LOCUS       NM_029696               1711 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus malate dehydrogenase 1B, NAD (soluble) (Mdh1b), mRNA.
ACCESSION   NM_029696 XM_989237
VERSION     NM_029696.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1711)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1711)
  AUTHORS   Bowman,C.E., Zhao,L., Hartung,T. and Wolfgang,M.J.
  TITLE     Requirement for the Mitochondrial Pyruvate Carrier in Mammalian
            Development Revealed by a Hypomorphic Allelic Series
  JOURNAL   Mol Cell Biol 36 (15), 2089-2104 (2016)
   PUBMED   27215380
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1711)
  AUTHORS   McClintock,T.S., Glasser,C.E., Bose,S.C. and Bergman,D.A.
  TITLE     Tissue expression patterns identify mouse cilia genes
  JOURNAL   Physiol Genomics 32 (2), 198-206 (2008)
   PUBMED   17971504
  REMARK    GeneRIF: Mdh1b is most abundantly expressed in tissues rich in
            highly ciliated cells, such as olfactory sensory neurons, and is
            predicted to be important to cilia.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC050786.1, BB573905.1 and AC099637.7.
            
            [WARNING] On Aug 3, 2024 this sequence was replaced by NM_029696.5.
            
            On Sep 21, 2008 this sequence version replaced NM_029696.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            transcript and genomic sequence to make the sequence consistent
            with the reference genome assembly. The extent of this transcript
            is supported by transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC050786.1, SRR5189685.124227.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-54                BC050786.1         1-54
            55-55               BB573905.1         78-78
            56-553              BC050786.1         56-553
            554-554             AC099637.7         44090-44090         c
            555-1711            BC050786.1         555-1711
FEATURES             Location/Qualifiers
     source          1..1711
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 32.31 cM"
     gene            1..1711
                     /gene="Mdh1b"
                     /gene_synonym="1700124B08Rik"
                     /note="malate dehydrogenase 1B, NAD (soluble)"
                     /db_xref="GeneID:76668"
                     /db_xref="MGI:MGI:1923918"
     exon            1..48
                     /gene="Mdh1b"
                     /gene_synonym="1700124B08Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             27..1529
                     /gene="Mdh1b"
                     /gene_synonym="1700124B08Rik"
                     /EC_number="1.1.1.-"
                     /codon_start=1
                     /product="putative malate dehydrogenase 1B"
                     /protein_id="NP_083972.3"
                     /db_xref="CCDS:CCDS15000.2"
                     /db_xref="GeneID:76668"
                     /db_xref="MGI:MGI:1923918"
                     /translation="MAKFVIAGKANCPYYAKAELLADYLQKNLPDFRIFKITQHPDKW
                     EDWVEDVCERNMWDHRTSPIIWRELLDRGGRGLLLGGYNEFLEHAQLYYGVTSNMTTE
                     LMMVIAKENMQTHTEQQLDKETMKDLISPLQVWIASAGTYVCCHLIPLLLSGEVFGMH
                     TEISLTLFDQEQREDCLRSIVMETQDLASPVLRTVSFCTTVKEAFLQAQVIIILDDST
                     EEEVYSLESCLRSRVPLCRLYGYLIEKNAHKSVKVIVGGKNFVNLKTTLLMQYAPNIA
                     SNIIAVALGVEGQAKAVLARKMKTTSANIKDVIIWGNITGNNYVDLRKAKVYNYESAV
                     KGPPGHYHSVLSLIFDREWITKEFVQTLKILSSTGKQFGGILAAHSIATTLKYWYHGS
                     PPGEIVSLGVMSEGQFDIPEGIVFSMPVKFENGTWVVLTDLEDISLSEKTLSRLTGDL
                     IQEKLVACGDLLTFQPIEEDPKDNEPSNTGMNEEKEQPGSDDSDEKNEDQ"
     exon            49..161
                     /gene="Mdh1b"
                     /gene_synonym="1700124B08Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            162..296
                     /gene="Mdh1b"
                     /gene_synonym="1700124B08Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            297..439
                     /gene="Mdh1b"
                     /gene_synonym="1700124B08Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            440..936
                     /gene="Mdh1b"
                     /gene_synonym="1700124B08Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            937..1078
                     /gene="Mdh1b"
                     /gene_synonym="1700124B08Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1079..1242
                     /gene="Mdh1b"
                     /gene_synonym="1700124B08Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1243..1382
                     /gene="Mdh1b"
                     /gene_synonym="1700124B08Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1383..1434
                     /gene="Mdh1b"
                     /gene_synonym="1700124B08Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1435..1500
                     /gene="Mdh1b"
                     /gene_synonym="1700124B08Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1501..1711
                     /gene="Mdh1b"
                     /gene_synonym="1700124B08Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1685..1690
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mdh1b"
                     /gene_synonym="1700124B08Rik"
                     /note="hexamer: AATAAA"
     polyA_site      1704
                     /gene="Mdh1b"
                     /gene_synonym="1700124B08Rik"
ORIGIN      
        1 ccagtttcta ggtcttgcta gaaatcatgg ccaaatttgt gatcgcgggt aaagcaaact
       61 gcccatatta tgctaaggca gaacttctgg cagactattt acaaaagaat cttcctgact
      121 ttcggatttt taagatcacg caacatcctg acaagtggga ggattgggtg gaagatgttt
      181 gtgaaaggaa tatgtgggac cacagaacct cccccattat ctggagagag ttgctggatc
      241 gtggaggcag gggcttgctt ttgggaggat acaatgagtt tctggaacat gcccagcttt
      301 actatggtgt cacttccaac atgacgacgg agttgatgat ggtcatcgct aaagagaaca
      361 tgcagacgca tacagaacaa cagttggata aagaaaccat gaaagatctc atcagccctt
      421 tgcaggtctg gattgccagt gcaggtactt acgtgtgctg ccacttaatt cccctcttgc
      481 taagcgggga agtgtttggg atgcacacag agatcagcct gaccctgttt gaccaggagc
      541 aaagggagga ctgcctcaga agcatagtga tggaaaccca ggacttggcc tcaccagtgc
      601 tccgcactgt gtccttctgc accacggtaa aggaggcctt ccttcaggcc caggtcatca
      661 tcatcctgga tgacagtaca gaggaagagg tgtacagcct ggagagctgc ctccggagca
      721 gggtgccgct gtgccgcctc tacggctacc tgatagagaa aaacgctcac aagtctgtca
      781 aggtcatcgt gggagggaaa aactttgtaa atctgaaaac aactttgctc atgcaatatg
      841 cccctaacat cgcgagcaac attatcgcag tggctctggg ggtagaaggc caagcaaaag
      901 cagtactggc ccgaaagatg aaaaccactt cagccaacat caaagatgtg ataatctggg
      961 gcaatatcac tggaaataac tacgttgatc tgaggaaagc aaaagtttac aactatgaga
     1021 gtgctgtcaa ggggcctcct ggacactatc actctgtgtt aagcttgatt tttgacagag
     1081 agtggatcac aaaagaattt gtgcagacac ttaaaatctt gagcagcact ggaaaacaat
     1141 ttggaggcat cttggctgca cacagcatag ccaccaccct gaagtactgg tatcatggct
     1201 caccacctgg agagattgtt tccttggggg taatgagtga aggccagttt gacattcctg
     1261 aagggatcgt cttttctatg ccagtgaaat ttgagaatgg aacgtgggtg gttcttactg
     1321 atcttgaaga catttcgctt agtgagaaga cactaagcag gctcacaggc gatctgattc
     1381 aggagaaact tgttgcatgt ggagacttat taacttttca gccaattgaa gaagatccca
     1441 aagataacga accttctaat acaggcatga atgaagaaaa ggaacagcct gggtccgatg
     1501 actctgatga aaaaaatgag gaccaataat agcttcaacc agaacaaata tgaaggaaag
     1561 acagaaagac ctgcaggtgt ctgcacttag ggaagaacag tgaaataaaa tagaccccaa
     1621 atctagcaga ttcacatgct gccacatcca atcccgcttt tgtcaattgc tgtatgtcct
     1681 caaaaataaa tgaatgtaaa ccgctgtctt a
//
