LOCUS       NM_025397                908 bp    mRNA    linear   ROD 12-FEB-2025
DEFINITION  Mus musculus mediator complex subunit 11 (Med11), mRNA.
ACCESSION   NM_025397
VERSION     NM_025397.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 908)
  AUTHORS   Kolonay,D.W., Sattler,K.M., Strawser,C., Rafael-Fortney,J.,
            Mihaylova,M.M., Miller,K.E., Lepper,C. and Baskin,K.K.
  TITLE     Temporal regulation of the Mediator complex during muscle
            proliferation, differentiation, regeneration, aging, and disease
  JOURNAL   Front Cell Dev Biol 12, 1331563 (2024)
   PUBMED   38690566
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 908)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 908)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
REFERENCE   4  (bases 1 to 908)
  AUTHORS   Tsai,K.L., Tomomori-Sato,C., Sato,S., Conaway,R.C., Conaway,J.W.
            and Asturias,F.J.
  TITLE     Subunit architecture and functional modular rearrangements of the
            transcriptional mediator complex
  JOURNAL   Cell 157 (6), 1430-1444 (2014)
   PUBMED   24882805
  REMARK    Erratum:[Cell. 2014 Jul 17;158(2):463]
REFERENCE   5  (bases 1 to 908)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   6  (bases 1 to 908)
  AUTHORS   Tomomori-Sato,C., Sato,S., Parmely,T.J., Banks,C.A., Sorokina,I.,
            Florens,L., Zybailov,B., Washburn,M.P., Brower,C.S., Conaway,R.C.
            and Conaway,J.W.
  TITLE     A mammalian mediator subunit that shares properties with
            Saccharomyces cerevisiae mediator subunit Cse2
  JOURNAL   J Biol Chem 279 (7), 5846-5851 (2004)
   PUBMED   14638676
REFERENCE   7  (bases 1 to 908)
  AUTHORS   Mittler,G., Kremmer,E., Timmers,H.T. and Meisterernst,M.
  TITLE     Novel critical role of a human Mediator complex for basal RNA
            polymerase II transcription
  JOURNAL   EMBO Rep 2 (9), 808-813 (2001)
   PUBMED   11559591
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY171915.1, AK008153.1 and CF740526.1.
            
            On Jan 25, 2019 this sequence version replaced NM_025397.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC025057.1, AK003984.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-363               BY171915.1         2-364
            364-715             AK008153.1         369-720
            716-908             CF740526.1         339-531
FEATURES             Location/Qualifiers
     source          1..908
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 42.99 cM"
     gene            1..908
                     /gene="Med11"
                     /gene_synonym="1110030J09Rik"
                     /note="mediator complex subunit 11"
                     /db_xref="GeneID:66172"
                     /db_xref="MGI:MGI:1913422"
     exon            1..146
                     /gene="Med11"
                     /gene_synonym="1110030J09Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             62..415
                     /gene="Med11"
                     /gene_synonym="1110030J09Rik"
                     /note="mediator of RNA polymerase II transcription,
                     subunit 11 homolog"
                     /codon_start=1
                     /product="mediator of RNA polymerase II transcription
                     subunit 11"
                     /protein_id="NP_079673.2"
                     /db_xref="CCDS:CCDS24947.1"
                     /db_xref="GeneID:66172"
                     /db_xref="MGI:MGI:1913422"
                     /translation="MATYSLANERLRALEDIEREIGAILQNAGTAILELSKEKTNERL
                     LDRQAAAFTTSVQHVEAELSAQIRYLTQVATGQPHEGSSYSSRKDCQMALKRVDYARL
                     KISDVARTCEQMLEN"
     exon            147..277
                     /gene="Med11"
                     /gene_synonym="1110030J09Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            278..908
                     /gene="Med11"
                     /gene_synonym="1110030J09Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      693..698
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Med11"
                     /gene_synonym="1110030J09Rik"
                     /note="hexamer: AATAAA"
     polyA_site      716
                     /gene="Med11"
                     /gene_synonym="1110030J09Rik"
                     /note="major polyA site"
     regulatory      879..884
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Med11"
                     /gene_synonym="1110030J09Rik"
                     /note="hexamer: AATAAA"
     polyA_site      908
                     /gene="Med11"
                     /gene_synonym="1110030J09Rik"
                     /note="major polyA site"
ORIGIN      
        1 atttccgggc tgtggcgcca cacctcgcaa aagacggcct gtggggcttt ccactggaac
       61 gatggctacc tacagtctgg cgaacgagcg gctgcgcgcc ctggaggata tcgagcgtga
      121 aatcggcgcc atcctccaga acgcaggaac ggcgatcctg gaactgtcca aggaaaagac
      181 taacgagcgg ctcctcgacc ggcaggcggc agccttcacc acttctgtgc agcacgtgga
      241 ggcagagcta tccgctcaaa tccgctacct cactcaggtg gccacagggc agccgcatga
      301 gggctccagc tactcttcca ggaaggactg tcaaatggct ctaaagcgag tagactacgc
      361 ccgcctcaag attagtgatg tggcgagaac ctgtgagcag atgctggaga actgagttcg
      421 gatgatccag agtgtgccct gcaccagaga ccgtaggatg gggagcagtg catcatacac
      481 gtgccctact ggtcagggca gacgaggacc acaaggcaga aaggagaact gaagaatcca
      541 aagccccagt gtacacacat ctcttctgac tcttccagca agacggccct gttttccact
      601 atgcaagatc agacagaggt cagaggtcaa ctcccaaccc acttcctcat gtgcaccctg
      661 ccctggagtt tcagaagact tggcccaata aaaataaatg tgttcttata agcacacaca
      721 gtggctcaca cctgtaggcc cggtacttgg gaagtagagg tgggaagatt gctgtagttt
      781 gagaccaacc tgggctaagt acatagaggg accctccttc aaaaggggaa gttatgttcc
      841 tcattggaag aaacaaaaca ggaactaagt gttttaataa taaaagctgt atttttttat
      901 aaagctaa
//
