LOCUS       NM_008617               1297 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus malate dehydrogenase 2, NAD (mitochondrial) (Mdh2),
            mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_008617
VERSION     NM_008617.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1297)
  AUTHORS   Ayyangar,U., Karkhanis,A., Tay,H., Afandi,A.F.B., Bhattacharjee,O.,
            Ks,L., Lee,S.H., Chan,J. and Raghavan,S.
  TITLE     Metabolic rewiring of macrophages by epidermal-derived lactate
            promotes sterile inflammation in the murine skin
  JOURNAL   EMBO J 43 (7), 1113-1134 (2024)
   PUBMED   38418556
REFERENCE   2  (bases 1 to 1297)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 1297)
  AUTHORS   Chong,D., Gu,Y., Zhang,T., Xu,Y., Bu,D., Chen,Z., Xu,N., Li,L.,
            Zhu,X., Wang,H., Li,Y., Zheng,F., Wang,D., Li,P., Xu,L., Hu,Z. and
            Li,C.
  TITLE     Neonatal ketone body elevation regulates postnatal heart
            development by promoting cardiomyocyte mitochondrial maturation and
            metabolic reprogramming
  JOURNAL   Cell Discov 8 (1), 106 (2022)
   PUBMED   36220812
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1297)
  AUTHORS   Molinie,T., Cougouilles,E., David,C., Cahoreau,E., Portais,J.C. and
            Mourier,A.
  TITLE     MDH2 produced OAA is a metabolic switch rewiring the fuelling of
            respiratory chain and TCA cycle
  JOURNAL   Biochim Biophys Acta Bioenerg 1863 (3), 148532 (2022)
   PUBMED   35063410
REFERENCE   5  (bases 1 to 1297)
  AUTHORS   Chen,J., Jin,J., Zhang,X., Yu,H., Zhu,X., Yu,L., Chen,Y., Liu,P.,
            Dong,X., Cao,X., Gu,Y., Bao,X., Xia,S. and Xu,Y.
  TITLE     Microglial lnc-U90926 facilitates neutrophil infiltration in
            ischemic stroke via MDH2/CXCL2 axis
  JOURNAL   Mol Ther 29 (9), 2873-2885 (2021)
   PUBMED   33895326
  REMARK    GeneRIF: Microglial lnc-U90926 facilitates neutrophil infiltration
            in ischemic stroke via MDH2/CXCL2 axis.
REFERENCE   6  (bases 1 to 1297)
  AUTHORS   Serikawa,T., Kuramoto,T., Hilbert,P., Mori,M., Yamada,J.,
            Dubay,C.J., Lindpainter,K., Ganten,D., Guenet,J.L., Lathrop,G.M. et
            al.
  TITLE     Rat gene mapping using PCR-analyzed microsatellites
  JOURNAL   Genetics 131 (3), 701-721 (1992)
   PUBMED   1628813
REFERENCE   7  (bases 1 to 1297)
  AUTHORS   Habets,G.G., van der Kammen,R.A., Willemsen,V., Balemans,M.,
            Wiegant,J. and Collard,J.G.
  TITLE     Sublocalization of an invasion-inducing locus and other genes on
            human chromosome 7
  JOURNAL   Cytogenet Cell Genet 60 (3-4), 200-205 (1992)
   PUBMED   1505215
REFERENCE   8  (bases 1 to 1297)
  AUTHORS   Kristensen,T., Lopez,R. and Prydz,H.
  TITLE     An estimate of the sequencing error frequency in the DNA sequence
            databases
  JOURNAL   DNA Seq 2 (6), 343-346 (1992)
   PUBMED   1446073
  REMARK    Erratum:[DNA Seq 1993;3(5):337]
REFERENCE   9  (bases 1 to 1297)
  AUTHORS   Lalley,P.A., Minna,J.D. and Francke,U.
  TITLE     Conservation of autosomal gene synteny groups in mouse and man
  JOURNAL   Nature 274 (5667), 160-163 (1978)
   PUBMED   662012
REFERENCE   10 (bases 1 to 1297)
  AUTHORS   Womack,J.E., Hawes,N.L., Soares,E.R. and Roderick,T.H.
  TITLE     Mitochondrial malate dehydrogenase (Mor-1) in the mouse: linkage to
            chromosome 5 markers
  JOURNAL   Biochem Genet 13 (9-10), 519-525 (1975)
   PUBMED   1203052
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC023482.1.
            
            On Jun 19, 2003 this sequence version replaced NM_008617.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC023482.1, AK135162.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1297
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 75.4 cM"
     gene            1..1297
                     /gene="Mdh2"
                     /gene_synonym="MDH; Mdh-2; Mor-1; Mor1"
                     /note="malate dehydrogenase 2, NAD (mitochondrial)"
                     /db_xref="GeneID:17448"
                     /db_xref="MGI:MGI:97050"
     exon            1..153
                     /gene="Mdh2"
                     /gene_synonym="MDH; Mdh-2; Mor-1; Mor1"
                     /inference="alignment:Splign:2.1.0"
     CDS             88..1104
                     /gene="Mdh2"
                     /gene_synonym="MDH; Mdh-2; Mor-1; Mor1"
                     /EC_number="1.1.1.37"
                     /note="mitochondrial malate dehydrogenase 2, NAD; malate
                     dehydrogenase, mitochondrial"
                     /codon_start=1
                     /product="malate dehydrogenase, mitochondrial precursor"
                     /protein_id="NP_032643.2"
                     /db_xref="CCDS:CCDS19746.1"
                     /db_xref="GeneID:17448"
                     /db_xref="MGI:MGI:97050"
                     /translation="MLSALARPAGAALRRSFSTSAQNNAKVAVLGASGGIGQPLSLLL
                     KNSPLVSRLTLYDIAHTPGVAADLSHIETRANVKGYLGPEQLPDCLKGCDVVVIPAGV
                     PRKPGMTRDDLFNTNATIVATLTAACAQHCPEAMVCIIANPVNSTIPITAEVFKKHGV
                     YNPNKIFGVTTLDIVRANTFVAELKGLDPARVNVPVIGGHAGKTIIPLISQCTPKVDF
                     PQDQLATLTGRIQEAGTEVVKAKAGAGSATLSMAYAGARFVFSLVDAMNGKEGVVECS
                     FVQSKETECTYFSTPLLLGKKGLEKNLGIGKITPFEEKMIAEAIPELKASIKKGEDFV
                     KNMK"
     exon            154..322
                     /gene="Mdh2"
                     /gene_synonym="MDH; Mdh-2; Mor-1; Mor1"
                     /inference="alignment:Splign:2.1.0"
     exon            323..406
                     /gene="Mdh2"
                     /gene_synonym="MDH; Mdh-2; Mor-1; Mor1"
                     /inference="alignment:Splign:2.1.0"
     exon            407..516
                     /gene="Mdh2"
                     /gene_synonym="MDH; Mdh-2; Mor-1; Mor1"
                     /inference="alignment:Splign:2.1.0"
     exon            517..642
                     /gene="Mdh2"
                     /gene_synonym="MDH; Mdh-2; Mor-1; Mor1"
                     /inference="alignment:Splign:2.1.0"
     exon            643..720
                     /gene="Mdh2"
                     /gene_synonym="MDH; Mdh-2; Mor-1; Mor1"
                     /inference="alignment:Splign:2.1.0"
     exon            721..820
                     /gene="Mdh2"
                     /gene_synonym="MDH; Mdh-2; Mor-1; Mor1"
                     /inference="alignment:Splign:2.1.0"
     exon            821..972
                     /gene="Mdh2"
                     /gene_synonym="MDH; Mdh-2; Mor-1; Mor1"
                     /inference="alignment:Splign:2.1.0"
     exon            973..1282
                     /gene="Mdh2"
                     /gene_synonym="MDH; Mdh-2; Mor-1; Mor1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcggccactg cgcagagtgg aggtcgttgg agtcactcgt cttcttgtag ctcctgccag
       61 tagctccgtg tcccgcccgc cctagccatg ctgtccgctc tcgcccgtcc tgccggcgcc
      121 gctctccgcc gcagcttcag cacttcggcc cagaacaatg ctaaagtggc tgtcctggga
      181 gcttctgggg gcattgggca acccctttca ctcctgctga agaacagccc cctagtgagc
      241 cgcctgaccc tctacgatat cgctcacaca cctggtgtgg cagcagatct gagtcacatt
      301 gagaccagag caaatgtgaa aggctacctt ggaccggagc agttgccaga ttgcctcaaa
      361 ggttgtgatg tggtggtcat cccagccgga gtgcccagga aaccaggaat gacacgggat
      421 gacctgttca acaccaacgc taccattgtg gccaccctga cggctgcctg tgcccagcac
      481 tgtcctgaag ccatggtttg catcattgcc aacccagtga actccaccat ccccatcaca
      541 gcagaagttt tcaagaagca cggtgtgtac aaccctaaca agatcttcgg tgtgacaacc
      601 cttgacatcg tcagagcgaa cacgtttgtg gcagagctaa agggtttgga tccagctcga
      661 gtcaacgtgc ctgtcattgg cggccacgcc gggaagacga tcatccccct gatctctcag
      721 tgtaccccga aggttgactt tccccaagac cagctggcca cactcaccgg gaggatccag
      781 gaggctggca cagaagtcgt gaaggccaag gctggagcag gttctgccac tctgtccatg
      841 gcttatgctg gagcccgctt tgtcttctcc ctcgtggacg ccatgaacgg gaaggaagga
      901 gtcgttgagt gttcttttgt tcagtccaaa gagacggaat gcacttactt ctctacgccc
      961 ttgctcttgg ggaaaaaggg cctggagaag aacctgggca ttggcaagat cactcctttt
     1021 gaggaaaaaa tgattgccga ggctatccct gagctgaaag cctccatcaa gaaaggcgag
     1081 gactttgtca agaacatgaa gtgagaggtg tgagcctcga gcagcagcag cagcagcatc
     1141 ctaacttatt cagcatcatg tctttggaac cacttgagaa tctagtttgc gttgatggag
     1201 ggtgttgagt cagcatcagc atctcttcca aattatgtct ggtctgttga taatgacagt
     1261 aaagcaggct ctgattttct ttaaaaaaaa aaaaaaa
//
