LOCUS       NM_026068               1179 bp    mRNA    linear   ROD 18-JUN-2024
DEFINITION  Mus musculus mediator complex subunit 31 (Med31), mRNA.
ACCESSION   NM_026068
VERSION     NM_026068.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1179)
  AUTHORS   Kolonay,D.W., Sattler,K.M., Strawser,C., Rafael-Fortney,J.,
            Mihaylova,M.M., Miller,K.E., Lepper,C. and Baskin,K.K.
  TITLE     Temporal regulation of the Mediator complex during muscle
            proliferation, differentiation, regeneration, aging, and disease
  JOURNAL   Front Cell Dev Biol 12, 1331563 (2024)
   PUBMED   38690566
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1179)
  AUTHORS   Tan,C., Zhu,S., Chen,Z., Liu,C., Li,Y.E., Zhu,M., Zhang,Z.,
            Zhang,Z., Zhang,L., Gu,Y., Liang,Z., Boyer,T.G., Ouyang,K.,
            Evans,S.M. and Fang,X.
  TITLE     Mediator complex proximal Tail subunit MED30 is critical for
            Mediator core stability and cardiomyocyte transcriptional network
  JOURNAL   PLoS Genet 17 (9), e1009785 (2021)
   PUBMED   34506481
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1179)
  AUTHORS   Mauldin,J.P., Lu,M., Das,S., Park,D., Ernst,P.B. and
            Ravichandran,K.S.
  TITLE     A link between the cytoplasmic engulfment protein Elmo1 and the
            Mediator complex subunit Med31
  JOURNAL   Curr Biol 23 (2), 162-167 (2013)
   PUBMED   23273896
  REMARK    GeneRIF: Elmo1 increased the cytoplasmic localization of Med31.
REFERENCE   4  (bases 1 to 1179)
  AUTHORS   Krebs,A.R., Demmers,J., Karmodiya,K., Chang,N.C., Chang,A.C. and
            Tora,L.
  TITLE     ATAC and Mediator coactivators form a stable complex and regulate a
            set of non-coding RNA genes
  JOURNAL   EMBO Rep 11 (7), 541-547 (2010)
   PUBMED   20508642
REFERENCE   5  (bases 1 to 1179)
  AUTHORS   Risley,M.D., Clowes,C., Yu,M., Mitchell,K. and Hentges,K.E.
  TITLE     The Mediator complex protein Med31 is required for embryonic growth
            and cell proliferation during mammalian development
  JOURNAL   Dev Biol 342 (2), 146-156 (2010)
   PUBMED   20347762
  REMARK    GeneRIF: As the Mediator complex is a transcriptional co-activator,
            results suggest that Med31 functions to promote the transcription
            of genes required for embryonic growth and cell proliferation.
REFERENCE   6  (bases 1 to 1179)
  AUTHORS   Li,X.C. and Schimenti,J.C.
  TITLE     Mouse pachytene checkpoint 2 (trip13) is required for completing
            meiotic recombination but not synapsis
  JOURNAL   PLoS Genet 3 (8), e130 (2007)
   PUBMED   17696610
  REMARK    Erratum:[PLoS Genet. 2007 Sep 7;3(9):e168. Li, Xin [corrected to
            Li, Xin Chenglin]]
REFERENCE   7  (bases 1 to 1179)
  AUTHORS   Kile,B.T., Hentges,K.E., Clark,A.T., Nakamura,H., Salinger,A.P.,
            Liu,B., Box,N., Stockton,D.W., Johnson,R.L., Behringer,R.R.,
            Bradley,A. and Justice,M.J.
  TITLE     Functional genetic analysis of mouse chromosome 11
  JOURNAL   Nature 425 (6953), 81-86 (2003)
   PUBMED   12955145
REFERENCE   8  (bases 1 to 1179)
  AUTHORS   Sato,S., Tomomori-Sato,C., Banks,C.A., Sorokina,I., Parmely,T.J.,
            Kong,S.E., Jin,J., Cai,Y., Lane,W.S., Brower,C.S., Conaway,R.C. and
            Conaway,J.W.
  TITLE     Identification of mammalian Mediator subunits with similarities to
            yeast Mediator subunits Srb5, Srb6, Med11, and Rox3
  JOURNAL   J Biol Chem 278 (17), 15123-15127 (2003)
   PUBMED   12584197
REFERENCE   9  (bases 1 to 1179)
  AUTHORS   Suzuki,H., Fukunishi,Y., Kagawa,I., Saito,R., Oda,H., Endo,T.,
            Kondo,S., Bono,H., Okazaki,Y. and Hayashizaki,Y.
  TITLE     Protein-protein interaction panel using mouse full-length cDNAs
  JOURNAL   Genome Res 11 (10), 1758-1765 (2001)
   PUBMED   11591653
REFERENCE   10 (bases 1 to 1179)
  AUTHORS   Mittler,G., Kremmer,E., Timmers,H.T. and Meisterernst,M.
  TITLE     Novel critical role of a human Mediator complex for basal RNA
            polymerase II transcription
  JOURNAL   EMBO Rep 2 (9), 808-813 (2001)
   PUBMED   11559591
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC051929.1.
            
            On Nov 29, 2004 this sequence version replaced NM_026068.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC051929.1, CA466405.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164134, SAMN01164138
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1179
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 43.93 cM"
     gene            1..1179
                     /gene="Med31"
                     /gene_synonym="3110004H13Rik; CGI-125; l11Jus15"
                     /note="mediator complex subunit 31"
                     /db_xref="GeneID:67279"
                     /db_xref="MGI:MGI:1914529"
     exon            1..632
                     /gene="Med31"
                     /gene_synonym="3110004H13Rik; CGI-125; l11Jus15"
                     /inference="alignment:Splign:2.1.0"
     CDS             605..1000
                     /gene="Med31"
                     /gene_synonym="3110004H13Rik; CGI-125; l11Jus15"
                     /note="mediator complex subunit SOH1; mediator of RNA
                     polymerase II transcription, subunit 31 homolog"
                     /codon_start=1
                     /product="mediator of RNA polymerase II transcription
                     subunit 31"
                     /protein_id="NP_080344.2"
                     /db_xref="CCDS:CCDS24981.1"
                     /db_xref="GeneID:67279"
                     /db_xref="MGI:MGI:1914529"
                     /translation="MAAAVAMETDDAGNRLRFQLELEFVQCLANPNYLNFLAQRGYFK
                     DKAFVNYLKYLLYWKEPEYAKYLKYPQCLHMLELLQYEHFRKELVNAQCAKFIDEQQI
                     LHWQHYSRKRVRLQQALAEQQQQNNTAGK"
     exon            633..710
                     /gene="Med31"
                     /gene_synonym="3110004H13Rik; CGI-125; l11Jus15"
                     /inference="alignment:Splign:2.1.0"
     exon            711..807
                     /gene="Med31"
                     /gene_synonym="3110004H13Rik; CGI-125; l11Jus15"
                     /inference="alignment:Splign:2.1.0"
     exon            808..1161
                     /gene="Med31"
                     /gene_synonym="3110004H13Rik; CGI-125; l11Jus15"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1142..1147
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Med31"
                     /gene_synonym="3110004H13Rik; CGI-125; l11Jus15"
                     /note="hexamer: AATAAA"
     polyA_site      1161
                     /gene="Med31"
                     /gene_synonym="3110004H13Rik; CGI-125; l11Jus15"
                     /note="major polyA site"
ORIGIN      
        1 cgtgctggga ggacacctca aggaactgag ggagtcgctt cgtggagggg gtgagggagg
       61 gcccctctcg gtggcgctgg gaggtctcca cctgccggga agacgttcga acctgccggg
      121 aggacgtctc cacgcggtgg gatgacgttt cctcgcggtg ggacgacgtc tccacgcgga
      181 cagtcgatgt ctccttgtgg cgggtgcttt ccactcgcgg ggcggaggac ttgctcctaa
      241 ggggcgaggc catcctgccc atacaccttg gtcaggtggg acaaagaggc ccaaggatca
      301 tgctctgcgt cacgtcacac agggaaaggt gacgtcaggg tggtgtatta cgtcggggta
      361 ggtagcagga ctctgagacc taaaaaatga gaagtcctcc ggcacgcccc gctcgatatc
      421 tgcgcgcgca gccggccggg tctgcacaga taggtggggc taattttccc ataagtgagg
      481 ttgtccccgc cctcgtgtcc cactctgccc cgcgaccgga agtaggagcc gtggcttccg
      541 gattctcacc aatcgaagtc gcggttcggt cggggctggt ggtgttcgcc tcactctgat
      601 tgttatggcc gcggccgtcg ctatggagac agatgatgct ggaaatcggc ttcggtttca
      661 gttggagttg gaatttgtgc aatgtttagc caacccaaac taccttaatt ttcttgccca
      721 aagaggttac ttcaaagaca aagcttttgt taattatctt aagtatttgc tttactggaa
      781 agaaccagaa tatgccaaat atctaaagta ccctcagtgc ttacatatgt tagagctgct
      841 ccagtatgag cactttcgca aggagctggt gaatgcgcag tgtgcgaagt tcatcgacga
      901 gcagcagatt ctgcactggc agcactactc tcggaagcgg gtgcgtcttc agcaagccct
      961 ggccgagcag cagcagcaga ataacacagc agggaaatga agagctgggg ccaggtcagg
     1021 ctcttaggac gtgtatataa tgtattgcta ttgtacagta cagagaaaaa gactcttctg
     1081 ccccctttac tgtagccctc agaaccatta gtgttatttt ttagttggca aattttttat
     1141 taataaatta tttctattta aaaaaaaaaa aaaaaaaaa
//
