LOCUS       NM_138675               3013 bp    mRNA    linear   ROD 18-JUN-2024
DEFINITION  Mus musculus mediator complex subunit 9 (Med9), mRNA.
ACCESSION   NM_138675
VERSION     NM_138675.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3013)
  AUTHORS   Kolonay,D.W., Sattler,K.M., Strawser,C., Rafael-Fortney,J.,
            Mihaylova,M.M., Miller,K.E., Lepper,C. and Baskin,K.K.
  TITLE     Temporal regulation of the Mediator complex during muscle
            proliferation, differentiation, regeneration, aging, and disease
  JOURNAL   Front Cell Dev Biol 12, 1331563 (2024)
   PUBMED   38690566
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3013)
  AUTHORS   Ricard,G., Molina,J., Chrast,J., Gu,W., Gheldof,N., Pradervand,S.,
            Schutz,F., Young,J.I., Lupski,J.R., Reymond,A. and Walz,K.
  TITLE     Phenotypic consequences of copy number variation: insights from
            Smith-Magenis and Potocki-Lupski syndrome mouse models
  JOURNAL   PLoS Biol 8 (11), e1000543 (2010)
   PUBMED   21124890
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3013)
  AUTHORS   Yan,J., Bi,W. and Lupski,J.R.
  TITLE     Penetrance of craniofacial anomalies in mouse models of
            Smith-Magenis syndrome is modified by genomic sequence surrounding
            Rai1: not all null alleles are alike
  JOURNAL   Am J Hum Genet 80 (3), 518-525 (2007)
   PUBMED   17273973
REFERENCE   4  (bases 1 to 3013)
  AUTHORS   Tomomori-Sato,C., Sato,S., Parmely,T.J., Banks,C.A., Sorokina,I.,
            Florens,L., Zybailov,B., Washburn,M.P., Brower,C.S., Conaway,R.C.
            and Conaway,J.W.
  TITLE     A mammalian mediator subunit that shares properties with
            Saccharomyces cerevisiae mediator subunit Cse2
  JOURNAL   J Biol Chem 279 (7), 5846-5851 (2004)
   PUBMED   14638676
REFERENCE   5  (bases 1 to 3013)
  AUTHORS   Mittler,G., Kremmer,E., Timmers,H.T. and Meisterernst,M.
  TITLE     Novel critical role of a human Mediator complex for basal RNA
            polymerase II transcription
  JOURNAL   EMBO Rep 2 (9), 808-813 (2001)
   PUBMED   11559591
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY295874.1 and AL603710.8.
            
            On Jan 7, 2006 this sequence version replaced NM_138675.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK147123.1, AK077295.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-390               BY295874.1         2-391
            391-3013            AL603710.8         118304-120926
FEATURES             Location/Qualifiers
     source          1..3013
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 37.81 cM"
     gene            1..3013
                     /gene="Med9"
                     /gene_synonym="Med25"
                     /note="mediator complex subunit 9"
                     /db_xref="GeneID:192191"
                     /db_xref="MGI:MGI:2183151"
     exon            1..265
                     /gene="Med9"
                     /gene_synonym="Med25"
                     /inference="alignment:Splign:2.1.0"
     CDS             54..482
                     /gene="Med9"
                     /gene_synonym="Med25"
                     /note="mediator of RNA polymerase II transcription,
                     subunit 9 homolog"
                     /codon_start=1
                     /product="mediator of RNA polymerase II transcription
                     subunit 9"
                     /protein_id="NP_619616.2"
                     /db_xref="CCDS:CCDS24780.1"
                     /db_xref="GeneID:192191"
                     /db_xref="MGI:MGI:2183151"
                     /translation="MASSGVAGGRQAEDTLQPPPELLPESKPPPPPQPLPVAALPPPA
                     APRPQSPAGAKEENYSFLPLVHNVIKCMDKDSPDLHQDLNALKTKFQELRKLIGTMPG
                     IHVSPEQQQQQLHSLREQVRTKNELLQKYKSLCMFEIPKD"
     exon            266..3013
                     /gene="Med9"
                     /gene_synonym="Med25"
                     /inference="alignment:Splign:2.1.0"
     regulatory      809..814
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Med9"
                     /gene_synonym="Med25"
                     /note="hexamer: ATTAAA"
     polyA_site      830
                     /gene="Med9"
                     /gene_synonym="Med25"
                     /note="major polyA site"
     regulatory      1887..1892
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Med9"
                     /gene_synonym="Med25"
                     /note="hexamer: ATTAAA"
     polyA_site      1912
                     /gene="Med9"
                     /gene_synonym="Med25"
     regulatory      2916..2921
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Med9"
                     /gene_synonym="Med25"
                     /note="hexamer: AATAAA"
     regulatory      2929..2934
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Med9"
                     /gene_synonym="Med25"
                     /note="hexamer: AATAAA"
     polyA_site      2941
                     /gene="Med9"
                     /gene_synonym="Med25"
     polyA_site      2948
                     /gene="Med9"
                     /gene_synonym="Med25"
     regulatory      2991..2996
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Med9"
                     /gene_synonym="Med25"
                     /note="hexamer: ATTAAA"
     polyA_site      3013
                     /gene="Med9"
                     /gene_synonym="Med25"
ORIGIN      
        1 agttgtgacg caagcaccca gcgcccctcg gcagctgctg gactcctggt gctatggctt
       61 cctctggggt ggcgggtggg agacaggccg aagatacgct acagccaccg cccgagctgc
      121 tgccggagtc caagccgcca ccaccgcctc agcctctgcc ggtcgctgcg ctcccgccgc
      181 cggcggctcc gcggcctcag tcccccgctg gcgcgaagga ggagaattac tcctttttgc
      241 cgttggttca caatgtcatc aaatgcatgg acaaggacag cccggatctc caccaggacc
      301 tgaacgccct caaaaccaag ttccaggagc tgcggaagct catcggcacc atgcccggca
      361 tccacgtgag ccccgagcag cagcagcagc agctccacag cctccgagag caagtgagga
      421 ccaagaacga gctgctgcag aagtacaaga gcctctgcat gtttgagatc cccaaggact
      481 aggccagccc ccaggagagc cgccgccaga cggaaagcat cacgcggtgc tccagctcct
      541 tgggagcccc gctcaaaact gggaggccac attcagctgg tgtggggcct cagtgctatc
      601 tcagccctga ccatgtccca gcagatctac agggcacaga gggagaggaa atagctgttc
      661 ccttctttcc ctcagctcct cccactcccg atagcatcag catggtatca ggtacatact
      721 gttcccatta acagcagttt catgaaacat ttgcatagaa ttcacggggt aaattaggcc
      781 tgtactcaga tggcatggat ttattataat taaagcaagc tgtgagagta tgaacattgt
      841 tttgaaaggc cagagggtgg gtggcttctc ccttgaaaca gttcacttcc ttttttgttt
      901 gaactactga atgaaactat atctctgggg gcgtcagccc agagctccac gatctagcca
      961 ccaactccag tttccagcct cctgcatgct agccttatag gctcttgctc cctttatctc
     1021 tatcacttca ggcagtgctc agaatagccg aagcactgct tgcctggggc cctttgtcct
     1081 tcccacactg gctcaaagag gctgttaagg aagcggctct gccctgattc gtatgccctg
     1141 gcttacctct gtctcccctt tagccaagaa gtcacatttg ctactctgca catggtccct
     1201 gcacacttct ggtttggagc aaagtagctg gcaggagcaa tcggggcagt ttctcagcca
     1261 gggttatgtg tggtttgaag ggcgtgggga gctaagtctg gaggttccat agctgtgttc
     1321 tacttgtaga gtgtactcag cgactcgcag gtaggacacc gtgttctctg tctctcaggg
     1381 actgttacac tgagggcacc atggcccttt ccttctcagg ggaaggtgag aagaacccag
     1441 ttattgtttg gatcttgaaa tgggcacagc ctgggctgac cagctgagga cttagcaggt
     1501 gcctgccaac tggccttctt ggcaggagcg ctggctgggg atgtttgtta gcaagcattc
     1561 tggtggcatt gcctatccaa gctgcctcac actgggaccc ggaatgtgtg aaagagggtt
     1621 ctgacttcca ggtatttggg cagaaaagtg agtttgagta gaggatgcca gttaagcacc
     1681 tctgccttgg gactgttact gaactgaatc agttacttgc tgcaaagttg aagcagtggc
     1741 tgggccagtt ttaaggctct gactggttcc tgtaagcgca gagcacatga aatgcaaggg
     1801 cttcagctct tcctgacagg gaagaaagaa ggcgtcctcg gaggcttctg ttccgtgtgg
     1861 tgacctgtca cattttcaga tatataatta aaagtgtggt ctgctctcag gacacatggt
     1921 ttgcctgttg gctctgtctc agtgcttgga ttcagcccct ggaattacag gttttataat
     1981 gaagaattag agtggtatgt tgagtaggtg gtgtagaggg aaatgttcac tgtgctcctt
     2041 ccacccagca tgtgcacctg ttcaactagc acaaaggcct gcatgtctcc tgcaggggaa
     2101 cttggggagc cagccagtca ttggtgagaa gtgagtgcct tgctgagatt tgaggaggtg
     2161 cagtgccttg gaagtggccc ttcccaaaac agggttgaca ggacacaccc ccatccccac
     2221 ccccaccccc acccccaaga cactttcgag catcccttga aggtcagaac tctcttggaa
     2281 aaccaagtgc ttggctccgc agctgcagca gtgttgactc cttagagacc atattgactc
     2341 ctgaccctat ttctcagctg cagaattgga ggcttcaagg tgacacttga accctgagtt
     2401 gacagtagga gtggcaagga gatcttggtc acaaactatg agcccttagc caacaggggg
     2461 atgggaaagt gcagaggagc tgggcctccc ctgcttgagt gcttctggga gctgcactag
     2521 aagcgagcta ctttccctgg ccaggtcctg gggcaaccct ggggcaaggg ataaacacag
     2581 agtgcaggca tcttcccaga cacacctctc cagctcagcc tccttatttg tggtaatcag
     2641 agtcggagtg tgacagcttc ctgtcacctg ccatgattag caggtggcct gtggaggaga
     2701 gtatgaatat tctccaaaac aaggccccct ggtataggcc aagtgaggca gagggtaaac
     2761 agagccagga ggtctagagc aggtcccact tggaagtggg aggccatttt ccgaaagcca
     2821 ggtccctctc cagttcttgg ccactggcac tgagcactga ggcaggaaac ctaaaagcaa
     2881 agcaccattt tccgtttcta aattatttta ttttaaataa aaaataataa taaagacctc
     2941 acacaataga aatgtagaga ttttgttcat gtcacattga cactggaact attaaagtgc
     3001 aagttttgtg ttt
//
