LOCUS       NM_001368423            8288 bp    mRNA    linear   ROD 11-FEB-2025
DEFINITION  Mus musculus MAM domain containing glycosylphosphatidylinositol
            anchor 1 (Mdga1), transcript variant 1, mRNA.
ACCESSION   NM_001368423 XM_006525040
VERSION     NM_001368423.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 8288)
  AUTHORS   Chen,P., Liu,Z., Zhang,Q., Lin,D., Song,L., Liu,J., Jiao,H.F.,
            Lai,X., Zou,S., Wang,S., Zhou,T., Li,B.M., Zhu,L., Pan,B.X. and
            Fei,E.
  TITLE     DSCAM Deficiency Leads to Premature Spine Maturation and
            Autism-like Behaviors
  JOURNAL   J Neurosci 42 (4), 532-551 (2022)
   PUBMED   34848499
REFERENCE   2  (bases 1 to 8288)
  AUTHORS   Kim,J., Kim,S., Kim,H., Hwang,I.W., Bae,S., Karki,S., Kim,D.,
            Ogelman,R., Bang,G., Kim,J.Y., Kajander,T., Um,J.W., Oh,W.C. and
            Ko,J.
  TITLE     MDGA1 negatively regulates amyloid precursor protein-mediated
            synapse inhibition in the hippocampus
  JOURNAL   Proc Natl Acad Sci U S A 119 (4) (2022)
   PUBMED   35074912
  REMARK    GeneRIF: MDGA1 negatively regulates amyloid precursor
            protein-mediated synapse inhibition in the hippocampus.
            Erratum:[Proc Natl Acad Sci U S A. 2024 Jun 25;121(26):e2410758121.
            doi: 10.1073/pnas.2410758121.. PMID: 38900803]
REFERENCE   3  (bases 1 to 8288)
  AUTHORS   Rudan Njavro,J., Klotz,J., Dislich,B., Wanngren,J., Shmueli,M.D.,
            Herber,J., Kuhn,P.H., Kumar,R., Koeglsperger,T., Conrad,M.,
            Wurst,W., Feederle,R., Vlachos,A., Michalakis,S., Jedlicka,P.,
            Muller,S.A. and Lichtenthaler,S.F.
  TITLE     Mouse brain proteomics establishes MDGA1 and CACHD1 as in vivo
            substrates of the Alzheimer protease BACE1
  JOURNAL   FASEB J 34 (2), 2465-2482 (2020)
   PUBMED   31908000
  REMARK    GeneRIF: Mouse brain proteomics establishes MDGA1 and CACHD1 as in
            vivo substrates of the Alzheimer protease BACE1.
REFERENCE   4  (bases 1 to 8288)
  AUTHORS   Hossain,M.R., Jamal,M., Tanoue,Y., Ojima,D., Takahashi,H.,
            Kubota,T., Ansary,T.M., Ito,A., Tanaka,N., Kinoshita,H.,
            Kishimoto,Y. and Yamamoto,T.
  TITLE     MDGA1-deficiency attenuates prepulse inhibition with alterations of
            dopamine and serotonin metabolism: An ex vivo HPLC-ECD analysis
  JOURNAL   Neurosci Lett 716, 134677 (2020)
   PUBMED   31812551
  REMARK    GeneRIF: MDGA1-deficiency attenuates prepulse inhibition with
            alterations of dopamine and serotonin metabolism: An ex vivo
            HPLC-ECD analysis.
REFERENCE   5  (bases 1 to 8288)
  AUTHORS   Ruiz-Reig,N., Andres,B., Lamonerie,T., Theil,T., Fairen,A. and
            Studer,M.
  TITLE     The caudo-ventral pallium is a novel pallial domain expressing
            Gdf10 and generating Ebf3-positive neurons of the medial amygdala
  JOURNAL   Brain Struct Funct 223 (7), 3279-3295 (2018)
   PUBMED   29869132
REFERENCE   6  (bases 1 to 8288)
  AUTHORS   Tissir,F., Qu,Y., Montcouquiol,M., Zhou,L., Komatsu,K., Shi,D.,
            Fujimori,T., Labeau,J., Tyteca,D., Courtoy,P., Poumay,Y., Uemura,T.
            and Goffinet,A.M.
  TITLE     Lack of cadherins Celsr2 and Celsr3 impairs ependymal ciliogenesis,
            leading to fatal hydrocephalus
  JOURNAL   Nat Neurosci 13 (6), 700-707 (2010)
   PUBMED   20473291
REFERENCE   7  (bases 1 to 8288)
  AUTHORS   Armentano,M., Chou,S.J., Tomassy,G.S., Leingartner,A., O'Leary,D.D.
            and Studer,M.
  TITLE     COUP-TFI regulates the balance of cortical patterning between
            frontal/motor and sensory areas
  JOURNAL   Nat Neurosci 10 (10), 1277-1286 (2007)
   PUBMED   17828260
REFERENCE   8  (bases 1 to 8288)
  AUTHORS   Takeuchi,A., Hamasaki,T., Litwack,E.D. and O'Leary,D.D.
  TITLE     Novel IgCAM, MDGA1, expressed in unique cortical area- and
            layer-specific patterns and transiently by distinct forebrain
            populations of Cajal-Retzius neurons
  JOURNAL   Cereb Cortex 17 (7), 1531-1541 (2007)
   PUBMED   16959869
  REMARK    GeneRIF: These findings show that MDGA1 is a unique marker for
            studies of cortical lamination and area patterning and together
            with recent reports suggest that MDGA1 has critical functions in
            forebrain/midbrain development.
REFERENCE   9  (bases 1 to 8288)
  AUTHORS   Yoshida,Y., Han,B., Mendelsohn,M. and Jessell,T.M.
  TITLE     PlexinA1 signaling directs the segregation of proprioceptive
            sensory axons in the developing spinal cord
  JOURNAL   Neuron 52 (5), 775-788 (2006)
   PUBMED   17145500
REFERENCE   10 (bases 1 to 8288)
  AUTHORS   Takeuchi,A. and O'Leary,D.D.
  TITLE     Radial migration of superficial layer cortical neurons controlled
            by novel Ig cell adhesion molecule MDGA1
  JOURNAL   J Neurosci 26 (17), 4460-4464 (2006)
   PUBMED   16641224
  REMARK    GeneRIF: We conclude that MDGA1 acts cell autonomously to control
            the migration of MDGA1-expressing superficial layer cortical
            neurons.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC151294.3 and AC154291.2.
            
            On Feb 13, 2019 this sequence version replaced XM_006525040.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR17784647.407748.1,
                                           SRR14995048.1835341.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1132              AC151294.3         81947-83078         c
            1133-1272           AC154291.2         170983-171122       c
            1273-1447           AC154291.2         165835-166009       c
            1448-1644           AC154291.2         163885-164081       c
            1645-1777           AC154291.2         163033-163165       c
            1778-2047           AC154291.2         162550-162819       c
            2048-2377           AC154291.2         159714-160043       c
            2378-2674           AC154291.2         156238-156534       c
            2675-2962           AC154291.2         155512-155799       c
            2963-3114           AC154291.2         154190-154341       c
            3115-3292           AC154291.2         153198-153375       c
            3293-3316           AC154291.2         152942-152965       c
            3317-3469           AC154291.2         151830-151982       c
            3470-3604           AC154291.2         151385-151519       c
            3605-3735           AC154291.2         146615-146745       c
            3736-3844           AC154291.2         146306-146414       c
            3845-8288           AC154291.2         141349-145792       c
FEATURES             Location/Qualifiers
     source          1..8288
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 15.54 cM"
     gene            1..8288
                     /gene="Mdga1"
                     /gene_synonym="1200011I03Rik; GPIM; Mamdc3"
                     /note="MAM domain containing glycosylphosphatidylinositol
                     anchor 1"
                     /db_xref="GeneID:74762"
                     /db_xref="MGI:MGI:1922012"
     exon            1..1132
                     /gene="Mdga1"
                     /gene_synonym="1200011I03Rik; GPIM; Mamdc3"
                     /inference="alignment:Splign:2.1.0"
     CDS             1066..3936
                     /gene="Mdga1"
                     /gene_synonym="1200011I03Rik; GPIM; Mamdc3"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; MAM domain-containing
                     glycosylphosphatidylinositol anchor protein 1"
                     /codon_start=1
                     /product="MAM domain-containing
                     glycosylphosphatidylinositol anchor protein 1 isoform 1
                     precursor"
                     /protein_id="NP_001355352.1"
                     /db_xref="CCDS:CCDS89052.1"
                     /db_xref="GeneID:74762"
                     /db_xref="MGI:MGI:1922012"
                     /translation="MEVTCLLLLALIPFHCRGQGVYAPAQAQIVHAGQACVVKEDNIS
                     ERVYTIRESDTLVLQCLVTGHPRPQVRWTKTAGSASDKFQETSVFNETLRIERIARTQ
                     GGRYYCKAENGVGVPAIKSIRVDVQYLDEPVLTVHQTVSDVRGNFYQEKTVFLRCTVS
                     SNPPARFIWKRGSDTLSHSQDNGVDIYEPLYTQGETKVLKLKNLRPQDYASYTCQVSV
                     RNVCGIPDKAITFQLTNTTAPPALKLSVNETLVVNPGENVTVQCLLTGGDPLPQLHWS
                     HGPGPLPLGALAQGGTLSIPSVQARDSGYYNCTATNNVGNPAKKTVNLLVRSLKNATF
                     QITPDMIKESENIQLGQDLKLSCHVDAVPQEKVNYQWFKNGKPARTSKRLLVTRNDPE
                     LPAVTSSLELIDLHFSDYGTYLCMASFPGSPVPDLSIEVNISSETVPPTISVPKGRAV
                     VTVREGSPAELQCEVRGKPRPPVLWSRVDKEAALLPSGLALEETPDGKLRLESVSRDM
                     SGTYRCQTARYNGFNVRPREAQVQLTVHFPPEVEPSSQDVRQALGRPVLLRCSLLRGS
                     PQRIASAVWRFKGQLLPPPPVLPAAAVETPDHAELRLDALTRDSSGNYECSVSNDVGS
                     ATCLFQVSAKAYSPEFYFDTPNPTRSHKLSKNYSYVLQWTQREPDAVDPVLNYRLSIR
                     QLNQHNAMVKAIPVRRVEKGQLLEYILTDLRVPHSYEIRLTPYTTFGAGDMASRIIHY
                     TEPINLPSLSDNTCHFEDEKICGYTQDLTDNFDWTRQNALTQNPKRSPNTGPPTDISG
                     TPEGYYMFIETSRPRELGDRARLVSPLYNASAKFYCVSFFYHMYGKHIGSLNLLVRSR
                     NKGTLDTHAWSLSGNKGNVWQQAHVPINPSGPFQIIFEGVRGSGYLGDIAIDDVTLKK
                     GECPRRQMDPNKVVVMPGSGAPRLSSLQLWGSMAIFLLALQR"
     exon            1133..1272
                     /gene="Mdga1"
                     /gene_synonym="1200011I03Rik; GPIM; Mamdc3"
                     /inference="alignment:Splign:2.1.0"
     exon            1273..1447
                     /gene="Mdga1"
                     /gene_synonym="1200011I03Rik; GPIM; Mamdc3"
                     /inference="alignment:Splign:2.1.0"
     exon            1448..1644
                     /gene="Mdga1"
                     /gene_synonym="1200011I03Rik; GPIM; Mamdc3"
                     /inference="alignment:Splign:2.1.0"
     exon            1645..1777
                     /gene="Mdga1"
                     /gene_synonym="1200011I03Rik; GPIM; Mamdc3"
                     /inference="alignment:Splign:2.1.0"
     exon            1778..2047
                     /gene="Mdga1"
                     /gene_synonym="1200011I03Rik; GPIM; Mamdc3"
                     /inference="alignment:Splign:2.1.0"
     exon            2048..2377
                     /gene="Mdga1"
                     /gene_synonym="1200011I03Rik; GPIM; Mamdc3"
                     /inference="alignment:Splign:2.1.0"
     exon            2378..2674
                     /gene="Mdga1"
                     /gene_synonym="1200011I03Rik; GPIM; Mamdc3"
                     /inference="alignment:Splign:2.1.0"
     exon            2675..2962
                     /gene="Mdga1"
                     /gene_synonym="1200011I03Rik; GPIM; Mamdc3"
                     /inference="alignment:Splign:2.1.0"
     exon            2963..3114
                     /gene="Mdga1"
                     /gene_synonym="1200011I03Rik; GPIM; Mamdc3"
                     /inference="alignment:Splign:2.1.0"
     exon            3115..3292
                     /gene="Mdga1"
                     /gene_synonym="1200011I03Rik; GPIM; Mamdc3"
                     /inference="alignment:Splign:2.1.0"
     exon            3293..3316
                     /gene="Mdga1"
                     /gene_synonym="1200011I03Rik; GPIM; Mamdc3"
                     /inference="alignment:Splign:2.1.0"
     exon            3317..3469
                     /gene="Mdga1"
                     /gene_synonym="1200011I03Rik; GPIM; Mamdc3"
                     /inference="alignment:Splign:2.1.0"
     exon            3470..3604
                     /gene="Mdga1"
                     /gene_synonym="1200011I03Rik; GPIM; Mamdc3"
                     /inference="alignment:Splign:2.1.0"
     exon            3605..3735
                     /gene="Mdga1"
                     /gene_synonym="1200011I03Rik; GPIM; Mamdc3"
                     /inference="alignment:Splign:2.1.0"
     exon            3736..3844
                     /gene="Mdga1"
                     /gene_synonym="1200011I03Rik; GPIM; Mamdc3"
                     /inference="alignment:Splign:2.1.0"
     exon            3845..8288
                     /gene="Mdga1"
                     /gene_synonym="1200011I03Rik; GPIM; Mamdc3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4166..4171
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mdga1"
                     /gene_synonym="1200011I03Rik; GPIM; Mamdc3"
                     /note="hexamer: ATTAAA"
     polyA_site      4189
                     /gene="Mdga1"
                     /gene_synonym="1200011I03Rik; GPIM; Mamdc3"
                     /note="major polyA site"
     regulatory      8266..8271
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mdga1"
                     /gene_synonym="1200011I03Rik; GPIM; Mamdc3"
                     /note="hexamer: AATAAA"
     polyA_site      8288
                     /gene="Mdga1"
                     /gene_synonym="1200011I03Rik; GPIM; Mamdc3"
ORIGIN      
        1 acagcgaagc ccaagttagg gagcgagcgg agcgctcccg cggccccgga gccggagtgg
       61 ccgcggtgcc ccggagcccg cccggccccg cccgctgggg ccctctcggg cccaggccgc
      121 cgggaggggg gcggggacgc ccaacttggg gcgcggcgca gccccgctct cccgagatcg
      181 cggagcccgg gaatgccacg gcggcggcca gacggcggga gaggagcggg gagagaggag
      241 gcggccagca gctcctgagc ccgggcctcc gcaagagcgc gaattatttt caaaggactc
      301 aaactttcct ctttcccttg ctggctgcgg tccctcttgc tttggaaccg ttctctggat
      361 tcccgcgggg gcgccgggac gcgatcgcct cccccggatt cctcggcggc ggctcggcta
      421 acttcgcgga ctcggggacc cggagcgctc gccccgctgc cgaacctagt cctcgctgct
      481 ccagcgctcc agaggaccgg gacccggcgc cctcgcctcc gggaagggcg cccagcccgg
      541 ctcccttggg tcgggctgcg gagccctcca cacctactgc aggactggag ccagcggatt
      601 aaccaaagca gagtccgggc ctcctggcct ggctccgcgg aggggcgtcc cctgggcggg
      661 gaaaagacaa gtttgtcagg catcggtggc ctgttggatc ggagcgcggc cgccgcagca
      721 gagaggtccc cccgcgttca gcaccctcgg tggacagccc tggggaccta ggactgctcg
      781 gtggccgagc tttctgggcc agggagctgg ctgctgcgcc cggtgcgcag aggcttcaag
      841 gtctggggca gcgccccctg cgtctccacc cgggcagccg ccctgtggga agaggacaga
      901 gccgagtcgc ggcttgctca gactcctagt ctcggtcgcc gccctctccg tcgcgactca
      961 gggaaaagga gggaacgcag agggcaaagc ggtgccccgg cggatgcgcc ccccgccgcc
     1021 tctcaggctg cgccgcctcg cggggatgaa gcactggccg tgaagatgga ggtgacctgt
     1081 cttctacttc tggcgcttat ccccttccac tgtcggggac aaggagtcta tgctccagcc
     1141 caggcccaga ttgtgcatgc ggggcaggcc tgtgtggtga aggaggataa catcagcgag
     1201 cgggtctaca ccatccggga gagcgacacc ctggtgctgc agtgcctggt cacgggacac
     1261 cctcggcccc aggtgcggtg gaccaaaact gccggcagcg catcggacaa gttccaggag
     1321 acgtcggtct tcaatgagac tctgcggatc gagcgcatcg cacgcacgca gggaggtcgc
     1381 tactactgca aggcggagaa cggagtgggc gtgccggcca tcaagtctat ccgcgtggac
     1441 gtgcagtact tggatgagcc tgtgctaacg gtgcatcaga cagtgagcga tgtccgaggc
     1501 aacttctacc aggagaagac cgtgtttcta cgctgtaccg tcagctccaa cccgcccgcc
     1561 cgctttatct ggaagcgggg ctccgacacc ctgtcccaca gccaggataa tggggttgac
     1621 atctacgagc ctctctatac tcagggggag acgaaggtcc tgaagctgaa gaacctgcgg
     1681 ccccaagact atgccagcta cacctgccag gtgtccgtgc gcaatgtgtg cggcatccca
     1741 gacaaggcta tcaccttcca gctcaccaac accacggcac ctccagcctt gaagctgtct
     1801 gtgaacgaaa ctctggtggt gaaccctggg gagaacgtga cagtgcagtg tctgctgacg
     1861 ggcggcgatc ccctccccca gctgcactgg tcccacggac ctggcccact gcccctgggt
     1921 gctctggctc agggtggtac cctcagcatc ccttcagtgc aggcccggga ttctggctac
     1981 tacaactgca cagccaccaa caatgtaggc aacccagcta agaagaccgt caacctgctg
     2041 gtgcgatccc tgaagaacgc cacattccag atcacccccg acatgatcaa agaaagcgag
     2101 aacattcaac tcggtcagga cctgaagctg tcatgccatg tggatgcggt gccccaggag
     2161 aaggtgaact atcagtggtt taaaaacggc aagccggcac gcacatccaa gcggctgctg
     2221 gtgacccgaa atgaccccga gttgcccgct gtcaccagca gcctggagct cattgacctg
     2281 cacttcagtg actacggcac ttatctgtgc atggcttcct tcccagggtc accagtgcct
     2341 gacctcagca tagaggtcaa catttcctca gagacagtac cacccaccat cagtgtgccc
     2401 aagggccgag cagtggtgac agtgagggag ggctctcctg ctgagctcca gtgcgaagtt
     2461 cgtggcaagc cccggcctcc agtgctatgg tctcgggtgg acaaggaggc cgcccttctg
     2521 ccctcggggc tggccctgga ggagactccg gatgggaagc tgcggctgga gagtgtgagc
     2581 cgcgacatga gcggcaccta ccgctgccag acagctcgct acaatggctt caacgtacga
     2641 ccccgggagg ctcaggtgca gctgacagtg cactttcctc cagaggtgga gcccagttcc
     2701 caggacgtgc gccaggcgct gggccggcct gtgctcctgc gctgctcgct tctgcgtggc
     2761 agtcctcagc gcatcgcctc ggccgtgtgg cgcttcaaag gacagctgct gcccccaccg
     2821 cctgttctcc ccgccgctgc tgtggagacc cccgatcacg ccgagctgcg cctggacgcc
     2881 ctgacccgtg acagcagcgg caactacgag tgcagcgtct ccaacgacgt gggctcagcc
     2941 acctgcctct tccaggtctc cgccaaagcc tacagcccgg agttttactt cgacaccccc
     3001 aaccccaccc gcagccacaa gctgtccaag aattactcct atgtgctaca gtggacacag
     3061 agagagcccg atgctgtgga ccccgtgctc aactacagac tcagcatccg acagttgaac
     3121 cagcacaatg ccatggtcaa ggccatcccc gttcgtcgtg tggagaaggg acagctgctg
     3181 gagtatatct tgactgacct ccgagtaccc cacagctatg agatccgcct cacaccctac
     3241 accacctttg gggctggtga catggcttcc cgcatcatcc actacacaga gcctatcaac
     3301 ttgcccagcc tgtcagacaa cacctgtcac tttgaggatg agaaaatctg cggctacacc
     3361 caggatctga cagacaactt tgactggacg cggcagaatg ctcttaccca gaaccccaag
     3421 cgctctccta atactgggcc ccctactgac atcagtggca cccctgaagg ctattacatg
     3481 ttcattgaga catccagacc cagggagctg ggggaccgtg caaggctggt gagtcccctg
     3541 tacaacgcca gtgccaagtt ctactgtgtc tctttcttct accacatgta tgggaaacac
     3601 atcggctccc tcaaccttct ggtgcggtcc aggaacaaag gcactctaga cacgcatgcc
     3661 tggtccctca gtggcaataa gggtaacgtg tggcagcagg cccatgtacc cattaacccc
     3721 agtgggccct tccagattat ttttgagggg gttcgaggct cgggctacct gggggatatt
     3781 gccatagatg atgtcacact gaagaaggga gagtgtcccc ggaggcagat ggatcccaac
     3841 aaagtggttg tgatgccagg cagcggagcc ccacgcctgt ccagcctgca actttgggga
     3901 tccatggcca tcttcctctt ggcgttgcaa agatgatgag agctgtgtgg cccccacccc
     3961 gccctgcccc cggcacacca aagtgtccac atcgtaccaa agactgaccc ctgccagccg
     4021 gggtgcctag gggcggggcc agcccaccag ggagggggcc ttcattggct acattgatga
     4081 gcagagaact cggacagagg ccaagccagg ctctggtggt tgttcaacac acgcacacac
     4141 tcacactcac tctcaccaca gatatattaa agcacaagtt tttattcgac ctgccagcac
     4201 cttctttact gtggagatgg gacttatgtg aatggcgtcc accacctcca gggaccttgg
     4261 tgcgacacgg gactcatctt gtctgcacac tgcgctgtgt ctgtctgacc ttgccttgtc
     4321 ccctgactca aggccgaact ccagcccaga ggcttgccag aagggagccg gatgtgggca
     4381 gaatatcaga cttgggctgc ctggatggag gtcacagggt gcagaggcag gccagtcggg
     4441 actccgtgag ctctccgact gccccttgat cagaggctga caaggaaggg gcacctgctg
     4501 cagagtggac acattgctca actcagatcc cccgacctgt tcctaggact ccctcttgcc
     4561 ctccccactg tacccacttg ggagggcccg cagcacaggg cttagggtat gtgcagtatg
     4621 aggactctct cccaccttct acctgactct gatcagccac tagatgccac tccagagagt
     4681 cccagcttgg gacttccagg aacaggggtc gctgatgtgt gaggagtggt gtccatatta
     4741 tatccccagg tgagcgttgg cattggggag cacagagcct ggcctctgtg accccatgtc
     4801 cccacagaga acatgaagtc acagtggagt ggatcccctg tttcttaggt atttgatcag
     4861 agagttctgg aagagtggac tggggaggat aagacactgt ctagtcagcc ctgtggagta
     4921 caggggtgaa ggagggagat ggatggaggt ggttgcgtct ctttgttccc tgggagctga
     4981 gaagaggttc ttgtccttgg aactgttagg atagggtcta gaactttcct ctttgggtcc
     5041 ctttacccac tacctagctt ccacaggaga gcagaatcct aatctctgtg tgtccatgtt
     5101 tgagtgtgtc tgtatgtgca tctctgcagg tgtgagagca tgtgtgccca tctgtgtcca
     5161 tgtaccactg tgcgcatcat tggatgggag cgtgcaggaa cacgaggtag ggcatagtaa
     5221 accctgtctc tgtgggtgag tggcagcggg caatcttcac ctcaatgaca tgtttgtggg
     5281 gtgctggccc tgtctgcagt ctcagattgc ctgctacggc ctttcaaccc cctttggatg
     5341 acaaagagct tacagatgac cctattgaag gctagctcct tggctggagg tgtggcacag
     5401 ggctcttccc tgtgcatcgt gggggtcagc ctcagggaag aggctggaac cccagcttca
     5461 tcgcagcacc cggaggctca ctgaggatcg agacccttgc tgcttagccc tcaaccccac
     5521 ctggcttgta tcatcatcac caccaccacc atcaccatct tcctcatcct catcatcacc
     5581 accatcatca ctggctgcta gaaggtcagg ccaggctaca gcagggcatc ctggtaccca
     5641 atcagtgtgg ccgccttcct ggcccttcaa gccctttgtc cgaagtgagt tgctctgttt
     5701 gcagaataag attctgtgac atctgcaggg tattgctcct taattatccc atctgtgccg
     5761 agtctactag cccaactaga ctgtgagtcc ctcccactct gagcccctcc ttcattcttg
     5821 ctcacgaggg acactagagt agaaaccttg tagaacggat tctataagcc agtagtccct
     5881 ggccctggct aaagaatcaa ctgatcaggg gtcagcctga gtgtagggtg tgatttaaca
     5941 tcatgggaac acagcctggt attagaaaca ttaagaaacc tcttaggaca acccaagagg
     6001 ggaagccagg gtcgtctcaa ctccagggcc tctgagtcag tgctatgttg gacaaacagc
     6061 tccctccgct cctcctgggg ttcctgcttc accctaagcc tgctccccca tattggccca
     6121 ctgtcctgac tgctttattg tggggactcc tccttctgta tcttagagct ggacacagga
     6181 aaggttcata gtatgtgtag gccccatgtt ccagaacctt ctttgtggtg agagcagcca
     6241 tgcctgaggg tgtgtggcct gagattacaa agcttgttta agaagcccac cctcgtgagc
     6301 aagtgagtga ggctggggtg tgctagtctg tgagagccca ctgtgtgctg gggctgtgtg
     6361 gtccttacgt gtgtgcatgt accagaagca tttggtcgtg tgcagggttg agagtaagtg
     6421 taactgtagg gcaggagcct tttgcacatg gacgcctgtg agcctacatt cctgtatgtt
     6481 tgagtgtggg gtccatgttg gggtaggtag cctgtgaaca ccccggttcc aggagaccag
     6541 gctaaaggga ttgagcggat ctctacagtg gcagcctcac tctctttgct ggggaaactg
     6601 agggaatttg tggccttaaa gcagggatcc cagagtaaag ctctcagggt tctgggtcct
     6661 tttactcctg gcccctacaa gttagtgtct gggaagagga aggcattctt gggaccaggc
     6721 agtaaagaac agctgatggg tggtagcctc agctcggctg tcctgcccct tgggaccaca
     6781 gttagttaac ctacatgcct cattcatcca tgaagacaaa gcctgctgct cctggcacac
     6841 tcctcccata attccctctt tcccactcac catccttctc ctgttctctg gaaacacctg
     6901 ttcagactag cggggccaga atgagcctcg gaaatgcagg ctttccactg cccaaacgca
     6961 gaagctggaa cagagatggg cgggcctggc tcaattcttg gaagcctagt gctacagccc
     7021 tggggatgtc gtagcaccga tcactgctcc tgggaacctc ttaccagaat agctacagac
     7081 agctgagtgg aactgaccct tctctgggtg ctctccatgt tgccgaggcc ggttacatgt
     7141 gtgacaggtg ttactcgaat attttgagag agaaaccatc ttcctgtcct actctggcct
     7201 cttctcccag actgcggaca cctcgcccat ggacagtacg gttgccacat ggagactgtt
     7261 actctcacca ctactgtctg cataggctgg gccgggaacg gaggctggcg gaggctggtg
     7321 tctcatcatc gggatcccct ccccaggacc aggagggctg cagaagacat gaagtgctct
     7381 tgggttttcc tctgattgga cagctccatg ggactgggga gggttgtttc cagggaatgt
     7441 cctaggagta tggtgaatga acctccctgt atgggagagt tcctgcaggc cactggctga
     7501 gctcagattc tgggttcatt ccgttctgtc agtactgggc atatgggtgt gtgtgtgtgt
     7561 gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtatgcagga gggccactct
     7621 tttctggaga tctcttcacc cttagcactg gaatggacct taaaggacat cgaatctggt
     7681 gtgcccactg tacaggtgtt aaaactgagg ttcagagaga aggcatctgc ctgtccccat
     7741 ccctctccct tccatgtttg gcctgcattc attgtccagg ggtcctgata aaaattctct
     7801 ccctcctagc aacttcctgc cctccaccca cccagacatc ccatttcccc cctaccccca
     7861 atctcagccc agttctgcag gaaggggcct gctccagggc atccccaacc attaccaccc
     7921 cctaccccag ggaagtctga tcatcaaatg cttatcccca gcccataagg gacaggaaag
     7981 tagggactat tcctgccctg gcgcctcaca gacagaggaa agccaatcct ccccccacat
     8041 gcccaggccc actcgtctgc cctacccacc ctgccaccaa gctaaaagca caacaggaga
     8101 ccccccacac acactcatgg gtgacacggg ggtctctcac gaccctgacg cacccttttg
     8161 ccttgctctc tgtctccacc cagcctctgt tttccaccac ccatctttcg ctcttccaca
     8221 aaccccaaaa tgtaacctct agttgcggac gcggttgttc caatcaataa agatgcagtg
     8281 ttctagaa
//
