LOCUS       NM_001370769            5412 bp    mRNA    linear   ROD 10-FEB-2024
DEFINITION  Mus musculus MDS1 and EVI1 complex locus (Mecom), transcript
            variant 5, mRNA.
ACCESSION   NM_001370769 XM_011249658
VERSION     NM_001370769.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5412)
  AUTHORS   Nagai,K., Niihori,T., Muto,A., Hayashi,Y., Abe,T., Igarashi,K. and
            Aoki,Y.
  TITLE     Mecom mutation related to radioulnar synostosis with
            amegakaryocytic thrombocytopenia reduces HSPCs in mice
  JOURNAL   Blood Adv 7 (18), 5409-5420 (2023)
   PUBMED   37099686
  REMARK    GeneRIF: Mecom mutation related to radioulnar synostosis with
            amegakaryocytic thrombocytopenia reduces HSPCs in mice.
REFERENCE   2  (bases 1 to 5412)
  AUTHORS   Qu,F., Li,W., Xu,J., Zhang,R., Ke,J., Ren,X., Meng,X., Qin,L.,
            Zhang,J., Lu,F., Zhou,X., Luo,X., Zhang,Z., Wang,M., Wu,G., Pei,D.,
            Chen,J., Cui,G., Suo,S. and Peng,G.
  TITLE     Three-dimensional molecular architecture of mouse organogenesis
  JOURNAL   Nat Commun 14 (1), 4599 (2023)
   PUBMED   37524711
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5412)
  AUTHORS   Masamoto,Y., Chiba,A., Mizuno,H., Hino,T., Hayashida,H., Sato,T.,
            Bando,M., Shirahige,K. and Kurokawa,M.
  TITLE     EVI1 exerts distinct roles in AML via ERG and cyclin D1 promoting a
            chemoresistant and immune-suppressive environment
  JOURNAL   Blood Adv 7 (8), 1577-1593 (2023)
   PUBMED   36269819
  REMARK    GeneRIF: EVI1 exerts distinct roles in AML via ERG and cyclin D1
            promoting a chemoresistant and immune-suppressive environment.
REFERENCE   4  (bases 1 to 5412)
  AUTHORS   Koh,C.P., Bahirvani,A.G., Wang,C.Q., Yokomizo,T., Ng,C.E.L., Du,L.,
            Tergaonkar,V., Voon,D.C., Kitamura,H., Hosoi,H., Sonoki,T.,
            Michelle,M.M.H., Tan,L.J., Niibori-Nambu,A., Zhang,Y.,
            Perkins,A.S., Hossain,Z., Tenen,D.G., Ito,Y., Venkatesh,B. and
            Osato,M.
  TITLE     Highly efficient Runx1 enhancer eR1-mediated genetic engineering
            for fetal, child and adult hematopoietic stem cells
  JOURNAL   Gene 851, 147049 (2023)
   PUBMED   36384171
REFERENCE   5  (bases 1 to 5412)
  AUTHORS   Liau,E.S., Jin,S., Chen,Y.C., Liu,W.S., Calon,M., Nedelec,S.,
            Nie,Q. and Chen,J.A.
  TITLE     Single-cell transcriptomic analysis reveals diversity within
            mammalian spinal motor neurons
  JOURNAL   Nat Commun 14 (1), 46 (2023)
   PUBMED   36596814
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5412)
  AUTHORS   Lock,L.F., Pines,J., Hunter,T., Gilbert,D.J., Gopalan,G.,
            Jenkins,N.A., Copeland,N.G. and Donovan,P.J.
  TITLE     A single cyclin A gene and multiple cyclin B1-related sequences are
            dispersed in the mouse genome
  JOURNAL   Genomics 13 (2), 415-424 (1992)
   PUBMED   1535334
REFERENCE   7  (bases 1 to 5412)
  AUTHORS   Chen,C.Y., Salles,G., Seldin,M.F., Kister,A.E., Reinherz,E.L. and
            Shipp,M.A.
  TITLE     Murine common acute lymphoblastic leukemia antigen (CD10 neutral
            endopeptidase 24.11). Molecular characterization, chromosomal
            localization, and modeling of the active site
  JOURNAL   J Immunol 148 (9), 2817-2825 (1992)
   PUBMED   1374101
REFERENCE   8  (bases 1 to 5412)
  AUTHORS   Spitkovsky,D.D., Royer-Pokora,B., Delius,H., Kisseljov,F.,
            Jenkins,N.A., Gilbert,D.J., Copeland,N.G. and Royer,H.D.
  TITLE     Tissue restricted expression and chromosomal localization of the
            YB-1 gene encoding a 42 kD nuclear CCAAT binding protein
  JOURNAL   Nucleic Acids Res 20 (4), 797-803 (1992)
   PUBMED   1542575
REFERENCE   9  (bases 1 to 5412)
  AUTHORS   Morishita,K., Parganas,E., Matsugi,T. and Ihle,J.N.
  TITLE     Expression of the Evi-1 zinc finger gene in 32Dc13 myeloid cells
            blocks granulocytic differentiation in response to granulocyte
            colony-stimulating factor
  JOURNAL   Mol Cell Biol 12 (1), 183-189 (1992)
   PUBMED   1370341
REFERENCE   10 (bases 1 to 5412)
  AUTHORS   Siracusa,L.D., Rosner,M.H., Vigano,M.A., Gilbert,D.J., Staudt,L.M.,
            Copeland,N.G. and Jenkins,N.A.
  TITLE     Chromosomal location of the octamer transcription factors, Otf-1,
            Otf-2, and Otf-3, defines multiple Otf-3-related sequences
            dispersed in the mouse genome
  JOURNAL   Genomics 10 (2), 313-326 (1991)
   PUBMED   1676977
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC119995.22, AL691419.10, AL929377.6 and AL772145.9.
            
            [WARNING] On Mar 12, 2024 this sequence was replaced by
            NM_001370769.3.
            
            On May 31, 2019 this sequence version replaced NM_001370769.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN01164142
                              [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-330               AC119995.22        82910-83239         c
            331-674             AL691419.10        196756-197099
            675-809             AL929377.6         17381-17515
            810-912             AL772145.9         329-431
            913-1129            AL772145.9         4375-4591
            1130-1277           AL772145.9         10900-11047
            1278-1431           AL772145.9         12583-12736
            1432-2788           AL772145.9         17120-18476
            2789-2876           AL772145.9         20731-20818
            2877-3043           AL772145.9         31258-31424
            3044-3121           AL772145.9         32551-32628
            3122-3291           AL772145.9         34849-35018
            3292-3436           AL772145.9         36960-37104
            3437-3673           AL772145.9         40528-40764
            3674-3857           AL772145.9         41588-41771
            3858-5412           AL772145.9         45227-46781
FEATURES             Location/Qualifiers
     source          1..5412
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 12.66 cM"
     gene            1..5412
                     /gene="Mecom"
                     /gene_synonym="D630039M04Rik; Evi-1; Evi1; Jbo; Mds; Mds1;
                     Mds1-Evi1; Prdm3; Znfpr1b1"
                     /note="MDS1 and EVI1 complex locus"
                     /db_xref="GeneID:14013"
                     /db_xref="MGI:MGI:95457"
     exon            1..330
                     /gene="Mecom"
                     /gene_synonym="D630039M04Rik; Evi-1; Evi1; Jbo; Mds; Mds1;
                     Mds1-Evi1; Prdm3; Znfpr1b1"
                     /inference="alignment:Splign:2.1.0"
     exon            331..674
                     /gene="Mecom"
                     /gene_synonym="D630039M04Rik; Evi-1; Evi1; Jbo; Mds; Mds1;
                     Mds1-Evi1; Prdm3; Znfpr1b1"
                     /inference="alignment:Splign:2.1.0"
     exon            675..809
                     /gene="Mecom"
                     /gene_synonym="D630039M04Rik; Evi-1; Evi1; Jbo; Mds; Mds1;
                     Mds1-Evi1; Prdm3; Znfpr1b1"
                     /inference="alignment:Splign:2.1.0"
     exon            810..912
                     /gene="Mecom"
                     /gene_synonym="D630039M04Rik; Evi-1; Evi1; Jbo; Mds; Mds1;
                     Mds1-Evi1; Prdm3; Znfpr1b1"
                     /inference="alignment:Splign:2.1.0"
     exon            913..1129
                     /gene="Mecom"
                     /gene_synonym="D630039M04Rik; Evi-1; Evi1; Jbo; Mds; Mds1;
                     Mds1-Evi1; Prdm3; Znfpr1b1"
                     /inference="alignment:Splign:2.1.0"
     exon            1130..1277
                     /gene="Mecom"
                     /gene_synonym="D630039M04Rik; Evi-1; Evi1; Jbo; Mds; Mds1;
                     Mds1-Evi1; Prdm3; Znfpr1b1"
                     /inference="alignment:Splign:2.1.0"
     exon            1278..1431
                     /gene="Mecom"
                     /gene_synonym="D630039M04Rik; Evi-1; Evi1; Jbo; Mds; Mds1;
                     Mds1-Evi1; Prdm3; Znfpr1b1"
                     /inference="alignment:Splign:2.1.0"
     exon            1432..2788
                     /gene="Mecom"
                     /gene_synonym="D630039M04Rik; Evi-1; Evi1; Jbo; Mds; Mds1;
                     Mds1-Evi1; Prdm3; Znfpr1b1"
                     /inference="alignment:Splign:2.1.0"
     exon            2789..2876
                     /gene="Mecom"
                     /gene_synonym="D630039M04Rik; Evi-1; Evi1; Jbo; Mds; Mds1;
                     Mds1-Evi1; Prdm3; Znfpr1b1"
                     /inference="alignment:Splign:2.1.0"
     exon            2877..3043
                     /gene="Mecom"
                     /gene_synonym="D630039M04Rik; Evi-1; Evi1; Jbo; Mds; Mds1;
                     Mds1-Evi1; Prdm3; Znfpr1b1"
                     /inference="alignment:Splign:2.1.0"
     exon            3044..3121
                     /gene="Mecom"
                     /gene_synonym="D630039M04Rik; Evi-1; Evi1; Jbo; Mds; Mds1;
                     Mds1-Evi1; Prdm3; Znfpr1b1"
                     /inference="alignment:Splign:2.1.0"
     exon            3122..3291
                     /gene="Mecom"
                     /gene_synonym="D630039M04Rik; Evi-1; Evi1; Jbo; Mds; Mds1;
                     Mds1-Evi1; Prdm3; Znfpr1b1"
                     /inference="alignment:Splign:2.1.0"
     exon            3292..3436
                     /gene="Mecom"
                     /gene_synonym="D630039M04Rik; Evi-1; Evi1; Jbo; Mds; Mds1;
                     Mds1-Evi1; Prdm3; Znfpr1b1"
                     /inference="alignment:Splign:2.1.0"
     exon            3437..3673
                     /gene="Mecom"
                     /gene_synonym="D630039M04Rik; Evi-1; Evi1; Jbo; Mds; Mds1;
                     Mds1-Evi1; Prdm3; Znfpr1b1"
                     /inference="alignment:Splign:2.1.0"
     exon            3674..3857
                     /gene="Mecom"
                     /gene_synonym="D630039M04Rik; Evi-1; Evi1; Jbo; Mds; Mds1;
                     Mds1-Evi1; Prdm3; Znfpr1b1"
                     /inference="alignment:Splign:2.1.0"
     exon            3858..5412
                     /gene="Mecom"
                     /gene_synonym="D630039M04Rik; Evi-1; Evi1; Jbo; Mds; Mds1;
                     Mds1-Evi1; Prdm3; Znfpr1b1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gctgagatgt tggaggggcg tctaacgcgc atgtgcgaag gtgtccaaac tgacaatgct
       61 agagatagcg agtgtggatt gagagaaaga gagagaggga gggagagaga gtgaaagacc
      121 gagtgtgtgc gtgtgtgtgc gtgtgtgaga cagaggagag agagagagag agagagagag
      181 agagagagag agagagagag agaagggagg gggagagaga gagcaaaaga aggaaaagat
      241 ccaagaaaaa aaaaacctaa ccacccagca gcggctgcag gactgggcac agcatgagat
      301 ccaaaggcag ggcaaggaaa ctggccacaa gtaatgagtg tgcctatggc aactatcctg
      361 aaataccttt ggaagaaatg ccagatgctg atgcagatgg gataaccagt gttccctccc
      421 tccacattca agagccatgc tctcctgcga cgtccagtga gtcatttact cctaaggagg
      481 gctcgccata caaagctccc atctacatcc ctgatgacat ccctattcct gatgagtttg
      541 agcttcgaga gtcaactatg cctggagcag gacttggaat atggaccaaa aggaagattg
      601 aaataggcga aaagtttggg ccatacatgg gagagcagag atcagacctg aaagattcca
      661 gctatggatg ggagatctta gatgagtttt gcaatgtgaa gttctgcata gatgccagtc
      721 aaccagatgt aggaagctgg ctcaagtaca tcagattcgc tggctgctat gatcagcaca
      781 accttgttgc atgccagata aatgatcaga tattctaccg agtagtcgca gacattgcgc
      841 ctggggaaga gctcttgctg ttcatgaaga gtgaagagga cccgcacgaa cccatggcgc
      901 ctgacatcca cgaagaacgg cagcaccgct gtgaggactg tgaccagctc tttgaatcca
      961 aggcagagct agccgatcac cagaagttcc catgcagcac acctcactcg gccttctcca
     1021 tggtggagga ggacttgcaa caaaacctgg agagtgagag cgatctccga gagatccatg
     1081 gcaaccagga ctgtaaggaa tgtgaccgag ttttccccga tctgcaaagc ttggagaagc
     1141 acatgctgtc acatactgag gagagggaat acaagtgtga tcagtgtccc aaggcattta
     1201 actggaagtc caatttaatt cgccaccaga tgtcacatga cagtggaaag cactatgagt
     1261 gtgaaaactg tgccaaggtt ttcacggacc ctagcaacct tcagcgacac attcgatctc
     1321 agcatgttgg tgcccgggct catgcttgcc ccgagtgtgg taaaacattt gccacttcgt
     1381 caggcctcaa acagcacaag cacatccaca gcagtgtgaa gccctttatc tgtgaggtct
     1441 gccataaatc ctatactcag ttttcaaacc tttgtcgtca taagcgcatg catgctgatt
     1501 gcagaaccca aatcaagtgc aaagactgtg gacaaatgtt cagcactacg tcttccttaa
     1561 ataaacacag gaggttttgt gagggcaaga accattttgc ggcaggtgga ttttttggcc
     1621 aaggcatttc acttcctgga accccagcta tggataaaac gtccatggtt aatatgagtc
     1681 atgccaaccc gggcctggct gactattttg gcaccaatag gcatcctgct ggtcttacct
     1741 ttccaacagc tcctggattt tcctttagct ttcctggtct gtttccttcg ggcttatacc
     1801 acaggcctcc tttgataccc gctagtcctc ctgttaaagg attatcaagt accgaacagt
     1861 caaacaaatg tcaaagtccc ctcttgacac atcctcagat actgccagct acacaggata
     1921 ttttgaaggc actatctaaa cacccacctg taggggacaa taagccagtg gaactgctgc
     1981 ccgagaggtc ctctgaagag aggccccttg agaaaatcag tgaccagtca gagagtagtg
     2041 accttgatga tgtcagtaca ccaagtggca gtgacctgga aacaacctcg ggctctgatc
     2101 tggaaagtga ccttgaaagt gataaagaga aatgtaaaga aaatggtaaa atgttcaaag
     2161 acaaagtaag ccctctgcag aatctggctt cgataactaa taagaaagaa cacaacaatc
     2221 attccgtttt ctcagcatct gtagaggagc aaagtgccgt gtcaggagct gtgaatgatt
     2281 ctataaaggc tattgcgtct attgctgaaa aatactttgg ttctacagga ctggtggggc
     2341 tgcaagacaa aaaagttgga gcgttacctt acccttccat gtttcccctc ccgttttttc
     2401 cagcattctc tcaatcaatg tacccatttc ctgatagaga cttgaggtcg ttacctttga
     2461 aaatggagcc ccaatcacca agtgaagtta agaaactgca gaagggaagc tctgagtccc
     2521 cttttgacct caccactaag agaaaggatg agaagccctt gacttcaggc ccctcgaagc
     2581 cttcaggaac accagccaca agccaagacc agcccctgga tctaagtatg ggcagtaggg
     2641 gtagagccag tgggacaaag ttgactgagc ctcgaaaaaa ccatgtgttt ggggaaaaga
     2701 aaggaagcaa catggatact aggccatctt cagatggctc cttgcagcat gccagaccca
     2761 ctcccttctt catggacccc atttatagag tagagaaaag aaagttaact gacccgcttg
     2821 aagctttgaa agaaaaatac ttgagacctt ctccaggatt cttgtttcac ccgcaaatgt
     2881 cagcaattga gaacatggca gaaaagctgg aaagcttcag cgccctcaaa cctgaggcca
     2941 gcgagctcct gcagtccgtg ccctccatgt tcagcttccg agctcctccc aacaccctgc
     3001 cagagaacct gctgcggaag gggaaagagc gctacacctg caggtactgt ggcaagatat
     3061 ttccaaggtc tgcgaaccta acacggcact tgagaaccca cacaggagag caaccttaca
     3121 gatgcaaata ctgtgataga tcattcagca tttcttccaa cctgcagcga catgtgcgca
     3181 acatccacaa caaggagaag ccatttaagt gtcatttatg tgacagatgt tttggtcaac
     3241 aaaccaatct tgacagacac ctgaagaaac atgagaacgg caacatgtct gggacggcaa
     3301 cgtcctcgcc tcactcagag ctagaaagcg caggcgcaat cctggatgac aaagaagatg
     3361 cgtactttac agagatccgc aatttcatcg ggaacagcaa ccatggtagc cagtctcctc
     3421 ggaacatgga agagaggatg aatggcagtc acttcaagga taaaaaggct ttggcaacca
     3481 gccaaaattc agatttattg gatgatgaag aagtagaaga tgaggtgttg ttggatgagg
     3541 aggatgaaga caatgatatt cctggaaagc ccagaaagga gctaggggtg actcgtttag
     3601 acgaggagat cccggaggat gactacgaag aagctggtgc cctggagatg agctgtaagg
     3661 cgtccccggt gaggtataaa gaggaagact ataaatctgg cctttctgct ctagatcaca
     3721 taaggcactt cacagatagc ctcaaaatga gggaaatgga agagaatcaa tacactgacg
     3781 ctgagctgtc ctccattagt tcttctcatg tgccagagga gcttaaacag acgttacaca
     3841 gaaagtccaa atcacaggca tatgctatga tgttgtcact gtctgacaag gattccctcc
     3901 atcccacctc ccacagttcc tccaacgtgt ggcacagcat ggcaagggct gcagcagaat
     3961 ccagtgccat ccagtccata agccatgtat gacattgtca aggttgacca gagtgggacc
     4021 aagtccaacg gtagcatggc tctttcatac agaacaattt acaagactgc tgagcaggat
     4081 gccttataac cctgaagggt cacgcattta aagtctggtg accttaaact gaatgagtaa
     4141 agaaagagag agaaaaagga agctatttat tctcaatatt ttgttttgca cagccaaggc
     4201 agctgctgac ttctggagga tcaattaatc caaaatgatt ggaggggaaa ggaaacctca
     4261 ccagggaagg catctttcat tccccctgcc gcagggcatg ggtggctgag aggagcagtt
     4321 gaaatggcag cattgatata aatggacatt tcatagaaat caaactctac tctacaggat
     4381 cacctgatct gactgggaac agtggcttct aactaccaga tttttttttt cctttttaaa
     4441 gttttatgta atttaatctt ttgcagatgg aagtagtcag aagaaatgca caatgattat
     4501 aggaagtgat agcaggattt tttgtcaccc cccacaccct cttaactttg gccttcttga
     4561 gtacattgtt taaaactagg gggaaaaaag ggtatgtgta tattgtaaac tatggatgct
     4621 catgcagaga ggttaagtcg gtgacataac tgtttatcac cactgtacca ctaatacaat
     4681 gtttgccaaa tccttgtaat gacatcttaa ttttagacaa tcatgtcact gtttttaatg
     4741 tttcaatttt tttgtgtgtt gtgtgtatca tgtatttatt tgttggcaaa ctatggtttg
     4801 ttgatcaaaa agagcactgt tcccgtcagc cactatttta tgatgtctga ggcacacccc
     4861 tttctgaatt ccaaggacca aggtgacatg acctgtgtat gggagtgccc aatagtgttt
     4921 ggcttttctt aacattcctt cctttttgtt gttgttgttt tgttttcctt tttaatgaac
     4981 taaataccaa tagatgcaac ttagtttttg taatactgaa atcgattcaa ttgtataaat
     5041 gattataatt tctttcatgg aagcatgatc cttctgatta agaactgtac cccatatttt
     5101 atgctggttg tctgcaagct tgtgcgatga tgttatgttc atgttaatcc tatttgtaaa
     5161 atgaagtgtt cctgacctta tgttaaaaag agagaagtaa ataacagaca ttattcagtt
     5221 attttgtcct ttatcgaaaa accagatttc atttttcctt tttgtttgtg atctcatttg
     5281 gaaataattg gcaagttgag gtactttctt cccatgcttt gtacaatata aactgttatg
     5341 cctttcagtg cgttactgtg ggaggagcaa ctaaaaaaaa aaataaagac ttccaaaaat
     5401 catgaaaaat aa
//
