LOCUS       NM_001048208            6861 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus mediator complex subunit 14 (Med14), transcript
            variant 1, mRNA.
ACCESSION   NM_001048208
VERSION     NM_001048208.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6861)
  AUTHORS   Kolonay,D.W., Sattler,K.M., Strawser,C., Rafael-Fortney,J.,
            Mihaylova,M.M., Miller,K.E., Lepper,C. and Baskin,K.K.
  TITLE     Temporal regulation of the Mediator complex during muscle
            proliferation, differentiation, regeneration, aging, and disease
  JOURNAL   Front Cell Dev Biol 12, 1331563 (2024)
   PUBMED   38690566
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6861)
  AUTHORS   Tan,C., Zhu,S., Chen,Z., Liu,C., Li,Y.E., Zhu,M., Zhang,Z.,
            Zhang,Z., Zhang,L., Gu,Y., Liang,Z., Boyer,T.G., Ouyang,K.,
            Evans,S.M. and Fang,X.
  TITLE     Mediator complex proximal Tail subunit MED30 is critical for
            Mediator core stability and cardiomyocyte transcriptional network
  JOURNAL   PLoS Genet 17 (9), e1009785 (2021)
   PUBMED   34506481
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6861)
  AUTHORS   Kagey,M.H., Newman,J.J., Bilodeau,S., Zhan,Y., Orlando,D.A., van
            Berkum,N.L., Ebmeier,C.C., Goossens,J., Rahl,P.B., Levine,S.S.,
            Taatjes,D.J., Dekker,J. and Young,R.A.
  TITLE     Mediator and cohesin connect gene expression and chromatin
            architecture
  JOURNAL   Nature 467 (7314), 430-435 (2010)
   PUBMED   20720539
  REMARK    Erratum:[Nature. 2011 Apr 14;472(7342):247]
REFERENCE   4  (bases 1 to 6861)
  AUTHORS   Cox,B.J., Vollmer,M., Tamplin,O., Lu,M., Biechele,S.,
            Gertsenstein,M., van Campenhout,C., Floss,T., Kuhn,R., Wurst,W.,
            Lickert,H. and Rossant,J.
  TITLE     Phenotypic annotation of the mouse X chromosome
  JOURNAL   Genome Res 20 (8), 1154-1164 (2010)
   PUBMED   20548051
REFERENCE   5  (bases 1 to 6861)
  AUTHORS   Krebs,A.R., Demmers,J., Karmodiya,K., Chang,N.C., Chang,A.C. and
            Tora,L.
  TITLE     ATAC and Mediator coactivators form a stable complex and regulate a
            set of non-coding RNA genes
  JOURNAL   EMBO Rep 11 (7), 541-547 (2010)
   PUBMED   20508642
REFERENCE   6  (bases 1 to 6861)
  AUTHORS   Malik,S., Guermah,M., Yuan,C.X., Wu,W., Yamamura,S. and Roeder,R.G.
  TITLE     Structural and functional organization of TRAP220, the
            TRAP/mediator subunit that is targeted by nuclear receptors
  JOURNAL   Mol Cell Biol 24 (18), 8244-8254 (2004)
   PUBMED   15340084
  REMARK    Erratum:[Mol Cell Biol. 2022 Nov 17;42(11):e0035922. doi:
            10.1128/mcb.00359-22.. PMID: 36255214]
REFERENCE   7  (bases 1 to 6861)
  AUTHORS   Sharov,A.A., Piao,Y., Matoba,R., Dudekula,D.B., Qian,Y.,
            VanBuren,V., Falco,G., Martin,P.R., Stagg,C.A., Bassey,U.C.,
            Wang,Y., Carter,M.G., Hamatani,T., Aiba,K., Akutsu,H., Sharova,L.,
            Tanaka,T.S., Kimber,W.L., Yoshikawa,T., Jaradat,S.A., Pantano,S.,
            Nagaraja,R., Boheler,K.R., Taub,D., Hodes,R.J., Longo,D.L.,
            Schlessinger,D., Keller,J., Klotz,E., Kelsoe,G., Umezawa,A.,
            Vescovi,A.L., Rossant,J., Kunath,T., Hogan,B.L., Curci,A.,
            D'Urso,M., Kelso,J., Hide,W. and Ko,M.S.
  TITLE     Transcriptome analysis of mouse stem cells and early embryos
  JOURNAL   PLoS Biol 1 (3), E74 (2003)
   PUBMED   14691545
REFERENCE   8  (bases 1 to 6861)
  AUTHORS   Ge,K., Guermah,M., Yuan,C.X., Ito,M., Wallberg,A.E.,
            Spiegelman,B.M. and Roeder,R.G.
  TITLE     Transcription coactivator TRAP220 is required for PPAR gamma
            2-stimulated adipogenesis
  JOURNAL   Nature 417 (6888), 563-567 (2002)
   PUBMED   12037571
REFERENCE   9  (bases 1 to 6861)
  AUTHORS   Mittler,G., Kremmer,E., Timmers,H.T. and Meisterernst,M.
  TITLE     Novel critical role of a human Mediator complex for basal RNA
            polymerase II transcription
  JOURNAL   EMBO Rep 2 (9), 808-813 (2001)
   PUBMED   11559591
REFERENCE   10 (bases 1 to 6861)
  AUTHORS   Takada,S., Kamiya,M., Arima,T., Kagebayashi,H., Shibata,H.,
            Muramatsu,M., Chapman,V.M., Wake,N., Hayashizaki,Y. and Takagi,N.
  TITLE     Detection and cloning of an X-linked locus associated with a NotI
            site that is not methylated on mouse inactivated X chromosome by
            the RLGS-M method
  JOURNAL   Genomics 61 (1), 92-100 (1999)
   PUBMED   10512684
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC065072.1, CN724751.1 and BX000537.11.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR13861859.4547559.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2510              BC065072.1         101-2610
            2511-3349           BC065072.1         2697-3535
            3350-4014           CN724751.1         22-686
            4015-4580           BC065072.1         4068-4633
            4581-6861           BX000537.11        121069-123349       c
FEATURES             Location/Qualifiers
     source          1..6861
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 7.52 cM"
     gene            1..6861
                     /gene="Med14"
                     /gene_synonym="9930001L01Rik; Crsp2; Gm641; ORF1; Trap170"
                     /note="mediator complex subunit 14"
                     /db_xref="GeneID:26896"
                     /db_xref="MGI:MGI:1349442"
     exon            1..507
                     /gene="Med14"
                     /gene_synonym="9930001L01Rik; Crsp2; Gm641; ORF1; Trap170"
                     /inference="alignment:Splign:2.1.0"
     CDS             275..4654
                     /gene="Med14"
                     /gene_synonym="9930001L01Rik; Crsp2; Gm641; ORF1; Trap170"
                     /note="isoform a is encoded by transcript variant 1;
                     cofactor required for Sp1 transcriptional activation,
                     subunit 2; mediator of RNA polymerase II transcription
                     subunit 14; CRSP complex subunit 2; thyroid hormone
                     receptor-associated protein complex 170 kDa component;
                     cofactor required for Sp1 transcriptional activation
                     subunit 2 (150 kDa)"
                     /codon_start=1
                     /product="mediator of RNA polymerase II transcription
                     subunit 14 isoform a"
                     /protein_id="NP_001041673.1"
                     /db_xref="CCDS:CCDS40874.1"
                     /db_xref="GeneID:26896"
                     /db_xref="MGI:MGI:1349442"
                     /translation="MAPVQLDNHQLIPPGGGGGSSGGGGSSSGSASAPAPPPPAAAVA
                     AAAAAAASPGYRLSTLIEFLLHRAYSELMVLTDLLPRKSDVERKIEIVQFASRTRQLF
                     VRLLALVKWANDAGKVEKCAMISSFLDQQAILFVDTADRLASLARDALVHARLPSFAI
                     PYAIDVLTTGSYPRLPTCIRDKIIPPDPITKIEKQATLHQLNQILRHRLVTTDLPPQL
                     ANLTVANGRVKFRVEGEFEATLTVMGDDPEVPWRLLKLEILVEDKETGDGRALVHSMQ
                     IDFIHQLVQSRLFADEKPLQDMYNCLHCFCLSLQLEVLHSQTLMLIRERWGDLVQVER
                     YHAGKSLSLSVWNQQVLGRKTGTASVHKVTIKIDENDVSKPLQIFHDPPLPASDSKLV
                     ERAMKIDHLSIEKLLIDSVHARAHQRLQELKAILRSFNANESSSIETALPALIVPILE
                     PCGNSECLHIFVDLHSGMFQLMLYGLDPATLEDMEKSLNDDMKRIIPWIQQLKFWLGQ
                     QRCKQSIKHLPTITTETLQLANYSTHPIGSLSKNKLFIKLTRLPQYYIVVEMLEVPNK
                     PTQLSYNYYFMSVSTADREDSPVMALLLQQFKDNIQDLMSYTKTGKQTRTGTKHKLSD
                     DPCPIDSKKAKRSGEMCAFNKVLAHFVAMCDTNMPFVGLRLELSNLEIPHQGVQVEGD
                     GFNHAIRLLKIPPCKGISEETQKALDRSLLDCTFRLQGRNNRTWVAELVFANCPLNGT
                     STREQGPSRHVYLTYENLLSEPVGGRKVVEMFLNDWSSIARLYECVLEFARSLPEIPA
                     HLNIFSEVRVYNYRKLILCYGTTKGSSISIQWNSIHQKFHIALGTVGPNSGCSNCHNT
                     ILHQLQEMFNKTPNVVQLLQVLFDTQAPLNAINKLPTVPMLGLTQRTNTAYQCFSILP
                     QSSTHIRLAFRNMYCIDIYCRSRGVVAIRDGAYSLFDNSKLVEGFYPAPGLKTFLNMF
                     VDSNQDARRRSVNEDDNPPSPIGGDMMDSLISQLQPPQQQPFPKQPGTSGAYPLTSPP
                     TSYHSTVNQSPSMMHTQSPGNLHAASSPSGALRAPSPASFVPTPPPSSHGISIGPGAS
                     FASPHGTLDPSSPYTMVSPSGRAGNWPGSPQVSGPSPATRLPGMSPANPSLHSPVPDV
                     SHSPRAGTSSQTMPTNMPPPRKLPQRSWAASIPTILTHSALNILLLPSPTPGLVPGLA
                     GSYLCSPLERFLGSVIMRRHLQRIIQQETLQLINSNEPGVIMFKTDALKCRVALSPKT
                     NQTLQLKVTPENAGQWKPDELQVLEKFFETRVAGPPFKANTLIAFTKLLGAPTHILRD
                     CVHIMKLELFPDQATQLKWNVQFCLTIPPSAPPIAPPGTPAVVLKSKMLFFLQLTQKT
                     SVPPQEPVSIIVPIIYDMASGTTQQADIPRQQNSSVAAPMMVSNILKRFAEMNPPRQG
                     ECTIFAAVRDLMANLTLPPGGRP"
     exon            508..534
                     /gene="Med14"
                     /gene_synonym="9930001L01Rik; Crsp2; Gm641; ORF1; Trap170"
                     /inference="alignment:Splign:2.1.0"
     exon            535..640
                     /gene="Med14"
                     /gene_synonym="9930001L01Rik; Crsp2; Gm641; ORF1; Trap170"
                     /inference="alignment:Splign:2.1.0"
     exon            641..814
                     /gene="Med14"
                     /gene_synonym="9930001L01Rik; Crsp2; Gm641; ORF1; Trap170"
                     /inference="alignment:Splign:2.1.0"
     exon            815..944
                     /gene="Med14"
                     /gene_synonym="9930001L01Rik; Crsp2; Gm641; ORF1; Trap170"
                     /inference="alignment:Splign:2.1.0"
     exon            945..1073
                     /gene="Med14"
                     /gene_synonym="9930001L01Rik; Crsp2; Gm641; ORF1; Trap170"
                     /inference="alignment:Splign:2.1.0"
     exon            1074..1181
                     /gene="Med14"
                     /gene_synonym="9930001L01Rik; Crsp2; Gm641; ORF1; Trap170"
                     /inference="alignment:Splign:2.1.0"
     exon            1182..1314
                     /gene="Med14"
                     /gene_synonym="9930001L01Rik; Crsp2; Gm641; ORF1; Trap170"
                     /inference="alignment:Splign:2.1.0"
     exon            1315..1465
                     /gene="Med14"
                     /gene_synonym="9930001L01Rik; Crsp2; Gm641; ORF1; Trap170"
                     /inference="alignment:Splign:2.1.0"
     exon            1466..1577
                     /gene="Med14"
                     /gene_synonym="9930001L01Rik; Crsp2; Gm641; ORF1; Trap170"
                     /inference="alignment:Splign:2.1.0"
     exon            1578..1703
                     /gene="Med14"
                     /gene_synonym="9930001L01Rik; Crsp2; Gm641; ORF1; Trap170"
                     /inference="alignment:Splign:2.1.0"
     exon            1704..1782
                     /gene="Med14"
                     /gene_synonym="9930001L01Rik; Crsp2; Gm641; ORF1; Trap170"
                     /inference="alignment:Splign:2.1.0"
     exon            1783..1942
                     /gene="Med14"
                     /gene_synonym="9930001L01Rik; Crsp2; Gm641; ORF1; Trap170"
                     /inference="alignment:Splign:2.1.0"
     exon            1943..2137
                     /gene="Med14"
                     /gene_synonym="9930001L01Rik; Crsp2; Gm641; ORF1; Trap170"
                     /inference="alignment:Splign:2.1.0"
     exon            2138..2272
                     /gene="Med14"
                     /gene_synonym="9930001L01Rik; Crsp2; Gm641; ORF1; Trap170"
                     /inference="alignment:Splign:2.1.0"
     exon            2273..2349
                     /gene="Med14"
                     /gene_synonym="9930001L01Rik; Crsp2; Gm641; ORF1; Trap170"
                     /inference="alignment:Splign:2.1.0"
     exon            2350..2510
                     /gene="Med14"
                     /gene_synonym="9930001L01Rik; Crsp2; Gm641; ORF1; Trap170"
                     /inference="alignment:Splign:2.1.0"
     exon            2511..2657
                     /gene="Med14"
                     /gene_synonym="9930001L01Rik; Crsp2; Gm641; ORF1; Trap170"
                     /inference="alignment:Splign:2.1.0"
     exon            2658..2749
                     /gene="Med14"
                     /gene_synonym="9930001L01Rik; Crsp2; Gm641; ORF1; Trap170"
                     /inference="alignment:Splign:2.1.0"
     exon            2750..2902
                     /gene="Med14"
                     /gene_synonym="9930001L01Rik; Crsp2; Gm641; ORF1; Trap170"
                     /inference="alignment:Splign:2.1.0"
     exon            2903..3172
                     /gene="Med14"
                     /gene_synonym="9930001L01Rik; Crsp2; Gm641; ORF1; Trap170"
                     /inference="alignment:Splign:2.1.0"
     exon            3173..3310
                     /gene="Med14"
                     /gene_synonym="9930001L01Rik; Crsp2; Gm641; ORF1; Trap170"
                     /inference="alignment:Splign:2.1.0"
     exon            3311..3422
                     /gene="Med14"
                     /gene_synonym="9930001L01Rik; Crsp2; Gm641; ORF1; Trap170"
                     /inference="alignment:Splign:2.1.0"
     exon            3423..3554
                     /gene="Med14"
                     /gene_synonym="9930001L01Rik; Crsp2; Gm641; ORF1; Trap170"
                     /inference="alignment:Splign:2.1.0"
     exon            3555..3737
                     /gene="Med14"
                     /gene_synonym="9930001L01Rik; Crsp2; Gm641; ORF1; Trap170"
                     /inference="alignment:Splign:2.1.0"
     exon            3738..3973
                     /gene="Med14"
                     /gene_synonym="9930001L01Rik; Crsp2; Gm641; ORF1; Trap170"
                     /inference="alignment:Splign:2.1.0"
     exon            3974..4153
                     /gene="Med14"
                     /gene_synonym="9930001L01Rik; Crsp2; Gm641; ORF1; Trap170"
                     /inference="alignment:Splign:2.1.0"
     exon            4154..4261
                     /gene="Med14"
                     /gene_synonym="9930001L01Rik; Crsp2; Gm641; ORF1; Trap170"
                     /inference="alignment:Splign:2.1.0"
     exon            4262..4387
                     /gene="Med14"
                     /gene_synonym="9930001L01Rik; Crsp2; Gm641; ORF1; Trap170"
                     /inference="alignment:Splign:2.1.0"
     exon            4388..4580
                     /gene="Med14"
                     /gene_synonym="9930001L01Rik; Crsp2; Gm641; ORF1; Trap170"
                     /inference="alignment:Splign:2.1.0"
     exon            4581..6861
                     /gene="Med14"
                     /gene_synonym="9930001L01Rik; Crsp2; Gm641; ORF1; Trap170"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6654..6659
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Med14"
                     /gene_synonym="9930001L01Rik; Crsp2; Gm641; ORF1; Trap170"
                     /note="hexamer: ATTAAA"
     polyA_site      6674
                     /gene="Med14"
                     /gene_synonym="9930001L01Rik; Crsp2; Gm641; ORF1; Trap170"
                     /note="major polyA site"
     polyA_site      6702
                     /gene="Med14"
                     /gene_synonym="9930001L01Rik; Crsp2; Gm641; ORF1; Trap170"
                     /note="major polyA site"
     regulatory      6835..6840
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Med14"
                     /gene_synonym="9930001L01Rik; Crsp2; Gm641; ORF1; Trap170"
                     /note="hexamer: AATAAA"
     polyA_site      6861
                     /gene="Med14"
                     /gene_synonym="9930001L01Rik; Crsp2; Gm641; ORF1; Trap170"
                     /note="major polyA site"
ORIGIN      
        1 cggccgctga gcagtcgcgg aagcttcccc acttgagtgg cggccggccc gcctctctgc
       61 cctcccgccc cacgctcgcc tccctgcggc cggccggccc ggccctacat gggggcgggc
      121 ctccgcagct tgggctcggc ttcctgttca gaggcggcct ggcgctaggc ggcggccact
      181 ctgcccgcgc ccgcctcggt gcggtcaccg agcccgggag gaggctccag ggccgcatct
      241 caggcggttg ccccgagccg ggctgtacgc cgccatggcc ccagtgcagc tggacaacca
      301 ccagctgatc cctcctggcg gcggcggtgg cagcagcggc ggcggaggca gcagcagcgg
      361 ctccgcgtct gccccggctc ccccgccgcc cgcagccgct gtggcggcgg cagctgcggc
      421 ggcagctagc cctggatacc ggcttagcac gctcatcgaa tttctgctcc accgggccta
      481 ctcggagctt atggtgttga cggacttatt gccaaggaaa tctgatgtgg aaaggaaaat
      541 agaaattgta cagtttgcta gccggacacg tcaactcttc gttcgattat tagctttagt
      601 aaaatgggcc aatgacgctg gcaaagtaga aaagtgtgcg atgatctcaa gctttttaga
      661 tcagcaagct atcttatttg tggataccgc tgaccgcttg gcctccttag ctagagatgc
      721 cctggtccat gcacgcctgc ctagttttgc tattccatat gccattgatg tactgactac
      781 tggctcttat ccacggcttc caacctgcat cagggacaaa attattcctc cagacccaat
      841 taccaaaatt gagaaacaag ccacacttca tcagcttaat cagattctta gacataggct
      901 tgtaacgaca gatcttcctc cacagctagc aaatcttaca gtggcaaatg gccgtgtgaa
      961 gtttcgagtt gaaggagaat ttgaagcaac cttgacagtg atgggtgatg acccagaagt
     1021 cccgtggcgt cttctcaagc tagaaattct agttgaggat aaggaaacag gagatgggcg
     1081 agctttggtt catagcatgc aaatcgattt tatccatcag ctggtccagt ctaggctctt
     1141 tgctgatgag aaacctcttc aggacatgta caactgccta cattgtttct gcttatcgct
     1201 tcaactagaa gtattacatt cccagacact aatgttaatc cgagagaggt ggggagacct
     1261 tgtacaggtg gaaagatacc atgctggaaa gagcctctcc ctctcagttt ggaatcaaca
     1321 ggttctaggg agaaaaacag gcacagcatc tgttcacaaa gttacaatta aaatcgatga
     1381 gaatgatgtc tccaagcctt tacagatttt tcatgatcct cctttgccag cttctgattc
     1441 taaattagta gaaagagcca tgaagattga ccacttatca atagaaaagc tcctgattga
     1501 cagtgtacac gcaagagccc accagaggct gcaggaactg aaggccattc ttagaagctt
     1561 caacgccaat gaaagctctt ccatagagac tgcacttcca gctcttattg tacccatctt
     1621 ggagccttgt ggtaattcgg agtgcctaca catttttgta gatttgcatt ctggaatgtt
     1681 ccaattgatg ctttatggac ttgacccagc cactctggag gacatggaaa aatctttgaa
     1741 tgatgacatg aagcggatca tcccttggat tcagcaactt aagttttggc tgggacaaca
     1801 gcgttgcaaa caatctataa aacatctgcc tacaataacc actgaaacgt tgcagcttgc
     1861 caactattca acacatccca ttggaagcct ttctaagaat aagctgttta ttaaacttac
     1921 tcgccttcca cagtactaca ttgttgtgga aatgcttgag gttcctaata agcctacgca
     1981 gctatcatat aactattact ttatgtcggt gagtactgca gatcgtgagg acagccctgt
     2041 catggcactg ctgctgcagc aattcaagga caacatccag gacctgatgt cctatacaaa
     2101 gactgggaaa cagaccagaa ctggtaccaa gcacaagttg tctgatgacc catgtccgat
     2161 agactccaag aaagccaaac gatcaggaga aatgtgtgcc ttcaataaag ttctagctca
     2221 ctttgttgct atgtgtgaca ccaacatgcc atttgttggt cttcgattgg agttgtctaa
     2281 cctcgagata ccacatcagg gagtgcaagt ggaaggtgat ggcttcaacc atgcaattcg
     2341 cttattaaag attcctccct gtaaaggaat aagtgaggaa acacagaagg ctctggaccg
     2401 ctctcttctt gattgcactt tccgattaca aggtagaaat aaccgcactt gggtggctga
     2461 attagtgttt gcaaattgtc cgcttaatgg cacttccacc agggagcaag gaccatcccg
     2521 acatgtttac ctgacgtatg aaaatttgtt gtctgaacct gttggtggca gaaaagtagt
     2581 tgaaatgttt cttaatgact ggagtagcat tgcccgttta tacgagtgtg tgttggaatt
     2641 tgcacgttct ctaccagaaa tacctgctca tctgaatatt ttctcagaag ttcgtgttta
     2701 taattatcga aagcttatct tatgttatgg aaccaccaaa ggaagctcaa ttagtattca
     2761 gtggaactcc attcatcaga aatttcacat tgcgttggga acagttggcc caaactcagg
     2821 ttgcagtaac tgtcacaata ccattctcca tcaacttcaa gaaatgttca acaaaacacc
     2881 aaatgtggtt cagttattac aggttttgtt tgatactcag gcaccattaa atgctatcaa
     2941 caaactccct actgttccaa tgttgggctt gacccagaga actaacaccg cctaccagtg
     3001 tttctccatt ttaccacaat catccaccca catcagactg gccttcagga acatgtactg
     3061 cattgacata tactgccgta gtcgaggcgt cgtggcaata cgggacggtg cctatagtct
     3121 ttttgataac agcaagttag ttgaaggctt ctatcctgca ccaggattaa agactttcct
     3181 gaacatgttt gttgatagca atcaagatgc tcggagaaga tctgtaaatg aggatgataa
     3241 ccctccttct cctataggag gtgacatgat ggactcttta atatcacagc tccagccacc
     3301 tcagcaacag ccatttccaa agcagccagg gacatcaggc gcttaccctc ttacttcacc
     3361 ccctacatcc tatcacagca cagttaatca gtccccctct atgatgcaca cacagtctcc
     3421 aggaaatctg catgctgcca gctcccccag tggggctttg agagccccat caccagcgtc
     3481 atttgttcca actcctcccc catcctcgca tggaatctca ataggaccag gggccagttt
     3541 tgctagtcca catggaaccc ttgaccctag ttctccatat actatggtgt caccaagtgg
     3601 acgagcagga aactggcctg ggtcacctca agtgtccgga ccctcaccag caacccgttt
     3661 gcctggaatg tcaccagcta acccatctct gcattctcct gttccagatg tttctcattc
     3721 tcctcgagct ggcacaagtt cccagacaat gccaaccaac atgcctccac ctcgaaaact
     3781 acctcagcgc tcctgggcag catctatacc caccattctc actcatagtg ccttgaacat
     3841 cttactgcta ccatctccaa cgccaggcct tgtgcctggc ctggcaggta gttacctttg
     3901 ttccccactt gagagattcc ttggatctgt catcatgaga cgacaccttc aaagaatcat
     3961 ccaacaggaa acgttgcagc tgatcaattc caatgaacct ggtgtaatca tgttcaagac
     4021 agatgccctg aaatgcagag tagcccttag tcccaaaacc aaccagaccc ttcagctaaa
     4081 agtgacacct gaaaatgcag gacaatggaa acccgatgag cttcaagttt tggagaaatt
     4141 cttcgaaaca agagttgcag gaccgccatt taaagccaac acacttatag ccttcaccaa
     4201 gctgttggga gcgccgacac acatcctccg ggactgtgtg catataatga agttggagtt
     4261 gttcccagat caagcaacgc agctgaaatg gaacgttcag ttttgcctca ccatccctcc
     4321 cagcgcacca ccaattgcac cgcctgggac accagctgtg gtcctgaaat ccaaaatgct
     4381 attttttctt caactaactc agaaaacatc agtccctccc caagaacctg ttagtataat
     4441 agttccaatt atttatgata tggcttcagg taccactcag caggcagaca ttcccagaca
     4501 gcagaactct tctgttgctg cgccaatgat ggtcagcaac attctgaaga ggtttgcaga
     4561 gatgaaccct ccacgacaag gtgaatgcac aatatttgca gctgttcgtg atttaatggc
     4621 taatcttaca ctgccccctg gtgggcgtcc atagacacta ttgtttttaa accaggaagg
     4681 ctgactaatg aaacaaaaca acacacacac acaaaaaggc tgaattcagc cttcagtttt
     4741 aaaaaggaaa aggacttttt ttaaccttaa gagctaaata ttctaaactg gcaacatttt
     4801 cagggtgcac ttcatcaaaa agaccatcaa tttttttgta tagtgaactt gtatagtgtg
     4861 tttaaatgcg acacatttca aactaggtaa cagatcagtg tcctcgtgcc agtaatagat
     4921 ttaatattct gttttatact ataaaataat gaaaatgcca aacttgttta tttaattgtt
     4981 ttcttatgtt ttgggtgtaa tggtcctttt tgatttttat ttttattttt taaggcaggt
     5041 ctgtcagttt tgaatactgt aaaactgtga caaactttat attgaagctg tattttaata
     5101 tgcccgcttt gaatccttac tccgaaatgg ttttgggagc tgttaaacac atcccaaaga
     5161 agcaatattt aataaaacta ggatctaaaa gagacacttg tgtatgtata agctctctag
     5221 agttcttagg gcctcccttc atctttaatc tggtggggcc agtcagtttt ttaattatgt
     5281 atgtctgaaa tttgaccaaa aacattcttg ttttaaggtt agtttcttca gacattccta
     5341 acctgactgg tgatagtctt tagcacctca gttgtttttc agtataggat tttgctaaaa
     5401 tgaaagagct ttgtctttaa aaaagagatc aaggatccca aagaatacga ttctcatatg
     5461 tgagaaaatg ggaacctttt tgctaggaaa atgtcatttt taaggtatac ttaaaaatgt
     5521 atacagcatt aactaggaac aaaaacgtga ctgctctaat ttgcatgacg tttttctttt
     5581 atcttattta actttttacc ttccccagcc catttggggt tgttctaaac aatctcaatt
     5641 taatctgtcg tcagcaagac aataggacgt tttgctggtc acaacctagt ccagtcattt
     5701 aaaaagtcca cagtgcagtg cctgtccagt gttcagtgga gtttctggca ctggtacatc
     5761 tcaataggat ttctttttaa gagtactgta ctgtctcttg aagccagtca gggacttttt
     5821 aaactttaat gaatatggtg tgattcaaat gtcttctgat aacttgatgt tatttggagg
     5881 agtttttgtt ttgttttgtt ttgtgtgttt ttttaaatga taatatcatg ctgagttatc
     5941 tagacaatgt attatccttg atgaaatttt agatgtttgt ctgattacat tttaagatga
     6001 ttgagcttct acaagtataa ccatgaaatt ctagtttttt aagtatctta ctgcaactgt
     6061 atcatgtgtt ctcctcaact tggcttgagt ctcccttgca gtcagagttg aggccttctt
     6121 tgtcttcttt gtctcttttc tgctttcatc tcctgctttt cacccaactc tgccactgtt
     6181 ccagagtagg tgactaaact ttgattcttc ctttagctta acctttttct ccttctgttt
     6241 ccagttctct tcacagtact aatcacatgg gttcggcaat ctaagatgtc ttgatcagga
     6301 gtcaatcctt ttctatttgg agctgaatcc tagctttcat gtagaaatct acatgtatat
     6361 acaagaaatg tatttttatc tgcaggatga tattgtttca aataatttta ttaatagaat
     6421 taacttttca ggtattttct cttttaagtg tggttttaaa atgttaaatg aatttttata
     6481 catgatgcat tcaatggcta cttttttcct aattataaca cctttgaatg cattgtgtaa
     6541 atcaagtaag ataggattca atgaacagaa tttgattttg atgcttatta agagtaaacc
     6601 aatgaatttg aattttgata tcatgcttgg tacttggaat tggtatatac tttattaaag
     6661 cttggaaata cttagcattt gaatcgtaac tttcaccacg aaccatgtct tttgcctctt
     6721 ttgttaacca gattcaatca aagaaactgg atgccatagt gatttttctc tagtaggtgg
     6781 tttggaactt gattttaagg tgttttcaat gtgattttag tatttacggt aataaataaa
     6841 atttatacaa gtttcagaga a
//
