LOCUS       NP_032641                572 aa            linear   ROD 17-DEC-2024
DEFINITION  NADP-dependent malic enzyme isoform 1 [Mus musculus].
ACCESSION   NP_032641 XP_914556
VERSION     NP_032641.2
DBSOURCE    REFSEQ: accession NM_008615.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 572)
  AUTHORS   Alektiar,J.M., Shan,M., Radyk,M.D., Zhang,L., Halbrook,C.J.,
            Lin,L., Espinoza,C., Mier,I.F., Lavoie,B.L., Salvatore,L., Pasca di
            Magliano,M., Cantley,L.C., Mueller,J.L. and Lyssiotis,C.A.
  TITLE     Malic enzyme 1 knockout has no deleterious phenotype and is favored
            in the male germline under standard laboratory conditions
  JOURNAL   PLoS One 19 (6), e0303577 (2024)
   PUBMED   38843233
  REMARK    GeneRIF: Malic enzyme 1 knockout has no deleterious phenotype and
            is favored in the male germline under standard laboratory
            conditions.
            Publication Status: Online-Only
REFERENCE   2  (residues 1 to 572)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (residues 1 to 572)
  AUTHORS   Oelkrug,R., Harder,L., Pedaran,M., Hoffmann,A., Kolms,B.,
            Inderhees,J., Gachkar,S., Resch,J., Johann,K., Johren,O., Krause,K.
            and Mittag,J.
  TITLE     Maternal thyroid hormone receptor beta activation in mice sparks
            brown fat thermogenesis in the offspring
  JOURNAL   Nat Commun 14 (1), 6742 (2023)
   PUBMED   37875497
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 572)
  AUTHORS   Simmen,F.A., Pabona,J.M.P., Al-Dwairi,A., Alhallak,I.,
            Montales,M.T.E. and Simmen,R.C.M.
  TITLE     Malic Enzyme 1 (ME1) Promotes Adiposity and Hepatic Steatosis and
            Induces Circulating Insulin and Leptin in Obese Female Mice
  JOURNAL   Int J Mol Sci 24 (7), 6613 (2023)
   PUBMED   37047583
  REMARK    GeneRIF: Malic Enzyme 1 (ME1) Promotes Adiposity and Hepatic
            Steatosis and Induces Circulating Insulin and Leptin in Obese
            Female Mice.
            Publication Status: Online-Only
REFERENCE   5  (residues 1 to 572)
  AUTHORS   Yu,H.F., Duan,C.C., Yang,Z.Q., Wang,Y.S., Yue,Z.P. and Guo,B.
  TITLE     Malic enzyme 1 is important for uterine decidualization in response
            to progesterone/cAMP/PKA/HB-EGF pathway
  JOURNAL   FASEB J 34 (3), 3820-3837 (2020)
   PUBMED   31944402
  REMARK    GeneRIF: Malic enzyme 1 is important for uterine decidualization in
            response to progesterone/cAMP/PKA/HB-EGF pathway.
REFERENCE   6  (residues 1 to 572)
  AUTHORS   Bonhomme,F., Benmehdi,F., Britton-Davidian,J. and Martin,S.
  TITLE     [Genetic analysis of interspecific crosses Mus musculus L. x Mus
            spretus Lataste: linkage of Adh-1 with Amy-1 on chromosome 3 and
            Es-14 with Mod-1 on chromosome 9]
  JOURNAL   C R Seances Acad Sci D 289 (6), 545-548 (1979)
   PUBMED   93520
REFERENCE   7  (residues 1 to 572)
  AUTHORS   Douglas,T.C. and Dawson,P.E.
  TITLE     Location of the gene for theta antigen in the mouse. III. The
            position of Thy-1 relative to Lap-1 and Mpi-1
  JOURNAL   J Hered 70 (4), 250-254 (1979)
   PUBMED   314952
REFERENCE   8  (residues 1 to 572)
  AUTHORS   Douglas,T.C., Meo,T. and Skarvall,H.
  TITLE     Location of the gene for theta antigen in the mouse. II.
            Three-point crosses place Thy-1 in proximal region of chromosome 9
  JOURNAL   J Hered 69 (4), 224-228 (1978)
   PUBMED   310441
REFERENCE   9  (residues 1 to 572)
  AUTHORS   Francke,U., Lalley,P.A., Moss,W., Ivy,J. and Minna,J.D.
  TITLE     Gene mapping in Mus musculus by interspecific cell hybridization:
            assignment of the genes for tripeptidase-1 to chromosome 10,
            dipeptidase-2 to chromosome 18, acid phosphatase-1 to chromosome
            12, and adenylate kinase-1 to chromosome 2
  JOURNAL   Cytogenet Cell Genet 19 (2-3), 57-84 (1977)
   PUBMED   198184
REFERENCE   10 (residues 1 to 572)
  AUTHORS   Krog,H.H., Wysocka,M., Kisielow,P. and Radzikowski,C.
  TITLE     Genetic characterization of important mouse strains used in cancer
            research
  JOURNAL   Hereditas 87 (2), 201-204 (1977)
   PUBMED   75870
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ070715.1, AK077968.1 and AV363687.1.
            
            On Dec 9, 2007 this sequence version replaced NP_032641.1.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK077968.1, AK004980.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849382
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..572
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 46.58 cM"
     Protein         1..572
                     /product="NADP-dependent malic enzyme isoform 1"
                     /EC_number="1.1.1.40"
                     /note="NADP-dependent malic enzyme; NADP-ME; malic enzyme,
                     supernatant"
                     /calculated_mol_wt=63823
     Site            1
                     /site_type="acetylation"
                     /note="N-acetylmethionine.
                     /evidence=ECO:0000250|UniProtKB:P48163; propagated from
                     UniProtKB/Swiss-Prot (P06801.2)"
     Region          2..551
                     /region_name="PLN03129"
                     /note="NADP-dependent malic enzyme; Provisional"
                     /db_xref="CDD:215594"
     Site            269
                     /site_type="other"
                     /note="Important for activity. /evidence=ECO:0000250;
                     propagated from UniProtKB/Swiss-Prot (P06801.2)"
     Site            336
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (P06801.2)"
     CDS             1..572
                     /gene="Me1"
                     /gene_synonym="D9Ertd267e; Mdh-1; Mod-1; Mod1"
                     /coded_by="NM_008615.2:165..1883"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS23383.1"
                     /db_xref="GeneID:17436"
                     /db_xref="MGI:MGI:97043"
ORIGIN      
        1 mepraprrrh thqrgylltr dphlnkdlaf tleerqqlni hgllppciis qelqvlriik
       61 nferlnsdfd rylllmdlqd rneklfysvl msdvekfmpi vytptvglac qqyslafrkp
      121 rglfisihdk ghiasvlnaw pedvvkaivv tdgerilglg dlgcngmgip vgklalytac
      181 ggvnpqqclp itldvgtene ellkdplyig lrhrrvrgpe ydafldefme aasskygmnc
      241 liqfedfanr nafrllnkyr nkyctfnddi qgtasvavag llaalritkn klsdqtvlfq
      301 gageaalgia hlvvmameke glskenarkk iwlvdskgli vkgrasltee kevfahehee
      361 mknleaivqk ikptaligva aiggafteqi lkdmaafner piifalsnpt skaecsaeqc
      421 ykvtkgraif asgspfdpvt lpdgrtlfpg qgnnsyvfpg valgvvacgl rhiddkvflt
      481 taevisqqvs dkhlqegrly pplntirgvs lkiavkivqd aykekmatvy pepqnkeefv
      541 ssqmystnyd qilpdcypwp aevqkiqtkv nq
//
