LOCUS       NM_148922               3131 bp    mRNA    linear   ROD 12-MAR-2024
DEFINITION  Mus musculus MDM1 nuclear protein (Mdm1), transcript variant 2,
            mRNA.
ACCESSION   NM_148922
VERSION     NM_148922.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3131)
  AUTHORS   Son,Y., Kim,S.J., Kim,H.Y., Lee,J. and Kim,J.R.
  TITLE     Mdm1 ablation results in retinal degeneration by specific
            intraflagellar transport defects of photoreceptor cells
  JOURNAL   Cell Death Dis 13 (9), 833 (2022)
   PUBMED   36171205
  REMARK    GeneRIF: Mdm1 ablation results in retinal degeneration by specific
            intraflagellar transport defects of photoreceptor cells.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3131)
  AUTHORS   Collin,G.B., Gogna,N., Chang,B., Damkham,N., Pinkney,J., Hyde,L.F.,
            Stone,L., Naggert,J.K., Nishina,P.M. and Krebs,M.P.
  TITLE     Mouse Models of Inherited Retinal Degeneration with Photoreceptor
            Cell Loss
  JOURNAL   Cells 9 (4), 931 (2020)
   PUBMED   32290105
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3131)
  AUTHORS   Van de Mark,D., Kong,D., Loncarek,J. and Stearns,T.
  TITLE     MDM1 is a microtubule-binding protein that negatively regulates
            centriole duplication
  JOURNAL   Mol Biol Cell 26 (21), 3788-3802 (2015)
   PUBMED   26337392
REFERENCE   4  (bases 1 to 3131)
  AUTHORS   Hoh,R.A., Stowe,T.R., Turk,E. and Stearns,T.
  TITLE     Transcriptional program of ciliated epithelial cells reveals new
            cilium and centrosome components and links to human disease
  JOURNAL   PLoS One 7 (12), e52166 (2012)
   PUBMED   23300604
REFERENCE   5  (bases 1 to 3131)
  AUTHORS   Won,J., Shi,L.Y., Hicks,W., Wang,J., Hurd,R., Naggert,J.K.,
            Chang,B. and Nishina,P.M.
  TITLE     Mouse model resources for vision research
  JOURNAL   J Ophthalmol 2011, 391384 (2011)
   PUBMED   21052544
REFERENCE   6  (bases 1 to 3131)
  AUTHORS   Bureau,J.F., Bihl,F., Brahic,M. and Le Paslier,D.
  TITLE     The gene coding for interferon-gamma is linked to the D12S335 and
            D12S313 microsatellites and to the MDM2 gene
  JOURNAL   Genomics 28 (1), 109-112 (1995)
   PUBMED   7590734
REFERENCE   7  (bases 1 to 3131)
  AUTHORS   Fakharzadeh,S.S., Trusko,S.P. and George,D.L.
  TITLE     Tumorigenic potential associated with enhanced expression of a gene
            that is amplified in a mouse tumor cell line
  JOURNAL   EMBO J 10 (6), 1565-1569 (1991)
   PUBMED   2026149
REFERENCE   8  (bases 1 to 3131)
  AUTHORS   Buckle,V.J., Guenet,J.L., Simon-Chazottes,D., Love,D.R. and
            Davies,K.E.
  TITLE     Localisation of a dystrophin-related autosomal gene to 6q24 in man,
            and to mouse chromosome 10 in the region of the dystrophia
            muscularis (dy) locus
  JOURNAL   Hum Genet 85 (3), 324-326 (1990)
   PUBMED   2203673
REFERENCE   9  (bases 1 to 3131)
  AUTHORS   Snyder,L.C., Trusko,S.P., Freeman,N., Eshleman,J.R.,
            Fakharzadeh,S.S. and George,D.L.
  TITLE     A gene amplified in a transformed mouse cell line undergoes complex
            transcriptional processing and encodes a nuclear protein
  JOURNAL   J Biol Chem 263 (32), 17150-17158 (1988)
   PUBMED   3182840
REFERENCE   10 (bases 1 to 3131)
  AUTHORS   Cahilly-Snyder,L., Yang-Feng,T., Francke,U. and George,D.L.
  TITLE     Molecular analysis and chromosomal mapping of amplified genes
            isolated from a transformed mouse 3T3 cell line
  JOURNAL   Somat Cell Mol Genet 13 (3), 235-244 (1987)
   PUBMED   3474784
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC158804.3, AK004789.2, AK011769.1 and BP768394.1.
            
            [WARNING] On Mar 15, 2024 this sequence was replaced by
            NM_148922.4.
            
            On Jul 8, 2009 this sequence version replaced NM_148922.2.
            
            Transcript Variant: This variant (2) contains an alternate in-frame
            exon in the 3' end of the coding region compared to variant 1. This
            results in a longer protein (isoform 2) compared to isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC052680.1, AK004789.2 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849382
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-45                AC158804.3         116524-116568
            46-1481             AK004789.2         1-1436
            1482-1525           AK011769.1         1437-1480
            1526-3119           AK004789.2         1481-3074
            3120-3131           BP768394.1         33-44               c
FEATURES             Location/Qualifiers
     source          1..3131
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 66.65 cM"
     gene            1..3131
                     /gene="Mdm1"
                     /gene_synonym="Arrd2; Mdm-1"
                     /note="MDM1 nuclear protein"
                     /db_xref="GeneID:17245"
                     /db_xref="MGI:MGI:96951"
     exon            1..176
                     /gene="Mdm1"
                     /gene_synonym="Arrd2; Mdm-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             159..2285
                     /gene="Mdm1"
                     /gene_synonym="Arrd2; Mdm-1"
                     /note="isoform 2 is encoded by transcript variant 2;
                     nuclear protein MDM1; double minute 1; mdm4 transformed
                     3T3 cell double minute 1 protein; transformed mouse 3T3
                     cell double minute 1"
                     /codon_start=1
                     /product="nuclear protein MDM1 isoform 2"
                     /protein_id="NP_683724.2"
                     /db_xref="CCDS:CCDS36069.1"
                     /db_xref="GeneID:17245"
                     /db_xref="MGI:MGI:96951"
                     /translation="MPVRFKGLSEYQRNFLWKKSYLSESYNPSVGQKYSWAGLRSDQL
                     GITKEPGFISKRRVPYHDPQISKYLEWNGTVRKKDTLVPPEPQAFGTPKPQEAEQGED
                     ANQEAVLSLEASRVPKRTRSHSADSRAEGVSDTVEKHQGVTRSHAPVSADVELRPSSK
                     QPLSQSIDPRLDRHLRKKAGLAVVPTNNALRNSEYQRQFVWKTSKESAPVFASNQVFR
                     NKSQIIPQFQGNTFTHETEYKRNFKGLTPVKEPKSREYLKGNSSLEMLTPVKKADEPL
                     DLEVDMASEDSDQSVKKPASWRHQRLGKVNSEYRAKFLSPAQYFYKAGAWTRVKENLS
                     NQVKELREKAESYRKRVQGTHFSRDHLNQIMSDSNCCWDVSSVTSSEGTVSSNIRALD
                     LAGDLTNHRTPQKHPPTKLEERKVASGEQPLKNSTRRLEMPEPAASVRRKLAWDAEES
                     TKEDTQEEPRAEEDGREERGQDKQTCAVELEKPDTQTPKADRLTEGSETSSVSSGKGG
                     RLPTPRLRELGIQRTHHDLTTPAVGGAVLVSPSKVKPPGLEQRRRASSQDGLETLKKD
                     ITKKGKPRPMSLLTSPAAGMKTVDPLPLREDCEANVLRFADTLPVSKILDRQPSTPGQ
                     LPPCAPPYCHPSSRIQGRLRDPEFQHNMGKPRTNNLQLHPHDAFNDEDADRLSEISAR
                     SAVSSLRAFQTLARAQKRKENFWGKP"
     exon            177..291
                     /gene="Mdm1"
                     /gene_synonym="Arrd2; Mdm-1"
                     /inference="alignment:Splign:2.1.0"
     exon            292..668
                     /gene="Mdm1"
                     /gene_synonym="Arrd2; Mdm-1"
                     /inference="alignment:Splign:2.1.0"
     exon            669..803
                     /gene="Mdm1"
                     /gene_synonym="Arrd2; Mdm-1"
                     /inference="alignment:Splign:2.1.0"
     exon            804..971
                     /gene="Mdm1"
                     /gene_synonym="Arrd2; Mdm-1"
                     /inference="alignment:Splign:2.1.0"
     exon            972..1066
                     /gene="Mdm1"
                     /gene_synonym="Arrd2; Mdm-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1067..1166
                     /gene="Mdm1"
                     /gene_synonym="Arrd2; Mdm-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1167..1342
                     /gene="Mdm1"
                     /gene_synonym="Arrd2; Mdm-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1343..1645
                     /gene="Mdm1"
                     /gene_synonym="Arrd2; Mdm-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1646..1755
                     /gene="Mdm1"
                     /gene_synonym="Arrd2; Mdm-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1756..1865
                     /gene="Mdm1"
                     /gene_synonym="Arrd2; Mdm-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1866..2112
                     /gene="Mdm1"
                     /gene_synonym="Arrd2; Mdm-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2113..2172
                     /gene="Mdm1"
                     /gene_synonym="Arrd2; Mdm-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2173..3121
                     /gene="Mdm1"
                     /gene_synonym="Arrd2; Mdm-1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggcggggcgg gagggcggcg cggagtgcgc cggcgcgtcg tcggggacgc cgggtccagg
       61 atcttgctag ggaaccagtg ttgtcgcgtc gtcccgcccc ctcggggctt ttgctcccgt
      121 taactgtcgg cggggcaggc tccgcagcgc agggcgacat gccggtgcgc ttcaaggggc
      181 tgagtgaata ccagagaaac ttcctgtgga aaaagtccta tttgtcagag tcttataatc
      241 cctcagtggg acaaaagtac tcatgggcag gacttagatc ggatcagttg gggatcacga
      301 aagaaccagg ttttatttca aaaagaagag ttccctacca tgaccctcag atttcaaaat
      361 acctggagtg gaacggaacc gtcagaaaga aggatacgct tgtcccacca gaaccccagg
      421 cctttggaac gccaaagcca caagaggctg agcaaggaga agatgccaat caagaagcag
      481 ttctctcact agaggcctcc agggttccca agagaactcg gtctcattct gcggactcga
      541 gagctgaagg ggtttcagac actgtggaaa agcaccaggg tgtcacgaga agccatgcgc
      601 cagttagcgc ggatgtggag ctgagacctt ccagcaaaca acctctctcc cagagcatag
      661 atcccaggtt ggataggcat cttcgtaaga aagctggatt ggccgttgtt cccacgaata
      721 atgccttgag aaattctgaa taccaaaggc agtttgtttg gaagacttct aaagaaagcg
      781 ctccagtgtt tgcatccaat caggttttcc gtaataaaag ccaaattatt ccacagttcc
      841 aaggcaatac attcacccac gagactgaat acaagcgaaa tttcaagggt ttaactccag
      901 tgaaggaacc aaagtcaaga gagtatttga aaggaaacag cagtctggag atgctgactc
      961 cagtaaagaa ggcagatgag cctttagact tagaagtaga catggcgtcg gaagactcag
     1021 accagtctgt aaagaagcct gcttcatgga gacaccaaag gcttggaaaa gtgaattctg
     1081 aatatagagc aaagttcctg agcccagccc agtatttcta taaagctgga gcttggaccc
     1141 gggtgaagga gaacctgtca aaccaggtta aggagctccg agaaaaggcc gaatcttaca
     1201 ggaagcgagt tcaggggaca catttttctc gggaccatct gaaccagatt atgtcggaca
     1261 gcaactgctg ttgggacgtc tcctcagtca caagctcgga aggcaccgtc agtagcaaca
     1321 tccgagcact ggatcttgct ggagacctta caaaccacag gaccccccag aaacaccctc
     1381 ctaccaaact agaagaaaga aaagttgcct cgggagagca gcccctgaaa aactccacca
     1441 ggagactgga gatgccagag cctgccgcct cggtcaggag gaagctggct tgggatgctg
     1501 aggagagcac gaaggaagac acccaggagg agcccagggc ggaggaggac gggagagagg
     1561 agagaggaca ggacaagcag acctgtgcgg tagagctgga gaaaccggac acacagacac
     1621 ccaaggcaga cagactgaca gaagggtcgg agacatcttc tgtttcctca gggaagggag
     1681 gcaggcttcc tacaccgagg ctgagagaac tcggtatcca gcggacgcac catgatctca
     1741 cgacgccagc tgttggtggc gcagtcttag tgtctccatc taaagtgaag ccaccaggcc
     1801 tcgagcagag gaggagagcg tcctcccaag atggcttaga aactctgaag aaagacatta
     1861 ctaagaaagg aaaaccccgt cccatgtctc tgttgacttc tccggctgct ggcatgaaga
     1921 cagttgatcc cctgcctctg cgagaagact gtgaagccaa tgtgctcaga tttgctgata
     1981 ctcttcctgt ttcgaaaatt ttggaccgtc agcccagcac ccctgggcag ctgcctccat
     2041 gtgccccgcc ttactgtcat ccgtccagca ggatccaggg ccgtctgcga gaccctgagt
     2101 ttcagcacaa catgggaaaa cccaggacga acaatttgca gctacatcca cacgatgcct
     2161 ttaatgatga agatgcagat agactgtctg agatctctgc tcgctctgca gtttccagcc
     2221 tccgggcttt ccagactcta gcccgagctc agaaaagaaa ggagaatttc tggggcaagc
     2281 cataaacctc tcatcttatc tagtgacaag ctggctcatc tttactcact cagtgtgtta
     2341 aggttttcag agggtttgga gtttcttcta acacttctga ctcagataat ttgaattttc
     2401 agtggctcat cttagccaga aaattgccat gcagctgtgt ctaagtctga ctctttgaga
     2461 gcacctttgc acttgtctga gtacaaaggt gcggggttgt gtatttcttc acacactctt
     2521 gacttttgtg tcaggtctcg ggggttgcta gtagaagcct gaaggtcatc tacagaatat
     2581 tctaaaggga gaaaatgaag tcaacattaa gatcttccaa cttaatttcc cctcagattg
     2641 gtcttaggca ttttaatagc tgtaggtgtc atgaaaagaa tctcactgtt ttattagcgc
     2701 cttctgtata cacaggtgca gtgttaagat gattggactt tgaaaagctg gctgtacata
     2761 tttttcttat ttatgtaaca aaatttgctg agagaatatg tatatttttg atctttttat
     2821 gtattttatt tgtataataa ctggcataca tttgaataat gtctagattt tgaaaaatga
     2881 tttgtgaaat ggagaattaa aattttgtag acatttaaaa atgaaaatta agtgtgcttg
     2941 gcttcttcag gaagttatca tgtggaataa atatcttcta gaagcattct attagaactg
     3001 cttaatcaaa aattatacta ctattgcagc tgctaaatgc agtgaaactg agtctacagt
     3061 attttttttt tcacaaatac gaggttttaa aaacagattc attaaaaaat ttaaacacca
     3121 aaaaaaaaaa a
//
