc ttgccttttc tgtaactcac catttattgt
     4921 atttacaaat ctagtaaggg ttttgatcac accaagttct ttgtattgag aagtctaggg
     4981 cagagctctg ggggattgtt attttacatt acctggccta gagtagcata ttagacaaca
     5041 gtcatcattg caagtaggag gaccgtaaat ggcattttac atgactgcaa gtattgttat
     5101 accgaatcct attttaaaag agttttagta acggtgagct gagaaattct ggtcatggtg
     5161 agcagcaggc gcaagccatg cagcctgtgg actgtgcgca ttgatatgtg gaggctgttg
     5221 atttcaacct tttttaaact tgtgtttttt agtaaaattg cttatttttt tcccaaaggt
     5281 ggaatttaat gttttgtagt gatgaatatg aaaatgcctg tcatctttag atcattgaaa
     5341 ggttaactaa catgagaatt tcagagcaaa ttccaatact cttttaaaaa gcgtgtctgc
     5401 cctctcttac ttctatgtat ttgtttatcg acacactcac cctttctgag atagcatttt
     5461 gctcccttga tccccccctt tttttgtccc ttcgaagagt aaatgctttg tatttctttc
     5521 tttaaaaaat ttactttaaa gaagaagcca cttgaacctt caataaaggc tgttgcctaa
     5581 acatggcgta cttcatctgt tcccgcctct gccatctgct acggtgtcgt cagttgtatg
     5641 gcattaattt cctgccacta gagatatttt gaagattgct tgaatgctgg tgtctgttag
     5701 aatgcttctg actacagatg taattaaagg cttttcttac tatgttttaa ccaaagatgt
     5761 ggagcaatcc aagccgcata tctactgcat taaatttgtc catttggtta ttcataatcg
     5821 ggtattgcat tttgccttcc ctgtccatac ctcaaattga ttgatacctc agtttaattc
     5881 agagaggttc gctaagtgtt ggattctagt tgtggtttga atgcagcagt gtactcttga
     5941 agtaagcagg caagggtcac tgcaggcatg aagcttggat tgcttcagat ggtttgccgt
     6001 atcgtttttc ttccttttcc ttttctgggg acttgtttcc attcaatgac aattaaaata
     6061 gcttgtaaat gagggcatac aagcatttgc aacaagtatt caaatagagg ctcacagcgg
     6121 cataagctgg actttgtcgc cactagatga caagatggta tacctaagct aaccacacgt
     6181 gtgtatctca agggacttaa attcagctgt ctgtagtgaa ttcaagtggg aaattttcaa
     6241 aagtttctcc tgctggaaat aaggtataat ttgtattttg cagacaattc agtaaagtta
     6301 ctggctttct tagtga
//
