LOCUS       NM_144933               3953 bp    mRNA    linear   ROD 11-FEB-2025
DEFINITION  Mus musculus mediator complex subunit 17 (Med17), transcript
            variant 1, mRNA.
ACCESSION   NM_144933
VERSION     NM_144933.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3953)
  AUTHORS   Kolonay,D.W., Sattler,K.M., Strawser,C., Rafael-Fortney,J.,
            Mihaylova,M.M., Miller,K.E., Lepper,C. and Baskin,K.K.
  TITLE     Temporal regulation of the Mediator complex during muscle
            proliferation, differentiation, regeneration, aging, and disease
  JOURNAL   Front Cell Dev Biol 12, 1331563 (2024)
   PUBMED   38690566
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3953)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 3953)
  AUTHORS   Meziane,H., Birling,M.C., Wendling,O., Leblanc,S., Dubos,A.,
            Selloum,M., Pavlovic,G., Sorg,T., Kalscheuer,V.M., Billuart,P.,
            Laumonnier,F., Chelly,J., van Bokhoven,H. and Herault,Y.
  TITLE     Large-Scale Functional Assessment of Genes Involved in Rare
            Diseases with Intellectual Disabilities Unravels Unique
            Developmental and Behaviour Profiles in Mouse Models
  JOURNAL   Biomedicines 10 (12), 3148 (2022)
   PUBMED   36551904
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3953)
  AUTHORS   Tan,C., Zhu,S., Chen,Z., Liu,C., Li,Y.E., Zhu,M., Zhang,Z.,
            Zhang,Z., Zhang,L., Gu,Y., Liang,Z., Boyer,T.G., Ouyang,K.,
            Evans,S.M. and Fang,X.
  TITLE     Mediator complex proximal Tail subunit MED30 is critical for
            Mediator core stability and cardiomyocyte transcriptional network
  JOURNAL   PLoS Genet 17 (9), e1009785 (2021)
   PUBMED   34506481
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3953)
  AUTHORS   Viscarra,J.A., Wang,Y., Hong,I.H. and Sul,H.S.
  TITLE     Transcriptional activation of lipogenesis by insulin requires
            phosphorylation of MED17 by CK2
  JOURNAL   Sci Signal 10 (467) (2017)
   PUBMED   28223413
  REMARK    GeneRIF: These results demonstrate that CK2-mediated
            phosphorylation of Ser(53) in MED17 is required for the
            transcriptional activation of lipogenic genes in response to
            insulin.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3953)
  AUTHORS   Hamatani,T., Falco,G., Carter,M.G., Akutsu,H., Stagg,C.A.,
            Sharov,A.A., Dudekula,D.B., VanBuren,V. and Ko,M.S.
  TITLE     Age-associated alteration of gene expression patterns in mouse
            oocytes
  JOURNAL   Hum Mol Genet 13 (19), 2263-2278 (2004)
   PUBMED   15317747
REFERENCE   7  (bases 1 to 3953)
  AUTHORS   Malik,S., Guermah,M., Yuan,C.X., Wu,W., Yamamura,S. and Roeder,R.G.
  TITLE     Structural and functional organization of TRAP220, the
            TRAP/mediator subunit that is targeted by nuclear receptors
  JOURNAL   Mol Cell Biol 24 (18), 8244-8254 (2004)
   PUBMED   15340084
  REMARK    Erratum:[Mol Cell Biol. 2022 Nov 17;42(11):e0035922. doi:
            10.1128/mcb.00359-22.. PMID: 36255214]
REFERENCE   8  (bases 1 to 3953)
  AUTHORS   Tomomori-Sato,C., Sato,S., Parmely,T.J., Banks,C.A., Sorokina,I.,
            Florens,L., Zybailov,B., Washburn,M.P., Brower,C.S., Conaway,R.C.
            and Conaway,J.W.
  TITLE     A mammalian mediator subunit that shares properties with
            Saccharomyces cerevisiae mediator subunit Cse2
  JOURNAL   J Biol Chem 279 (7), 5846-5851 (2004)
   PUBMED   14638676
REFERENCE   9  (bases 1 to 3953)
  AUTHORS   Ge,K., Guermah,M., Yuan,C.X., Ito,M., Wallberg,A.E.,
            Spiegelman,B.M. and Roeder,R.G.
  TITLE     Transcription coactivator TRAP220 is required for PPAR gamma
            2-stimulated adipogenesis
  JOURNAL   Nature 417 (6888), 563-567 (2002)
   PUBMED   12037571
REFERENCE   10 (bases 1 to 3953)
  AUTHORS   Mittler,G., Kremmer,E., Timmers,H.T. and Meisterernst,M.
  TITLE     Novel critical role of a human Mediator complex for basal RNA
            polymerase II transcription
  JOURNAL   EMBO Rep 2 (9), 808-813 (2001)
   PUBMED   11559591
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ078373.1 and BC020185.1.
            
            On Jun 21, 2018 this sequence version replaced NM_144933.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC020185.1, AK033151.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164135, SAMN01164139
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-39                CJ078373.1         2-40
            40-3953             BC020185.1         1-3914
FEATURES             Location/Qualifiers
     source          1..3953
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 4.74 cM"
     gene            1..3953
                     /gene="Med17"
                     /gene_synonym="77kDa; C330002H14Rik; Crsp6; Trap80"
                     /note="mediator complex subunit 17"
                     /db_xref="GeneID:234959"
                     /db_xref="MGI:MGI:2182585"
     exon            1..357
                     /gene="Med17"
                     /gene_synonym="77kDa; C330002H14Rik; Crsp6; Trap80"
                     /inference="alignment:Splign:2.1.0"
     CDS             114..2063
                     /gene="Med17"
                     /gene_synonym="77kDa; C330002H14Rik; Crsp6; Trap80"
                     /note="isoform 1 is encoded by transcript variant 1;
                     mediator of RNA polymerase II transcription subunit 17;
                     CRSP complex subunit 6; thyroid hormone
                     receptor-associated protein complex 80 kDa component;
                     cofactor required for Sp1 transcriptional activation,
                     subunit 6 (77kD)"
                     /codon_start=1
                     /product="mediator of RNA polymerase II transcription
                     subunit 17 isoform 1"
                     /protein_id="NP_659182.1"
                     /db_xref="CCDS:CCDS22834.1"
                     /db_xref="GeneID:234959"
                     /db_xref="MGI:MGI:2182585"
                     /translation="MSGVRAVRISIESACEKQVQEVGLDGTETYLQPLSMSQNLARLA
                     QRIDFSQGSGSEEEEAAGPDGDAPDWGGAGADQDDEEGLVKFQPSLWPWDSVRNNLRS
                     ALTEMCVLYDVLSIVRDKKFMTLDPVSQDALPPKQSPQTLQLISKKKSLAGAAQILLK
                     GAERLTKSVAENQENKLQRDFNSELLRLRQHWKLRKVGDKILGDLSYRSAGSLFPHHG
                     TFEVIKNTDIDLDKKIPEDYCPLDVQIPSDLEGSAYIKVSIQKQAPDIGDLGTVNLFK
                     RPLPKSKPGSPHWQTKLEAAQNVLLCKEIFAQLSREAVQIKSQIPHIVVKNQIISQPF
                     PSLQLSISLCHSSDDKKSQKCAAEKPGQEDHLYVLEHNLHLLIREFHKQTLSSIVMPH
                     PASAPFGHKRMRLSGPQAFDKNEINSIQSTEGLLEKIIKQAKHIFLRSRTAATIDSLA
                     SRIEDPQIQAHWSNINDVYESSVKVLITSQGYEQICKSIQLQLNIGVEQVRVVHRDGR
                     VIMLSHQEQELQDFLLSQMSQHQVHAVQQLAKVMGWQVLSFSNHVGLGPIESIGNASA
                     ITVASPSGDYAISVRNGPESGSKIMVQFPRNQCKDLPKSDVLQDSKWSHLRGPFKEVQ
                     WNKMEGRNFVYKMELLMSALSPCLL"
     exon            358..524
                     /gene="Med17"
                     /gene_synonym="77kDa; C330002H14Rik; Crsp6; Trap80"
                     /inference="alignment:Splign:2.1.0"
     exon            525..744
                     /gene="Med17"
                     /gene_synonym="77kDa; C330002H14Rik; Crsp6; Trap80"
                     /inference="alignment:Splign:2.1.0"
     exon            745..881
                     /gene="Med17"
                     /gene_synonym="77kDa; C330002H14Rik; Crsp6; Trap80"
                     /inference="alignment:Splign:2.1.0"
     exon            882..966
                     /gene="Med17"
                     /gene_synonym="77kDa; C330002H14Rik; Crsp6; Trap80"
                     /inference="alignment:Splign:2.1.0"
     exon            967..1119
                     /gene="Med17"
                     /gene_synonym="77kDa; C330002H14Rik; Crsp6; Trap80"
                     /inference="alignment:Splign:2.1.0"
     exon            1120..1250
                     /gene="Med17"
                     /gene_synonym="77kDa; C330002H14Rik; Crsp6; Trap80"
                     /inference="alignment:Splign:2.1.0"
     exon            1251..1435
                     /gene="Med17"
                     /gene_synonym="77kDa; C330002H14Rik; Crsp6; Trap80"
                     /inference="alignment:Splign:2.1.0"
     exon            1436..1573
                     /gene="Med17"
                     /gene_synonym="77kDa; C330002H14Rik; Crsp6; Trap80"
                     /inference="alignment:Splign:2.1.0"
     exon            1574..1691
                     /gene="Med17"
                     /gene_synonym="77kDa; C330002H14Rik; Crsp6; Trap80"
                     /inference="alignment:Splign:2.1.0"
     exon            1692..1851
                     /gene="Med17"
                     /gene_synonym="77kDa; C330002H14Rik; Crsp6; Trap80"
                     /inference="alignment:Splign:2.1.0"
     exon            1852..3939
                     /gene="Med17"
                     /gene_synonym="77kDa; C330002H14Rik; Crsp6; Trap80"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2399..2404
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Med17"
                     /gene_synonym="77kDa; C330002H14Rik; Crsp6; Trap80"
                     /note="hexamer: CATAAA"
     polyA_site      2421
                     /gene="Med17"
                     /gene_synonym="77kDa; C330002H14Rik; Crsp6; Trap80"
                     /note="major polyA site"
     polyA_site      2961
                     /gene="Med17"
                     /gene_synonym="77kDa; C330002H14Rik; Crsp6; Trap80"
     regulatory      2996..3001
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Med17"
                     /gene_synonym="77kDa; C330002H14Rik; Crsp6; Trap80"
                     /note="hexamer: AGTAAA"
     polyA_site      3023
                     /gene="Med17"
                     /gene_synonym="77kDa; C330002H14Rik; Crsp6; Trap80"
     regulatory      3921..3926
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Med17"
                     /gene_synonym="77kDa; C330002H14Rik; Crsp6; Trap80"
                     /note="hexamer: AATAAA"
     polyA_site      3939
                     /gene="Med17"
                     /gene_synonym="77kDa; C330002H14Rik; Crsp6; Trap80"
ORIGIN      
        1 gtagtttgct tcctcccggc cgccgcgtcg ggcttgcggg aagcttgttc cagccttccg
       61 tgtcggtgct gtactctgag tctccggcga gtcgccctca ggccgccgcc agcatgtcgg
      121 gcgtgcgagc cgtgcgcatc agcatcgagt cggcctgcga gaagcaggtg caggaggtgg
      181 gccttgatgg caccgagacg tacctgcagc cgctgtccat gtcgcagaac ctggcgcgcc
      241 tggcacagcg catcgacttc agccagggct ctggctctga ggaggaggag gcggcagggc
      301 ctgacggcga tgcgccggac tgggggggcg cgggagccga ccaggacgac gaggaggggt
      361 tggtaaaatt ccaaccttct ttgtggcctt gggactctgt gaggaacaat ttgcgaagtg
      421 cccttacaga gatgtgtgtt ctctatgatg tcctcagtat tgtcagggac aaaaagttca
      481 tgactctgga ccccgtctct caggatgctc ttcctcccaa acagagtcca caaacgctgc
      541 agctgatctc caagaagaag tccctcgctg gagcagctca gatcctactg aagggggcag
      601 aaagactgac caagtcagtg gctgagaacc aggaaaacaa gctccagcga gacttcaatt
      661 ctgagctcct gagactccgg cagcactgga agctgaggaa ggtgggcgac aagatcctgg
      721 gtgacctgag ctacagaagt gcaggttctc tctttcctca tcatggtacc tttgaagtga
      781 taaagaatac agacattgac ttggataaga agataccaga agattactgt cctctggatg
      841 tccaaattcc tagtgattta gaggggtctg cgtatatcaa ggtttctatt cagaaacagg
      901 ctccagacat tggtgatctt ggcacagtta acctttttaa gagacctttg cccaaatcca
      961 agccaggttc cccacactgg cagacaaaat tagaagcagc acaaaatgtt cttctttgta
     1021 aagaaatttt tgcacagctc tcccgggaag ccgttcagat taagtctcag atccctcaca
     1081 ttgtggtgaa aaaccagatc atctctcagc cctttccaag cttgcagttg tccatttctc
     1141 tgtgccactc ctcagatgat aagaagtcgc agaagtgtgc cgcagagaag cctgggcaag
     1201 aggatcacct ctacgtcctg gagcacaacc tgcacctgct gatcagagag tttcataaac
     1261 agaccttgag ttccattgtg atgccacacc cagcaagtgc tccctttggc cacaagagga
     1321 tgagactctc aggtcctcaa gcttttgata aaaatgaaat taattcaata cagtccacag
     1381 aaggactcct agaaaaaata attaaacagg caaagcatat ttttctaagg agcagaactg
     1441 ctgcaaccat tgacagcttg gcaagtcgca ttgaggaccc ccagatccag gcccactggt
     1501 caaacatcaa tgatgtgtat gagtctagtg taaaagtttt gatcacatct cagggttatg
     1561 aacagatctg caagtccatc cagctgcagt tgaacattgg tgtggagcag gtccgtgttg
     1621 tgcacagaga tggtcgggta atcatgttgt ctcatcagga gcaggagcta caggacttcc
     1681 ttctgtctca gatgtcacag caccaggtgc acgcggttca gcagcttgcc aaggttatgg
     1741 gctggcaggt cctcagcttc agtaaccatg tgggacttgg gcccatagag agcattggca
     1801 atgcttcggc catcaccgtg gcctcgccaa gtggagacta tgcgatttca gttcgtaacg
     1861 gacctgagag tggcagcaag attatggttc agtttccccg taaccagtgc aaagaccttc
     1921 cgaagagtga tgttttacaa gacagcaagt ggagtcatct ccgaggacca ttcaaggagg
     1981 ttcagtggaa caagatggaa ggccgaaact tcgtttataa aatggagctg cttatgtctg
     2041 ccctgagccc ctgtctgctg tgattttctc cagaacaagt tccagaaata ctgactgttt
     2101 gcagatcagt tataagcaca agggagagat gtcttccata taagtcccga gtgcagactc
     2161 atgtgcactg ctgctccaat ctttcacggg agccctgttt aaaagttacg tttactttgc
     2221 agcctgaatt ctctcacttt ataagtgacg agtactttgg aatgaaaaat gtatgtacag
     2281 ttatagtatg cagtatgggg agatgtaaaa tagtacattt tttatacagc taacctgaaa
     2341 atattactaa cttaagggct tgaatttgct ttttttaaaa ttccatcttt aatgttaaca
     2401 taaactttgt gtttaaaaaa atctccccaa gtattttgtg aatttctcat aacccatatg
     2461 agctgtctct caagtcagct gctcctgctg tttctttaaa aatcacccaa gaacatctta
     2521 caacacagat tcactgagca ccccaggccc tgttcctgaa gttcaccaag atcacgcaca
     2581 gtagtcttcc ctagtacctg gggctcttgg ggtgttgggg atgtgaagtg cctttgtagc
     2641 cctcttcctc acctgggtct tcatgaacag gtcaaaggca gagggaacca aaggacgtcc
     2701 cataacacag tctctgtttt ccctgttagt agtcactgcc tttgcattcc acttgaaatt
     2761 tgacaagttg agatataaag gagatgtgcc aagtgtgaca actcatgcct ctaaccctag
     2821 gactaagggt tgaagaccgg aagctcaaga gttcaagttc agcttgatct gcaagagttc
     2881 caggctattt ggggctatgt aggaaaaacc ttgtttcaaa gttttttttt ttgttttttt
     2941 ttaaaaagca ttgtatgaat actcatgctg tggattatgt ttgcaagggg gaaagagtaa
     3001 aatttaatag ggacaaacat gaagcatgaa gtgagggaat gctgagacac atgaggaaaa
     3061 acagccaggt catgtgtata atggagttga ggtggagccc agtgggaggg tgcttgccta
     3121 gcatgcatga gcacccagat tcaagctcca gacttagagg gaggaaaggg cattgggggt
     3181 gatggttgga atgtgtactg tgatgtgtgt gtgtctagaa agacactgcg ttctcaaaag
     3241 tgaggttggg gagagggaac ttgcactgca ttggggactt gcgtatcttc acttttcaag
     3301 tagcgtagtt ttgtaattag agattcttga aaggcaagag aaatcatgac tccagctgcc
     3361 cttaaggatt ggcagctgag atggtggtca catgcagaat cacatatatt gacaatccac
     3421 cgctcttctc agtgaaactt gatgtagttg tggtaacagt agtttcccag ttcattctag
     3481 aggtgtctga tgtcaggaaa cagcataata agccaattct gatacatgac agctggagga
     3541 atgagccttc actgccctgg taccactcta ggcaactgca tctgagacat gttcctgaag
     3601 gtcagctgtg acgctttgaa tgtaattggc ccccattgac ccatagggag tggcactatt
     3661 agaaggtgtc accttgctgg aggaagtgaa gtcactgtgg gggtgggctt tgaggtctca
     3721 tatgcaccca ttgtggtaca cagtttctcc ctgctgcctt gcggatcaag acgtagaact
     3781 tcatgtccag catgtctgtc tatatgctgc catgttatct gccatgatga taagggacta
     3841 aacctctgaa actataagcc agccccaatt agatgttttg ctttgtagga gttgctctgg
     3901 tcatggtgtc tcttcacagc aataaaatcc taagactcaa aaaaaaaaaa aaa
//
