LOCUS       NP_683724                708 aa            linear   ROD 05-MAY-2025
DEFINITION  nuclear protein MDM1 isoform 2 [Mus musculus].
ACCESSION   NP_683724
VERSION     NP_683724.2
DBSOURCE    REFSEQ: accession NM_148922.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 708)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (residues 1 to 708)
  AUTHORS   Son,Y., Kim,S.J., Kim,H.Y., Lee,J. and Kim,J.R.
  TITLE     Mdm1 ablation results in retinal degeneration by specific
            intraflagellar transport defects of photoreceptor cells
  JOURNAL   Cell Death Dis 13 (9), 833 (2022)
   PUBMED   36171205
  REMARK    GeneRIF: Mdm1 ablation results in retinal degeneration by specific
            intraflagellar transport defects of photoreceptor cells.
            Publication Status: Online-Only
REFERENCE   3  (residues 1 to 708)
  AUTHORS   Collin,G.B., Gogna,N., Chang,B., Damkham,N., Pinkney,J., Hyde,L.F.,
            Stone,L., Naggert,J.K., Nishina,P.M. and Krebs,M.P.
  TITLE     Mouse Models of Inherited Retinal Degeneration with Photoreceptor
            Cell Loss
  JOURNAL   Cells 9 (4), 931 (2020)
   PUBMED   32290105
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   4  (residues 1 to 708)
  AUTHORS   Van de Mark,D., Kong,D., Loncarek,J. and Stearns,T.
  TITLE     MDM1 is a microtubule-binding protein that negatively regulates
            centriole duplication
  JOURNAL   Mol Biol Cell 26 (21), 3788-3802 (2015)
   PUBMED   26337392
REFERENCE   5  (residues 1 to 708)
  AUTHORS   Hoh,R.A., Stowe,T.R., Turk,E. and Stearns,T.
  TITLE     Transcriptional program of ciliated epithelial cells reveals new
            cilium and centrosome components and links to human disease
  JOURNAL   PLoS One 7 (12), e52166 (2012)
   PUBMED   23300604
REFERENCE   6  (residues 1 to 708)
  AUTHORS   Bureau,J.F., Bihl,F., Brahic,M. and Le Paslier,D.
  TITLE     The gene coding for interferon-gamma is linked to the D12S335 and
            D12S313 microsatellites and to the MDM2 gene
  JOURNAL   Genomics 28 (1), 109-112 (1995)
   PUBMED   7590734
REFERENCE   7  (residues 1 to 708)
  AUTHORS   Fakharzadeh,S.S., Trusko,S.P. and George,D.L.
  TITLE     Tumorigenic potential associated with enhanced expression of a gene
            that is amplified in a mouse tumor cell line
  JOURNAL   EMBO J 10 (6), 1565-1569 (1991)
   PUBMED   2026149
REFERENCE   8  (residues 1 to 708)
  AUTHORS   Buckle,V.J., Guenet,J.L., Simon-Chazottes,D., Love,D.R. and
            Davies,K.E.
  TITLE     Localisation of a dystrophin-related autosomal gene to 6q24 in man,
            and to mouse chromosome 10 in the region of the dystrophia
            muscularis (dy) locus
  JOURNAL   Hum Genet 85 (3), 324-326 (1990)
   PUBMED   2203673
REFERENCE   9  (residues 1 to 708)
  AUTHORS   Snyder,L.C., Trusko,S.P., Freeman,N., Eshleman,J.R.,
            Fakharzadeh,S.S. and George,D.L.
  TITLE     A gene amplified in a transformed mouse cell line undergoes complex
            transcriptional processing and encodes a nuclear protein
  JOURNAL   J Biol Chem 263 (32), 17150-17158 (1988)
   PUBMED   3182840
REFERENCE   10 (residues 1 to 708)
  AUTHORS   Cahilly-Snyder,L., Yang-Feng,T., Francke,U. and George,D.L.
  TITLE     Molecular analysis and chromosomal mapping of amplified genes
            isolated from a transformed mouse 3T3 cell line
  JOURNAL   Somat Cell Mol Genet 13 (3), 235-244 (1987)
   PUBMED   3474784
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC158804.3.
            
            On Jul 8, 2009 this sequence version replaced NP_683724.1.
            
            Transcript Variant: This variant (2) contains an alternate in-frame
            exon in the 3' end of the coding region compared to variant 1. This
            results in a longer protein (isoform 2) compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK004789.2, AK011769.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849382
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..708
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 66.65 cM"
     Protein         1..708
                     /product="nuclear protein MDM1 isoform 2"
                     /note="nuclear protein MDM1; double minute 1; mdm4
                     transformed 3T3 cell double minute 1 protein; transformed
                     mouse 3T3 cell double minute 1"
                     /calculated_mol_wt=79559
     Region          9..544
                     /region_name="MDM1"
                     /note="Nuclear protein MDM1; pfam15501"
                     /db_xref="CDD:464751"
     Region          9..15
                     /region_name="ST]-E-Y-X(3)-F motif 1, required for
                     efficient microtubule binding and stabilization.
                     /evidence=ECO:0000250|UniProtKB:Q8TC05"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9D067.2)"
     Region          79..166
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9D067.2)"
     Site            124
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q9D067.2)"
     Site            127
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q9D067.2)"
     Region          193..199
                     /region_name="ST]-E-Y-X(3)-F motif 2, required for
                     efficient microtubule binding and stabilization.
                     /evidence=ECO:0000250|UniProtKB:Q8TC05"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9D067.2)"
     Region          236..242
                     /region_name="ST]-E-Y-X(3)-F motif 3, required for
                     efficient microtubule binding.
                     /evidence=ECO:0000250|UniProtKB:Q8TC05"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9D067.2)"
     Site            284
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q5PQN4; propagated from
                     UniProtKB/Swiss-Prot (Q9D067.2)"
     Site            287
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q5PQN4; propagated from
                     UniProtKB/Swiss-Prot (Q9D067.2)"
     Region          307..313
                     /region_name="ST]-E-Y-X(3)-F motif 4, required for
                     efficient microtubule binding and stabilization.
                     /evidence=ECO:0000250|UniProtKB:Q8TC05"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9D067.2)"
     Site            315
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q9D067.2)"
     Region          394..590
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9D067.2)"
     Site            418
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q9D067.2)"
     Site            555
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q9D067.2)"
     Site            556
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q9D067.2)"
     Site            581
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q8TC05; propagated from
                     UniProtKB/Swiss-Prot (Q9D067.2)"
     CDS             1..708
                     /gene="Mdm1"
                     /gene_synonym="Arrd2; Mdm-1"
                     /coded_by="NM_148922.4:114..2240"
                     /note="isoform 2 is encoded by transcript variant 2"
                     /db_xref="CCDS:CCDS36069.1"
                     /db_xref="GeneID:17245"
                     /db_xref="MGI:MGI:96951"
ORIGIN      
        1 mpvrfkglse yqrnflwkks ylsesynpsv gqkyswaglr sdqlgitkep gfiskrrvpy
       61 hdpqiskyle wngtvrkkdt lvppepqafg tpkpqeaeqg edanqeavls leasrvpkrt
      121 rshsadsrae gvsdtvekhq gvtrshapvs advelrpssk qplsqsidpr ldrhlrkkag
      181 lavvptnnal rnseyqrqfv wktskesapv fasnqvfrnk sqiipqfqgn tftheteykr
      241 nfkgltpvke pksreylkgn sslemltpvk kadepldlev dmasedsdqs vkkpaswrhq
      301 rlgkvnseyr akflspaqyf ykagawtrvk enlsnqvkel rekaesyrkr vqgthfsrdh
      361 lnqimsdsnc cwdvssvtss egtvssnira ldlagdltnh rtpqkhpptk leerkvasge
      421 qplknstrrl empepaasvr rklawdaees tkedtqeepr aeedgreerg qdkqtcavel
      481 ekpdtqtpka drltegsets svssgkggrl ptprlrelgi qrthhdlttp avggavlvsp
      541 skvkppgleq rrrassqdgl etlkkditkk gkprpmsllt spaagmktvd plplredcea
      601 nvlrfadtlp vskildrqps tpgqlppcap pychpssriq grlrdpefqh nmgkprtnnl
      661 qlhphdafnd edadrlseis arsavsslra fqtlaraqkr kenfwgkp
//
