LOCUS       NM_025885               2807 bp    mRNA    linear   ROD 18-JUN-2024
DEFINITION  Mus musculus mediator complex subunit 19 (Med19), mRNA.
ACCESSION   NM_025885 XM_355343
VERSION     NM_025885.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2807)
  AUTHORS   Kolonay,D.W., Sattler,K.M., Strawser,C., Rafael-Fortney,J.,
            Mihaylova,M.M., Miller,K.E., Lepper,C. and Baskin,K.K.
  TITLE     Temporal regulation of the Mediator complex during muscle
            proliferation, differentiation, regeneration, aging, and disease
  JOURNAL   Front Cell Dev Biol 12, 1331563 (2024)
   PUBMED   38690566
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2807)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 2807)
  AUTHORS   Dean,J.M., He,A., Tan,M., Wang,J., Lu,D., Razani,B. and Lodhi,I.J.
  TITLE     MED19 Regulates Adipogenesis and Maintenance of White Adipose
            Tissue Mass by Mediating PPARgamma-Dependent Gene Expression
  JOURNAL   Cell Rep 33 (1), 108228 (2020)
   PUBMED   33027649
REFERENCE   4  (bases 1 to 2807)
  AUTHORS   Tsai,K.L., Tomomori-Sato,C., Sato,S., Conaway,R.C., Conaway,J.W.
            and Asturias,F.J.
  TITLE     Subunit architecture and functional modular rearrangements of the
            transcriptional mediator complex
  JOURNAL   Cell 157 (6), 1430-1444 (2014)
   PUBMED   24882805
  REMARK    Erratum:[Cell. 2014 Jul 17;158(2):463]
REFERENCE   5  (bases 1 to 2807)
  AUTHORS   Tomomori-Sato,C., Sato,S., Parmely,T.J., Banks,C.A., Sorokina,I.,
            Florens,L., Zybailov,B., Washburn,M.P., Brower,C.S., Conaway,R.C.
            and Conaway,J.W.
  TITLE     A mammalian mediator subunit that shares properties with
            Saccharomyces cerevisiae mediator subunit Cse2
  JOURNAL   J Biol Chem 279 (7), 5846-5851 (2004)
   PUBMED   14638676
REFERENCE   6  (bases 1 to 2807)
  AUTHORS   Sato,S., Tomomori-Sato,C., Banks,C.A., Sorokina,I., Parmely,T.J.,
            Kong,S.E., Jin,J., Cai,Y., Lane,W.S., Brower,C.S., Conaway,R.C. and
            Conaway,J.W.
  TITLE     Identification of mammalian Mediator subunits with similarities to
            yeast Mediator subunits Srb5, Srb6, Med11, and Rox3
  JOURNAL   J Biol Chem 278 (17), 15123-15127 (2003)
   PUBMED   12584197
REFERENCE   7  (bases 1 to 2807)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   8  (bases 1 to 2807)
  AUTHORS   Mittler,G., Kremmer,E., Timmers,H.T. and Meisterernst,M.
  TITLE     Novel critical role of a human Mediator complex for basal RNA
            polymerase II transcription
  JOURNAL   EMBO Rep 2 (9), 808-813 (2001)
   PUBMED   11559591
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL929079.14.
            
            On Jan 26, 2023 this sequence version replaced NM_025885.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK010552.1, AK168787.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-237               AL929079.14        79094-79330
            238-494             AL929079.14        85860-86116
            495-591             AL929079.14        86272-86368
            592-686             AL929079.14        86860-86954
            687-2807            AL929079.14        87535-89655
FEATURES             Location/Qualifiers
     source          1..2807
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 49.45 cM"
     gene            1..2807
                     /gene="Med19"
                     /gene_synonym="2410018M14Rik; 3110040A13Rik; LCMR1"
                     /note="mediator complex subunit 19"
                     /db_xref="GeneID:381379"
                     /db_xref="MGI:MGI:1914234"
     exon            1..237
                     /gene="Med19"
                     /gene_synonym="2410018M14Rik; 3110040A13Rik; LCMR1"
                     /inference="alignment:Splign:2.1.0"
     exon            238..494
                     /gene="Med19"
                     /gene_synonym="2410018M14Rik; 3110040A13Rik; LCMR1"
                     /inference="alignment:Splign:2.1.0"
     exon            495..591
                     /gene="Med19"
                     /gene_synonym="2410018M14Rik; 3110040A13Rik; LCMR1"
                     /inference="alignment:Splign:2.1.0"
     exon            592..686
                     /gene="Med19"
                     /gene_synonym="2410018M14Rik; 3110040A13Rik; LCMR1"
                     /inference="alignment:Splign:2.1.0"
     exon            687..2807
                     /gene="Med19"
                     /gene_synonym="2410018M14Rik; 3110040A13Rik; LCMR1"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      1603
                     /gene="Med19"
                     /gene_synonym="2410018M14Rik; 3110040A13Rik; LCMR1"
                     /note="major polyA site"
     regulatory      1866..1871
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Med19"
                     /gene_synonym="2410018M14Rik; 3110040A13Rik; LCMR1"
                     /note="hexamer: AATAAA"
     polyA_site      1886
                     /gene="Med19"
                     /gene_synonym="2410018M14Rik; 3110040A13Rik; LCMR1"
                     /note="major polyA site"
     regulatory      2011..2016
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Med19"
                     /gene_synonym="2410018M14Rik; 3110040A13Rik; LCMR1"
                     /note="hexamer: AATAAA"
     polyA_site      2038
                     /gene="Med19"
                     /gene_synonym="2410018M14Rik; 3110040A13Rik; LCMR1"
     regulatory      2779..2784
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Med19"
                     /gene_synonym="2410018M14Rik; 3110040A13Rik; LCMR1"
                     /note="hexamer: AATAAA"
     polyA_site      2807
                     /gene="Med19"
                     /gene_synonym="2410018M14Rik; 3110040A13Rik; LCMR1"
ORIGIN      
        1 aaccaggagc gcagagtgct atggagaact tcacggcact gtttggagct cagactgacc
       61 ccccaccgcc accaagcgcc ctaggctttg ggcctggaaa gccacccccg ccaccccctc
      121 ctcctccggg aggtggtcca ggcgcagccc cgccctcgac ggcaacctcg gcccccgcag
      181 gagcggataa gtcgacggct ggaagtggcc ccttctacct gatgcgggaa ttgccaggca
      241 gcacagagct gacgggcagc accaatttaa tcacacacta caacctggag caggcctata
      301 ataagttctg tgggaagaaa gtgaaggaga agctaagtaa cttcctgcct gacctgccag
      361 ggatgattga tctccctggc tctcatgaca acagcagcct ccgatccctc attgagaagc
      421 ctcctattct tggtggctct tttaatccaa tcacagggac catgctgtct ggtttccgcc
      481 tccacactgg cccgttgcca gagcagtgtc gtctgatgca tattcagcca cccaagaaga
      541 agaataagca taagcacaaa cagagccgca cccaggatcc tgttccccca gaaacaccat
      601 ctgattcaga tcacaagaag aagaaaaaga agaaagagga ggatcctgaa cgaaaaagga
      661 agaagaaaga aaagaagaag aagaagaacc gacatagtcc agaccaccca ggtatgggca
      721 gctctcaagc cagcagcagc agcagcctcc gctaatagga ctactggact tggccaagga
      781 tggctttcct gtgatactga acctgctgat aaaaacttgt cttccaggca gttggaccct
      841 gttgtggggg catccaacag ctggagaggg gccagcccct gctgtgcatg tgactaatac
      901 actttaggga aggaccatgc ttttttatgg ttatgtccaa ttggcatttt catggattcc
      961 tttttacaag aatctgtttt tctttttttt ccctcttttg tgcaatttga tcctaggact
     1021 tcaatgtttt gttttaaagc gtgtttaaca aactgaccgg tatggctgcc ttttaagagg
     1081 caagtgccat tctatttgaa tcaaagttta ggacaaggca ttaagatgca agagattttg
     1141 gatcttgcca tcacattatt tccttagcag gctggaactg gaaaatcaaa atgcgaatag
     1201 agaacatggt ctgaaaacag taacttgcta ctattttcct accatagaca caaaatactc
     1261 gctgattatg ctcagagcag agtgcatgga tgatcttcac ctttcacctg gaaagctggc
     1321 ccaaataagg tttatacctg tgtttatata ccacagggaa ctggtgagcc acaatcacgg
     1381 atatatttta gcaggaaaag ccaattagta tttgtctcat tatgctccca cctttttctg
     1441 gagcctgacc cctaagactt gtgaacacta ggcaagtttt atcttttcct ttccctctct
     1501 tgactttttt tttcccccct acatactttt taaatgaacc tctggcaaga agcttaatgc
     1561 tggatttggt tgttttgaaa aaagttttgg tttggttttt gtaggttgtt ttttgttgtt
     1621 gttgtttttg acacatcaca ctatgcaacc ttggctggct atgaacacta ggctggcccc
     1681 aagcttgaga gacccatctg cctctaccca ccaagttctg ggatcaaagg catacaccac
     1741 catgcttagc tgtttttact ttcaaaagga aacaaaggaa tagcaagaga ttcaacagag
     1801 aggatgtatt tgttatgaaa agctaggttt ttctcaccca gcagggcatt taattggata
     1861 gccagaataa aaacagaacc agagaatgag gtttctcttt tgactcccta agaccattca
     1921 ccctgcctta accagacaaa acacaagtca ggggggactg gttagatcag gatttatttt
     1981 attccttgtt ggtttaaaat ggctaatcag aataaaaaaa ttaaagggtc tctgtataga
     2041 ggctggagtc ttccctgttt aaaggttaga acccagctac cccctctacc cagcaccata
     2101 ttgagatggg ctaaggggta aaccccaagg gacactcgga ggggcctagg cctgccactc
     2161 cttctctcta tcccattttt ggcatgtgat gaaaaatatt gctttttgga ttcttctctc
     2221 ctggccttgg attttaagat ttttctgatt atagggaagc attgaagggg ctcactgaag
     2281 cccaacacag tccctgtctc ccaagaatgg agggcagggt tgcctggtgt ttcttaaatt
     2341 aggccaagct ctcttcctga tctcccacca ccgtcatgta actgacccct ttcctgggga
     2401 aactagatgt gaaggagcct aaaaaactct cccaagttct tttatctgag aaccccagat
     2461 gtacccaggt ttctttccta atctcttagc accagcagag agtgctactt ccttagttgg
     2521 taactgggac aaaagagagg gaaccattga gaaaaggaag actttaatgt ctctcttttc
     2581 ctgctggtct aaggaaaggg aagaataaaa tccccctcct tatgtatata tatatatata
     2641 tatctatata tccctccctt gttttcccat cccaggatag atatataatt tctttgatat
     2701 ttataatata tatatatata tatatgtaca cacacacctg gtaacggaga agaggaaaaa
     2761 aatagaatcc gtaacaataa taaaaaaaat tatttctggt ttaaaaa
//
