LOCUS       NM_001045484            1339 bp    mRNA    linear   ROD 18-MAR-2025
DEFINITION  Mus musculus myocyte enhancer factor 2B (Mef2b), mRNA.
ACCESSION   NM_001045484 XM_486121 XM_922052
VERSION     NM_001045484.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1339)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1339)
  AUTHORS   Kamath,S.P. and Chen,A.I.
  TITLE     Myocyte Enhancer Factor 2c Regulates Dendritic Complexity and
            Connectivity of Cerebellar Purkinje Cells
  JOURNAL   Mol Neurobiol 56 (6), 4102-4119 (2019)
   PUBMED   30276662
REFERENCE   3  (bases 1 to 1339)
  AUTHORS   Brescia,P., Schneider,C., Holmes,A.B., Shen,Q., Hussein,S.,
            Pasqualucci,L., Basso,K. and Dalla-Favera,R.
  TITLE     MEF2B Instructs Germinal Center Development and Acts as an Oncogene
            in B Cell Lymphomagenesis
  JOURNAL   Cancer Cell 34 (3), 453-465 (2018)
   PUBMED   30205047
  REMARK    GeneRIF: Mef2b deletion reduces germinal center (GC) formation in
            mice and identify MEF2B transcriptional targets in GC, with roles
            in cell proliferation, apoptosis, GC confinement, and
            differentiation. The most common lymphoma-associated MEF2B mutant
            (MEF2BD83V) is hypomorphic yet escapes binding and negative
            regulation by components of the HUCA complex and class IIa HDACs.
REFERENCE   4  (bases 1 to 1339)
  AUTHORS   Omori,Y., Kitamura,T., Yoshida,S., Kuwahara,R., Chaya,T., Irie,S.
            and Furukawa,T.
  TITLE     Mef2d is essential for the maturation and integrity of retinal
            photoreceptor and bipolar cells
  JOURNAL   Genes Cells 20 (5), 408-426 (2015)
   PUBMED   25757744
REFERENCE   5  (bases 1 to 1339)
  AUTHORS   Estrella,N.L., Desjardins,C.A., Nocco,S.E., Clark,A.L.,
            Maksimenko,Y. and Naya,F.J.
  TITLE     MEF2 transcription factors regulate distinct gene programs in
            mammalian skeletal muscle differentiation
  JOURNAL   J Biol Chem 290 (2), 1256-1268 (2015)
   PUBMED   25416778
  REMARK    GeneRIF: Whereas MEF2A is absolutely required for proper myoblast
            differentiation, MEF2B, -C, and -D were found to be dispensable for
            this process.
REFERENCE   6  (bases 1 to 1339)
  AUTHORS   Molkentin,J.D., Firulli,A.B., Black,B.L., Martin,J.F., Hustad,C.M.,
            Copeland,N., Jenkins,N., Lyons,G. and Olson,E.N.
  TITLE     MEF2B is a potent transactivator expressed in early myogenic
            lineages
  JOURNAL   Mol Cell Biol 16 (7), 3814-3824 (1996)
   PUBMED   8668199
REFERENCE   7  (bases 1 to 1339)
  AUTHORS   Ross,R.S., Navankasattusas,S., Harvey,R.P. and Chien,K.R.
  TITLE     An HF-1a/HF-1b/MEF-2 combinatorial element confers cardiac
            ventricular specificity and established an anterior-posterior
            gradient of expression
  JOURNAL   Development 122 (6), 1799-1809 (1996)
   PUBMED   8674419
REFERENCE   8  (bases 1 to 1339)
  AUTHORS   Olson,E.N., Perry,M. and Schulz,R.A.
  TITLE     Regulation of muscle differentiation by the MEF2 family of MADS box
            transcription factors
  JOURNAL   Dev Biol 172 (1), 2-14 (1995)
   PUBMED   7589800
  REMARK    Review article
REFERENCE   9  (bases 1 to 1339)
  AUTHORS   Hidaka,K., Morisaki,T., Byun,S.H., Hashido,K., Toyama,K. and
            Mukai,T.
  TITLE     The MEF2B homologue differentially expressed in mouse embryonal
            carcinoma cells
  JOURNAL   Biochem Biophys Res Commun 213 (2), 555-560 (1995)
   PUBMED   7646512
REFERENCE   10 (bases 1 to 1339)
  AUTHORS   Lyons,G.E., Micales,B.K., Schwarz,J., Martin,J.F. and Olson,E.N.
  TITLE     Expression of mef2 genes in the mouse central nervous system
            suggests a role in neuronal maturation
  JOURNAL   J Neurosci 15 (8), 5727-5738 (1995)
   PUBMED   7643214
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC124327.9 and BC045147.1.
            
            On Jun 12, 2015 this sequence version replaced NM_001045484.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC045147.1, D87835.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849383
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-17                AC124327.9         12480-12496
            18-1339             BC045147.1         1-1322
FEATURES             Location/Qualifiers
     source          1..1339
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 34.15 cM"
     gene            1..1339
                     /gene="Mef2b"
                     /gene_synonym="17259"
                     /note="myocyte enhancer factor 2B"
                     /db_xref="GeneID:17259"
                     /db_xref="MGI:MGI:104526"
     exon            1..84
                     /gene="Mef2b"
                     /gene_synonym="17259"
                     /inference="alignment:Splign:2.1.0"
     exon            85..160
                     /gene="Mef2b"
                     /gene_synonym="17259"
                     /inference="alignment:Splign:2.1.0"
     CDS             107..1126
                     /gene="Mef2b"
                     /gene_synonym="17259"
                     /codon_start=1
                     /product="myocyte-specific enhancer factor 2B"
                     /protein_id="NP_001038949.1"
                     /db_xref="CCDS:CCDS40368.1"
                     /db_xref="GeneID:17259"
                     /db_xref="MGI:MGI:104526"
                     /translation="MGRKKIQISRILDQRNRQVTFTKRKFGLMKKAYELSVLCDCDIA
                     LIIFNSAQRLFQYASSDMDRVLLKYTEYSEPHESRTNADILQTLKRRGVGLDGPELDM
                     EEGPEGPGEKLLRTLGGDRGSASPPPRIYPVAPAMSVSELSYRVPPATPGCDPGGLGE
                     APSVHSRPPHFRPPGLGHPIFSPSHLASKTPPPLYLATDGRRPDLPPGLRSLYSGLQS
                     PGAPGPALGSFAFLPSGSTDCSPGDAAQGPLQPSPWPPTRDAVDPARPVARSLCKEGP
                     PSRGASPPTPPVSIKSERLSPVTGTSGDFPRSFPYPLLLARPLAEPLRPSASLHRLTP
                     DSWPR"
     exon            161..364
                     /gene="Mef2b"
                     /gene_synonym="17259"
                     /inference="alignment:Splign:2.1.0"
     exon            365..499
                     /gene="Mef2b"
                     /gene_synonym="17259"
                     /inference="alignment:Splign:2.1.0"
     exon            500..629
                     /gene="Mef2b"
                     /gene_synonym="17259"
                     /inference="alignment:Splign:2.1.0"
     exon            630..733
                     /gene="Mef2b"
                     /gene_synonym="17259"
                     /inference="alignment:Splign:2.1.0"
     exon            734..818
                     /gene="Mef2b"
                     /gene_synonym="17259"
                     /inference="alignment:Splign:2.1.0"
     exon            819..906
                     /gene="Mef2b"
                     /gene_synonym="17259"
                     /inference="alignment:Splign:2.1.0"
     exon            907..1329
                     /gene="Mef2b"
                     /gene_synonym="17259"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      1329
                     /gene="Mef2b"
                     /gene_synonym="17259"
                     /note="major polyA site"
ORIGIN      
        1 agtgcagcag aagcataggc gcctggaccc tcacagtgcg cagcaggtgt ggccagcagg
       61 gaccagactc ccgggactcc tgagccgctc tgcacagcta cccacgatgg ggaggaaaaa
      121 aatccagatc tcacgaattc tagaccaaag gaacaggcag gtgactttca ccaagcgcaa
      181 gttcggactg atgaagaagg cttatgagct gagcgtgctt tgtgactgcg acattgccct
      241 gatcatcttc aacagcgcgc aacgcctctt ccagtatgcg agcagcgaca tggaccgggt
      301 gctgctcaaa tacaccgagt acagtgagcc gcacgagagc cgcaccaacg cggatatcct
      361 tcagacactg aagaggaggg gcgtgggcct tgatgggccc gagctggata tggaggaggg
      421 gccagaaggt cctggagaga agctgctgag gacactgggg ggtgacagag gctcggcctc
      481 gcccccgcct cggatctatc ccgtggcccc cgcaatgtcg gtttcagagc tgtcctaccg
      541 ggtcccacca gccactccag gctgtgatcc tggcgggctg ggggaggccc cgtctgtcca
      601 cagccgcccg cctcactttc gacccccggg cctgggacac ccgatcttct ctccaagcca
      661 ccttgcgagc aagacgcccc cgcctctgta cctggcgact gatgggcgga ggccagacct
      721 gccccctggc ctgagaagcc tgtacagcgg cctgcagagt cccggtgccc caggccccgc
      781 tctgggtagc tttgccttct taccatcagg ctccacagat tgcagcccgg gagacgcagc
      841 tcagggaccc ctgcaaccct caccctggcc accaacgagg gacgctgtag accccgcccg
      901 gccagttgcc cgcagtctgt gcaaggaggg tccccccagc cgaggggcct cccctccgac
      961 acctccggtc agcatcaagt ctgagcgact gtctccagtc actgggacct ctggcgactt
     1021 ccccaggtcc ttcccctacc cgctgctcct tgccaggccc cttgcagagc cactgcggcc
     1081 ctcggcctcc ctgcaccgct tgacccctga cagctggcca cggtagcgct ccaagaggtt
     1141 cctccagcct ccacagagtt cccgaagtct caggttccct ataccaccag gacggacgga
     1201 cgagggcacc cactgtgcat cactaaggcc ctgtcccttc ctgggggccg ctgcatcaat
     1261 aaagcccaag gactcgggag ggcactgggc agcccctagc tcagagctcc cgagcctgga
     1321 atagccacaa aaaaaaaaa
//
