LOCUS       NM_026039               1677 bp    mRNA    linear   ROD 18-JUN-2024
DEFINITION  Mus musculus mediator complex subunit 18 (Med18), mRNA.
ACCESSION   NM_026039
VERSION     NM_026039.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1677)
  AUTHORS   Kolonay,D.W., Sattler,K.M., Strawser,C., Rafael-Fortney,J.,
            Mihaylova,M.M., Miller,K.E., Lepper,C. and Baskin,K.K.
  TITLE     Temporal regulation of the Mediator complex during muscle
            proliferation, differentiation, regeneration, aging, and disease
  JOURNAL   Front Cell Dev Biol 12, 1331563 (2024)
   PUBMED   38690566
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1677)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 1677)
  AUTHORS   Tan,C., Zhu,S., Chen,Z., Liu,C., Li,Y.E., Zhu,M., Zhang,Z.,
            Zhang,Z., Zhang,L., Gu,Y., Liang,Z., Boyer,T.G., Ouyang,K.,
            Evans,S.M. and Fang,X.
  TITLE     Mediator complex proximal Tail subunit MED30 is critical for
            Mediator core stability and cardiomyocyte transcriptional network
  JOURNAL   PLoS Genet 17 (9), e1009785 (2021)
   PUBMED   34506481
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1677)
  AUTHORS   Liu,X., Jiao,Y., Cao,Y., Deng,N., Ma,Y., Hasty,K.A., Kang,A.,
            Chen,H., Stuart,J.M. and Gu,W.
  TITLE     Decreased expression levels of Ifi genes is associated to the
            increased resistance to spontaneous arthritis disease in mice
            deficiency of IL-1RA
  JOURNAL   BMC Immunol 17 (1), 25 (2016)
   PUBMED   27480124
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1677)
  AUTHORS   Krebs,A.R., Demmers,J., Karmodiya,K., Chang,N.C., Chang,A.C. and
            Tora,L.
  TITLE     ATAC and Mediator coactivators form a stable complex and regulate a
            set of non-coding RNA genes
  JOURNAL   EMBO Rep 11 (7), 541-547 (2010)
   PUBMED   20508642
REFERENCE   6  (bases 1 to 1677)
  AUTHORS   Tomomori-Sato,C., Sato,S., Parmely,T.J., Banks,C.A., Sorokina,I.,
            Florens,L., Zybailov,B., Washburn,M.P., Brower,C.S., Conaway,R.C.
            and Conaway,J.W.
  TITLE     A mammalian mediator subunit that shares properties with
            Saccharomyces cerevisiae mediator subunit Cse2
  JOURNAL   J Biol Chem 279 (7), 5846-5851 (2004)
   PUBMED   14638676
REFERENCE   7  (bases 1 to 1677)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   8  (bases 1 to 1677)
  AUTHORS   Mittler,G., Kremmer,E., Timmers,H.T. and Meisterernst,M.
  TITLE     Novel critical role of a human Mediator complex for basal RNA
            polymerase II transcription
  JOURNAL   EMBO Rep 2 (9), 808-813 (2001)
   PUBMED   11559591
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK012886.1 and AL805897.13.
            
            On Jul 30, 2009 this sequence version replaced NM_026039.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK159696.1, AK012886.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1132              AK012886.1         2-1133
            1133-1677           AL805897.13        108880-109424
FEATURES             Location/Qualifiers
     source          1..1677
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 65.4 cM"
     gene            1..1677
                     /gene="Med18"
                     /gene_synonym="2810046C01Rik"
                     /note="mediator complex subunit 18"
                     /db_xref="GeneID:67219"
                     /db_xref="MGI:MGI:1914469"
     exon            1..148
                     /gene="Med18"
                     /gene_synonym="2810046C01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            149..292
                     /gene="Med18"
                     /gene_synonym="2810046C01Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             220..846
                     /gene="Med18"
                     /gene_synonym="2810046C01Rik"
                     /note="mediator of RNA polymerase II transcription,
                     subunit 18 homolog"
                     /codon_start=1
                     /product="mediator of RNA polymerase II transcription
                     subunit 18"
                     /protein_id="NP_080315.1"
                     /db_xref="CCDS:CCDS18725.1"
                     /db_xref="GeneID:67219"
                     /db_xref="MGI:MGI:1914469"
                     /translation="MEAPPVTMMPVTGGTINMMEYLLQGSVLDHSLESLIHRLRGLCD
                     NMEPETFLDHEMVFLLKGQQASPFVLRARRSMDRAGAPWHLRYLGQPEMGDKNRHALV
                     RNCVDIATSENLTDFLMEMGFRMDHEFVAKGHLFRKGIMKVVVYKIFRILVPGNTDST
                     EALSLSYLVELSVVAPAGQDMVSDDMRNFAEQLKPLVHLEKIDPKRLM"
     exon            293..1677
                     /gene="Med18"
                     /gene_synonym="2810046C01Rik"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ttcctaccgg aagtgctgaa gggagagttt ggcggtttct ctggctctgc gctggcggca
       61 tttgggggtg cggattgcgg gtgtgcacgc gtggatttaa ttccagcttt acaaggatct
      121 gtagcgcgga cggagacgtg ttgctagtgt ggatcctgtg cttctccggt tggaagatct
      181 gtttgcagtt ctgttgtctt gaacctaatt agaggcatca tggaggcgcc tccagtcacc
      241 atgatgcccg tcactggggg caccattaac atgatggagt acctcctgca gggaagtgtt
      301 ttggaccaca gtttggaaag cctcatccat cgcctccgag gtttgtgtga caacatggag
      361 cctgagacct tccttgatca cgagatggtc ttcctgctta agggccagca ggccagcccg
      421 ttcgtcctaa gggcccggcg ctccatggac agggcagggg caccctggca tctgcgatac
      481 ctgggacagc ccgaaatggg agacaagaac cgccacgccc tggtgcgcaa ctgtgtggac
      541 atcgccacgt ctgagaacct cacggacttc ctgatggaga tgggcttccg catggaccat
      601 gagtttgtcg ccaaaggaca cctgtttcgg aagggcatca tgaaggttgt ggtgtacaag
      661 attttccgaa tcctggtccc agggaacacg gacagcaccg aggccctgtc cctctcctat
      721 cttgtggaat taagtgttgt cgccccggct gggcaggaca tggtctctga tgacatgagg
      781 aactttgcag agcagctcaa acctctggtt cacctggaaa aaatagaccc caaaaggctg
      841 atgtgatgaa gaaagtttgt cggcctttta ggcctgtccc cacctgggag gtgagagact
      901 tcgaaagtag cccaggtact gctgccagcc gggcccactt ccttccagaa gatgatggcg
      961 agacctggtt cctttcaact gtttccttca cttggtaatg tctctttttt cttgcaacag
     1021 ggttttacca tggaattcac tacataaact agctaccctg gaactcagga ccctgtactt
     1081 cccgcctaag tgcctgcaag gtccttatta aacctgactg ttcatcttct tgataggctt
     1141 ttccaatgaa agacccagga taatatggag atttgttcaa gtcctccctc cactcaaaaa
     1201 gagggaactg gaataaatta gcttttcaga ggaaaggtca aaaaacaact cataatattt
     1261 tgcttttttt ttcttttttc tcttcttttc ttttcttttt tgtttttttt ttttgttttt
     1321 tgtttgtttg tttgtttgtt tgtttgtttt gtttttcaat acaagacagg gtttctctgt
     1381 gttgctttgg ctgccctgga actcactttg tagaccaggc tggcctcaaa ctcagaaatc
     1441 cacctgcctc tgcctcccga gtactggaat taaaggcgtg cgataacacg caagcccggc
     1501 tgtttgtttt tttttttttg tttttttttt gtttttttta gagaaacatt ttttattcct
     1561 ttatttattt gttgttttct tcatatgttt taaattgtgt tgttttgcca ttgatataca
     1621 aggtttacaa tggtggtgtg agccagcatt gtgtggtaat aaagactgaa aagactc
//
