LOCUS       NM_001193266            9834 bp    mRNA    linear   ROD 12-NOV-2024
DEFINITION  Mus musculus MAM domain containing glycosylphosphatidylinositol
            anchor 2 (Mdga2), transcript variant A, mRNA.
ACCESSION   NM_001193266
VERSION     NM_001193266.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 9834)
  AUTHORS   Fertan,E., Wong,A.A., Montbrun,T.S.G., Purdon,M.K., Roddick,K.M.,
            Yamamoto,T. and Brown,R.E.
  TITLE     Early postnatal development of the MDGA2+/- mouse model of synaptic
            dysfunction
  JOURNAL   Behav Brain Res 452, 114590 (2023)
   PUBMED   37499910
  REMARK    GeneRIF: Early postnatal development of the MDGA2[+/-] mouse model
            of synaptic dysfunction.
REFERENCE   2  (bases 1 to 9834)
  AUTHORS   Chen,P., Liu,Z., Zhang,Q., Lin,D., Song,L., Liu,J., Jiao,H.F.,
            Lai,X., Zou,S., Wang,S., Zhou,T., Li,B.M., Zhu,L., Pan,B.X. and
            Fei,E.
  TITLE     DSCAM Deficiency Leads to Premature Spine Maturation and
            Autism-like Behaviors
  JOURNAL   J Neurosci 42 (4), 532-551 (2022)
   PUBMED   34848499
REFERENCE   3  (bases 1 to 9834)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 9834)
  AUTHORS   Gautam,M., Xie,E.F., Kocak,N. and Ozdinler,P.H.
  TITLE     Mitoautophagy: A Unique Self-Destructive Path Mitochondria of Upper
            Motor Neurons With TDP-43 Pathology Take, Very Early in ALS
  JOURNAL   Front Cell Neurosci 13, 489 (2019)
   PUBMED   31787882
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 9834)
  AUTHORS   Barham,C., Fil,D., Byrum,S.D., Rahmatallah,Y., Glazko,G. and
            Kiaei,M.
  TITLE     RNA-Seq Analysis of Spinal Cord Tissues from hPFN1G118V Transgenic
            Mouse Model of ALS at Pre-symptomatic and End-Stages of Disease
  JOURNAL   Sci Rep 8 (1), 13737 (2018)
   PUBMED   30213953
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 9834)
  AUTHORS   Pettem,K.L., Yokomaku,D., Takahashi,H., Ge,Y. and Craig,A.M.
  TITLE     Interaction between autism-linked MDGAs and neuroligins suppresses
            inhibitory synapse development
  JOURNAL   J Cell Biol 200 (3), 321-336 (2013)
   PUBMED   23358245
  REMARK    GeneRIF: MDGA binding and suppression of synaptogenic activity was
            selective for neuroligin-2 and not neuroligin-1 excitatory synapse
            organizer.
REFERENCE   7  (bases 1 to 9834)
  AUTHORS   Suzuki,M., Solter,D. and Watanabe,T.
  TITLE     Transgene insertion in intronic sequences of Mdga2 gene shows
            methylation in an imprinted manner in an Acrodysplasia (Adp) mouse
            line
  JOURNAL   Biochem Biophys Res Commun 418 (3), 439-444 (2012)
   PUBMED   22281501
  REMARK    GeneRIF: The transgene was inserted into the intronic sequences
            between exon 3 and exon 4 of the Mdga2 gene;the transgene was
            highly or under methylated in normal and deformed mice,
            respectively.
REFERENCE   8  (bases 1 to 9834)
  AUTHORS   Watanabe,T., Tarttelin,E., Neubuser,A., Kimura,M. and Solter,D.
  TITLE     Fine genetic mapping defines the genetic order of Pax9, Tcf3a, and
            Acrodysplasia (Adp)
  JOURNAL   Mamm Genome 5 (12), 768-770 (1994)
   PUBMED   7894157
REFERENCE   9  (bases 1 to 9834)
  AUTHORS   Boulter,C.A., Aguzzi,A., Evans,M.J. and Affara,N.
  TITLE     A chimaeric mouse model for autosomal-dominant polycystic kidney
            disease
  JOURNAL   Contrib Nephrol 97, 60-70 (1992)
   PUBMED   1633717
REFERENCE   10 (bases 1 to 9834)
  AUTHORS   DeLoia,J.A. and Solter,D.
  TITLE     A transgene insertional mutation at an imprinted locus in the mouse
            genome
  JOURNAL   Dev Suppl, 73-79 (1990)
   PUBMED   2090433
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK137667.1 and AC164164.3.
            
            Transcript Variant: This variant (A) represents the longer
            transcript and encodes the longer isoform (A).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK137667.1, BC137901.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164139 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: downstream AUG is associated
                                                with N-terminal localization
                                                signal
            RefSeq Select criteria           :: based on conservation,
                                                expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-4452              AK137667.1         2-4453
            4453-9834           AC164164.3         52898-58279         c
FEATURES             Location/Qualifiers
     source          1..9834
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 27.63 cM"
     gene            1..9834
                     /gene="Mdga2"
                     /gene_synonym="6720489L24Rik; 9330209L04Rik; Adp; Mamdc1;
                     Tg(Prnp-PFN1*G118V)838Kiaei"
                     /note="MAM domain containing glycosylphosphatidylinositol
                     anchor 2"
                     /db_xref="GeneID:320772"
                     /db_xref="MGI:MGI:2444706"
     exon            1..1580
                     /gene="Mdga2"
                     /gene_synonym="6720489L24Rik; 9330209L04Rik; Adp; Mamdc1;
                     Tg(Prnp-PFN1*G118V)838Kiaei"
                     /inference="alignment:Splign:2.1.0"
     CDS             1508..4378
                     /gene="Mdga2"
                     /gene_synonym="6720489L24Rik; 9330209L04Rik; Adp; Mamdc1;
                     Tg(Prnp-PFN1*G118V)838Kiaei"
                     /note="isoform A precursor is encoded by transcript
                     variant A; MAM domain containing 1; MAM domain-containing
                     glycosylphosphatidylinositol anchor protein 2;
                     acrodysplasia"
                     /codon_start=1
                     /product="MAM domain-containing
                     glycosylphosphatidylinositol anchor protein 2 isoform A
                     precursor"
                     /protein_id="NP_001180195.2"
                     /db_xref="CCDS:CCDS56842.2"
                     /db_xref="GeneID:320772"
                     /db_xref="MGI:MGI:2444706"
                     /translation="MDLVYGLVWLLTVLLEGISGQGVYAPPTVRIVHSGLACNIEEER
                     YSERVYTIREGETLELTCLVTGHPRPQIRWTKTAGSASDRFQDSSVFNETLRITNIQR
                     HQGGRYYCKAENGLGSPAIKSIRVDVYYLDDPVVTVHQSIGEAKEQFYYERTVFLRCV
                     ANSNPPVRYSWRRGQEVLLQGSDKGVEIYEPFFTQGETKILKLKNLRPQDYANYSCIA
                     SVRNVCNIPDKMVSFRLSNKTASPSIKLLVDDPIVVNPGEAITLVCVTTGGEPTPSLT
                     WVRSFGTLPEKIVLNGGTLTIPAITSDDAGTYSCIANNNVGNPAKKSTNIIVRALKKG
                     RFWITPDPYHKDDNIQIGREVKISCQVEAVPSEELTFSWFKNGRPLRSSERMVITQTD
                     PDVSPGTTNLDIIDLKFTDFGTYTCVASLKGGGISDISIDVNISSSTVPPNLTVPQEK
                     SPLVTREGDTIELQCQVTGKPKPIILWSRADKEVAMPDGTMQMESYDGTLRIVNVSRE
                     MSGMYRCQTSQYNGFNVKPREALVQLIVQYPPAVEPAFLEIRQGQDRSVTMSCRVLRA
                     YPIRVLTYEWRLGNKLLRTGQFDSQEYTEYPLKSLSNENYGVYNCSIINEAGAGRCSF
                     LVTGKAYAPEFYYDTYNPVWQNRHRVYSYSLQWTQMNPDAVDRIVAYRLGIRQAGQQR
                     WWEQEIKINGNIQKGELITYNLTELIKPEAYEVRLTPLTKFGEGDSTIRVIKYTAPVN
                     PHLREFHCGFEDGNICLFTQDDTDNFDWTKQSTATRNTKYTPNTGPSADRSGSKEGFY
                     MYIETSRPRLEGEKARLLSPVFSIAPKNPYGPTNSAYCFSFFYHMYGQHIGVLNVYLR
                     LKGQTTIENPLWSSSGNKGQRWNEAHVNIYPITSFQLIFEGIRGPGIEGDIAIDDVSI
                     AEGECAKQDLPTKNSVDGAVGILVHIWLFPVIILISILSPRR"
     exon            1581..1720
                     /gene="Mdga2"
                     /gene_synonym="6720489L24Rik; 9330209L04Rik; Adp; Mamdc1;
                     Tg(Prnp-PFN1*G118V)838Kiaei"
                     /inference="alignment:Splign:2.1.0"
     exon            1721..1895
                     /gene="Mdga2"
                     /gene_synonym="6720489L24Rik; 9330209L04Rik; Adp; Mamdc1;
                     Tg(Prnp-PFN1*G118V)838Kiaei"
                     /inference="alignment:Splign:2.1.0"
     exon            1896..2092
                     /gene="Mdga2"
                     /gene_synonym="6720489L24Rik; 9330209L04Rik; Adp; Mamdc1;
                     Tg(Prnp-PFN1*G118V)838Kiaei"
                     /inference="alignment:Splign:2.1.0"
     exon            2093..2225
                     /gene="Mdga2"
                     /gene_synonym="6720489L24Rik; 9330209L04Rik; Adp; Mamdc1;
                     Tg(Prnp-PFN1*G118V)838Kiaei"
                     /inference="alignment:Splign:2.1.0"
     exon            2226..2495
                     /gene="Mdga2"
                     /gene_synonym="6720489L24Rik; 9330209L04Rik; Adp; Mamdc1;
                     Tg(Prnp-PFN1*G118V)838Kiaei"
                     /inference="alignment:Splign:2.1.0"
     exon            2496..2825
                     /gene="Mdga2"
                     /gene_synonym="6720489L24Rik; 9330209L04Rik; Adp; Mamdc1;
                     Tg(Prnp-PFN1*G118V)838Kiaei"
                     /inference="alignment:Splign:2.1.0"
     exon            2826..3119
                     /gene="Mdga2"
                     /gene_synonym="6720489L24Rik; 9330209L04Rik; Adp; Mamdc1;
                     Tg(Prnp-PFN1*G118V)838Kiaei"
                     /inference="alignment:Splign:2.1.0"
     exon            3120..3389
                     /gene="Mdga2"
                     /gene_synonym="6720489L24Rik; 9330209L04Rik; Adp; Mamdc1;
                     Tg(Prnp-PFN1*G118V)838Kiaei"
                     /inference="alignment:Splign:2.1.0"
     exon            3390..3538
                     /gene="Mdga2"
                     /gene_synonym="6720489L24Rik; 9330209L04Rik; Adp; Mamdc1;
                     Tg(Prnp-PFN1*G118V)838Kiaei"
                     /inference="alignment:Splign:2.1.0"
     exon            3539..3716
                     /gene="Mdga2"
                     /gene_synonym="6720489L24Rik; 9330209L04Rik; Adp; Mamdc1;
                     Tg(Prnp-PFN1*G118V)838Kiaei"
                     /inference="alignment:Splign:2.1.0"
     exon            3717..3737
                     /gene="Mdga2"
                     /gene_synonym="6720489L24Rik; 9330209L04Rik; Adp; Mamdc1;
                     Tg(Prnp-PFN1*G118V)838Kiaei"
                     /inference="alignment:Splign:2.1.0"
     exon            3738..3893
                     /gene="Mdga2"
                     /gene_synonym="6720489L24Rik; 9330209L04Rik; Adp; Mamdc1;
                     Tg(Prnp-PFN1*G118V)838Kiaei"
                     /inference="alignment:Splign:2.1.0"
     exon            3894..4052
                     /gene="Mdga2"
                     /gene_synonym="6720489L24Rik; 9330209L04Rik; Adp; Mamdc1;
                     Tg(Prnp-PFN1*G118V)838Kiaei"
                     /inference="alignment:Splign:2.1.0"
     exon            4053..4183
                     /gene="Mdga2"
                     /gene_synonym="6720489L24Rik; 9330209L04Rik; Adp; Mamdc1;
                     Tg(Prnp-PFN1*G118V)838Kiaei"
                     /inference="alignment:Splign:2.1.0"
     exon            4184..4289
                     /gene="Mdga2"
                     /gene_synonym="6720489L24Rik; 9330209L04Rik; Adp; Mamdc1;
                     Tg(Prnp-PFN1*G118V)838Kiaei"
                     /inference="alignment:Splign:2.1.0"
     exon            4290..9834
                     /gene="Mdga2"
                     /gene_synonym="6720489L24Rik; 9330209L04Rik; Adp; Mamdc1;
                     Tg(Prnp-PFN1*G118V)838Kiaei"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6306..6311
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mdga2"
                     /gene_synonym="6720489L24Rik; 9330209L04Rik; Adp; Mamdc1;
                     Tg(Prnp-PFN1*G118V)838Kiaei"
                     /note="hexamer: AATAAA"
     polyA_site      6337
                     /gene="Mdga2"
                     /gene_synonym="6720489L24Rik; 9330209L04Rik; Adp; Mamdc1;
                     Tg(Prnp-PFN1*G118V)838Kiaei"
                     /note="major polyA site"
     regulatory      8513..8518
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mdga2"
                     /gene_synonym="6720489L24Rik; 9330209L04Rik; Adp; Mamdc1;
                     Tg(Prnp-PFN1*G118V)838Kiaei"
                     /note="hexamer: AATAAA"
     polyA_site      8535
                     /gene="Mdga2"
                     /gene_synonym="6720489L24Rik; 9330209L04Rik; Adp; Mamdc1;
                     Tg(Prnp-PFN1*G118V)838Kiaei"
     regulatory      9525..9530
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mdga2"
                     /gene_synonym="6720489L24Rik; 9330209L04Rik; Adp; Mamdc1;
                     Tg(Prnp-PFN1*G118V)838Kiaei"
                     /note="hexamer: AATAAA"
     polyA_site      9559
                     /gene="Mdga2"
                     /gene_synonym="6720489L24Rik; 9330209L04Rik; Adp; Mamdc1;
                     Tg(Prnp-PFN1*G118V)838Kiaei"
ORIGIN      
        1 ccccggcagc ctggccgcct gcgctccgcg tccgccgctt ctccatcctc ctcctcttct
       61 tcctcctcct cctccttcct atcgcctccg cggtgcgcaa cccccagcgt caatccaggg
      121 atcccgagca agcgtagggc cccggacgct cctctgccca gcttgggcat ctctgccgca
      181 actgcggccc gcaaggcggc cgcgcagccg gggtgccctc agcaggcggc cgcttctctg
      241 ttccgctccg gatgccagca ctccgttagc ccgggtgggg aaagcccttc tgcggctccc
      301 gggtctaaac tcccgccagt ctccaccgcc cccaccccct ccacctggcg ggggcggcgc
      361 ggaagcgaag aggactcgcg gtacgggtgg gcacgcgtgg acggtgtgcg gatctgctct
      421 gcgctcggca tcctccctct cctgcaagtg gtggtgctcg gactctgctt ttggctccgg
      481 agattggtgc tgcctccagg agcaccctct ttgctggcgg ggcgctcaag gctgtttgga
      541 agagccgtgg cggtggcggc agcggctgag gctggtgcct ggcgagctcc agacgggcgc
      601 tccgctcccg cttggaccct ttcgccctcc tctctcctcc tccgctccct cctccccatc
      661 ccccgtttcc cactcctcct cttcctcctc ctcctcttcc tctccccgct cggcgatgcg
      721 agtctctgtc gtgtaacagg attggcgttg caatggcaac tgatggaatg ggggaaggca
      781 agacagcagg gctgggggct ccggactgcg ggcgggcgag ccgctgccgc cgcttgacgc
      841 tcctctgggg accttcgcga gttactttgt aaaggcgaac ccgggcgagg gagccccgct
      901 tcgtgcccgg gtcagaggcc acttcctgct ccctggctgt ccagcgcggt tcgcgtcgcg
      961 cggcgccccc agggctcctg cccgctcctg ccgcttgccc gcgcccggag cccggagccg
     1021 cttccctgaa gaacacttgt cctcacagct ctgcttccca tcaccgcccc ctgctcctcc
     1081 ccggcgtctg cgattttccc aggcgcccgg tgtgagtgcg gcttgtgtgt gagtgcatgt
     1141 attggggtat tgtgtagtgg gagtgtgttc ccgcgtgtgt gtgcttatac gtgtgtgctt
     1201 gtgcgtgtgt gtgtgtgtgt gtgtgtgagc gtgtgtgtga gcgtgtgtgt gcgtgtgtgt
     1261 gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtgtgtgtgc atgagtgtgg ggtgtgtggg
     1321 gctccagcgc tccgctcacg gccgccgcca gggaaggaca gacggacagt gcttcctccc
     1381 attgctagca gttcccgggc acctcgactc ggcccgggca caagtggagc gcgccttgct
     1441 ggccgctggc ctccagaagg tcccactgcg tcccccttgg gctggatatg ttcatgttca
     1501 cgtgaagatg gatttagtgt acggtctcgt gtggctgctg acagtcctcc tggagggaat
     1561 ctctggccaa ggagtgtacg ctcccccgac agttcggatt gtgcactcag gattggcctg
     1621 taatatcgag gaggagcgct actccgaaag ggtctatacc atccgggaag gagaaactct
     1681 agaattgacc tgcctggtta ctggacatcc acgcccacag atcaggtgga ccaaaacagc
     1741 aggaagcgcc tctgacagat tccaagactc aagtgtcttc aatgagactt tgaggattac
     1801 aaacattcag agacaccaag gaggccgata ttactgtaaa gcagagaatg gcttggggtc
     1861 accagcaata aagtcgatcc gagtggatgt gtactacttg gatgatccag tagtaactgt
     1921 tcatcaaagt ataggtgaag ctaaagaaca attttactat gagagaacag tgtttctccg
     1981 atgtgtggcc aattccaacc cccctgtgcg ctatagctgg agacgtggtc aggaggtatt
     2041 actacaagga tctgacaagg gagtggagat ttatgagccc ttttttaccc agggggaaac
     2101 gaagatctta aagctaaaga atcttcgccc tcaagattat gctaactaca gctgcattgc
     2161 ttcagtaagg aacgtgtgta atattccaga caagatggtg tcgtttagac tttccaataa
     2221 aactgcttct ccgtcaatta agctcttggt ggatgatcct atagttgtaa atcctggaga
     2281 ggccataacg ttagtatgtg ttacaactgg aggagagcct acaccctctc ttacctgggt
     2341 caggtccttc gggactctgc ctgaaaagat tgttttgaat ggagggacat tgaccatacc
     2401 tgccatcacc tctgatgacg ctggtactta cagctgcatt gccaataata atgtgggaaa
     2461 ccctgcaaaa aagtccacca acatcattgt gagagcatta aaaaaaggac gattttggat
     2521 cactcctgat ccttatcaca aagatgacaa catccagatt gggcgtgagg tgaaaatatc
     2581 ttgccaagta gaagctgttc cctctgagga gttaacattc agttggttta aaaatggtcg
     2641 tccattaaga agttctgaac ggatggttat tacacagact gaccctgatg tgtcccccgg
     2701 aacaacaaac ttggatatca ttgacttaaa attcacagac tttgggactt acacatgcgt
     2761 ggcctctctg aagggaggag gaatatctga tatcagtatt gatgttaaca tttccagcag
     2821 tacagttcca cccaatctga ctgttccaca ggaaaaatca cctttggtca ccagagaagg
     2881 agacacaata gaacttcagt gtcaagtaac tgggaaacca aaaccaatca tcctttggtc
     2941 tagagcagat aaagaagttg caatgcctga tgggacaatg caaatggaaa gttatgatgg
     3001 gaccctgagg attgtgaatg tttcaaggga aatgtcagga atgtacagat gccagaccag
     3061 ccagtacaat ggattcaacg tgaagccaag agaagccttg gtgcagctca ttgtgcagta
     3121 tcccccagct gtggaaccag cattcttgga aatccgtcaa ggacaggaca gaagtgtgac
     3181 catgagctgt agggtcctga gagcctatcc aatacgagtg ctgacctatg agtggcgtct
     3241 gggcaataaa ttattacgga ccggacagtt tgactctcag gagtatacag agtacccact
     3301 aaagagtctt tccaatgaaa actatggagt ttataactgc agcatcataa atgaagctgg
     3361 agcagggaga tgcagctttc ttgttacagg aaaggcctat gccccagagt tctactatga
     3421 cacctacaac cccgtgtggc agaaccgaca ccgagtgtat tcttacagtc tacagtggac
     3481 acaaatgaac cctgatgcag ttgatcgaat tgttgcatac cgcttgggta ttcggcaggc
     3541 tggacagcaa cgctggtggg aacaggagat taaaataaat ggaaatattc agaaaggaga
     3601 actgattaca tataacttga ctgaacttat taaaccagag gcctatgaag tccgattgac
     3661 tcctctcact aaatttggtg aaggagattc aacaattcgt gtaattaaat atacagcacc
     3721 tgtaaatcct catttgaggg aatttcactg tggatttgaa gatggtaata tttgtttgtt
     3781 cacccaagac gatacggata actttgactg gacaaagcaa agcactgcaa caaggaacac
     3841 aaaatacacc cctaacacgg gtcccagtgc agatcggagt ggttccaaag aaggttttta
     3901 tatgtacatt gagacatcgc gacccagact agaaggcgaa aaggctcgac ttctcagccc
     3961 tgtattcagc atagctccca aaaatccata tggacctaca aatagtgcat attgtttcag
     4021 tttcttctat cacatgtacg ggcaacatat aggggtttta aatgtatatc tacgtttgaa
     4081 agggcagaca acgatagaga atccgctatg gtcgtcgagt gggaacaaag gacaacgatg
     4141 gaatgaagct catgttaata tatatccaat tacttcattt cagttaattt ttgaaggcat
     4201 tcgaggtcct gggatagagg gtgacatcgc cattgatgat gtatcaattg ctgaaggaga
     4261 atgtgcaaaa caagacctac caactaagaa ttccgtggat ggtgctgttg ggatcttagt
     4321 tcatatatgg ctttttccag ttatcatcct catctctatc ttaagccctc gaaggtgacc
     4381 ttatcctggc agaggctata aatgattcac caggcactgg catgaagaaa gagtctttgt
     4441 aaatggacac tgaaaaaaca aactaccaaa gattcctcca ctgactactg actcaaaaat
     4501 taaataataa aaacaacatt tttttaagca ctggggatta aaaaaaaaga catcatggaa
     4561 atataactta ttccaaacta catatagaag atattcttgg cctgggtaca aaagagccct
     4621 tcaggtgctt ttgtggctaa aatgattaca gcttcatctg gttgaactct ggaaaaagaa
     4681 aataaaagaa aaagaaagaa tgagagaaaa agaagaagaa aaagagctat agaaatcctc
     4741 gtcaaagcac aaagtcatgg ctggttttgt ttcaaatgaa tagtttgctt gttaccatgg
     4801 aaacctaatg gcctgccaac aaaaacctca ctgtaaacag ggtacgtgga gagctggcat
     4861 ttattttcct ttcaagaagg ttttatgtag agaattaaat aaatgtaggc ccttttacct
     4921 ttggctgtta cccttccttg aaaatactcc aaactcggaa ttatttaaag gtttcatatc
     4981 cctccccgcc ttatcccacc ccacttttac tgttgtttgg gttttgttct tgttgttctt
     5041 gttgttcttg ttgttgttac tgtttgttgt agttcttttc tttttccttt tttctttctt
     5101 ttttctccct cacatggcta agctagataa ctgtatgatg tctctttttg catgcactac
     5161 tatccaggat ggtaaacctg ggcttacata ttacacaggc ttatcggagt ttgcttgcgg
     5221 ccacttgaca cccaaactac gtcatctgtt cctatgaaga aaccaaacca ccatctttta
     5281 taaattgcca tggaaaccaa gtgccttcaa tgaaacaagc ctgaataatt ttcaactcag
     5341 aagcttgcac tgctaacaat ggtttgtgta aaactatttt gtaaacagac gacacagcct
     5401 aaatgtgcaa attacaggca agacacccta gccgcttctg aagaagaaag gacccacgct
     5461 gctgcgtaaa cccatgcaga ttatgtgttt cacctcctag acagccatgg ccttttggct
     5521 taatgtccat agaaagtaac ttccattgag accagacatg ggagcaacac ttttttcttc
     5581 caggttatta aatgggtcaa ccagagcaaa aggttgttga gataatactt agcgcagaag
     5641 gtggtaaaac acagaagtga ttttttttta ctctaacctc catttcaaat gagattggct
     5701 ttgcctttag agggaacgag gaaatgtttg agattgccgt gcatacaaac tctgccgcgg
     5761 aactgggcct gaaaacaatc tggctttatt ctaaacactg agggtaatat gcctctgccc
     5821 tttagtcaga ctctgtgcaa attgtgaaat attattttat tattttaaca agattaaaaa
     5881 aaacactttt acaaaaaaac aaaaacctgt aaaaatgatt ttgagctacc tgaggacaaa
     5941 ccataacttt aaccagccag ttttccaatg cattgtaaat ttcacttaaa cctgttggtt
     6001 atgacaattt gaagatcttt ttccttaaat tatctcagct tttaacttca tttaaaaaga
     6061 cttttgtcta aagaagaata ttattattat ctgttctttc aacaccccag gatttaaaaa
     6121 aaaattactg attatgcaag taattgggat ctaagtatta aattgcagca tttgcaaata
     6181 ttaatataaa aagcacaaca aaaatgtagt ggaaatgaca aagcttgatt tttttaaaaa
     6241 caactgtaga aatgtttgtg caaattcaat aattcaactt aaaatataat tttacagctc
     6301 tgttcaataa agcctctttc cgggtgagga gcgataagcg gtatgtgtgt ttgttgggca
     6361 atatttactt atcattacaa tgagattagt tatgcaattt attggttata ttatcttggg
     6421 ataaatcatc agtgcttcat acacacttga tgtctgcagg aacaaatttt aaagaacata
     6481 caacacattc tcttttattt gttaaacaca taagtaaaaa aatgttgtac tctgtaggta
     6541 aaatgcaaac cgacatgcaa gttaaaattt attgttaaat ttcatagtcg ggtcaaaagg
     6601 ggacatatca gaataccaac atagtgatag aatcaatatg acccaagtcc cttaactcac
     6661 acaaaggaag taaatgatta tcgtcattta tttgaattaa ttagtcatat tgaaattaaa
     6721 aatttttttc aaagtcatcc atctattcta tcaaaccaaa gatttgcagc aggtgataac
     6781 tgggcactta gcatgggaaa gatctgcatt cacctgcatt tccagcatac agccacccac
     6841 cccagttctg tgctccccaa gatgagtaaa acacacgttt attttattag gtcttttttc
     6901 attctctctg ccaggacact gatatgtgtc tcctgtttaa agagagcctc tatttgtcat
     6961 cttctttcaa ttgcctttaa gctgatttgc gtgaggcttt tgtaaatgaa cttaaaatgg
     7021 aaaaacccct taaatgttga attttggaag gtacacatgt catgtcaaga aaactcacag
     7081 ggtttttttt ccttctcagt ttttccaagc aaagaagctg ttgtgagtga aagtttcaat
     7141 tgtatcatta agcatttatc aaacgttaaa gtagttccta aatttccaca tagtaagaga
     7201 acacactcca gaagttaaag agaactggct ggtactccaa aattaatttt tattaaacat
     7261 ctaagaagtt gcagatggtt gtgaagaaca aggggcaatc agaggggaaa gcagacagac
     7321 tagcgaggtg gtgagaaact gaatttctcg catgagattt acaatgattt acatcagtta
     7381 gtcaaaccaa cagaatcacg gtttttacat cagatcaaat gctcagttgc tttaatgaaa
     7441 gtaaacatct aaaaatgtgg aaaattttta aatgattagg ataaatgaac tggaaacttt
     7501 gtgaaatcat cttgtcttta atcgaagtaa tgattgtgga acccttaaaa cactttccca
     7561 ttcctaacat tgttatattt atcaaaactg gacccaatga cacgttcccc ttaccatttt
     7621 gctaatgtgt cagctataat ttgagaagcc tcgtgggttc ctgatttttt tttttaaact
     7681 ggggaagcat ttagcaatca gggttttatt ttctgggaga aatgatatgc tgtgtcatct
     7741 ccagttattg acagtaactg atctgcatta gttaggagtg gtaccgcttt catcagttca
     7801 atgatgctac tttacaggtt aacatttcta gagttgggcc tgttttcatt gcaattagca
     7861 gcactgtcat gtagtgatat ggagcatgca cacagagctg agaggacttg agtactgtca
     7921 gatgtgacaa acaagactaa atatgatctt tccttgaaag ttaaaagtga gaaaaaaata
     7981 ttgcccaatc acacttatca ggtgtatgaa taatcatgga ctatgcagtt ttgaaaaaaa
     8041 taacctactt acttttcctt tcttttaaaa tacgtctttt ttttaggatg atttacatac
     8101 atacctaccc atgattttcc attttctacc ttttttcctg ttatgtgtat ttagagttcc
     8161 agcatggact atatgtatca ctggtctgct gtggtccctg gtgccatggg gcttatggta
     8221 ttcaacagat tatgagtttg gcccatgatt tatattcctg taagagaact gatggatgct
     8281 tggttacaaa gtcagacagc ggaccttgac actaatggca cttcacattt cccacagaat
     8341 tggctcagca tagcaatgaa ttatatctga attagaatct aactagtctg ttttaccatg
     8401 taatatacaa tggaaacaat tccattcttt acttggacat atgataaaat ataaattaca
     8461 gctgtactaa cttttcacca gacatgcaat tttattctaa atactttata ataataaact
     8521 tatctgcaaa caaaatgtgt aatttgaata ataattaatt catttatttc tatactataa
     8581 acatgactgt ggtattactc agaatcattt taattttgtg tttctcttgg tgattttaaa
     8641 gttggtgaca gactggtctg attttggata aaacaaaact tttcaaatga tcctcctaaa
     8701 tttgtgttcc ttattacaaa acctattttg tttactgtgc ctttcaaata tcagggccac
     8761 tgaatagaca tttaaactgg aaaaaaaaat taaccttccc caaatatatt ctagttgctg
     8821 actacttcca cggtttcagc tgtgtctcaa caaagcagaa ggtacactct tcttgcaact
     8881 gggcagttga tttcaatgag gagttattgc attttctgtg aaaacaataa gatcataggg
     8941 ttcaatccca aactatttct tttcctacaa cattcccttt gtgactagcc catttaattc
     9001 attttcttag cgttactttt agaaaggaat gtctgtcctt ttctactgtc ttagaagaaa
     9061 aactactaca aaataaattt gatttttttc aaatctcata ggaaaagttt gttgtatatt
     9121 catagtatat ctacatataa ttgtatgtgt tattacatga gtaaagaaaa attaaatctt
     9181 gacactataa tgtgaagtat gtcagccagg gaagtcccta gtgggttaat gtctgcttag
     9241 aaatagaagt gagagattga gataaagctt ccacatattt ctatatgaat tacttcatga
     9301 gcatatggtc atttgaaaat taatacgtct atgagtagtg atttcactac tctgaaccca
     9361 tattgagaat ctcaaactgg aatccaaaat ttggaatagg gctgaggtta aactctgggt
     9421 agaaactgca atagttttct caaggatata tttgcaactg attgaattta atttcaattg
     9481 tactaatttt ccatgagttg atttgcaatg tattcttatt tttcaataaa acgttgggaa
     9541 attccatgag tagggagaag cttggtagtt ttgcttgtct tcgtatggct cttcattgtt
     9601 gccctgggat tccgggcttt cctttttatt tcctgagtct caacagtata tttaaatgta
     9661 taagtttaat caaatatgca ttgtgttaaa tttatatgaa acattggaga ccataaaatt
     9721 tagatttatc ttaatttaca ttttgatatt ttccttcttc caaatagttt cagatagttg
     9781 tatgttattt tccttggaat ttttttcaat aaatgaaatt atgttaaata ctct
//
