LOCUS       NM_027212                871 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus mediator complex subunit 30 (Med30), mRNA.
ACCESSION   NM_027212
VERSION     NM_027212.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 871)
  AUTHORS   Kolonay,D.W., Sattler,K.M., Strawser,C., Rafael-Fortney,J.,
            Mihaylova,M.M., Miller,K.E., Lepper,C. and Baskin,K.K.
  TITLE     Temporal regulation of the Mediator complex during muscle
            proliferation, differentiation, regeneration, aging, and disease
  JOURNAL   Front Cell Dev Biol 12, 1331563 (2024)
   PUBMED   38690566
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 871)
  AUTHORS   Tan,C., Zhu,S., Chen,Z., Liu,C., Li,Y.E., Zhu,M., Zhang,Z.,
            Zhang,Z., Zhang,L., Gu,Y., Liang,Z., Boyer,T.G., Ouyang,K.,
            Evans,S.M. and Fang,X.
  TITLE     Mediator complex proximal Tail subunit MED30 is critical for
            Mediator core stability and cardiomyocyte transcriptional network
  JOURNAL   PLoS Genet 17 (9), e1009785 (2021)
   PUBMED   34506481
  REMARK    GeneRIF: Mediator complex proximal Tail subunit MED30 is critical
            for Mediator core stability and cardiomyocyte transcriptional
            network.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 871)
  AUTHORS   Lewandowski,J.P., Du,F., Zhang,S., Powell,M.B., Falkenstein,K.N.,
            Ji,H. and Vokes,S.A.
  TITLE     Spatiotemporal regulation of GLI target genes in the mammalian limb
            bud
  JOURNAL   Dev Biol 406 (1), 92-103 (2015)
   PUBMED   26238476
REFERENCE   4  (bases 1 to 871)
  AUTHORS   Lee,Y.J., Han,M.E., Baek,S.J., Kim,S.Y. and Oh,S.O.
  TITLE     MED30 Regulates the Proliferation and Motility of Gastric Cancer
            Cells
  JOURNAL   PLoS One 10 (6), e0130826 (2015)
   PUBMED   26110885
  REMARK    GeneRIF: MED30 was overexpressed in gastric cancer tissues and cell
            lines. Moreover, MED30 overexpression increased the proliferation,
            migration, and invasion of gastric cancer cells
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 871)
  AUTHORS   Tsai,K.L., Tomomori-Sato,C., Sato,S., Conaway,R.C., Conaway,J.W.
            and Asturias,F.J.
  TITLE     Subunit architecture and functional modular rearrangements of the
            transcriptional mediator complex
  JOURNAL   Cell 157 (6), 1430-1444 (2014)
   PUBMED   24882805
  REMARK    Erratum:[Cell. 2014 Jul 17;158(2):463]
REFERENCE   6  (bases 1 to 871)
  AUTHORS   Malik,S., Guermah,M., Yuan,C.X., Wu,W., Yamamura,S. and Roeder,R.G.
  TITLE     Structural and functional organization of TRAP220, the
            TRAP/mediator subunit that is targeted by nuclear receptors
  JOURNAL   Mol Cell Biol 24 (18), 8244-8254 (2004)
   PUBMED   15340084
  REMARK    Erratum:[Mol Cell Biol. 2022 Nov 17;42(11):e0035922. doi:
            10.1128/mcb.00359-22.. PMID: 36255214]
REFERENCE   7  (bases 1 to 871)
  AUTHORS   Sato,S., Tomomori-Sato,C., Banks,C.A., Sorokina,I., Parmely,T.J.,
            Kong,S.E., Jin,J., Cai,Y., Lane,W.S., Brower,C.S., Conaway,R.C. and
            Conaway,J.W.
  TITLE     Identification of mammalian Mediator subunits with similarities to
            yeast Mediator subunits Srb5, Srb6, Med11, and Rox3
  JOURNAL   J Biol Chem 278 (17), 15123-15127 (2003)
   PUBMED   12584197
REFERENCE   8  (bases 1 to 871)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   9  (bases 1 to 871)
  AUTHORS   Suzuki,H., Fukunishi,Y., Kagawa,I., Saito,R., Oda,H., Endo,T.,
            Kondo,S., Bono,H., Okazaki,Y. and Hayashizaki,Y.
  TITLE     Protein-protein interaction panel using mouse full-length cDNAs
  JOURNAL   Genome Res 11 (10), 1758-1765 (2001)
   PUBMED   11591653
REFERENCE   10 (bases 1 to 871)
  AUTHORS   Mittler,G., Kremmer,E., Timmers,H.T. and Meisterernst,M.
  TITLE     Novel critical role of a human Mediator complex for basal RNA
            polymerase II transcription
  JOURNAL   EMBO Rep 2 (9), 808-813 (2001)
   PUBMED   11559591
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AK011104.1.
            
            On Apr 5, 2007 this sequence version replaced NM_027212.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK011104.1, AK146250.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-871               AK011104.1         2-872
FEATURES             Location/Qualifiers
     source          1..871
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 19.95 cM"
     gene            1..871
                     /gene="Med30"
                     /gene_synonym="1810038N03Rik; 2510044J04Rik; Thrap6;
                     TRAP25"
                     /note="mediator complex subunit 30"
                     /db_xref="GeneID:69790"
                     /db_xref="MGI:MGI:1917040"
     exon            1..242
                     /gene="Med30"
                     /gene_synonym="1810038N03Rik; 2510044J04Rik; Thrap6;
                     TRAP25"
                     /inference="alignment:Splign:2.1.0"
     CDS             66..602
                     /gene="Med30"
                     /gene_synonym="1810038N03Rik; 2510044J04Rik; Thrap6;
                     TRAP25"
                     /note="thyroid hormone receptor associated protein 6;
                     TRAP/Mediator complex component TRAP25; thyroid hormone
                     receptor-associated protein complex 25 kDa component"
                     /codon_start=1
                     /product="mediator of RNA polymerase II transcription
                     subunit 30"
                     /protein_id="NP_081488.1"
                     /db_xref="CCDS:CCDS27465.1"
                     /db_xref="GeneID:69790"
                     /db_xref="MGI:MGI:1917040"
                     /translation="MSTPPLAPTGMASGPFGGPQAQQAAREVNTATLCRIGQETVQDI
                     VYRTMEIFQLLRNMQLPNGVTYHTGTYQDRLTKLQDHLRQLSILFRKLRLVYDKCNEN
                     CGGMDPIPVEQLIPYVDEDGSKNDDRAGPPRFASEERREIVEVNKKLKQKNQQLKQIM
                     DQLRNLIWDINAMLAMRN"
     exon            243..401
                     /gene="Med30"
                     /gene_synonym="1810038N03Rik; 2510044J04Rik; Thrap6;
                     TRAP25"
                     /inference="alignment:Splign:2.1.0"
     exon            402..506
                     /gene="Med30"
                     /gene_synonym="1810038N03Rik; 2510044J04Rik; Thrap6;
                     TRAP25"
                     /inference="alignment:Splign:2.1.0"
     exon            507..871
                     /gene="Med30"
                     /gene_synonym="1810038N03Rik; 2510044J04Rik; Thrap6;
                     TRAP25"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtggcgccg cttttttgaa atcggccgag tgggctcgcg ccggacccga gccgccgggg
       61 gtgccatgtc cacccctccg ctggcgccca cgggcatggc gtccgggccc ttcggcggcc
      121 cgcaggctca gcaggccgcg cgcgaggtca acacggccac gctgtgccgc atcgggcagg
      181 agaccgtgca ggacatcgtg taccgcacca tggagatctt ccagctgctc aggaacatgc
      241 agctgccaaa tggtgtcact taccatactg gaacttacca agaccggcta acaaagctgc
      301 aggaccacct tcggcaactt tctattctct tcaggaagct gcgactggtc tatgacaaat
      361 gtaatgagaa ctgtggtggg atggacccca ttcctgttga gcaactgatt ccatatgtgg
      421 atgaagatgg ctcaaagaac gacgaccggg ctggtccacc tcgttttgct agcgaagaga
      481 gacgagaaat tgtagaagta aataagaaac tcaaacagaa gaatcaacag ctgaagcaga
      541 ttatggatca attacggaat ctcatctggg acataaatgc catgctggca atgaggaact
      601 aaagcgatat ttaaatctcc tgctctactc atgtgatgaa gttgggtttt tcccccctct
      661 tgagtattcc tccctttgaa aaacgttatt tatgtcttta ttttaacagc tagcactaaa
      721 gtttctgttt tcactttaaa gtatttacta gctttttttt taatactgtg ggttttatga
      781 aagattattg taataccttt gatagggtat aaattttggt taatcttcag aaattgaata
      841 aattaaaaaa tacaaataaa aatttaaaca t
//
