LOCUS       NM_025426               2560 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus mediator complex subunit 7 (Med7), transcript variant
            1, mRNA.
ACCESSION   NM_025426
VERSION     NM_025426.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2560)
  AUTHORS   Kolonay,D.W., Sattler,K.M., Strawser,C., Rafael-Fortney,J.,
            Mihaylova,M.M., Miller,K.E., Lepper,C. and Baskin,K.K.
  TITLE     Temporal regulation of the Mediator complex during muscle
            proliferation, differentiation, regeneration, aging, and disease
  JOURNAL   Front Cell Dev Biol 12, 1331563 (2024)
   PUBMED   38690566
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2560)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2560)
  AUTHORS   Chen,J., Melton,C., Suh,N., Oh,J.S., Horner,K., Xie,F., Sette,C.,
            Blelloch,R. and Conti,M.
  TITLE     Genome-wide analysis of translation reveals a critical role for
            deleted in azoospermia-like (Dazl) at the oocyte-to-zygote
            transition
  JOURNAL   Genes Dev 25 (7), 755-766 (2011)
   PUBMED   21460039
REFERENCE   4  (bases 1 to 2560)
  AUTHORS   Kagey,M.H., Newman,J.J., Bilodeau,S., Zhan,Y., Orlando,D.A., van
            Berkum,N.L., Ebmeier,C.C., Goossens,J., Rahl,P.B., Levine,S.S.,
            Taatjes,D.J., Dekker,J. and Young,R.A.
  TITLE     Mediator and cohesin connect gene expression and chromatin
            architecture
  JOURNAL   Nature 467 (7314), 430-435 (2010)
   PUBMED   20720539
  REMARK    Erratum:[Nature. 2011 Apr 14;472(7342):247]
REFERENCE   5  (bases 1 to 2560)
  AUTHORS   Sansom,S.N., Griffiths,D.S., Faedo,A., Kleinjan,D.J., Ruan,Y.,
            Smith,J., van Heyningen,V., Rubenstein,J.L. and Livesey,F.J.
  TITLE     The level of the transcription factor Pax6 is essential for
            controlling the balance between neural stem cell self-renewal and
            neurogenesis
  JOURNAL   PLoS Genet 5 (6), e1000511 (2009)
   PUBMED   19521500
REFERENCE   6  (bases 1 to 2560)
  AUTHORS   Lau,N.C., Seto,A.G., Kim,J., Kuramochi-Miyagawa,S., Nakano,T.,
            Bartel,D.P. and Kingston,R.E.
  TITLE     Characterization of the piRNA complex from rat testes
  JOURNAL   Science 313 (5785), 363-367 (2006)
   PUBMED   16778019
REFERENCE   7  (bases 1 to 2560)
  AUTHORS   Malik,S., Guermah,M., Yuan,C.X., Wu,W., Yamamura,S. and Roeder,R.G.
  TITLE     Structural and functional organization of TRAP220, the
            TRAP/mediator subunit that is targeted by nuclear receptors
  JOURNAL   Mol Cell Biol 24 (18), 8244-8254 (2004)
   PUBMED   15340084
  REMARK    Erratum:[Mol Cell Biol. 2022 Nov 17;42(11):e0035922. doi:
            10.1128/mcb.00359-22.. PMID: 36255214]
REFERENCE   8  (bases 1 to 2560)
  AUTHORS   Mittler,G., Kremmer,E., Timmers,H.T. and Meisterernst,M.
  TITLE     Novel critical role of a human Mediator complex for basal RNA
            polymerase II transcription
  JOURNAL   EMBO Rep 2 (9), 808-813 (2001)
   PUBMED   11559591
REFERENCE   9  (bases 1 to 2560)
  AUTHORS   Sasaki,N., Nagaoka,S., Itoh,M., Izawa,M., Konno,H., Carninci,P.,
            Yoshiki,A., Kusakabe,M., Moriuchi,T., Muramatsu,M., Okazaki,Y. and
            Hayashizaki,Y.
  TITLE     Characterization of gene expression in mouse blastocyst using
            single-pass sequencing of 3995 clones
  JOURNAL   Genomics 49 (2), 167-179 (1998)
   PUBMED   9598303
  REMARK    Erratum:[Genomics 1998 Dec 15;54(3):583]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ145922.1, AK147739.1, AK010357.1 and AL669948.8.
            
            On Sep 14, 2007 this sequence version replaced NM_025426.2.
            
            Transcript Variant: This variant (1) represents the longest
            transcript.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK147739.1, AK167407.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-10                CJ145922.1         3-12
            11-11               AK147739.1         1-1
            12-49               AK010357.1         22-59
            50-2543             AK147739.1         40-2533
            2544-2560           AL669948.8         18595-18611
FEATURES             Location/Qualifiers
     source          1..2560
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 27.88 cM"
     gene            1..2560
                     /gene="Med7"
                     /gene_synonym="1110063B05Rik; Crsp33; Crsp9"
                     /note="mediator complex subunit 7"
                     /db_xref="GeneID:66213"
                     /db_xref="MGI:MGI:1913463"
     exon            1..231
                     /gene="Med7"
                     /gene_synonym="1110063B05Rik; Crsp33; Crsp9"
                     /inference="alignment:Splign:2.1.0"
     exon            232..401
                     /gene="Med7"
                     /gene_synonym="1110063B05Rik; Crsp33; Crsp9"
                     /inference="alignment:Splign:2.1.0"
     exon            402..2560
                     /gene="Med7"
                     /gene_synonym="1110063B05Rik; Crsp33; Crsp9"
                     /inference="alignment:Splign:2.1.0"
     CDS             419..1120
                     /gene="Med7"
                     /gene_synonym="1110063B05Rik; Crsp33; Crsp9"
                     /note="cofactor required for Sp1 transcriptional
                     activation, subunit 9, 33kDa; CRSP complex subunit 9;
                     cofactor required for Sp1 transcriptional activation
                     subunit 9"
                     /codon_start=1
                     /product="mediator of RNA polymerase II transcription
                     subunit 7"
                     /protein_id="NP_079702.3"
                     /db_xref="CCDS:CCDS36134.1"
                     /db_xref="GeneID:66213"
                     /db_xref="MGI:MGI:1913463"
                     /translation="MGEPQQVSALPPPPMQYIKEYTDENIQEGLAPKPPPPIKDSYMM
                     FGNQFQCDDLIIRPLESQGIERLHPMQFDHKKELRKLNMSILINFLDLLDILIRSPGS
                     IKREEKLEDLKLLFVHVHHLINEYRPHQARETLRVMMEVQKRQRLETAERFQKHLERV
                     IEMIQNCLASLPDDLPHSEAGMRVKAEPMDTDDNSNCPGQNEQQRESSGHRRDQIIEK
                     DAALCVLIDEMNERP"
     regulatory      1348..1353
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Med7"
                     /gene_synonym="1110063B05Rik; Crsp33; Crsp9"
                     /note="hexamer: AATAAA"
     polyA_site      1372
                     /gene="Med7"
                     /gene_synonym="1110063B05Rik; Crsp33; Crsp9"
                     /note="major polyA site"
     regulatory      1411..1416
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Med7"
                     /gene_synonym="1110063B05Rik; Crsp33; Crsp9"
                     /note="hexamer: AATAAA"
     regulatory      1441..1446
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Med7"
                     /gene_synonym="1110063B05Rik; Crsp33; Crsp9"
                     /note="hexamer: TATAAA"
     polyA_site      1442
                     /gene="Med7"
                     /gene_synonym="1110063B05Rik; Crsp33; Crsp9"
                     /note="major polyA site"
     polyA_site      1467
                     /gene="Med7"
                     /gene_synonym="1110063B05Rik; Crsp33; Crsp9"
     regulatory      2528..2533
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Med7"
                     /gene_synonym="1110063B05Rik; Crsp33; Crsp9"
                     /note="hexamer: AATAAA"
     polyA_site      2555
                     /gene="Med7"
                     /gene_synonym="1110063B05Rik; Crsp33; Crsp9"
ORIGIN      
        1 ccgctgcgct gaggaaaagt cactaccgga aaagcaagaa agagctgagg tgagcgggcg
       61 gcggcggttg gcgaccgcag cctaagtctg tctctccgcc cccgcggttg cgtctctccc
      121 ggcgtggagc gccgaagtcc ggcgcgggac agcctgggac gcccgggcta gccttcctcc
      181 cggttcctcc gcgaagcctc cccggggcct gaggcaggcg gccggccgaa ggatcatctg
      241 tccctatcgg gtgagttagc acacctgttg tcttgggtgg tcaacacgtt ctcaattttc
      301 aaggtgtatt tcctatcagg aaacttgaag ataatatggt ctgaacccac agtgaacttc
      361 tgaacatcgt agttgtgttg atcaggctgc tctggtctta ggttcttgat tgtctacaat
      421 gggtgaacca cagcaagtga gtgcacttcc accgcctcca atgcagtaca tcaaggaata
      481 tacagatgaa aatattcagg aaggcttggc tcccaagcct cctcctccaa ttaaagacag
      541 ctacatgatg tttggcaacc agttccaatg tgatgatctt atcattcgcc ctttagaaag
      601 tcagggcatt gaacggcttc atcctatgca atttgatcat aagaaagagc tgagaaaact
      661 caatatgtct atactgatta atttcttaga ccttttagac atcttaataa gaagtcctgg
      721 gagtataaaa cgagaagaaa agctagaaga tcttaagcta ctttttgtac atgtacatca
      781 tcttataaat gaatatcgac cccaccaagc aagagagact ttgagagtca tgatggaggt
      841 ccagaaacgc cagcgccttg aaacagctga gaggtttcag aaacatctgg aacgagtcat
      901 tgaaatgatt cagaattgct tggcttcttt gcccgatgat ttgccccatt cagaagcagg
      961 gatgagagtt aaagctgagc cgatggatac tgatgataac agcaattgtc ctggacagaa
     1021 tgaacaacaa agagaaagtt caggtcacag aagggaccag attatagaaa aagatgctgc
     1081 cttatgtgtg ctaattgatg aaatgaatga aaggccatga agaatattcc tttttttcct
     1141 tttagtaagt agcatcatat attagtttat ttcctctcag acagtcttaa gaggtataac
     1201 taaagatact aagagacttt ttttcaattg aaatgctgta ggtggtaatt taacactaaa
     1261 cataggccag caagtatatt tgagtaattg ccataaaaaa gctgaatgtt tgctattgtt
     1321 tgagatagtc ctattttttg gagttggaat aaaaacttga agtaataacg aattgtcatt
     1381 cttggaaaaa aagttatttg cttcgagact aataaagggc atcaagtgta catgtgaaat
     1441 tataaaatgt ttagatttat tccaaaataa tatagaaagt ttatttttct gattactgtt
     1501 ccagcaaact cagtatcaca gcttttctcc tccttattct ccatagaata tttgttaggg
     1561 actctttttt tgccccagtc aggtaatgat gtggttatga tccaattcta tgagaaatgt
     1621 acatacttca ccttcacaga tggatacagg cttcccccaa aagataactc tattgagtag
     1681 ctattcagtc tcaacatagc ttcttttctg gtttgtgttt gctaagacta tcctagtctc
     1741 ttagccatca taccaccctc agaagagtct tgcttccaaa gtaatctaat cagaacacct
     1801 tgtccagttt atatcctttt caaacacatg tatatgttgg tagcacagtt ctaatcacaa
     1861 agctacccac aactcaatcc gtctttagtc attacagatg aggaagtaga ggttcagaga
     1921 agttgactta accaactaat aagtggcaga atcaagttag aaagtaggta ttcagtttca
     1981 tagccaaagt actgaacttc attctctatc ctctagtctg tcatactgga aatcataact
     2041 agagctactc cagttttcta atcttgaaat ccaccctagt aaatacctca tgacactaga
     2101 ctcaagagga tacatttgtt gattggaaga atgacttctc tttaaacata ctcaggaggc
     2161 agggtttgtt ggttaagact tccatatctt aagatggtgc ttgtaattct acctaaaaac
     2221 ccttcttagt aggtaatgtt cctaactaag actcataaga attaaaactt cacatttatg
     2281 gtttggttgg gcaagagtct atgtgggata agaaatcggc aaagattttt cttgttttgc
     2341 ccccttctcc cttttttggt tccttgtcat cttcatctgg tggtaaactt actgtacagc
     2401 catttaatag gcattgaaag gtatacaatt tctctttcat aatactcatc tatggcttga
     2461 cagcagtcat agacaatagg taaatgaaag cactgctcta atccaactct catatatgaa
     2521 caattggaat aaaatatgga cgctgaaaat tgaaactcaa
//
