LOCUS       NM_001012335             922 bp    mRNA    linear   ROD 28-JAN-2025
DEFINITION  Mus musculus midkine (Mdk), transcript variant 2, mRNA.
ACCESSION   NM_001012335
VERSION     NM_001012335.3
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 922)
  AUTHORS   Zhu,Z., Zou,Q., Wang,C., Li,D., Yang,Y., Xiao,Y., Jin,Y., Yan,J.,
            Luo,L., Sun,Y. and Liang,X.
  TITLE     Isl Identifies the Extraembryonic Mesodermal/Allantois Progenitors
            and is Required for Placenta Morphogenesis and Vasculature
            Formation
  JOURNAL   Adv Sci (Weinh) 11 (32), e2400238 (2024)
   PUBMED   38923264
REFERENCE   2  (bases 1 to 922)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 922)
  AUTHORS   Qiu,X., Guo,Y., Liu,M.F., Zhang,B., Li,J., Wei,J.F. and Li,M.
  TITLE     Single-cell RNA-sequencing analysis reveals enhanced non-canonical
            neurotrophic factor signaling in the subacute phase of traumatic
            brain injury
  JOURNAL   CNS Neurosci Ther 29 (11), 3446-3459 (2023)
   PUBMED   37269057
  REMARK    GeneRIF: Single-cell RNA-sequencing analysis reveals enhanced
            non-canonical neurotrophic factor signaling in the subacute phase
            of traumatic brain injury.
REFERENCE   4  (bases 1 to 922)
  AUTHORS   Inoh,K., Muramatsu,H., Ochiai,K., Torii,S. and Muramatsu,T.
  TITLE     Midkine, a heparin-binding cytokine, plays key roles in
            intraperitoneal adhesions
  JOURNAL   Biochem Biophys Res Commun 317 (1), 108-113 (2004)
   PUBMED   15047154
REFERENCE   5  (bases 1 to 922)
  AUTHORS   Naito,A., Yoshikura,H. and Iwamoto,A.
  TITLE     Similarity of the genomic structure between the two members in a
            new family of heparin-binding factors
  JOURNAL   Biochem Biophys Res Commun 183 (2), 701-707 (1992)
   PUBMED   1550576
REFERENCE   6  (bases 1 to 922)
  AUTHORS   Haas,I.G., Simon-Chazottes,D. and Guenet,J.L.
  TITLE     The gene coding for the immunoglobulin heavy chain binding protein
            BiP (Hsce-70) maps to mouse chromosome 2
  JOURNAL   Mamm Genome 3 (11), 659-660 (1992)
   PUBMED   1450517
REFERENCE   7  (bases 1 to 922)
  AUTHORS   Simon-Chazottes,D., Matsubara,S., Miyauchi,T., Muramatsu,T. and
            Guenet,J.L.
  TITLE     Chromosomal localization of two cell surface-associated molecules
            of potential importance in development: midkine (Mdk) and basigin
            (Bsg)
  JOURNAL   Mamm Genome 2 (4), 269-271 (1992)
   PUBMED   1347477
REFERENCE   8  (bases 1 to 922)
  AUTHORS   Tomomura,M., Kadomatsu,K., Matsubara,S. and Muramatsu,T.
  TITLE     A retinoic acid-responsive gene, MK, found in the teratocarcinoma
            system. Heterogeneity of the transcript and the nature of the
            translation product
  JOURNAL   J Biol Chem 265 (18), 10765-10770 (1990)
   PUBMED   2355021
REFERENCE   9  (bases 1 to 922)
  AUTHORS   Matsubara,S., Tomomura,M., Kadomatsu,K. and Muramatsu,T.
  TITLE     Structure of a retinoic acid-responsive gene, MK, which is
            transiently activated during the differentiation of embryonal
            carcinoma cells and the mid-gestation period of mouse embryogenesis
  JOURNAL   J Biol Chem 265 (16), 9441-9443 (1990)
   PUBMED   2345177
REFERENCE   10 (bases 1 to 922)
  AUTHORS   Kadomatsu,K., Tomomura,M. and Muramatsu,T.
  TITLE     cDNA cloning and sequencing of a new gene intensely expressed in
            early differentiation stages of embryonal carcinoma cells and in
            mid-gestation period of mouse embryogenesis
  JOURNAL   Biochem Biophys Res Commun 151 (3), 1312-1318 (1988)
   PUBMED   3355557
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL731772.9.
            
            On Oct 27, 2022 this sequence version replaced NM_001012335.2.
            
            Summary: This gene encodes a secreted growth factor that belongs to
            the pleiotrophin/midkine heparin-binding protein family and
            functions in a variety of biological processes. The encoded
            cytokine promotes the growth, differentiation, survival and
            migration of several target cells including leucocytes involved in
            inflammation. This protein plays a role in the formation of scar
            tissue and intraperitoneal adhesions, and promotes neurite
            outgrowth and neuron survival. The protein encoded by this gene is
            associated with obesity and inhibition of insulin signaling in fat
            cells. A pseudogene of this gene is present on chromosome 11.
            Alternative splicing results in multiple transcript variants.
            [provided by RefSeq, Apr 2014].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CF738400.1, AA222497.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164137, SAMN01164138
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-212               AL731772.9         69145-69356         c
            213-289             AL731772.9         68983-69059         c
            290-448             AL731772.9         68707-68865         c
            449-610             AL731772.9         68429-68590         c
            611-922             AL731772.9         67415-67726         c
FEATURES             Location/Qualifiers
     source          1..922
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 50.63 cM"
     gene            1..922
                     /gene="Mdk"
                     /gene_synonym="Mek; MK"
                     /note="midkine"
                     /db_xref="GeneID:17242"
                     /db_xref="MGI:MGI:96949"
     exon            1..212
                     /gene="Mdk"
                     /gene_synonym="Mek; MK"
                     /inference="alignment:Splign:2.1.0"
     exon            213..289
                     /gene="Mdk"
                     /gene_synonym="Mek; MK"
                     /inference="alignment:Splign:2.1.0"
     CDS             214..636
                     /gene="Mdk"
                     /gene_synonym="Mek; MK"
                     /note="isoform a precursor is encoded by transcript
                     variant 2; retinoic acid-induced differentiation factor;
                     retinoic acid-responsive protein; retanoic acid-responsive
                     protein"
                     /codon_start=1
                     /product="midkine isoform a precursor"
                     /protein_id="NP_001012335.1"
                     /db_xref="CCDS:CCDS16440.1"
                     /db_xref="GeneID:17242"
                     /db_xref="MGI:MGI:96949"
                     /translation="MQHRGFFLLALLALLVVTSAVAKKKEKVKKGSECSEWTWGPCTP
                     SSKDCGMGFREGTCGAQTQRVHCKVPCNWKKEFGADCKYKFESWGACDGSTGTKARQG
                     TLKKARYNAQCQETIRVTKPCTSKTKSKTKAKKGKGKD"
     exon            290..448
                     /gene="Mdk"
                     /gene_synonym="Mek; MK"
                     /inference="alignment:Splign:2.1.0"
     exon            449..610
                     /gene="Mdk"
                     /gene_synonym="Mek; MK"
                     /inference="alignment:Splign:2.1.0"
     exon            611..922
                     /gene="Mdk"
                     /gene_synonym="Mek; MK"
                     /inference="alignment:Splign:2.1.0"
     regulatory      875..880
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mdk"
                     /gene_synonym="Mek; MK"
                     /note="hexamer: AATAAA"
     regulatory      880..885
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mdk"
                     /gene_synonym="Mek; MK"
                     /note="hexamer: AATAAA"
     polyA_site      897
                     /gene="Mdk"
                     /gene_synonym="Mek; MK"
     regulatory      899..904
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mdk"
                     /gene_synonym="Mek; MK"
                     /note="hexamer: AATAAA"
     polyA_site      900
                     /gene="Mdk"
                     /gene_synonym="Mek; MK"
                     /note="major polyA site"
     polyA_site      922
                     /gene="Mdk"
                     /gene_synonym="Mek; MK"
ORIGIN      
        1 cttagcggga caggccggag cgggagggag cgaagcatcg agcagtgagc gagtgagcgc
       61 acgcagtggc tgtggcccca gtcccttcag gcggctgctc tgccaccaag ggggctgagg
      121 tgggggtggg ggtacgctga gacatcggtt ccaagtcctc cctccgtctc ccccttgtcg
      181 gtccgacgtt ttgggcctgg aaagtgggac aagatgcagc accgaggctt cttccttctc
      241 gcccttcttg ccctcttggt ggtcacgtcc gcggtggcca aaaaaaaaga gaaggtgaag
      301 aagggcagcg agtgttcgga gtggacctgg gggccctgca cccccagcag caaggactgc
      361 ggcatgggct tccgcgaggg tacctgtggg gcccagaccc agcgcgtcca ttgcaaggtg
      421 ccctgcaact ggaagaagga atttggagcc gactgcaaat acaagtttga gagctggggg
      481 gcgtgtgatg ggagcactgg caccaaagcc cgccaaggga ccctgaagaa ggcgcggtac
      541 aatgcccagt gccaggagac catccgcgtg actaagccct gcacctccaa gaccaagtca
      601 aagaccaaag ccaagaaagg aaaaggaaag gactaagtca ggaggccaga gagcctccgg
      661 cctcgcctgg agcctgaacg gagccctcct ctcccacagg cccaagatat aacccaccag
      721 tgccttttgt cttcctgtca gctctgtcaa tcacgcctgt cctctcacgc ccacaccaag
      781 tgcccaaagt ggggagggac aagagattct ggaaagtgag cctccccata ccctcttttg
      841 ttctccccac cctgatactt gttattaaga aatgaataaa ataaactcac ttttttccaa
      901 taaaagcttc ttttttaata ta
//
