LOCUS       NM_138596                862 bp    mRNA    linear   ROD 18-FEB-2025
DEFINITION  Mus musculus mediator complex subunit 10 (Med10), transcript
            variant 1, mRNA.
ACCESSION   NM_138596 XM_906925
VERSION     NM_138596.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 862)
  AUTHORS   Kolonay,D.W., Sattler,K.M., Strawser,C., Rafael-Fortney,J.,
            Mihaylova,M.M., Miller,K.E., Lepper,C. and Baskin,K.K.
  TITLE     Temporal regulation of the Mediator complex during muscle
            proliferation, differentiation, regeneration, aging, and disease
  JOURNAL   Front Cell Dev Biol 12, 1331563 (2024)
   PUBMED   38690566
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 862)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 862)
  AUTHORS   Kagey,M.H., Newman,J.J., Bilodeau,S., Zhan,Y., Orlando,D.A., van
            Berkum,N.L., Ebmeier,C.C., Goossens,J., Rahl,P.B., Levine,S.S.,
            Taatjes,D.J., Dekker,J. and Young,R.A.
  TITLE     Mediator and cohesin connect gene expression and chromatin
            architecture
  JOURNAL   Nature 467 (7314), 430-435 (2010)
   PUBMED   20720539
  REMARK    Erratum:[Nature. 2011 Apr 14;472(7342):247]
REFERENCE   4  (bases 1 to 862)
  AUTHORS   Malik,S., Guermah,M., Yuan,C.X., Wu,W., Yamamura,S. and Roeder,R.G.
  TITLE     Structural and functional organization of TRAP220, the
            TRAP/mediator subunit that is targeted by nuclear receptors
  JOURNAL   Mol Cell Biol 24 (18), 8244-8254 (2004)
   PUBMED   15340084
  REMARK    Erratum:[Mol Cell Biol. 2022 Nov 17;42(11):e0035922. doi:
            10.1128/mcb.00359-22.. PMID: 36255214]
REFERENCE   5  (bases 1 to 862)
  AUTHORS   Mittler,G., Kremmer,E., Timmers,H.T. and Meisterernst,M.
  TITLE     Novel critical role of a human Mediator complex for basal RNA
            polymerase II transcription
  JOURNAL   EMBO Rep 2 (9), 808-813 (2001)
   PUBMED   11559591
REFERENCE   6  (bases 1 to 862)
  AUTHORS   Ko,M.S., Threat,T.A., Wang,X., Horton,J.H., Cui,Y., Wang,X.,
            Pryor,E., Paris,J., Wells-Smith,J., Kitchen,J.R., Rowe,L.B.,
            Eppig,J., Satoh,T., Brant,L., Fujiwara,H., Yotsumoto,S. and
            Nakashima,H.
  TITLE     Genome-wide mapping of unselected transcripts from extraembryonic
            tissue of 7.5-day mouse embryos reveals enrichment in the t-complex
            and under-representation on the X chromosome
  JOURNAL   Hum Mol Genet 7 (12), 1967-1978 (1998)
   PUBMED   9811942
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK013992.1.
            
            On Apr 6, 2007 this sequence version replaced NM_138596.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK013992.1, AK156498.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-862               AK013992.1         5-866
FEATURES             Location/Qualifiers
     source          1..862
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 35.55 cM"
     gene            1..862
                     /gene="Med10"
                     /gene_synonym="D13Wsu50e"
                     /note="mediator complex subunit 10"
                     /db_xref="GeneID:28077"
                     /db_xref="MGI:MGI:106331"
     exon            1..171
                     /gene="Med10"
                     /gene_synonym="D13Wsu50e"
                     /inference="alignment:Splign:2.1.0"
     CDS             50..457
                     /gene="Med10"
                     /gene_synonym="D13Wsu50e"
                     /note="isoform 1 is encoded by transcript variant 1;
                     mediator of RNA polymerase II transcription subunit 10;
                     mediator of RNA polymerase II transcription, subunit 10
                     homolog (NUT2, S. cerevisiae)"
                     /codon_start=1
                     /product="mediator of RNA polymerase II transcription
                     subunit 10 isoform 1"
                     /protein_id="NP_613062.1"
                     /db_xref="CCDS:CCDS26625.1"
                     /db_xref="GeneID:28077"
                     /db_xref="MGI:MGI:106331"
                     /translation="MAEKFDHLEEHLEKFVENIRQLGIIVSDFQPSSQAGLSQKLNFI
                     VTGLQDIDKCRQQLHDITVPLEVFEYIDQGRNPQLYTKECLERALAKNEQVKGKIDTM
                     KKFKSLLIQELSKVFPEDMAKYRSIRGEDHPPS"
     exon            172..255
                     /gene="Med10"
                     /gene_synonym="D13Wsu50e"
                     /inference="alignment:Splign:2.1.0"
     exon            256..358
                     /gene="Med10"
                     /gene_synonym="D13Wsu50e"
                     /inference="alignment:Splign:2.1.0"
     exon            359..862
                     /gene="Med10"
                     /gene_synonym="D13Wsu50e"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggacccggag tcgctcggag ctgaggctaa gaggcgggcg gagccggcga tggcggagaa
       61 gtttgaccat ctggaggagc acctggagaa gttcgtggag aacattcggc agctcggcat
      121 catcgtcagc gacttccagc ccagcagcca ggcggggctg agccagaagc taaactttat
      181 tgttacgggc ttacaggaca tagataaatg cagacagcag ctgcacgata tcacggtgcc
      241 tctggaagtt tttgaataca ttgatcaagg tcggaatccc cagctctaca ccaaagaatg
      301 cctggagagg gctctagcta aaaacgagca agtcaagggc aagatcgaca caatgaagaa
      361 atttaaaagc ctactgattc aggaactttc taaagtgttt ccagaagaca tggccaagta
      421 tcggagcatt cggggggaag atcacccacc gtcctaagtg aagatcccat acccttgtaa
      481 taaccagact gagccagtga gaagctgtgc ctgccactgc tgccttccag ccacatgaac
      541 tggcctggcc cctacctcct gtttccatca ttttgatctt gtgggactcg ggctggggga
      601 gcagagctgt gcctcagctg tccctgcagc tcttagaccc tcggtgaccc cttctttctc
      661 caggggaaca ggcaggaaga caaccgtgct gaaatgtgaa atgtgatggg gctcctactt
      721 gacatttcct ttttatgtat gctgttctgt tacactatcc ataagagaaa actcggtttt
      781 atagttacat tttcagatgt tgtgtataag aacataactg ttttcatggg tttcaactag
      841 acataataaa gtccaaagtt tt
//
