LOCUS       NM_025297               1337 bp    mRNA    linear   ROD 26-SEP-2023
DEFINITION  Mus musculus mitochondrial trans-2-enoyl-CoA reductase (Mecr),
            mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_025297
VERSION     NM_025297.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1337)
  AUTHORS   Qian S, Ma L, Peng S, Xu Y, Wu K, Shen S, Zhang X, Sun Y and Ye J.
  TITLE     ATP reduces mitochondrial MECR protein in liver of diet-induced
            obese mice in mechanism of insulin resistance
  JOURNAL   Biosci Rep 40 (6) (2020)
   PUBMED   32440681
  REMARK    GeneRIF: ATP reduces mitochondrial MECR protein in liver of
            diet-induced obese mice in mechanism of insulin resistance.
REFERENCE   2  (bases 1 to 1337)
  AUTHORS   Ingham NJ, Pearson SA, Vancollie VE, Rook V, Lewis MA, Chen J,
            Buniello A, Martelletti E, Preite L, Lam CC, Weiss FD, Powis Z,
            Suwannarat P, Lelliott CJ, Dawson SJ, White JK and Steel KP.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1337)
  AUTHORS   Nair RR, Koivisto H, Jokivarsi K, Miinalainen IJ, Autio KJ,
            Manninen A, Poutiainen P, Tanila H, Hiltunen JK and Kastaniotis AJ.
  TITLE     Impaired Mitochondrial Fatty Acid Synthesis Leads to
            Neurodegeneration in Mice
  JOURNAL   J Neurosci 38 (45), 9781-9800 (2018)
   PUBMED   30266742
REFERENCE   4  (bases 1 to 1337)
  AUTHORS   Nair RR, Keratar JM, Autio KJ, Masud AJ, Finnila MAJ,
            Autio-Harmainen HI, Miinalainen IJ, Nieminen PA, Hiltunen JK and
            Kastaniotis AJ.
  TITLE     Genetic modifications of Mecr reveal a role for mitochondrial
            2-enoyl-CoA/ACP reductase in placental development in mice
  JOURNAL   Hum Mol Genet 26 (11), 2104-2117 (2017)
   PUBMED   28369354
REFERENCE   5  (bases 1 to 1337)
  AUTHORS   Liu X, Jiao Y, Cao Y, Deng N, Ma Y, Hasty KA, Kang A, Chen H,
            Stuart JM and Gu W.
  TITLE     Decreased expression levels of Ifi genes is associated to the
            increased resistance to spontaneous arthritis disease in mice
            deficiency of IL-1RA
  JOURNAL   BMC Immunol 17 (1), 25 (2016)
   PUBMED   27480124
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1337)
  AUTHORS   Chen Z, Leskinen H, Liimatta E, Sormunen RT, Miinalainen IJ,
            Hassinen IE and Hiltunen JK.
  TITLE     Myocardial overexpression of Mecr, a gene of mitochondrial FAS II
            leads to cardiac dysfunction in mouse
  JOURNAL   PLoS One 4 (5), e5589 (2009)
   PUBMED   19440339
  REMARK    GeneRIF: The results showed a ventricular dilatation behind
            impaired heart function upon Mecr overexpression, concurrent with
            appearance of dysmorphic mitochondria
REFERENCE   7  (bases 1 to 1337)
  AUTHORS   Chen ZJ, Pudas R, Sharma S, Smart OS, Juffer AH, Hiltunen JK,
            Wierenga RK and Haapalainen AM.
  TITLE     Structural enzymological studies of 2-enoyl thioester reductase of
            the human mitochondrial FAS II pathway: new insights into its
            substrate recognition properties
  JOURNAL   J Mol Biol 379 (4), 830-844 (2008)
   PUBMED   18479707
REFERENCE   8  (bases 1 to 1337)
  AUTHORS   Masuda N, Yasumo H, Furusawa T, Tsukamoto T, Sadano H and Osumi T.
  TITLE     Nuclear receptor binding factor-1 (NRBF-1), a protein interacting
            with a wide spectrum of nuclear hormone receptors
  JOURNAL   Gene 221 (2), 225-233 (1998)
   PUBMED   9795230
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY017691.1, AK002533.1, BQ746166.1 and BY693002.1.
            
            [WARNING] On Oct 17, 2023 this sequence was replaced by
            NM_025297.3.
            
            On Apr 21, 2009 this sequence version replaced NM_025297.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK002533.1, BC003864.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on conservation,
                                                  expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-289               BY017691.1         1-289
            290-656             AK002533.1         290-656
            657-1205            BQ746166.1         98-646
            1206-1337           BY693002.1         276-407
FEATURES             Location/Qualifiers
     source          1..1337
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 64.52 cM"
     gene            1..1337
                     /gene="Mecr"
                     /gene_synonym="NRBF-1; Nrbf1"
                     /note="mitochondrial trans-2-enoyl-CoA reductase"
                     /db_xref="GeneID:26922"
                     /db_xref="MGI:MGI:1349441"
     exon            1..208
                     /gene="Mecr"
                     /gene_synonym="NRBF-1; Nrbf1"
                     /inference="alignment:Splign:2.1.0"
     CDS             33..1154
                     /gene="Mecr"
                     /gene_synonym="NRBF-1; Nrbf1"
                     /EC_number="1.3.1.104"
                     /note="trans-2-enoyl-CoA reductase, mitochondrial; nuclear
                     receptor binding factor 1; 2-enoyl thioester reductase;
                     enoyl-[acyl-carrier-protein] reductase, mitochondrial"
                     /codon_start=1
                     /product="enoyl-[acyl-carrier-protein] reductase,
                     mitochondrial precursor"
                     /protein_id="NP_079573.2"
                     /db_xref="CCDS:CCDS18715.1"
                     /db_xref="GeneID:26922"
                     /db_xref="MGI:MGI:1349441"
                     /translation="MLVSQRVTGARARAPQLAGLLEAWYRHGRTTSSYSALSEPSRVR
                     ALVYGNHGDPAKVVQLKNLELTAVEGSDVHVRMLAAPINPSDINMIQGNYGLLPKLPA
                     VGGNEGVGQVIAVGSSVSALKPGDWVIPANAGLGTWRTEAVFSEEALIGIPKDIPLQS
                     AATLGVNPCTAYRMLVDFEQLQPGDSVIQNASNSGVGQAVIQIASALRLKTINVVRDR
                     PDIKKLTDRLKDLGADYVLTEEELRMPETKTIFKDLPLPRLALNCVGGKSSTELLRHL
                     APGGTMVTYGGMAKQPVTASVSLLIFKDLKLRGFWLSQWKKNHSPDEFKELILTLCNL
                     IRQGRLTAPSCSEVPLQGYQQALEASMKPFVSSKQILTM"
     exon            209..306
                     /gene="Mecr"
                     /gene_synonym="NRBF-1; Nrbf1"
                     /inference="alignment:Splign:2.1.0"
     exon            307..438
                     /gene="Mecr"
                     /gene_synonym="NRBF-1; Nrbf1"
                     /inference="alignment:Splign:2.1.0"
     exon            439..582
                     /gene="Mecr"
                     /gene_synonym="NRBF-1; Nrbf1"
                     /inference="alignment:Splign:2.1.0"
     exon            583..685
                     /gene="Mecr"
                     /gene_synonym="NRBF-1; Nrbf1"
                     /inference="alignment:Splign:2.1.0"
     exon            686..788
                     /gene="Mecr"
                     /gene_synonym="NRBF-1; Nrbf1"
                     /inference="alignment:Splign:2.1.0"
     exon            789..862
                     /gene="Mecr"
                     /gene_synonym="NRBF-1; Nrbf1"
                     /inference="alignment:Splign:2.1.0"
     exon            863..923
                     /gene="Mecr"
                     /gene_synonym="NRBF-1; Nrbf1"
                     /inference="alignment:Splign:2.1.0"
     exon            924..996
                     /gene="Mecr"
                     /gene_synonym="NRBF-1; Nrbf1"
                     /inference="alignment:Splign:2.1.0"
     exon            997..1337
                     /gene="Mecr"
                     /gene_synonym="NRBF-1; Nrbf1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gagcgccgga ttctgccagt gctggaagca gcatgttggt cagccagcga gtgacagggg
       61 cgcgagcccg ggcacctcag cttgcgggtc tcctcgaggc ttggtaccgc cacggccgga
      121 ccacatcctc ctactccgct ctctctgagc cgtcacgggt gcgggcgctg gtctatggca
      181 accatgggga tccagccaag gtcgtccagc tgaagaacct ggagctcact gctgtggaag
      241 gatctgacgt ccacgtgagg atgctggcag cccctatcaa tccatctgac ataaatatga
      301 tccaagggaa ctatggcctc cttcccaagc tgcctgctgt tggagggaac gaaggcgttg
      361 ggcaggtgat agcggtgggc agcagtgtgt ctgcattgaa gccaggagat tgggtgatcc
      421 cagcaaatgc gggtttggga acctggcgga ctgaggcggt gttcagtgag gaagcactga
      481 ttggaatccc taaggacatt cctctccaga gcgctgccac cctaggtgtc aacccctgca
      541 cagcctacag gatgttggtg gactttgaac agctgcagcc aggggactct gtcatccaga
      601 atgcatccaa cagtggagtg ggccaagcag tcattcagat cgcctcagcc cttcgcctaa
      661 agaccatcaa cgttgtccga gacagacccg acatcaagaa gctaactgac agactgaagg
      721 atctaggagc tgattatgtc ctcacagagg aagagctaag gatgcccgag acaaaaacca
      781 tcttcaagga cctgccgctg ccccgattgg ctctcaactg tgttggtggg aagagttcta
      841 cagagctgct ccggcaccta gcgcccggag gaaccatggt gacctatggg ggaatggcca
      901 aacagcctgt aacagcctct gtgagtctgc tcatttttaa ggacctcaaa cttcggggct
      961 tttggttgtc ccagtggaag aagaaccaca gtccagatga gttcaaggag ctgattctca
     1021 ctctctgcaa cctcatccgc caaggccggc tcacagcccc atcctgttct gaggttccac
     1081 tgcagggcta ccagcaggct ttggaagcct ccatgaagcc ttttgtgtct tcgaagcaga
     1141 ttctcaccat gtgattgctc cagaggacca ggaggaaagc aggagaggca agactggctg
     1201 tctgctggcc cctccatgag aaccccagcc ttcccagact gcctcaccca tattgtctct
     1261 tcctaccagg agggtggggg accaactcta ggctccctaa taaaccctta acttcccgag
     1321 tggaggatga agagtac
//
