LOCUS       NM_010787                877 bp    mRNA    linear   ROD 05-JUN-2024
DEFINITION  Mus musculus male enhanced antigen 1 (Mea1), transcript variant 2,
            mRNA.
ACCESSION   NM_010787
VERSION     NM_010787.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 877)
  AUTHORS   Hwang,I., Kim,B.S., Ko,H.R., Cho,S., Lee,H.Y., Cho,S.W., Ryu,D.,
            Shim,S. and Ahn,J.Y.
  TITLE     Cerebellar dysfunction and schizophrenia-like behavior in
            Ebp1-deficient mice
  JOURNAL   Mol Psychiatry 27 (4), 2030-2041 (2022)
   PUBMED   35165395
REFERENCE   2  (bases 1 to 877)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   3  (bases 1 to 877)
  AUTHORS   Ortega-Lazaro,J.C. and del Mazo,J.
  TITLE     Expression of the B56delta subunit of protein phosphatase 2A and
            Mea1 in mouse spermatogenesis. Identification of a new B56gamma
            subunit (B56gamma4) specifically expressed in testis
  JOURNAL   Cytogenet Genome Res 103 (3-4), 345-351 (2003)
   PUBMED   15051958
  REMARK    GeneRIF: A comparative expression study of Mea1 and the B56delta
            subunit of protein phosphatase 2A in spermatogenesis.
REFERENCE   4  (bases 1 to 877)
  AUTHORS   Ohinata,Y., Sutou,S., Kondo,M., Takahashi,T. and Mitsui,Y.
  TITLE     Male-enhanced antigen-1 gene flanked by two overlapping genes is
            expressed in late spermatogenesis
  JOURNAL   Biol Reprod 67 (6), 1824-1831 (2002)
   PUBMED   12444059
  REMARK    GeneRIF: localization of the male-enhanced antigen-1 suggests that
            it may function in the very late stages of spermiogenesis
REFERENCE   5  (bases 1 to 877)
  AUTHORS   Kondo,M., Sato,S. and Sutou,S.
  TITLE     Cloning and sequence analysis of cDNA encoding the bovine
            testis-derived male-enhanced antigen (Mea)
  JOURNAL   Biochim Biophys Acta 1216 (3), 483-486 (1993)
   PUBMED   8268232
REFERENCE   6  (bases 1 to 877)
  AUTHORS   Himmelbauer,H. and Silver,L.M.
  TITLE     High-resolution comparative mapping of mouse chromosome 17
  JOURNAL   Genomics 17 (1), 110-120 (1993)
   PUBMED   8406442
REFERENCE   7  (bases 1 to 877)
  AUTHORS   Lau,Y.F., Chan,K.M. and Sparkes,R.
  TITLE     Male-enhanced antigen gene is phylogenetically conserved and
            expressed at late stages of spermatogenesis
  JOURNAL   Proc Natl Acad Sci U S A 86 (21), 8462-8466 (1989)
   PUBMED   2813404
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ042312.1, AK010904.1 and BY510335.1.
            
            On Mar 29, 2013 this sequence version replaced NM_010787.1.
            
            Transcript Variant: This variant (2) has an alternate exon in place
            of the first exon compared to variant 1. The resulting isoform (b)
            is shorter at the N-terminus compared to isoform a. Variants 2, 3,
            4, and 5 all encode the same isoform (b).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK010904.1, BY710300.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3                 CJ042312.1         124-126
            4-858               AK010904.1         2-856
            859-877             BY510335.1         389-407
FEATURES             Location/Qualifiers
     source          1..877
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 22.9 cM"
     gene            1..877
                     /gene="Mea1"
                     /gene_synonym="Mea-1"
                     /note="male enhanced antigen 1"
                     /db_xref="GeneID:17256"
                     /db_xref="MGI:MGI:96957"
     exon            1..85
                     /gene="Mea1"
                     /gene_synonym="Mea-1"
                     /inference="alignment:Splign:2.1.0"
     exon            86..366
                     /gene="Mea1"
                     /gene_synonym="Mea-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             97..621
                     /gene="Mea1"
                     /gene_synonym="Mea-1"
                     /note="isoform b is encoded by transcript variant 2"
                     /codon_start=1
                     /product="male-enhanced antigen 1 isoform b"
                     /protein_id="NP_034917.1"
                     /db_xref="CCDS:CCDS28835.1"
                     /db_xref="GeneID:17256"
                     /db_xref="MGI:MGI:96957"
                     /translation="MAAVVLGGDTMGPERIFPNQTEDLGPHQGPTEGTGDWSSEEPEE
                     EQEETGAGPAGYSYQPLNQDPEQEEVELAPVGEGEDGAADIQDRIQALGLHLPDPPLE
                     SEDEDEEGAAALSSHSSIPMDPEHVELVKRTMAGVSLPAPGVPAWAREISDAQWEDVV
                     QKALQARQASPAWK"
     exon            367..469
                     /gene="Mea1"
                     /gene_synonym="Mea-1"
                     /inference="alignment:Splign:2.1.0"
     exon            470..877
                     /gene="Mea1"
                     /gene_synonym="Mea-1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      828..833
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mea1"
                     /gene_synonym="Mea-1"
                     /note="hexamer: AATAAA"
     polyA_site      860
                     /gene="Mea1"
                     /gene_synonym="Mea-1"
                     /note="major polyA site"
ORIGIN      
        1 gccggaagtg aaggtgcggg tccggctgtg ggctctgaga gggtgaggcg cgaggaaata
       61 ccaacgccga gaatcagtgg ggcggcccct gcccggatgg cagcagtagt tctaggggga
      121 gacaccatgg gccctgagcg tatcttcccc aatcagactg aggacttagg gccacatcag
      181 ggtcctacag aaggaactgg ggattggagc agtgaagaac ccgaggaaga gcaggaggaa
      241 acaggagcag gcccagcagg ctactcgtac cagcccctca atcaagaccc tgaacaagaa
      301 gaggtggaat tggcaccagt gggtgaagga gaagatggag ctgctgacat ccaagatcgg
      361 atccaggccc tggggcttca tctgccagac cctccattgg agagtgagga tgaagatgag
      421 gagggagccg ccgcattgag cagccacagc tctatcccca tggacccaga acatgtagag
      481 ctggtgaaaa ggacgatggc tggagtaagc ctgcctgcac caggggttcc tgcctgggct
      541 cgggagatct cggacgctca gtgggaagat gtggtacaga aagccctcca agcccggcag
      601 gcatcccctg cctggaagtg accagagagc gagctgcctt acctccctac attccaagtc
      661 aggaccagca caggactaac aactctggtc ttaacagcct cctccttccc atgtcccttt
      721 cacaccaagg cgactcagac ctctcagaga cccactttat tcagttctgt acatatgggg
      781 acatcggccc aagcccagcc caccttagca tgtatcactc tgtggagaat aaagcaccct
      841 gtgtacacag ccagaagcca caccgcctgt gctcctg
//
