LOCUS       NM_001277311             858 bp    mRNA    linear   ROD 06-JUN-2024
DEFINITION  Mus musculus male enhanced antigen 1 (Mea1), transcript variant 4,
            mRNA.
ACCESSION   NM_001277311
VERSION     NM_001277311.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 858)
  AUTHORS   Hwang,I., Kim,B.S., Ko,H.R., Cho,S., Lee,H.Y., Cho,S.W., Ryu,D.,
            Shim,S. and Ahn,J.Y.
  TITLE     Cerebellar dysfunction and schizophrenia-like behavior in
            Ebp1-deficient mice
  JOURNAL   Mol Psychiatry 27 (4), 2030-2041 (2022)
   PUBMED   35165395
REFERENCE   2  (bases 1 to 858)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   3  (bases 1 to 858)
  AUTHORS   Ortega-Lazaro,J.C. and del Mazo,J.
  TITLE     Expression of the B56delta subunit of protein phosphatase 2A and
            Mea1 in mouse spermatogenesis. Identification of a new B56gamma
            subunit (B56gamma4) specifically expressed in testis
  JOURNAL   Cytogenet Genome Res 103 (3-4), 345-351 (2003)
   PUBMED   15051958
  REMARK    GeneRIF: A comparative expression study of Mea1 and the B56delta
            subunit of protein phosphatase 2A in spermatogenesis.
REFERENCE   4  (bases 1 to 858)
  AUTHORS   Ohinata,Y., Sutou,S., Kondo,M., Takahashi,T. and Mitsui,Y.
  TITLE     Male-enhanced antigen-1 gene flanked by two overlapping genes is
            expressed in late spermatogenesis
  JOURNAL   Biol Reprod 67 (6), 1824-1831 (2002)
   PUBMED   12444059
  REMARK    GeneRIF: localization of the male-enhanced antigen-1 suggests that
            it may function in the very late stages of spermiogenesis
REFERENCE   5  (bases 1 to 858)
  AUTHORS   Kondo,M., Sato,S. and Sutou,S.
  TITLE     Cloning and sequence analysis of cDNA encoding the bovine
            testis-derived male-enhanced antigen (Mea)
  JOURNAL   Biochim Biophys Acta 1216 (3), 483-486 (1993)
   PUBMED   8268232
REFERENCE   6  (bases 1 to 858)
  AUTHORS   Himmelbauer,H. and Silver,L.M.
  TITLE     High-resolution comparative mapping of mouse chromosome 17
  JOURNAL   Genomics 17 (1), 110-120 (1993)
   PUBMED   8406442
REFERENCE   7  (bases 1 to 858)
  AUTHORS   Lau,Y.F., Chan,K.M. and Sparkes,R.
  TITLE     Male-enhanced antigen gene is phylogenetically conserved and
            expressed at late stages of spermatogenesis
  JOURNAL   Proc Natl Acad Sci U S A 86 (21), 8462-8466 (1989)
   PUBMED   2813404
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CT030702.11, AK010904.1 and BY510335.1.
            
            Transcript Variant: This variant (4) has an alternate exon in place
            of the first exon compared to variant 1. The resulting isoform (b)
            is shorter at the N-terminus compared to isoform a. Variants 2, 3,
            4, and 5 all encode the same isoform (b).
            
            ##Evidence-Data-START##
            Transcript exon combination :: CN840909.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849379, SAMN00849384
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-66                CT030702.11        189015-189080       c
            67-839              AK010904.1         84-856
            840-858             BY510335.1         389-407
FEATURES             Location/Qualifiers
     source          1..858
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 22.9 cM"
     gene            1..858
                     /gene="Mea1"
                     /gene_synonym="Mea-1"
                     /note="male enhanced antigen 1"
                     /db_xref="GeneID:17256"
                     /db_xref="MGI:MGI:96957"
     exon            1..66
                     /gene="Mea1"
                     /gene_synonym="Mea-1"
                     /inference="alignment:Splign:2.1.0"
     exon            67..347
                     /gene="Mea1"
                     /gene_synonym="Mea-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             78..602
                     /gene="Mea1"
                     /gene_synonym="Mea-1"
                     /note="isoform b is encoded by transcript variant 4"
                     /codon_start=1
                     /product="male-enhanced antigen 1 isoform b"
                     /protein_id="NP_001264240.1"
                     /db_xref="CCDS:CCDS28835.1"
                     /db_xref="GeneID:17256"
                     /db_xref="MGI:MGI:96957"
                     /translation="MAAVVLGGDTMGPERIFPNQTEDLGPHQGPTEGTGDWSSEEPEE
                     EQEETGAGPAGYSYQPLNQDPEQEEVELAPVGEGEDGAADIQDRIQALGLHLPDPPLE
                     SEDEDEEGAAALSSHSSIPMDPEHVELVKRTMAGVSLPAPGVPAWAREISDAQWEDVV
                     QKALQARQASPAWK"
     exon            348..450
                     /gene="Mea1"
                     /gene_synonym="Mea-1"
                     /inference="alignment:Splign:2.1.0"
     exon            451..858
                     /gene="Mea1"
                     /gene_synonym="Mea-1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      809..814
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mea1"
                     /gene_synonym="Mea-1"
                     /note="hexamer: AATAAA"
     polyA_site      841
                     /gene="Mea1"
                     /gene_synonym="Mea-1"
                     /note="major polyA site"
ORIGIN      
        1 ggtccccaac gagataaaca ctgccagact tcgtccttcc ggcgggcagc gggacgcgca
       61 cgtgcacccc tgcccggatg gcagcagtag ttctaggggg agacaccatg ggccctgagc
      121 gtatcttccc caatcagact gaggacttag ggccacatca gggtcctaca gaaggaactg
      181 gggattggag cagtgaagaa cccgaggaag agcaggagga aacaggagca ggcccagcag
      241 gctactcgta ccagcccctc aatcaagacc ctgaacaaga agaggtggaa ttggcaccag
      301 tgggtgaagg agaagatgga gctgctgaca tccaagatcg gatccaggcc ctggggcttc
      361 atctgccaga ccctccattg gagagtgagg atgaagatga ggagggagcc gccgcattga
      421 gcagccacag ctctatcccc atggacccag aacatgtaga gctggtgaaa aggacgatgg
      481 ctggagtaag cctgcctgca ccaggggttc ctgcctgggc tcgggagatc tcggacgctc
      541 agtgggaaga tgtggtacag aaagccctcc aagcccggca ggcatcccct gcctggaagt
      601 gaccagagag cgagctgcct tacctcccta cattccaagt caggaccagc acaggactaa
      661 caactctggt cttaacagcc tcctccttcc catgtccctt tcacaccaag gcgactcaga
      721 cctctcagag acccacttta ttcagttctg tacatatggg gacatcggcc caagcccagc
      781 ccaccttagc atgtatcact ctgtggagaa taaagcaccc tgtgtacaca gccagaagcc
      841 acaccgcctg tgctcctg
//
