LOCUS       NM_001080118            8015 bp    mRNA    linear   ROD 31-DEC-2024
DEFINITION  Mus musculus mediator complex subunit 1 (Med1), transcript variant
            3, mRNA.
ACCESSION   NM_001080118
VERSION     NM_001080118.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 8015)
  AUTHORS   Yuan,N., Su,Y., Gao,Y., Yang,B., Zhang,T., Wang,Q., Zhang,D.,
            Shi,L., Jiao,A., Lei,L., Sun,L. and Zhang,B.
  TITLE     Med1 controls thymic T-cell migration into lymph node through
            enhancer-based Foxo1-Klf2 transcription program
  JOURNAL   Eur J Immunol 54 (10), e2350887 (2024)
   PUBMED   39072704
REFERENCE   2  (bases 1 to 8015)
  AUTHORS   Kolonay,D.W., Sattler,K.M., Strawser,C., Rafael-Fortney,J.,
            Mihaylova,M.M., Miller,K.E., Lepper,C. and Baskin,K.K.
  TITLE     Temporal regulation of the Mediator complex during muscle
            proliferation, differentiation, regeneration, aging, and disease
  JOURNAL   Front Cell Dev Biol 12, 1331563 (2024)
   PUBMED   38690566
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 8015)
  AUTHORS   Chaudhuri,S.M., Weinberg,S.E., Wang,D., Yalom,L.K., Montauti,E.,
            Iyer,R., Tang,A.Y., Torres Acosta,M.A., Shen,J., Mani,N.L.,
            Wang,S., Liu,K., Lu,W., Bui,T.M., Manzanares,L.D., Dehghani,Z.,
            Wai,C.M., Gao,B., Wei,J., Yue,F., Cui,W., Singer,B.D., Sumagin,R.,
            Zhang,Y. and Fang,D.
  TITLE     Mediator complex subunit 1 architects a tumorigenic Treg cell
            program independent of inflammation
  JOURNAL   Cell Rep Med 5 (3), 101441 (2024)
   PUBMED   38428427
  REMARK    GeneRIF: Mediator complex subunit 1 architects a tumorigenic Treg
            cell program independent of inflammation.
REFERENCE   4  (bases 1 to 8015)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   5  (bases 1 to 8015)
  AUTHORS   Zheng,H., Jiao,A., Liu,H., Lei,L., Ding,R., Feng,Z., Zhang,D.,
            Zhang,L. and Zhang,B.
  TITLE     Effect of Med1 on T cell development and CD4+ T cell
            differentiation in immune response
  JOURNAL   Zhong Nan Da Xue Xue Bao Yi Xue Ban 48 (9), 1296-1303 (2023)
   PUBMED   38044640
  REMARK    GeneRIF: Effect of Med1 on T cell development and CD4[+] T cell
            differentiation in immune response.
REFERENCE   6  (bases 1 to 8015)
  AUTHORS   Zilliacus,J., Holter,E., Wakui,H., Tazawa,H., Treuter,E. and
            Gustafsson,J.A.
  TITLE     Regulation of glucocorticoid receptor activity by 14--3-3-dependent
            intracellular relocalization of the corepressor RIP140
  JOURNAL   Mol Endocrinol 15 (4), 501-511 (2001)
   PUBMED   11266503
REFERENCE   7  (bases 1 to 8015)
  AUTHORS   Zhu,Y., Qi,C., Jia,Y., Nye,J.S., Rao,M.S. and Reddy,J.K.
  TITLE     Deletion of PBP/PPARBP, the gene for nuclear receptor coactivator
            peroxisome proliferator-activated receptor-binding protein, results
            in embryonic lethality
  JOURNAL   J Biol Chem 275 (20), 14779-14782 (2000)
   PUBMED   10747854
REFERENCE   8  (bases 1 to 8015)
  AUTHORS   Ito,M., Yuan,C.X., Okano,H.J., Darnell,R.B. and Roeder,R.G.
  TITLE     Involvement of the TRAP220 component of the TRAP/SMCC coactivator
            complex in embryonic development and thyroid hormone action
  JOURNAL   Mol Cell 5 (4), 683-693 (2000)
   PUBMED   10882104
REFERENCE   9  (bases 1 to 8015)
  AUTHORS   Jain,S., Pulikuri,S., Zhu,Y., Qi,C., Kanwar,Y.S., Yeldandi,A.V.,
            Rao,M.S. and Reddy,J.K.
  TITLE     Differential expression of the peroxisome proliferator-activated
            receptor gamma (PPARgamma) and its coactivators steroid receptor
            coactivator-1 and PPAR-binding protein PBP in the brown fat,
            urinary bladder, colon, and breast of the mouse
  JOURNAL   Am J Pathol 153 (2), 349-354 (1998)
   PUBMED   9708794
REFERENCE   10 (bases 1 to 8015)
  AUTHORS   Zhu,Y., Qi,C., Jain,S., Rao,M.S. and Reddy,J.K.
  TITLE     Isolation and characterization of PBP, a protein that interacts
            with peroxisome proliferator-activated receptor
  JOURNAL   J Biol Chem 272 (41), 25500-25506 (1997)
   PUBMED   9325263
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL591205.13.
            
            On Dec 29, 2022 this sequence version replaced NM_001080118.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK049203.1, SRR10223970.14654.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164142 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-225               AL591205.13        76146-76370         c
            226-332             AL591205.13        72269-72375         c
            333-411             AL591205.13        66929-67007         c
            412-466             AL591205.13        63341-63395         c
            467-599             AL591205.13        63104-63236         c
            600-628             AL591205.13        62199-62227         c
            629-700             AL591205.13        56308-56379         c
            701-775             AL591205.13        54783-54857         c
            776-849             AL591205.13        54035-54108         c
            850-939             AL591205.13        52450-52539         c
            940-1051            AL591205.13        50606-50717         c
            1052-1176           AL591205.13        49786-49910         c
            1177-1295           AL591205.13        49343-49461         c
            1296-1497           AL591205.13        46887-47088         c
            1498-1593           AL591205.13        44231-44326         c
            1594-1699           AL591205.13        44024-44129         c
            1700-8015           AL591205.13        35241-41556         c
FEATURES             Location/Qualifiers
     source          1..8015
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 61.75 cM"
     gene            1..8015
                     /gene="Med1"
                     /gene_synonym="CRSP210; DRIP205; l11Jus15; PBP; Pparbp;
                     TRAP220; TRIP-2"
                     /note="mediator complex subunit 1"
                     /db_xref="GeneID:19014"
                     /db_xref="MGI:MGI:1100846"
     exon            1..225
                     /gene="Med1"
                     /gene_synonym="CRSP210; DRIP205; l11Jus15; PBP; Pparbp;
                     TRAP220; TRIP-2"
                     /inference="alignment:Splign:2.1.0"
     CDS             201..4928
                     /gene="Med1"
                     /gene_synonym="CRSP210; DRIP205; l11Jus15; PBP; Pparbp;
                     TRAP220; TRIP-2"
                     /note="isoform 3 is encoded by transcript variant 3; Ppar
                     binding protein; mediator of RNA polymerase II
                     transcription subunit 1; PPAR-binding protein; thyroid
                     receptor-interacting protein 2; peroxisome
                     proliferator-activated receptor-binding protein; thyroid
                     hormone receptor-associated protein complex 220 kDa
                     component; TR-interacting protein 2"
                     /codon_start=1
                     /product="mediator of RNA polymerase II transcription
                     subunit 1 isoform 3"
                     /protein_id="NP_001073587.1"
                     /db_xref="CCDS:CCDS36300.1"
                     /db_xref="GeneID:19014"
                     /db_xref="MGI:MGI:1100846"
                     /translation="MKAQGETEDSERLSKMSSLLERLHAKFNQNRPWSETIKLVRQVM
                     EKRVVMSSGGHQHLVSCLETLQKALKVTSLPAMTDRLESIARQNGLGSHLSASGTECY
                     ITSDMFYVEVQLDPAGQLCDVKVAHHGENPVSCPELVQQLREKNFEEFSKHLKGLVNL
                     YNLPGDNKLKTKMYLALQSLEQDLSKMAIMYWKATNAAPLDKILHGSVGYLTPRSGGH
                     LMNMKYYASPSDLLDDKTASPIILHEKNVPRSLGMNASVTIEGTSAMYKLPIAPLIMG
                     SHPADNKWTPSFSAVTSANSVDLPACFFLKFPQPIPVSKAFVQKLQNCTGIPLFETPP
                     TYLPLYELITQFELSKDPDPLPLNHNMRFYAALPGQQHCYFLNKDAPLPDGQSLQGTL
                     VSKITFQHPGRVPLILNMIRHQVAYNTLIGSCVKRTILKEDSPGLLQFEVCPLSESRF
                     SVSFQHPVNDSLVCVVMDVQDSTHVSCKLYKGLSDALICTDDFIAKVVQRCMSIPVTM
                     RAIRRKAETIQADTPALSLIAETVEDMVKKNLPPASSPGYGMTTGNNPMSGTTTPTNT
                     FPGGPITTLFNMSMSIKDRHESVGHGEDFSKVSQNPILTSLLQITGNGGSTIGSSPTP
                     PHHTPPPVSSMAGNTKNHPMLMNLLKDNPAQDFSTLYGSSPLERQNSSSGSPRMEMCS
                     GSNKAKKKKSSRVPPDKPKHQTEDDFQRELFSMDVDSQNPMFDVSMTADALDTPHITP
                     APSQCSTPPATYPQPVSHPQPSIQRMVRLSSSDSIGPDVTDILSDIAEEASKLPSTSD
                     DCPPIGTPVRDSSSSGHSQSALFDSDVFQTNNNENPYTDPADLIADAAGSPNSDSPTN
                     HFFPDGVDFNPDLLNSQSQSGFGEEYFDESSQSGDNDDFKGFASQALNTLGMPMLGGD
                     NGEPKFKGSSQADTVDFSIISVAGKALGAADLMEHHSGSQSPLLTTGELGKEKTQKRV
                     KEGNGTGASSGSGPGSDSKPGKRSRTPSNDGKSKDKPPKRKKADTEGKSPSHSSSNRP
                     FTPPTSTGGSKSPGSSGRSQTPPGVATPPIPKITIQIPKGTVMVGKPSSHSQYTSSGS
                     VSSSGSKSHHSHSSSSSSLASASTSGKVKSSKSEGSSSSKLSGSMYASQGSSGSSQSK
                     NSSQTGGKPGSSPITKHGLSSGSSSTKMKPQGKPSSLMNPSISKPNISPSHSRPPGGS
                     DKLASPMKPVPGTPPSSKAKSPISSGSSGSHVSGTSSSSGMKSSSGSASSGSVSQKTP
                     PASNSCTPSSSSFSSSGSSMSSSQNQHGSSKGKSPSRNKKPSLTAVIDKLKHGVVTSG
                     PGGEDPIDSQMGASTNSSNHPMSSKHNTSGGEFQSKREKSDKDKSKVSASGGSVDSSK
                     KTSESKNVGSTGVAKIIISKHDGGSPSIKAKVTLQKPGESGGDGLRPQIASSKNYGSP
                     LISGSTPKHERGSPSHSKSPAYTPQNVDSESESGSSIAERSYQNSPSSEDGIRPLPEY
                     STEKHKKHKKEKKKVRDKDRDKKKSHSMKPENWSKSPISSDPTASVTNNPILSADRPS
                     RLSPDFMIGEEDDDLMDVALIGN"
     exon            226..332
                     /gene="Med1"
                     /gene_synonym="CRSP210; DRIP205; l11Jus15; PBP; Pparbp;
                     TRAP220; TRIP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            333..411
                     /gene="Med1"
                     /gene_synonym="CRSP210; DRIP205; l11Jus15; PBP; Pparbp;
                     TRAP220; TRIP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            412..466
                     /gene="Med1"
                     /gene_synonym="CRSP210; DRIP205; l11Jus15; PBP; Pparbp;
                     TRAP220; TRIP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            467..599
                     /gene="Med1"
                     /gene_synonym="CRSP210; DRIP205; l11Jus15; PBP; Pparbp;
                     TRAP220; TRIP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            600..628
                     /gene="Med1"
                     /gene_synonym="CRSP210; DRIP205; l11Jus15; PBP; Pparbp;
                     TRAP220; TRIP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            629..700
                     /gene="Med1"
                     /gene_synonym="CRSP210; DRIP205; l11Jus15; PBP; Pparbp;
                     TRAP220; TRIP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            701..775
                     /gene="Med1"
                     /gene_synonym="CRSP210; DRIP205; l11Jus15; PBP; Pparbp;
                     TRAP220; TRIP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            776..849
                     /gene="Med1"
                     /gene_synonym="CRSP210; DRIP205; l11Jus15; PBP; Pparbp;
                     TRAP220; TRIP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            850..939
                     /gene="Med1"
                     /gene_synonym="CRSP210; DRIP205; l11Jus15; PBP; Pparbp;
                     TRAP220; TRIP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            940..1051
                     /gene="Med1"
                     /gene_synonym="CRSP210; DRIP205; l11Jus15; PBP; Pparbp;
                     TRAP220; TRIP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1052..1176
                     /gene="Med1"
                     /gene_synonym="CRSP210; DRIP205; l11Jus15; PBP; Pparbp;
                     TRAP220; TRIP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1177..1295
                     /gene="Med1"
                     /gene_synonym="CRSP210; DRIP205; l11Jus15; PBP; Pparbp;
                     TRAP220; TRIP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1296..1497
                     /gene="Med1"
                     /gene_synonym="CRSP210; DRIP205; l11Jus15; PBP; Pparbp;
                     TRAP220; TRIP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1498..1593
                     /gene="Med1"
                     /gene_synonym="CRSP210; DRIP205; l11Jus15; PBP; Pparbp;
                     TRAP220; TRIP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1594..1699
                     /gene="Med1"
                     /gene_synonym="CRSP210; DRIP205; l11Jus15; PBP; Pparbp;
                     TRAP220; TRIP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1700..8015
                     /gene="Med1"
                     /gene_synonym="CRSP210; DRIP205; l11Jus15; PBP; Pparbp;
                     TRAP220; TRIP-2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7991..7996
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Med1"
                     /gene_synonym="CRSP210; DRIP205; l11Jus15; PBP; Pparbp;
                     TRAP220; TRIP-2"
                     /note="hexamer: AATAAA"
     polyA_site      8015
                     /gene="Med1"
                     /gene_synonym="CRSP210; DRIP205; l11Jus15; PBP; Pparbp;
                     TRAP220; TRIP-2"
                     /note="major polyA site"
ORIGIN      
        1 aagttccgtt ggggaagatg gcggcggccg cgagcaccct tctcttcttg ccgccgggga
       61 cttcagactg agccttcccc ggaagagtcg gggccgctgg tgcgccgctt ccccggagcc
      121 caggctaact tggttcccct ctgagtggcg gggaaaggct ccccggctcg tggcggaccc
      181 aagacctccc cgctgtcagg atgaaggctc agggggaaac cgaggactca gagaggctga
      241 gtaagatgag ctccctcctg gaacggctcc atgcaaaatt taaccagaac agaccttgga
      301 gtgaaaccat taagcttgtg cgtcaagtaa tggagaagag ggtcgtaatg agttctggag
      361 ggcatcagca tttggtcagc tgtttggaga cattgcagaa ggctctcaaa gtaacatctt
      421 tgccagcaat gactgatcgt ttggaatcta tagccagaca gaatggactg ggctctcacc
      481 tcagtgccag tggcactgag tgttacatca cgtcagatat gttctatgtg gaagtgcagt
      541 tagatcctgc aggacagctt tgtgatgtca aagtggctca ccatggggag aatcctgtga
      601 gctgtccaga gcttgtacag cagttaaggg aaaagaattt tgaggaattt tccaagcatc
      661 ttaagggtct tgttaatctg tataatctcc caggggacaa caaactgaag actaaaatgt
      721 atctggctct ccaatcctta gaacaggacc tttctaaaat ggctattatg tactggaagg
      781 caaccaacgc cgctcccttg gataagattc ttcatggaag tgttggttat ctcaccccgc
      841 ggagtggggg tcatttaatg aatatgaaat actatgcctc tccatctgac ctgctggatg
      901 ataagactgc ctctcctatc attttgcatg aaaagaatgt tcctcggtct ttgggaatga
      961 atgcctcagt gacaattgaa ggaacctctg ctatgtacaa actcccaatt gccccattaa
     1021 ttatggggtc acacccagct gacaacaaat ggaccccttc tttctccgca gtcactagtg
     1081 ccaacagtgt tgatcttcct gcgtgtttct tcttgaaatt tccccagcca attccagtat
     1141 ctaaagcatt tgttcagaaa ctgcaaaatt gcacaggaat cccgttgttt gagactccgc
     1201 ccacttacct gcccctgtat gaactcatca ctcagtttga gctgtcaaag gatcctgacc
     1261 ctttaccttt gaatcacaac atgcgatttt acgctgctct tccaggtcag cagcactgct
     1321 attttctcaa taaagatgct cctcttcctg atggtcagag cctgcaggga acactggtca
     1381 gcaaaatcac cttccagcac cctggccgag ttcctcttat cttgaatatg atcagacacc
     1441 aagtggccta taacactcta attggaagct gtgtcaaaag aactatttta aaagaagatt
     1501 ctcctgggct cctccagttt gaagtgtgtc ctctctcaga atctcgcttc agtgtatctt
     1561 ttcagcaccc tgtgaatgac tcccttgtgt gtgtggtgat ggatgtgcaa gactcaacac
     1621 atgtgagctg taaactctac aaggggctgt cagatgcact aatctgtaca gacgacttca
     1681 ttgccaaagt tgttcaaaga tgtatgtcca ttcctgtgac gatgagggct attcggagga
     1741 aggctgaaac catacaggct gacaccccag cactgtctct cattgcagag acagttgaag
     1801 acatggtgaa aaagaacctg cccccggcta gcagcccagg gtatggcatg accacaggca
     1861 acaacccaat gagtggtacc actacaccaa ccaacacctt tccggggggt cccattacca
     1921 ccttgtttaa tatgagcatg agcatcaaag atcggcatga gtcggtgggc catggggagg
     1981 acttcagcaa ggtgtctcag aacccaattc ttaccagttt gttgcaaatc acagggaacg
     2041 gggggtctac cattggctcg agtccgaccc ctcctcatca cacgccgcca cctgtctctt
     2101 cgatggccgg caacaccaag aaccacccga tgctcatgaa ccttcttaaa gataaccctg
     2161 cccaggattt ctcaaccctt tatggaagca gccctttaga aaggcagaac tcctcttccg
     2221 gatcaccccg gatggaaatg tgctcgggga gcaacaaggc caagaagaag aagtcgtcaa
     2281 gagtcccacc tgacaaaccc aagcaccaga ctgaagacga tttccagagg gagctctttt
     2341 ccatggatgt cgactcacag aaccctatgt ttgacgtcag catgaccgct gacgcgctgg
     2401 atacacctca tatcacccca gctccaagcc agtgtagcac tcccccagca acgtacccac
     2461 agccagtgtc tcacccccag cccagtattc agaggatggt ccgactgtcc agttcagaca
     2521 gcattggccc agatgtaact gatattcttt cagatattgc cgaagaagct tcaaagcttc
     2581 ccagcacgag tgatgactgc ccaccaattg gcacccctgt tcgagattcc tcaagttctg
     2641 ggcattctca gagtgccctc tttgattctg atgtctttca aactaataat aatgaaaatc
     2701 catacactga tccagctgac cttattgcag atgctgctgg aagccccaat agtgattctc
     2761 ctaccaatca ttttttccct gatggagtag atttcaatcc tgatttgttg aacagccaaa
     2821 gccaaagtgg ttttggagag gagtattttg atgaaagtag tcagagtggg gataatgatg
     2881 atttcaaagg atttgcatct caggcattaa atacattggg gatgccaatg cttggaggtg
     2941 acaatgggga gccaaaattt aagggcagca gccaggctga cacggtggac ttcagtatta
     3001 tatcagtagc cggtaaggct ttgggtgctg cagatctgat ggagcaccac agtgggagtc
     3061 agagtccttt actgaccact ggagaattag ggaaagaaaa aactcaaaag agggtgaagg
     3121 aaggcaacgg cacaggtgct agcagtggat caggtccagg gtcagacagc aagccaggca
     3181 agcgcagccg cactccctcc aatgatggga agagcaagga taagcctcca aagcggaaga
     3241 aggcagacac tgaggggaag tccccatctc acagttcttc taatagacct ttcaccccac
     3301 ctaccagcac gggtgggtcc aaatccccag gcagttcagg acgatctcag acgcccccag
     3361 gtgttgccac cccgcccatt cccaagatta ccattcagat tcctaaaggg acagtgatgg
     3421 tgggcaagcc ctcctctcac agtcagtaca ctagcagtgg ttctgtgtct tcctctggca
     3481 gcaaaagcca ccatagtcat tcttcctcct cctcttcctt agcttctgct tccacctcag
     3541 gcaaggtgaa aagcagtaaa tctgaaggct catcaagttc caagctcagt ggcagtatgt
     3601 atgctagcca agggtcttct ggatccagcc agtccaaaaa ttcatctcag actgggggga
     3661 agccaggctc ctctcccatt accaaacatg gactgagcag tgggtccagc agtaccaaga
     3721 tgaaacctca aggcaagcca tcctccctta tgaacccttc tataagtaag ccaaacatat
     3781 ccccttccca ttcaaggcct cccggaggct cagataagct tgcctctcca atgaagcctg
     3841 ttcctggaac ccccccatcc tctaaagcca agtcccctat cagttcaggt tccagtggtt
     3901 ctcatgtgtc aggaactagt tcaagctctg gtatgaagtc atcttcaggg tcagcatcct
     3961 caggctcagt gtctcaaaaa acccctccag catctaattc ttgtacacca tcttcctctt
     4021 cgttttcctc aagtggttct tccatgtcat cctctcagaa tcaacatggc agttccaaag
     4081 ggaaatctcc cagtaggaat aagaagcctt ccttgacagc tgtcatagat aaattgaagc
     4141 atggggtggt taccagtggg cctgggggtg aggatccaat agacagtcag atgggcgcaa
     4201 gcacaaattc ttctaaccat cccatgtcct ccaaacataa cacgtcagga ggggagttcc
     4261 agagcaaacg tgagaaaagt gataaagaca aatccaaggt ctctgcttct ggggggtcag
     4321 tggattcctc taagaagact tcagagtcaa aaaatgtggg gagcacgggg gtggcaaaaa
     4381 tcattatcag caagcacgac ggaggctccc cgagcatcaa agccaaagtg acgctacaga
     4441 aacctggaga aagtggtgga gatgggctca ggccacagat agcctcatca aagaactatg
     4501 gctctccact tatcagtggt tccactccaa agcacgaacg gggttctccc agccacagta
     4561 agtcgccagc atatacacca cagaatgtgg acagtgaaag tgagtcaggc tcctccatag
     4621 cagagagatc ctaccagaac agtcccagct cagaggatgg tatccgacca cttccagagt
     4681 acagcactga gaagcataag aagcacaaaa aggaaaagaa gaaagtcaga gacaaagaca
     4741 gagacaagaa gaagtctcac agcatgaagc cagagaactg gtcgaaatcc cccatttctt
     4801 cagatccgac ggcgtctgtg acaaataacc ctatcttatc tgcagacagg ccttctaggc
     4861 tcagccctga cttcatgatt ggggaggaag atgatgatct catggatgtg gccctgattg
     4921 gcaattagcc taactttcta aacagacacg tccagaggag aaactaatga tatatgtaaa
     4981 ccaacccgag gggtgagtca gacaggccct gtcagtgctt aagagcccta aagggcatgg
     5041 cctctacacc aagctgggta catttataaa catacatcta gaccctgctg ccgaaaccat
     5101 gtggttggtt gttcagaaac aagtcatatt tctttgccag aaagcaatga ataaattact
     5161 tgcttaaggg gagaggggtg gtgggagagg gtgtagagag ggaggggtgg gaaattgttg
     5221 tgggaaatat tcatatattt ttctcccttt ttccattttc aggacatgct ttaaactcat
     5281 tttagtgcat gtatttgaag ggctgggcag aaaatgaaaa agcaatacat tccttgatgc
     5341 attcgcatga aggttgctca cctgtgggag atgcccattg gaagcatggg cacgggaagg
     5401 actttgacag ttctggacac tgaaagcaat gtttggtgtc tgtttcttag gagtgatggg
     5461 ggagggaaaa ttattttagt tatttatttg taatatttta atccttgatg tttgttttta
     5521 tgcaatgttt gttcctaaat ctatgaaggt tatggttcag aacagtagga ggcaggtagc
     5581 aaggctcgcc tggtggggag ctcgcagcct gtgctgacgc tgcagcacca gtcccacaga
     5641 gctaatcaca gcctgtcttt ggagttgaat agaaaaacca aaactattat ctttggaggt
     5701 ttttcacagg gttcagacac cataggaata ttaggagtga gttacctccc tatgcagata
     5761 aaagatttat cttctttcat taaaaaggaa gggtggcttt ggggggtata catttgtttt
     5821 cagagtctat accctatcgt ataaaaatca gtatagaatt aatagttctc ctacttccac
     5881 aatgtgccaa aagtctacat cccagcattt tgtttgcagg agagctgatg ccattcctaa
     5941 gagctggact ctttgtttct cttcatcaca agaagaagga gttcagactt aaatcactcc
     6001 actgtatgct ccccgagata aacagttaaa aaaaaaaaaa gcagccatag ttcacttaaa
     6061 acaatttcaa gctcacttga agtgattagg gcctggaatg ctaagtgagc atgaagataa
     6121 cccttgctac cgtgtagcac acagtcggac ctttttggag aaacaggtct gagtctggat
     6181 tctgagggac atcaaaggaa gacctcataa atagagaaat gcaggagacc gttttgagtg
     6241 caacagaagt tctcagtatt tggagggtcc tctcaaaagt ccgcggcctt actttgattt
     6301 caccacctgc actgtgccat tcctgatgat tccgtttggg atctgtatca gcggggtggg
     6361 ggtggggcgt gatccccagc acaactcttc tggattacaa aacaagcaaa agccaggtga
     6421 ttcatgtttg tgtgtgttat aagtggagtg acttcatcag atacggacga tttctacatc
     6481 caacactgca ggttgttgga gttagcatag acttggaaaa tctactgcgg ctttctttcc
     6541 tagttctctt tttttttttt ttttttttgt tttttttgtt tgtttttttt gttttttgtt
     6601 tttttggtgt tctccctttt ctggtcattg gttttcaaca actccgccat ttctgtgtcc
     6661 caaggcaata aataggaaac aaaatattgg aaagtggagc aagaaaagtt atctgttccc
     6721 ctatcagagc ccggtgtctt gggtgacatg ggcagggtgt attggagtgc tttctcttgt
     6781 ggtgctgaca tagtagccgt gcggtatctc agataaaacc aggttggatt tctcagaaat
     6841 ttgccacctg gttgtgaatc ctatcttctt agtttctgca ggaaaattgt tgttatatgg
     6901 ggtttcattt tgttgtgggt ggggacaatc tcatggggaa aatgtactgc atagtataag
     6961 gggctcaggc cccccgagca gagtcaagaa ataccaaaat cagtaaactg ggaagctttt
     7021 ctctctttct gtcttcatcc cagatcaaag aatcccgagt taggatctgg atgaaggata
     7081 agcccctgaa ttgctgatgg gcacacccca cacaatgacc cagcatctga acttgcttaa
     7141 cagggagccg gggctaaact gcttcaccct gcctgggaac cagggagcac tgcatttctc
     7201 cacagggtgg aggagaagcg gcaggataaa ccaagcctgg gacacctccc tcccatccag
     7261 gtgtgctcac cctcctgttt gaaagacggc aaggacatga agtcaacgtg tacctatttg
     7321 ctgctgctgc tgctgctgga gtttatggtt ttttttttct tttttttgac ctattcttct
     7381 gtctttgggc ttcatgttaa gggtctttgg acaaaaatct gctctgatgt acaagaatat
     7441 ttcagtgtat cttaaaacaa gtgttttcga ggtgagcaag gggacctgat gtaattgcca
     7501 aagccagctt gagggtgata actcttgaat tggattttcc ttttgtcagg ccaaggcctg
     7561 aaaaatctgt aacagcaata tatcatgaat tttcagaaga gccagtgggt cccatagtgt
     7621 cctcactggt cccagcagat gtcagtatac aaaacataat caatccctgg gcaatcttgt
     7681 gctctacttt atcttcatcc ttagccacgt cctcctgtca tttgtctcgg agtcacgttt
     7741 tggagagaca ggaagtatta tcttagaaac taggttggga aaatgttcaa ctatagagct
     7801 gagatttaaa ttttgagttt aaaaatgtac atcaggagca atggaaaggg tgttttctta
     7861 aaggcatttc taatttgctt ttctgtgtgt atgtctgttc tgtaaataat tttttcattt
     7921 ttgaaagtgg ataaaatctg tggattttcc ctcttaaaac aacacaaaaa taaaactttc
     7981 tttacatgca aataaatttc tttgataaaa agaaa
//
