LOCUS       NM_023397               1679 bp    mRNA    linear   ROD 11-FEB-2025
DEFINITION  Mus musculus magnesium-dependent phosphatase 1 (Mdp1), transcript
            variant 1, mRNA.
ACCESSION   NM_023397
VERSION     NM_023397.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1679)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1679)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
REFERENCE   3  (bases 1 to 1679)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   4  (bases 1 to 1679)
  AUTHORS   Peisach,E., Selengut,J.D., Dunaway-Mariano,D. and Allen,K.N.
  TITLE     X-ray crystal structure of the hypothetical phosphotyrosine
            phosphatase MDP-1 of the haloacid dehalogenase superfamily
  JOURNAL   Biochemistry 43 (40), 12770-12779 (2004)
   PUBMED   15461449
  REMARK    GeneRIF: X ray crystallography of MDP-1
REFERENCE   5  (bases 1 to 1679)
  AUTHORS   Selengut,J.D.
  TITLE     MDP-1 is a new and distinct member of the haloacid dehalogenase
            family of aspartate-dependent phosphohydrolases
  JOURNAL   Biochemistry 40 (42), 12704-12711 (2001)
   PUBMED   11601995
REFERENCE   6  (bases 1 to 1679)
  AUTHORS   Selengut,J.D. and Levine,R.L.
  TITLE     MDP-1: A novel eukaryotic magnesium-dependent phosphatase
  JOURNAL   Biochemistry 39 (28), 8315-8324 (2000)
   PUBMED   10889041
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK007319.1, BC046613.2 and AI846874.1.
            
            On Jul 31, 2018 this sequence version replaced NM_023397.4.
            
            Transcript Variant: This variant (1) represents the shorter
            transcript and encodes the functional protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7345562.1955054.1,
                                           SRR7345562.2655985.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164138
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-670               AK007319.1         42-711
            671-1649            BC046613.2         634-1612
            1650-1679           AI846874.1         1-30                c
FEATURES             Location/Qualifiers
     source          1..1679
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 28.19 cM"
     gene            1..1679
                     /gene="Mdp1"
                     /gene_synonym="1810034K20Rik"
                     /note="magnesium-dependent phosphatase 1"
                     /db_xref="GeneID:67881"
                     /db_xref="MGI:MGI:1915131"
     exon            1..114
                     /gene="Mdp1"
                     /gene_synonym="1810034K20Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             78..572
                     /gene="Mdp1"
                     /gene_synonym="1810034K20Rik"
                     /EC_number="3.1.3.48"
                     /note="MDP-1"
                     /codon_start=1
                     /product="magnesium-dependent phosphatase 1"
                     /protein_id="NP_075886.1"
                     /db_xref="CCDS:CCDS27123.1"
                     /db_xref="GeneID:67881"
                     /db_xref="MGI:MGI:1915131"
                     /translation="MTRLPKLAVFDLDYTLWPFWVDTHVDPPFHKSSDGTVRDRRGQN
                     IQLYPEVPEVLGRLQSLGVPVAAASRTSEIQGANQLLELFDLGKYFIQREIYPGSKVT
                     HFERLHHKTGVPFSQMVFFDDENRNIIDVGRLGVTCIHIRDGMSLQTLTQGLETFAKA
                     QAGL"
     exon            115..175
                     /gene="Mdp1"
                     /gene_synonym="1810034K20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            176..286
                     /gene="Mdp1"
                     /gene_synonym="1810034K20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            287..394
                     /gene="Mdp1"
                     /gene_synonym="1810034K20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            395..480
                     /gene="Mdp1"
                     /gene_synonym="1810034K20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            481..1666
                     /gene="Mdp1"
                     /gene_synonym="1810034K20Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      646..651
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mdp1"
                     /gene_synonym="1810034K20Rik"
                     /note="hexamer: ATTAAA"
     polyA_site      687
                     /gene="Mdp1"
                     /gene_synonym="1810034K20Rik"
                     /note="major polyA site"
     regulatory      1643..1648
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mdp1"
                     /gene_synonym="1810034K20Rik"
                     /note="hexamer: AATAAA"
     polyA_site      1666
                     /gene="Mdp1"
                     /gene_synonym="1810034K20Rik"
ORIGIN      
        1 gtggctcgcc cgccgcctac ttggccgcca tagaattggg acacactcag cgccaagttt
       61 ggatttgcgg gtggatcatg acgcggctgc caaagcttgc ggtttttgat ctggattaca
      121 cgctctggcc tttctgggta gatacacacg tagacccccc attccacaag agcagcgatg
      181 gaactgtacg agacaggcgg ggccagaaca tccaattgta cccggaggtg cccgaggtct
      241 tgggaagact gcagagcctt ggcgtgcctg tcgccgctgc ttctcggaca agtgagatac
      301 aaggggccaa ccaactcctg gagctctttg accttggcaa atactttatt cagcgggaaa
      361 tctacccagg cagcaaagtc acacactttg agaggttgca ccacaagacc ggagttcctt
      421 tctctcagat ggtcttcttt gatgatgaga atcggaatat catagacgtt ggcagacttg
      481 gcgttacctg cattcacatc cgggatggga tgagtcttca aacgttaact caaggattag
      541 agacatttgc aaaggcccaa gctggactct gaggtccaat cctgtggata agcctcatct
      601 gcagtgtaaa actaaaatca agaaagcctt gtcaggggct cttgtattaa agtgtccacg
      661 tgtgacagtc agggttctgc caccgtatgg gttgtttcca tttttctttt ctttttcaca
      721 aagatttatt tatgtatatg atactgtcat tgtcttcaga cacaccagaa gagggtatcg
      781 tatcagatcc cattacagat ggctgtgagt taccatgtgg ttgctgggaa ttgacctcag
      841 gacctctgga agagcaggca gtgctcttaa ccactgagcc atctctccag tctgtttcca
      901 tttttctaac atgtaaactg aagttgtgtc ctgattagag tgcaccaggt tgttgtttcc
      961 ttgtgttgga acccaccctg agacctcctc caacggtttc aaatagtggg gtgccataac
     1021 gctgtgcatt tctttgtagg gactaaaagt taatactgtt tggaaataag gttggggccg
     1081 gccggccttt tctggtagta gggagtagct caggaatgag ccaaccatag cacgaggctt
     1141 tgtccctcca aggttttaat tgcgctatat cctgattgat gatgtcatgg ctatctatat
     1201 cctggaggga ttggccaagg cccttctcag aatggtgata gtctagagga aggcaggcaa
     1261 gccgagggat agaggcggga gagagagagc aatgaatgga ctctggactc ggcagactct
     1321 ttaggaggtg tgaccctggg agacattggg cctcctggga ggtgctggcc agaagggaat
     1381 gggaacaaca agagccaggc aagaagaggc ccaggagaca ggctggcctg aaaaccttga
     1441 cccagcctgg caccctgttg ccagaggcca accttatcca accgccttgt cccagtcagc
     1501 cttgagctgg actgagtcag ggggtgtgaa tggatggtgg tgagacaatt gttaactcct
     1561 gtggcatgca tgggcttgag gggactgctt tccaggtggc tgtatccagt cgtttctaaa
     1621 atgttgttgc ttacttcatt tgaataaaag agatccaaag tgaaaaaaaa aaaaaaaaa
//
