LOCUS       NM_001033713            5552 bp    mRNA    linear   ROD 05-JUN-2024
DEFINITION  Mus musculus myocyte enhancer factor 2A (Mef2a), transcript variant
            1, mRNA.
ACCESSION   NM_001033713 NM_013597 XM_355912 XM_895321 XM_895322 XM_906166
            XM_919621 XM_919628 XM_919638 XM_919643 XM_919654 XM_919662
            XM_919670 XM_919681 XM_919688 XM_919695
VERSION     NM_001033713.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5552)
  AUTHORS   Steiman,S., Miyake,T. and McDermott,J.C.
  TITLE     FoxP1 Represses MEF2A in Striated Muscle
  JOURNAL   Mol Cell Biol 44 (2), 57-71 (2024)
   PUBMED   38483114
  REMARK    GeneRIF: FoxP1 Represses MEF2A in Striated Muscle.
REFERENCE   2  (bases 1 to 5552)
  AUTHORS   Shen,X., Zhao,X., He,H., Zhao,J., Wei,Y., Chen,Y., Han,S., Zhu,Y.,
            Zhang,Y., Zhu,Q. and Yin,H.
  TITLE     Evolutionary conserved circular MEF2A RNAs regulate myogenic
            differentiation and skeletal muscle development
  JOURNAL   PLoS Genet 19 (9), e1010923 (2023)
   PUBMED   37676887
  REMARK    GeneRIF: Evolutionary conserved circular MEF2A RNAs regulate
            myogenic differentiation and skeletal muscle development.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5552)
  AUTHORS   Boogerd,C.J., Perini,I., Kyriakopoulou,E., Han,S.J., La,P., van der
            Swaan,B., Berkhout,J.B., Versteeg,D., Monshouwer-Kloots,J. and van
            Rooij,E.
  TITLE     Cardiomyocyte proliferation is suppressed by ARID1A-mediated YAP
            inhibition during cardiac maturation
  JOURNAL   Nat Commun 14 (1), 4716 (2023)
   PUBMED   37543677
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5552)
  AUTHORS   Zhou,G., Hou,F., He,H., Xue,Y., Wang,Y., Chen,X. and Zhu,F.
  TITLE     Myocyte Enhancer Factor 2A Contributes to the TGF-beta1-Mediated
            Cholangiocyte Epithelial to Mesenchymal Transition and Senescence
            in Cholestatic Liver Fibrosis
  JOURNAL   Front Biosci (Landmark Ed) 27 (12), 324 (2022)
   PUBMED   36624941
  REMARK    GeneRIF: Myocyte Enhancer Factor 2A Contributes to the
            TGF-beta1-Mediated Cholangiocyte Epithelial to Mesenchymal
            Transition and Senescence in Cholestatic Liver Fibrosis.
REFERENCE   5  (bases 1 to 5552)
  AUTHORS   Wang,I.F., Wang,Y., Yang,Y.H., Huang,G.J., Tsai,K.J. and Shen,C.J.
  TITLE     Activation of a hippocampal CREB-pCREB-miRNA-MEF2 axis modulates
            individual variation of spatial learning and memory capability
  JOURNAL   Cell Rep 36 (5), 109477 (2021)
   PUBMED   34348143
  REMARK    GeneRIF: Activation of a hippocampal CREB-pCREB-miRNA-MEF2 axis
            modulates individual variation of spatial learning and memory
            capability.
REFERENCE   6  (bases 1 to 5552)
  AUTHORS   Hidaka,K., Morisaki,T., Byun,S.H., Hashido,K., Toyama,K. and
            Mukai,T.
  TITLE     The MEF2B homologue differentially expressed in mouse embryonal
            carcinoma cells
  JOURNAL   Biochem Biophys Res Commun 213 (2), 555-560 (1995)
   PUBMED   7646512
REFERENCE   7  (bases 1 to 5552)
  AUTHORS   Lyons,G.E., Micales,B.K., Schwarz,J., Martin,J.F. and Olson,E.N.
  TITLE     Expression of mef2 genes in the mouse central nervous system
            suggests a role in neuronal maturation
  JOURNAL   J Neurosci 15 (8), 5727-5738 (1995)
   PUBMED   7643214
REFERENCE   8  (bases 1 to 5552)
  AUTHORS   Kaushal,S., Schneider,J.W., Nadal-Ginard,B. and Mahdavi,V.
  TITLE     Activation of the myogenic lineage by MEF2A, a factor that induces
            and cooperates with MyoD
  JOURNAL   Science 266 (5188), 1236-1240 (1994)
   PUBMED   7973707
REFERENCE   9  (bases 1 to 5552)
  AUTHORS   Edmondson,D.G., Lyons,G.E., Martin,J.F. and Olson,E.N.
  TITLE     Mef2 gene expression marks the cardiac and skeletal muscle lineages
            during mouse embryogenesis
  JOURNAL   Development 120 (5), 1251-1263 (1994)
   PUBMED   8026334
REFERENCE   10 (bases 1 to 5552)
  AUTHORS   Komuro,I., Schalling,M., Jahn,L., Bodmer,R., Jenkins,N.A.,
            Copeland,N.G. and Izumo,S.
  TITLE     Gtx: a novel murine homeobox-containing gene, expressed
            specifically in glial cells of the brain and germ cells of testis,
            has a transcriptional repressor activity in vitro for a
            serum-inducible promoter
  JOURNAL   EMBO J 12 (4), 1387-1401 (1993)
   PUBMED   8096811
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK052385.1, BC061128.1, AC120123.19, AK132678.1, AK136368.1,
            AC158751.7 and AI849762.1.
            
            On or before Mar 28, 2014 this sequence version replaced
            NM_013597.2, NM_001033713.1.
            
            Transcript Variant: This variant (1) encodes the canonical isoform
            (a). Variants 1 and 7 both encode the same isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC061128.1, SRR1660811.75845.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-29                AK052385.1         2-30
            30-260              BC061128.1         1-231
            261-261             AC120123.19        160872-160872
            262-2877            BC061128.1         233-2848
            2878-3625           AK132678.1         2736-3483
            3626-4042           AK136368.1         968-1384
            4043-4043           AC158751.7         66886-66886
            4044-5462           AK136368.1         1385-2803
            5463-5552           AI849762.1         1-90                c
FEATURES             Location/Qualifiers
     source          1..5552
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 36.72 cM"
     gene            1..5552
                     /gene="Mef2a"
                     /gene_synonym="A430079H05Rik"
                     /note="myocyte enhancer factor 2A"
                     /db_xref="GeneID:17258"
                     /db_xref="MGI:MGI:99532"
     exon            1..146
                     /gene="Mef2a"
                     /gene_synonym="A430079H05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            147..199
                     /gene="Mef2a"
                     /gene_synonym="A430079H05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            200..390
                     /gene="Mef2a"
                     /gene_synonym="A430079H05Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             337..1833
                     /gene="Mef2a"
                     /gene_synonym="A430079H05Rik"
                     /note="isoform a is encoded by transcript variant 1;
                     myocyte-specific enhancer factor 2A"
                     /codon_start=1
                     /product="myocyte-specific enhancer factor 2A isoform a"
                     /protein_id="NP_001028885.1"
                     /db_xref="CCDS:CCDS39981.1"
                     /db_xref="GeneID:17258"
                     /db_xref="MGI:MGI:99532"
                     /translation="MGRKKIQITRIMDERNRQVTFTKRKFGLMKKAYELSVLCDCEIA
                     LIIFNSSNKLFQYASTDMDKVLLKYTEYNEPHESRTNSDIVETLRKKGLNGCESPDAD
                     DYFEHSPLSEDRFSKLNEDSDFIFKRGPPGLPPQNFSMSVTVPVTSPNALSYTNPGSS
                     LVSPSLAASSTLADSSMLSPPPATLHRNVSPGAPQRPPSTGSASGMLSTTDLTVPNGA
                     GNSPVGNGFVNSRASPNLIGNTGANSLGKVMPTKSPPPPGGGSLGMNSRKPDLRVVIP
                     PSSKGMMPPLSEEEELELNAQRISSSQATQPLATPVVSVTTPSLPPQGLVYSAMPTAY
                     NTDYSLTSADLSALQGFTSPGMLSLGQASAWQQHHLGQAALSSLVAGGQLSQGSNLSI
                     NTNQNINIKSEPISPPRDRMTPSGFQQQQQQPQQQPPPQPPQPQPRQEMGRSPVDSLS
                     SSSSSYDGSDREDPRGDFHSPIVLGRPPNTEDRESPSVKRMRMDTWVT"
     exon            391..594
                     /gene="Mef2a"
                     /gene_synonym="A430079H05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            595..726
                     /gene="Mef2a"
                     /gene_synonym="A430079H05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            727..946
                     /gene="Mef2a"
                     /gene_synonym="A430079H05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            947..1006
                     /gene="Mef2a"
                     /gene_synonym="A430079H05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1007..1194
                     /gene="Mef2a"
                     /gene_synonym="A430079H05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1195..1218
                     /gene="Mef2a"
                     /gene_synonym="A430079H05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1219..1345
                     /gene="Mef2a"
                     /gene_synonym="A430079H05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1346..1472
                     /gene="Mef2a"
                     /gene_synonym="A430079H05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1473..5538
                     /gene="Mef2a"
                     /gene_synonym="A430079H05Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5367..5372
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mef2a"
                     /gene_synonym="A430079H05Rik"
                     /note="hexamer: AAGAAA"
     polyA_site      5388
                     /gene="Mef2a"
                     /gene_synonym="A430079H05Rik"
                     /note="major polyA site"
     regulatory      5510..5515
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mef2a"
                     /gene_synonym="A430079H05Rik"
                     /note="hexamer: AGTAAA"
     polyA_site      5536
                     /gene="Mef2a"
                     /gene_synonym="A430079H05Rik"
                     /note="major polyA site"
ORIGIN      
        1 aaaaatagcc ccggtgtggg gatccgtgcg cggatgtccc ggcgagtccc gggctgaagg
       61 aggcggctcc gggcggcgcg gagtgctgtg gcgggccggg ccggggctgc ggcgtgtgcg
      121 cgcccgccgg cagtagcgga gactcggaat tgcatcttgt ggaaaagaaa caaagaagag
      181 ttttctgcaa gaatcaaaca tttttaagac aatttcaacg gcagccctgg actagaaggt
      241 taaataatag gagctgtgta cgatgcatta ggagattgga gaaaattagc ttctgaagta
      301 attattagga atataaggaa gacaaggtga ctgaaaatgg ggcgaaagaa gatacaaatc
      361 acacgcataa tggatgagag gaaccgacag gttactttta caaagcgaaa gtttggattg
      421 atgaagaaag cctatgaact cagtgtgctc tgtgactgtg aaatagcact catcattttc
      481 aacagctcta ataagctgtt tcagtacgct agcactgaca tggacaaagt ccttctcaaa
      541 tacactgagt ataacgagcc tcatgaaagc aggacgaact cggatatcgt tgagacgtta
      601 agaaagaaag gccttaatgg ttgtgagagc cctgatgctg acgattactt tgagcacagt
      661 ccactctcgg aggacagatt cagcaaacta aatgaagata gtgattttat tttcaaacga
      721 ggccctcctg gcttgccacc tcagaacttc tcaatgtctg tcacagtccc tgtgaccagc
      781 cctaatgctt tgtcgtacac taacccaggg agttcactcg tgtcaccgtc tttggcagcc
      841 agctcaacat tagcagattc gagcatgctg tctccacccc cagccacgct acatagaaat
      901 gtgtccccag gagctccgca gagaccacca agtaccggca gtgcaagtgg gatgttgagc
      961 actacagacc tcacggtgcc aaatggagct ggaaatagtc ctgtggggaa tggatttgta
     1021 aactcaaggg cctctccaaa tttgattgga aatactggtg caaatagttt aggcaaagtc
     1081 atgcctacaa agtctccccc gccaccaggt ggtggcagtc ttggaatgaa cagtcggaaa
     1141 ccagatctac gagttgtcat tcccccatca agcaagggca tgatgccccc actttcggag
     1201 gaagaggaat tggagttgaa tgcccaaagg ataagcagtt ctcaagccac tcaacctctt
     1261 gccacgcctg tagtgtctgt gacaactccg agcttgcctc cacagggact agtgtactca
     1321 gcaatgccga cagcctacaa cactgattac tcactgacca gcgctgacct gtctgccctg
     1381 caaggcttta cttcccctgg aatgctgtct ctggggcagg cttcagcctg gcagcagcac
     1441 catctaggac aagcagccct cagctctctg gtggctggag ggcagttatc tcagggttca
     1501 aatttgtcca ttaacaccaa ccagaacatc aacattaagt cagagccaat ttcacctccc
     1561 cgtgatagaa tgaccccatc aggcttccaa cagcagcagc agcagccaca acagcagcca
     1621 ccgccacaac ctccacagcc ccaaccccgg caggaaatgg ggcgctcccc tgtggacagt
     1681 ctgagcagct ccagcagctc ctatgatggc agtgaccggg aggatccacg gggtgacttc
     1741 cattctccaa ttgtgcttgg ccgacctcca aatactgagg acagagaaag cccttctgta
     1801 aaacgcatga ggatggacac atgggtgacc taaggcttcc tggttcatgt ttgttctttg
     1861 tgttactgca gtgaactgcc ctacatatct taaattggtg aataaggaca tgagttcaat
     1921 atatttatat gtacatgcat acatatatat ccctttacat atatatatgt atgttggtgt
     1981 gagtgtgtgt gtatgtgtgg gtgtgtgttg catacacaaa atcaggcact tactgcaaac
     2041 tccttgtagg tctgcagatg tgtgtccaca tggcagacaa agcaccctgt agaaacagac
     2101 cagtctggca cttccttgga ctacttgttt cgtaagataa agtttttgca gagaaacgtg
     2161 tacccatata taattcttcc acattagcct gcagaaacct agggggcccc ctatttgttt
     2221 tatttaactg tgcggtgact gtagttactt cagaaaacaa aatgctttgt agaacagagc
     2281 agtagaaaag caggaaccaa gaaagcaata ctgtacataa aatgtcattt atattaataa
     2341 cccaacttgg catgggtcta ttgcaaaggg gtgcatggga aagggctgtt gatattaaac
     2401 aaacaaacaa taaacaaaaa gccccacaca taactgtttt gcacgtgcaa aaaaaatgta
     2461 ttgggtcaaa gaagtgattt ttagctatta aaaagagaga atagaaaaca cgcatgaaat
     2521 attcagaaat actagcctag aaatatagag cattaacaaa ataaaattaa tatattaagt
     2581 tataattgga atatgtcaga agtttctttt acattcatat ctttaaaaat taaagaaact
     2641 gattttaggt catgtatatt ttataagaaa gaaaacaccc ttaatgaatt gatgactata
     2701 tataaaatta tatccactac ttttgaacac attctgctga attatttata taagccaaag
     2761 ctgtatgttg taactttttt ttaaagaata gctttatctt gttttaactt tttagtttta
     2821 ttttaagagg ggagaaaaaa caaaaatatc ttgcaagcag aaccttggaa aaaaaaagcc
     2881 atgaacactt attattctat atgtaaatta aaagttgagc caaactcttt gtgtatatag
     2941 catcttaaat atattatcac ctttgatgta agtacctatg tattgtatgg tcaccagatt
     3001 aaaaagtata tttttgtgga ttgccgccaa tttgggggga aaggcgaagt ccttaagtag
     3061 agtattcact gtttaatatt tactattttg ttaatatact gtactttgga ttttaattat
     3121 cagcccagct tttcagaggc ctgtgtaaag ggttcccctc actggtggtg aatgtgtgat
     3181 gttctgttgt gagctttgtg ctgtatgggg tgagcatcat tatatatttt atatgtgtac
     3241 ataaatagca aagtggcaag aaattggtgt taagtccatc ctgcataaat ataaaatgtg
     3301 ttgtaacaga ttttataagg cgttatttaa aacctgcctt ttgtggggga aaaatggtag
     3361 aaagatgacc taatttaact aatattagag aaaatggcag aatagtagat gagcacaaag
     3421 gttttataag tggtaaataa ttagaaaaat atctgtaggg aaagggatct ttttctcctt
     3481 gactctaaag atagaatgac gcagctggtt acaaaatcca ggagggcttt agcgtccgtg
     3541 cgtgcgcagg aaggcacggg cgtgcaggga acagctctct tatggtgcaa accctcgaca
     3601 cgattctcgg tgtcctgacg gaaactggtg ccaccctcag cttggatttt gaacaaggcc
     3661 ttactcttac agggagacag ctcgttggtg atggcaagtt gatccgttta ctgggcttgt
     3721 gccatgaaca aaattcaaag tcctgtatat cttttatcct agatttttaa atactccttt
     3781 tcctgaaaat taaagggttt aaaaatggct gctattttat attgaacaat gttgagcagc
     3841 tacctgcagt ttttacttcc attttgcttt cccccccccg acttccctaa attctgctcc
     3901 ttttgatgtt tcctcatctg ctgtcctgac aactcatcgc cagccttcct gcccggcaca
     3961 caggtattag gcacacacac cgtggcgagc gagcgggcac aggctgtgca gcggagagcg
     4021 cctcactgac cgttggctag cacgtgttag cagaagccaa aaaagtgggg tgatgtttgc
     4081 tctcctctct gtggtctcaa cactcggctc ttactcagaa aagagtaggc ttgctttctg
     4141 agatgtacgg aattgactta caggcacgtt cttcataagg tcagacctga ctaaaacaag
     4201 acagtctccc aacactgaat gtccaagata acccttacca ctttgtaaac catttatagc
     4261 tttgaaagta ttaagtgacc ctttcatcat tatttatgca tgttcatgaa cttctgctgt
     4321 atactggaat aggagttaac acattcacat ttactgtcta ttttcttgtg tgccttatgc
     4381 gatggctttt ctgactgtat ctcaatagtc tttctttcta tgcaggtttg taatcaggac
     4441 aactactgtt ttctaaagga atattacacg aggctcggag tttgtattta aattacactg
     4501 accaagtcac aatgtattcc gttttcagga actgaatatc tgactgttaa tcttccccca
     4561 tatgcccagt gtgatctgga gcgtatgggt ctgacatcct tcacccagat gctcatgtgt
     4621 gaacacatcc acatccacgg ctctcagtgg aagccagcct agagcaggga ggacactgac
     4681 agtgttgctt taaactgact tttcttaccc tttgagactc atgtgttttg tataagacac
     4741 catcacagga aagttttctc ccttcagata acatatttta ttattaaaaa gaaaaacaaa
     4801 aaaagcttaa gttgcactgg acatgggaag ttccctcagg actctaagtg gttctatact
     4861 gagagtgagt gtcaccgctg tgtcaacaca ggtggtccca gtcaaaactc catcctttga
     4921 gccctaatta catccattgt gttacaaaac taaatcaggg gtttgttcta aaagaacaat
     4981 acatgtttca ccatttcctt tcaactgtaa agacgactaa tgtattaaca taatttctgt
     5041 attaaccatc atgcgcacaa gaaatacata gtaaatacgg aacctgaaaa ctcctggcat
     5101 tggatcataa aaagctagat gattagaatg tgaaaagaac tttacaaatg taaaactttt
     5161 atttctctgt agaaactttc ttcactttgc tgtgcaagaa gacactgctt tgctatattt
     5221 aaaatggctt ttttaaaaga gatttatgta tttggtaaat gtttgtagtc aacagttcac
     5281 acaaagaagc tgtactcggt ttgatcatgt aaaaccgttt ggcggcacaa gctggacttt
     5341 gttgccatcc ttgagatgaa ccttttaaga aaaataagtt aatctcaatt tttccctgaa
     5401 tgtgttgttt tttcttcatt atacaataaa tattatagtg aagtttttat caaatggtta
     5461 agacaatgct tgaggttgtt gtaagctatt tgtctcctgc actcactcca gtaaagatgg
     5521 cctggctttg accatacaaa aaaaaaaaaa aa
//
