LOCUS       NM_001347445            9323 bp    mRNA    linear   ROD 23-DEC-2022
DEFINITION  Mus musculus mediator complex subunit 13-like (Med13l), transcript
            variant 1, mRNA.
ACCESSION   NM_001347445 XM_006530496
VERSION     NM_001347445.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 9323)
  AUTHORS   Hamada N, Iwamoto I, Nishikawa M and Nagata KI.
  TITLE     Expression Analyses of Mediator Complex Subunit 13-Like: A
            Responsible Gene for Neurodevelopmental Disorders during Mouse
            Brain Development
  JOURNAL   Dev Neurosci 43 (1), 43-52 (2021)
   PUBMED   33794529
  REMARK    GeneRIF: Expression Analyses of Mediator Complex Subunit 13-Like: A
            Responsible Gene for Neurodevelopmental Disorders during Mouse
            Brain Development.
REFERENCE   2  (bases 1 to 9323)
  AUTHORS   van Weerd JH, Mohan RA, van Duijvenboden K, Hooijkaas IB, Wakker V,
            Boukens BJ, Barnett P and Christoffels VM.
  TITLE     Trait-associated noncoding variant regions affect TBX3 regulation
            and cardiac conduction
  JOURNAL   Elife 9, e56697 (2020)
   PUBMED   32672536
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 9323)
  AUTHORS   Sardar S, Kanne K and Andersson A.
  TITLE     Analysis of Polymorphisms in the Mediator Complex Subunit 13-like
            (Med13L) Gene in the Context of Immune Function and Development of
            Experimental Arthritis
  JOURNAL   Arch Immunol Ther Exp (Warsz) 66 (5), 365-377 (2018)
   PUBMED   29951696
  REMARK    GeneRIF: this study shows that Med13L polymorphisms between the
            B10.RIII and RIIIS/J mouse strains do not affect immune phenotype,
            collagen-induced arthritis development and autoantibody production
            in these mice
REFERENCE   4  (bases 1 to 9323)
  AUTHORS   Dimitrova E, Kondo T, Feldmann A, Nakayama M, Koseki Y, Konietzny
            R, Kessler BM, Koseki H and Klose RJ.
  TITLE     FBXL19 recruits CDK-Mediator to CpG islands of developmental genes
            priming them for activation during lineage commitment
  JOURNAL   Elife 7, e37084 (2018)
   PUBMED   29809150
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 9323)
  AUTHORS   Miao YL, Gambini A, Zhang Y, Padilla-Banks E, Jefferson WN,
            Bernhardt ML, Huang W, Li L and Williams CJ.
  TITLE     Mediator complex component MED13 regulates zygotic genome
            activation and is required for postimplantation development in the
            mouse
  JOURNAL   Biol Reprod 98 (4), 449-464 (2018)
   PUBMED   29325037
REFERENCE   6  (bases 1 to 9323)
  AUTHORS   Musante L, Bartsch O, Ropers HH and Kalscheuer VM.
  TITLE     cDNA cloning and characterization of the human THRAP2 gene which
            maps to chromosome 12q24, and its mouse ortholog Thrap2
  JOURNAL   Gene 332, 119-127 (2004)
   PUBMED   15145061
  REMARK    GeneRIF: Transcripts were most abundant in heart.
REFERENCE   7  (bases 1 to 9323)
  AUTHORS   Okazaki N, Kikuno R, Ohara R, Inamoto S, Aizawa H, Yuasa S,
            Nakajima D, Nagase T, Ohara O and Koga H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: II. The complete nucleotide sequences of 400 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 10 (1), 35-48 (2003)
   PUBMED   12693553
REFERENCE   8  (bases 1 to 9323)
  AUTHORS   Stryke D, Kawamoto M, Huang CC, Johns SJ, King LA, Harper CA, Meng
            EC, Lee RE, Yee A, L'Italien L, Chuang PT, Young SG, Skarnes WC,
            Babbitt PC and Ferrin TE.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   9  (bases 1 to 9323)
  AUTHORS   Ito M, Okano HJ, Darnell RB and Roeder RG.
  TITLE     The TRAP100 component of the TRAP/Mediator complex is essential in
            broad transcriptional events and development
  JOURNAL   EMBO J 21 (13), 3464-3475 (2002)
   PUBMED   12093747
REFERENCE   10 (bases 1 to 9323)
  AUTHORS   Araki K, Imaizumi T, Sekimoto T, Yoshinobu K, Yoshimuta J, Akizuki
            M, Miura K, Araki M and Yamamura K.
  TITLE     Exchangeable gene trap using the Cre/mutated lox system
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 45 (5), 737-750 (1999)
   PUBMED   10512203
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC129552.20 and AC117585.8.
            
            [WARNING] On Apr 18, 2023 this sequence was replaced by
            NM_001347445.2.
            
            On Nov 30, 2016 this sequence version replaced XM_006530496.3.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN00849374,
                              SAMN00849375 [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-139               AC129552.20        38717-38855
            140-377             AC129552.20        71331-71568
            378-462             AC129552.20        149011-149095
            463-546             AC117585.8         33745-33828
            547-692             AC117585.8         71340-71485
            693-887             AC117585.8         74232-74426
            888-1061            AC117585.8         74622-74795
            1062-1227           AC117585.8         76845-77010
            1228-1332           AC117585.8         79118-79222
            1333-2064           AC117585.8         81005-81736
            2065-2290           AC117585.8         82627-82852
            2291-2396           AC117585.8         83769-83874
            2397-2521           AC117585.8         84185-84309
            2522-2621           AC117585.8         86816-86915
            2622-2842           AC117585.8         91172-91392
            2843-3048           AC117585.8         91652-91857
            3049-3998           AC117585.8         94683-95632
            3999-4178           AC117585.8         97866-98045
            4179-4402           AC117585.8         98499-98722
            4403-4595           AC117585.8         100176-100368
            4596-5013           AC117585.8         101421-101838
            5014-5233           AC117585.8         102466-102685
            5234-5422           AC117585.8         103703-103891
            5423-5646           AC117585.8         104388-104611
            5647-5816           AC117585.8         104697-104866
            5817-5975           AC117585.8         107120-107278
            5976-6152           AC117585.8         108396-108572
            6153-6310           AC117585.8         109934-110091
            6311-6472           AC117585.8         111959-112120
            6473-6585           AC117585.8         114143-114255
            6586-9323           AC117585.8         115558-118295
FEATURES             Location/Qualifiers
     source          1..9323
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5"
     gene            1..9323
                     /gene="Med13l"
                     /gene_synonym="2210413I17Rik; 6330591G05Rik;
                     9030618F05Rik; mKIAA1025; Thrap2; Trap240L"
                     /note="mediator complex subunit 13-like"
                     /db_xref="GeneID:76199"
                     /db_xref="MGI:MGI:2670178"
     exon            1..139
                     /gene="Med13l"
                     /gene_synonym="2210413I17Rik; 6330591G05Rik;
                     9030618F05Rik; mKIAA1025; Thrap2; Trap240L"
                     /inference="alignment:Splign:2.1.0"
     CDS             68..6718
                     /gene="Med13l"
                     /gene_synonym="2210413I17Rik; 6330591G05Rik;
                     9030618F05Rik; mKIAA1025; Thrap2; Trap240L"
                     /note="isoform 1 is encoded by transcript variant 1;
                     mediator of RNA polymerase II transcription subunit
                     13-like; thyroid hormone receptor-associated protein
                     complex 240 kDa component-like; thyroid hormone receptor
                     associated protein 2"
                     /codon_start=1
                     /product="mediator of RNA polymerase II transcription
                     subunit 13-like isoform 1"
                     /protein_id="NP_001334374.1"
                     /db_xref="CCDS:CCDS84948.1"
                     /db_xref="GeneID:76199"
                     /db_xref="MGI:MGI:2670178"
                     /translation="MTAAANWVANGASLEDCHSNLFSLAELTGIKWRRYNFGGHGDCG
                     PIISAPAQDDPILLSFIRCLQANLLCVWRRDVKPDCKELWIFWWGDEPNLVGVIHHEL
                     QVVEEGLWENGLSYECRTLLFKAIHNLLERCLMDKNFVRIGKWFVRPYDKDEKPVNKS
                     EHLSCAFTFFLHGESNVCTSVEIAQHQPIYLINEEHLHMAQSSPAPFQVLVSPYGLNG
                     TLTGHAYKMSDPAARKLIEEWHCFYPMVLRKREEPREEAELGYDDDFPVAVEVIVGGV
                     RMVYPSAFVLVSQNDIPVPQSGHGTVAQQGLGSVKDPSNCGMPLTPPTSPEQVVIGES
                     GGVQSAASHLGSQDGGMSTMHSPKRSRKTPPKLHSHMVRRVWRECILSRAQSKRSQMS
                     TPTREEEAAHSPAAWDFVDPTQRVSCSCSRHKLLKRCAVGPSRPPAISQPGFSAGLPS
                     SSSLPPPASSKHKTTERQEKGDKLQKRPLVPFHHRPSVAEELCVEQDAPGQKLGLAGI
                     DASLEVSNTRKYDKQMAVPSRNTSKQMNLNPMDSPHSPISPLPPTLSPQPRGQEAESL
                     DPPSVPVNPALYGNGLDLQQLSTIEDRTVLVGQRLPLMAEASETALYSGLRPSYTESS
                     DRWWQSFRLPSSEDAEFRPPELQGERFDTALDLNPESTALQRLLAQPNKRFKIWQDEQ
                     PQVQPLPFLDPSPLSQQPGDTLGEVNDPYTFEDGDIKYIFTANKKCKQGTEKDSLKKN
                     KSEDGFGTKDVTTPGHSTPVPDGKNAMSIFSSATKTDVRQDSAAGRAGSGSLTQVTDL
                     APSLHDLDNIFDNSDEDELGAVSPALRSSKMPTVGTEERPPGKDGRAAGPYPPTVADL
                     QRMFPTPPSLEQHPAFSPVMNYKDGVSSETVTALGMMESPVVSMVPTHLTEFRMEVED
                     GLGSPKPEEIKDFSYVHKVPQFQPFVGSSMFAPLKTLPSHCLLPLKTPDACLFRPSWA
                     VPPKMEQLPMPPAASSIRDGYNNVPSVGSLADPDYLNTPQMNTPVTLNSAAPASNSGA
                     GVLPSPATPRFSVPTPRTPRTPRTPRGGGTASGQGSVKYDSTDQGSPASTPSTTRPLN
                     SVEPATMQPIPEAHSLYVTLILSDSVMNVFKDRNFDSCCICACNMNIKGADVGLYIPD
                     SSKEDQYRCTCGFSAIVNRKLGYNSGLFLEDELDIFGKNSDIGQAAERRLMMCQSSGQ
                     STLLPQVEGARKAPEPPVSLLLLLQNQHTQPFASLSFLDYISSANRHALPCVSWTYDR
                     VQADNNDYWTECFNALEQGRQYVDNPTGGKVDEALVRSATVHCWPHSNVLDTSMLSSQ
                     DVVRMLLSLQPFLQDAIQKKRTGRTWENIQHVQGPLTWQQFHKMAGRGTYGSEESPEP
                     LPIPTLLVGYDKEFLTISPFSLPFWERLLLEPYGGHRDVAYIVVCPENEALLEGAKTF
                     FRDLSAVYEMCRLGQHKPICKVLRDGIMRVGKTVAQKLTEELVSEWFNQPWSSEESDN
                     HSRLKLYAQVCRHHLAPYLATLQLDSGLLMPPKHQSPPAEAQGQATPGNAGSLPSNSG
                     SGAPPAGSAFNPTSSSSANPTTSSSSASSGPPGSSAASAPGITQMNTTSSSGFGGGVG
                     GQNPSAGGSSTDRTPGNVACGDTEPGQSCTQSSQDGQDSVTERERIGIPTEPDSADSH
                     AYPPAVVIYMVDPFTYTAEEDSSSGNFWLLSLMRCYTEMLDHLPEHMRSSFILQIVPC
                     QYMLQTMKDEHVFYIQYLKSMAFSVYCQCRRPLPTQIHIKSLTGFGPAASIEMTLKNP
                     ERPSPIQLYSPPFILAPIKDKQTEPGETFGEASQKYNVLFVGYCLSHDQRWLLASCTD
                     LHGELLETCVVNIALPSRTLHVPLSVRSRKSKVSARKVGLQKLWEWCLGIVQMTSLPW
                     RVVIGRLGRLGHGELKDWSILLGECSLQTISKQLKDVCRMCGISAADSPSILSACLVA
                     MEPQGSFVVMPDAVTMGSVFGRSTALNMQSSQLNTPQDASCTHILVFPTSSTIQVAPA
                     NYPNEDGFSPNNDDMFVDLPFPDDMDNDIGILMTGNLHSSPNSSPVPSPGSPSGIGVG
                     SHFQHSRSQGERLLSREAPEELKQQPLALGYFVSTAKAENLPQWFWSSCPQARNQCPL
                     FLKASLHHHISVAQTDELLPARTSQRAPHPLDSKTTSDVLRFVLEQYNALSWLTCNPA
                     TQDRTSCLPVHFVVLTQLYNAIMNML"
     exon            140..377
                     /gene="Med13l"
                     /gene_synonym="2210413I17Rik; 6330591G05Rik;
                     9030618F05Rik; mKIAA1025; Thrap2; Trap240L"
                     /inference="alignment:Splign:2.1.0"
     exon            378..462
                     /gene="Med13l"
                     /gene_synonym="2210413I17Rik; 6330591G05Rik;
                     9030618F05Rik; mKIAA1025; Thrap2; Trap240L"
                     /inference="alignment:Splign:2.1.0"
     exon            463..546
                     /gene="Med13l"
                     /gene_synonym="2210413I17Rik; 6330591G05Rik;
                     9030618F05Rik; mKIAA1025; Thrap2; Trap240L"
                     /inference="alignment:Splign:2.1.0"
     exon            547..692
                     /gene="Med13l"
                     /gene_synonym="2210413I17Rik; 6330591G05Rik;
                     9030618F05Rik; mKIAA1025; Thrap2; Trap240L"
                     /inference="alignment:Splign:2.1.0"
     exon            693..887
                     /gene="Med13l"
                     /gene_synonym="2210413I17Rik; 6330591G05Rik;
                     9030618F05Rik; mKIAA1025; Thrap2; Trap240L"
                     /inference="alignment:Splign:2.1.0"
     exon            888..1061
                     /gene="Med13l"
                     /gene_synonym="2210413I17Rik; 6330591G05Rik;
                     9030618F05Rik; mKIAA1025; Thrap2; Trap240L"
                     /inference="alignment:Splign:2.1.0"
     exon            1062..1227
                     /gene="Med13l"
                     /gene_synonym="2210413I17Rik; 6330591G05Rik;
                     9030618F05Rik; mKIAA1025; Thrap2; Trap240L"
                     /inference="alignment:Splign:2.1.0"
     exon            1228..1332
                     /gene="Med13l"
                     /gene_synonym="2210413I17Rik; 6330591G05Rik;
                     9030618F05Rik; mKIAA1025; Thrap2; Trap240L"
                     /inference="alignment:Splign:2.1.0"
     exon            1333..2064
                     /gene="Med13l"
                     /gene_synonym="2210413I17Rik; 6330591G05Rik;
                     9030618F05Rik; mKIAA1025; Thrap2; Trap240L"
                     /inference="alignment:Splign:2.1.0"
     exon            2065..2290
                     /gene="Med13l"
                     /gene_synonym="2210413I17Rik; 6330591G05Rik;
                     9030618F05Rik; mKIAA1025; Thrap2; Trap240L"
                     /inference="alignment:Splign:2.1.0"
     exon            2291..2396
                     /gene="Med13l"
                     /gene_synonym="2210413I17Rik; 6330591G05Rik;
                     9030618F05Rik; mKIAA1025; Thrap2; Trap240L"
                     /inference="alignment:Splign:2.1.0"
     exon            2397..2521
                     /gene="Med13l"
                     /gene_synonym="2210413I17Rik; 6330591G05Rik;
                     9030618F05Rik; mKIAA1025; Thrap2; Trap240L"
                     /inference="alignment:Splign:2.1.0"
     exon            2522..2621
                     /gene="Med13l"
                     /gene_synonym="2210413I17Rik; 6330591G05Rik;
                     9030618F05Rik; mKIAA1025; Thrap2; Trap240L"
                     /inference="alignment:Splign:2.1.0"
     exon            2622..2842
                     /gene="Med13l"
                     /gene_synonym="2210413I17Rik; 6330591G05Rik;
                     9030618F05Rik; mKIAA1025; Thrap2; Trap240L"
                     /inference="alignment:Splign:2.1.0"
     exon            2843..3048
                     /gene="Med13l"
                     /gene_synonym="2210413I17Rik; 6330591G05Rik;
                     9030618F05Rik; mKIAA1025; Thrap2; Trap240L"
                     /inference="alignment:Splign:2.1.0"
     exon            3049..3998
                     /gene="Med13l"
                     /gene_synonym="2210413I17Rik; 6330591G05Rik;
                     9030618F05Rik; mKIAA1025; Thrap2; Trap240L"
                     /inference="alignment:Splign:2.1.0"
     exon            3999..4178
                     /gene="Med13l"
                     /gene_synonym="2210413I17Rik; 6330591G05Rik;
                     9030618F05Rik; mKIAA1025; Thrap2; Trap240L"
                     /inference="alignment:Splign:2.1.0"
     exon            4179..4402
                     /gene="Med13l"
                     /gene_synonym="2210413I17Rik; 6330591G05Rik;
                     9030618F05Rik; mKIAA1025; Thrap2; Trap240L"
                     /inference="alignment:Splign:2.1.0"
     exon            4403..4595
                     /gene="Med13l"
                     /gene_synonym="2210413I17Rik; 6330591G05Rik;
                     9030618F05Rik; mKIAA1025; Thrap2; Trap240L"
                     /inference="alignment:Splign:2.1.0"
     exon            4596..5013
                     /gene="Med13l"
                     /gene_synonym="2210413I17Rik; 6330591G05Rik;
                     9030618F05Rik; mKIAA1025; Thrap2; Trap240L"
                     /inference="alignment:Splign:2.1.0"
     exon            5014..5233
                     /gene="Med13l"
                     /gene_synonym="2210413I17Rik; 6330591G05Rik;
                     9030618F05Rik; mKIAA1025; Thrap2; Trap240L"
                     /inference="alignment:Splign:2.1.0"
     exon            5234..5422
                     /gene="Med13l"
                     /gene_synonym="2210413I17Rik; 6330591G05Rik;
                     9030618F05Rik; mKIAA1025; Thrap2; Trap240L"
                     /inference="alignment:Splign:2.1.0"
     exon            5423..5646
                     /gene="Med13l"
                     /gene_synonym="2210413I17Rik; 6330591G05Rik;
                     9030618F05Rik; mKIAA1025; Thrap2; Trap240L"
                     /inference="alignment:Splign:2.1.0"
     exon            5647..5816
                     /gene="Med13l"
                     /gene_synonym="2210413I17Rik; 6330591G05Rik;
                     9030618F05Rik; mKIAA1025; Thrap2; Trap240L"
                     /inference="alignment:Splign:2.1.0"
     exon            5817..5975
                     /gene="Med13l"
                     /gene_synonym="2210413I17Rik; 6330591G05Rik;
                     9030618F05Rik; mKIAA1025; Thrap2; Trap240L"
                     /inference="alignment:Splign:2.1.0"
     exon            5976..6152
                     /gene="Med13l"
                     /gene_synonym="2210413I17Rik; 6330591G05Rik;
                     9030618F05Rik; mKIAA1025; Thrap2; Trap240L"
                     /inference="alignment:Splign:2.1.0"
     exon            6153..6310
                     /gene="Med13l"
                     /gene_synonym="2210413I17Rik; 6330591G05Rik;
                     9030618F05Rik; mKIAA1025; Thrap2; Trap240L"
                     /inference="alignment:Splign:2.1.0"
     exon            6311..6472
                     /gene="Med13l"
                     /gene_synonym="2210413I17Rik; 6330591G05Rik;
                     9030618F05Rik; mKIAA1025; Thrap2; Trap240L"
                     /inference="alignment:Splign:2.1.0"
     exon            6473..6585
                     /gene="Med13l"
                     /gene_synonym="2210413I17Rik; 6330591G05Rik;
                     9030618F05Rik; mKIAA1025; Thrap2; Trap240L"
                     /inference="alignment:Splign:2.1.0"
     exon            6586..9323
                     /gene="Med13l"
                     /gene_synonym="2210413I17Rik; 6330591G05Rik;
                     9030618F05Rik; mKIAA1025; Thrap2; Trap240L"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgccgccgcc gcccggcccg gcccgctccg acatgccccg ctctggcggc cgggctcgcg
       61 gaggaccatg accgccgcgg cgaactgggt agcgaacggg gcgagcctgg aggattgtca
      121 ctccaacctc ttctcgctgg ctgaactcac aggaatcaaa tggcgtaggt acaattttgg
      181 agggcacggg gactgtggac ccataatttc agccccagcc caagatgatc caatcctgtt
      241 aagtttcatc cgctgtctgc aagccaacct gctgtgtgta tggcgtcgtg atgtcaagcc
      301 agattgcaaa gagctctgga tattctggtg gggagatgaa cccaacctag tgggagtaat
      361 acatcatgaa ctgcaggttg tggaagaagg actctgggaa aatggccttt cctatgaatg
      421 taggacgctg ctcttcaaag caatccacaa tctgttagaa aggtgcctaa tggataagaa
      481 cttcgtgcgg atcgggaagt ggtttgtgcg gccctatgac aaggatgaaa agccagtcaa
      541 caaaagtgag catctttcct gtgctttcac attcttcctt catggagaga gtaacgtgtg
      601 cacaagtgtg gagatagctc agcaccagcc gatctatttg atcaacgagg aacacttaca
      661 catggcccaa tcttcacctg caccatttca agtactggtg agtccttacg gcttaaatgg
      721 cacactaaca gggcatgcat acaagatgtc tgacccggcc gcccgcaagc tgattgagga
      781 atggcactgt ttctacccga tggtgctgag gaagagggag gagcctcgag aagaggctga
      841 gctggggtat gacgacgact tcccggtggc agttgaagtc attgttggtg gcgtccggat
      901 ggtctaccct tcggctttcg tgttggtctc tcagaatgac atcccagttc ctcagagtgg
      961 gcacggcaca gttgcacagc aggggcttgg tagtgtgaaa gaccccagta actgtgggat
     1021 gcctctgacg cctcccacct ccccagagca ggtggttata ggagagagcg gaggtgtgca
     1081 gagtgctgcc agtcacctcg gttcccagga tggagggatg tcaactatgc acagtccgaa
     1141 gagatcaagg aagacccctc ctaaactgca cagtcacatg gtccgtcgag tctggcggga
     1201 gtgcatcctc agccgagccc agtctaagag gagccagatg tcgacgccca ctcgggaaga
     1261 agaggctgct cacagtcctg ctgcctggga ttttgtggac ccaacccaaa gagtcagctg
     1321 ctcctgctcc aggcataaac tgttaaaacg gtgtgcagta ggacccagcc gacctcccgc
     1381 catctctcag ccaggcttca gtgcaggact gccatcatct tcatccttac caccccctgc
     1441 ttcttccaag cacaaaacca cagaaagaca agaaaaagga gacaagttgc aaaagagacc
     1501 cttggtgccc tttcaccata ggccctctgt ggccgaagaa ttatgcgtgg agcaggatgc
     1561 gcctgggcag aagctagggc tggcagggat agacgcctcc ttagaggtgt cgaacactcg
     1621 aaagtatgat aagcaaatgg ccgtgccttc cagaaataca agcaagcaaa tgaatctgaa
     1681 tcctatggat tctcctcatt cccccatctc ccctctgccc cccacactca gccctcagcc
     1741 acgaggtcag gaggcagaga gtttggaccc accttctgtc cctgtgaacc ctgccctcta
     1801 tggaaatggg ctagaccttc agcagctgtc tactatagag gacagaactg tcctcgtagg
     1861 ccaaagactg cctctgatgg cagaggccag tgagacagcc ttgtacagtg ggctcaggcc
     1921 ttcatacacc gagtcgtcag acaggtggtg gcagagtttt cgtctcccat ccagtgagga
     1981 tgctgagttc cggcctccag agctgcaggg ggagaggttt gacactgccc tggacctgaa
     2041 tcccgagagc acggccctgc aaagactctt agcacaacct aacaagcggt tcaaaatctg
     2101 gcaggatgag cagcctcagg tgcagcctct ccccttcctc gacccatcac ctctgtccca
     2161 gcagcctgga gacactctgg gagaagtcaa cgacccatac acctttgagg atggcgacat
     2221 aaagtacatc ttcacagcaa ataagaaatg caagcagggg acggagaagg actccctgaa
     2281 aaagaacaag tcagaggatg gatttggtac caaggatgtc actacaccag gtcattccac
     2341 gccggtgcct gatgggaaaa atgccatgtc tattttcagt tctgctacta aaacagatgt
     2401 ccggcaggac agcgctgctg gcagagccgg ctctgggagc cttacccagg tgacagattt
     2461 ggcaccttcc ctgcacgact tagacaacat ctttgataac tctgatgaag acgagcttgg
     2521 ggccgtgtcc cctgctctac gttcatccaa gatgcctact gttgggactg aggagcggcc
     2581 ccctgggaag gacggaagag ctgctggccc ttaccctcca acagttgcag acttgcaaag
     2641 gatgttcccc acccctccgt cattggaaca gcaccctgca ttttctcctg tgatgaacta
     2701 taaagatgga gtaagttcag agacagtgac tgcactgggc atgatggaga gtcccgtggt
     2761 cagcatggtc cccacacacc tcacggagtt taggatggaa gtggaagatg gcttaggaag
     2821 ccccaagcca gaggagataa aggacttttc ctatgtgcac aaagtgccgc agttccagcc
     2881 tttcgtggga tcctccatgt ttgctccact gaagacgctg ccgagccatt gcctgctgcc
     2941 tctgaagaca cctgacgcct gtctgttccg gccctcatgg gcggtccctc ctaagatgga
     3001 acagctgccc atgccccctg cagcctcttc tattagagac ggctacaata acgtgcctag
     3061 tgtcgggagc cttgcagacc cagactatct gaacacacca cagatgaaca cacctgtgac
     3121 actcaacagc gccgcccctg ccagcaacag tggagctgga gttctcccat ctccagctac
     3181 ccctcggttc tctgtcccca caccacgaac ccccaggact ccaagaactc ccagaggtgg
     3241 gggcactgct agtggccaag ggtctgtgaa atatgacagc acagatcagg ggtcaccagc
     3301 ttccaccccc tctaccacaa ggccccttaa ctctgtggag cctgccacca tgcagccaat
     3361 tcctgaggcc cacagtctct atgtcaccct cattctgtca gattctgtga tgaatgtctt
     3421 caaggacagg aactttgaca gctgttgcat ttgtgcctgc aacatgaaca tcaaaggggc
     3481 agatgtcggg ctgtacatcc ccgattcctc caaggaggac cagtaccgct gcacctgtgg
     3541 gtttagtgcg atcgtgaacc gtaaacttgg ctacaactcg gggctcttcc tcgaagatga
     3601 gctggatatt tttggcaaga attctgacat cggccaagct gcagaaagac gcctgatgat
     3661 gtgccagtcc tccggccagt ccaccttgct tcctcaggtg gagggtgccc ggaaagcccc
     3721 agagcccccc gtaagcctcc tcctcctcct tcagaatcag cacacgcagc ccttcgcttc
     3781 tctcagcttc ctggattaca tctcctccgc caatcgccat gcactcccct gtgtgagctg
     3841 gacttatgac cgtgtgcagg cagataacaa tgattactgg acagagtgct tcaacgcatt
     3901 ggaacagggg aggcaatatg tggataatcc cacaggcggg aaagtggacg aggctctggt
     3961 gagaagtgcc accgtacatt gttggccgca cagcaacgtg ctggacacaa gcatgctctc
     4021 atcccaagat gtggtgcgca tgctgctgtc cctgcagccc ttcctgcagg atgccatcca
     4081 gaagaagcgc acgggcagga cctgggagaa catccagcat gtgcaggggc cgctcacctg
     4141 gcagcagttc cataagatgg cggggcgcgg gacctacggt tccgaagagt ctcctgagcc
     4201 gctgcccatc cccactctgc tggtgggcta cgacaaggag ttcttgacca tctcgccctt
     4261 ctccttgccc ttctgggaga ggctgctctt ggagccctat gggggccacc gtgatgttgc
     4321 ttatattgtg gtgtgtccag aaaatgaggc cttgctcgaa ggagccaaaa ctttcttcag
     4381 ggacttgagt gctgtatatg agatgtgtcg gctgggacag cacaagccca tctgcaaagt
     4441 gctccgtgat gggatcatgc gtgtgggcaa gaccgtggcg cagaagctga cagaggagct
     4501 tgtgagcgag tggtttaacc agccatggag cagtgaggag agtgacaatc attccagact
     4561 caaactttat gctcaagttt gccgccatca cctagcacct tatttagcca ctctgcagct
     4621 cgacagtggc ctgctgatgc cacctaagca ccagagccca ccagcagaag cacagggaca
     4681 agccacgcct gggaatgctg ggtctttacc ttcgaattca ggctcaggag cacctccagc
     4741 tggcagtgca ttcaatccca cctccagcag ctctgcaaac cccacaacaa gtagttcatc
     4801 tgcctcctct gggccgccag gctcctcagc tgcctctgct ccaggcatca ctcagatgaa
     4861 cactacctct tcttcaggat tcggtggtgg tgttggaggg cagaacccca gtgcgggggg
     4921 cagctctaca gatcgaaccc cagggaatgt ggcttgtgga gacactgagc ctgggcagag
     4981 ctgcacccag tcctcacagg atggacaaga cagtgttaca gagagggaga gaataggaat
     5041 ccccacggag cctgactctg cagacagcca tgcctaccct ccagccgtcg tcatttacat
     5101 ggtggacccc ttcacctaca ctgcggagga ggactccagc tctggaaact tctggctgct
     5161 gagcttgatg cgctgctaca cggagatgct ggatcactta cccgagcaca tgagaagctc
     5221 gttcattctc cagattgtgc cttgccagta catgctgcag accatgaagg atgagcatgt
     5281 cttctacatt caatacttga agtccatggc gttctcagtg tactgccagt gcaggcggcc
     5341 tctgcctaca cagatccaca ttaaatccct cacaggcttc gggcctgcag ccagcattga
     5401 gatgaccctc aagaacccgg agcggcccag tccaatccag ctttattccc ctccctttat
     5461 attggctcca atcaaagaca agcagacaga accgggagag acctttggtg aggcgagcca
     5521 gaaatacaat gtgctctttg tgggctattg tctgtctcat gaccagcgct ggctcttggc
     5581 atcctgcact gacctgcatg gggagttact ggagacctgt gttgtaaaca ttgctttacc
     5641 gagcaggacc cttcatgttc ctctgtctgt caggtcacgg aagagtaaag tgtctgcacg
     5701 gaaggtcggg ctgcagaagc tgtgggagtg gtgcctgggc attgtccaga tgacttctct
     5761 gccctggaga gttgtcattg gccgcttggg gcgtcttggc cacggggagc tgaaagattg
     5821 gagtatcctc cttggagaat gttcactgca gacaatcagc aaacagctca aggatgtgtg
     5881 ccgaatgtgt gggatctctg ctgcagactc tccttccatc ctcagtgcct gcttggttgc
     5941 catggagccc caggggtcct ttgtagtgat gccagatgct gtcacaatgg gctctgtgtt
     6001 tggccgaagc actgcattga atatgcagtc gtcccagctg aacacacctc aggacgcctc
     6061 ctgcacccac atcttggtgt tcccgacatc atcaaccatc caggtggctc cagccaacta
     6121 ccccaatgag gatgggttta gccccaacaa tgatgacatg tttgtagacc ttccattccc
     6181 agacgacatg gacaatgaca ttggcatcct catgaccggg aacctccact cctctcccaa
     6241 ctcctctccg gttccctccc cgggctctcc ctctggaatc ggtgtgggct ctcacttcca
     6301 gcacagtcgg agccagggag agcggcttct gtctcgggag gctccagagg aactcaagca
     6361 gcagcccctg gcccttgggt attttgtgtc cactgccaaa gcggagaacc tcccgcagtg
     6421 gttttggtca tcgtgccccc aggcccggaa ccagtgccca ctcttcctga aggcttccct
     6481 gcatcaccac atctctgtag cgcagaccga tgagctcctt cctgccagga cctctcagcg
     6541 ggctccacac cctctggact ccaagaccac atctgacgtt ctaaggtttg tgctggagca
     6601 gtacaacgcc ctatcctggc tcacgtgcaa tccagccacc caggaccgca cttcctgcct
     6661 tcccgtccac ttcgtggtgc tcacgcagct gtacaatgcc atcatgaaca tgctctaacc
     6721 gggaagggaa gcgcttgccc tctgcctcag ctcctcctgc agccttggcc agggagcctg
     6781 ctccactctg caaatgcccg gcctttttta gagcactccc tataccccgc actgtgacgc
     6841 cttctgagca ggctcatgct cctcctgcag tgttcattgc cacagtgact tcttgacgtg
     6901 tctcacgagg acctggaaat ttccataagc agtgacttga gccaatgtgt gatatgtgca
     6961 gcctgcagtc cccgggaagt ggcggctgtt ggtggctgaa gaggcaagga gaagagacac
     7021 cgtccttttg cacaagagcc tgctctcagc ctctgtttag taccaggctg tccagccctc
     7081 tgaatgcaat cctctagcca atggtggatg cctgggggtc tcccatactt cataacctgg
     7141 gatgtgtcac aactaagagc cagctccagg acaggatcta gtgctggggc ctctgcctcc
     7201 cccgcctgtc aggagggttt tagttgatgg cacacctgtg tagacacagg aggtctgggg
     7261 acagctgcat tctgtttatt tatttttcat tttgttgtaa gtttttttgc gactttgttt
     7321 tttctaatct tgaggaccag gtacagtagc tgaagcccac tgagacccac cgtaggattc
     7381 tctgagtaca tacctctgtc ctagaagcca agaaaggagt gagaagaagc ggggaggcca
     7441 cctagtggta gactcggtca gacagtctgt ggctgcagcc tgtgtaggtt gcacccctat
     7501 atgaagatgg tcaggctcag ccccgagctg gaggcaagga ccttcatcac ttctctatac
     7561 agtcacatgg aaataccttt tctagagaat tcttacagaa agccaggtct ctcctttcat
     7621 tagatcaaaa gggactcgtg tacatatcac aaccaaagtg tttgctcacg aaaccagtta
     7681 caaacacagt gaattttttc tggaccatag gaatattgtt tcaaagaaat agtgcaactc
     7741 aaccgttaca tcagtacttg aagctgagcc tctatgtggg actttaaaaa aaaaaaaaaa
     7801 agccttttta aagcattcgc agctgattga agtattcttg actccctgtc ccagacctta
     7861 gggttgactt tgaaaccctg tttctagccc ttatgtcgta tgtttctgtc tgtgggtggt
     7921 gggtgtagac cggcttccca gagcctcctg acaggcccgg cactgagccc ggctcccgtg
     7981 ggagagtcat gcaaactaag ttcttccaag agactttcat gtcctggtta ttaacaaaga
     8041 aaaggaaaaa aatgtaataa ttgatatggt tttgtaaaag tatttttctt gagataatct
     8101 aacgtttaaa acattatatt aacatgtggt ggggatgtga aagcagagaa ataacttgta
     8161 catgggtgac tgttctctgt ctcaccaact gggggggttg ctttccaatg tatagcttaa
     8221 aaaatctgat atatcaaacc gtttgtatct aacgtgtaca gtgtaaaatt gacttaaaat
     8281 atcgcagtgc tattttttct tatcagcgag gaaatcctca aggccttttg aagagcgtaa
     8341 gatgacggag atgtaaactt gtataaagtc acctcgggga ggacgggctg taaactagat
     8401 atttgtaatc tttaccactt gggattgctt cctctcagag ttcaccagaa ctttgaattt
     8461 ctctctctct ctctcttttt taaatgggct gtttttactg caggggcttt tcttccctag
     8521 aaacccaact ctacgcagaa aaagtgaaaa ggaaaaaaaa aacacaaaaa aaaccagaaa
     8581 aaaaagctat aaaaagtttt aaaagaaggc agcaaagggt agtttccatc tggtgtcttt
     8641 tatttaagtt ttttaagtta agaaaagctg gtgacatatt tatacgtttt tgtgcaaaaa
     8701 ataaatgaat ggcaatagat ttaaagaaat cttattatgt acttctgtgt gcaaaagtct
     8761 gtataatatt tcccctaaat atgcattatt ttacctgtga gttttttaca gaattaatct
     8821 gaaatgtaca agccctggat ttgctacaga gtgagaagtt attttatttt attttttttt
     8881 tattttttat tttgagaaaa ctgcagaaat cagaactcct accatggttt gaaaagggag
     8941 gcgggagggg aggcgggagg gctggtccgg catgcctgta tgtatctctc aagagccttt
     9001 tttttaaaat gtaaaagctg tacatttttg ggaagttctg attttctttt tctttttttt
     9061 tttctttttg tttcctttta ccttcaagca ttttgcagtg cgcttctttt atatctagca
     9121 gacaattgga aagaaataca aaacctatgt gacgttcatt taagaaccac agcccagtgc
     9181 tggttcaata cactaaagac tttgataaaa gagaatcaat ggcaaaggtc tccattttaa
     9241 atgtcattca tatatacctt gtggatgaga gctatatact tttacacact tttttagagg
     9301 aataaattat tgaattactg aaa
//
