LOCUS       NM_175088               3435 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus MyoD family inhibitor domain containing (Mdfic), mRNA.
ACCESSION   NM_175088
VERSION     NM_175088.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3435)
  AUTHORS   Zhou,Z., Ma,X., Lin,Y., Cheng,D., Bavi,N., Secker,G.A., Li,J.V.,
            Janbandhu,V., Sutton,D.L., Scott,H.S., Yao,M., Harvey,R.P.,
            Harvey,N.L., Corry,B., Zhang,Y. and Cox,C.D.
  TITLE     MyoD-family inhibitor proteins act as auxiliary subunits of Piezo
            channels
  JOURNAL   Science 381 (6659), 799-804 (2023)
   PUBMED   37590348
  REMARK    GeneRIF: MyoD-family inhibitor proteins act as auxiliary subunits
            of Piezo channels.
REFERENCE   2  (bases 1 to 3435)
  AUTHORS   Byrne,A.B., Brouillard,P., Sutton,D.L., Kazenwadel,J.,
            Montazaribarforoushi,S., Secker,G.A., Oszmiana,A., Babic,M.,
            Betterman,K.L., Brautigan,P.J., White,M., Piltz,S.G., Thomas,P.Q.,
            Hahn,C.N., Rath,M., Felbor,U., Korenke,G.C., Smith,C.L., Wood,K.H.,
            Sheppard,S.E., Adams,D.M., Kariminejad,A., Helaers,R., Boon,L.M.,
            Revencu,N., Moore,L., Barnett,C., Haan,E., Arts,P., Vikkula,M.,
            Scott,H.S. and Harvey,N.L.
  TITLE     Pathogenic variants in MDFIC cause recessive central conducting
            lymphatic anomaly with lymphedema
  JOURNAL   Sci Transl Med 14 (634), eabm4869 (2022)
   PUBMED   35235341
  REMARK    GeneRIF: Pathogenic variants in MDFIC cause recessive central
            conducting lymphatic anomaly with lymphedema.
REFERENCE   3  (bases 1 to 3435)
  AUTHORS   Lumayag,S., Haldin,C.E., Corbett,N.J., Wahlin,K.J., Cowan,C.,
            Turturro,S., Larsen,P.E., Kovacs,B., Witmer,P.D., Valle,D.,
            Zack,D.J., Nicholson,D.A. and Xu,S.
  TITLE     Inactivation of the microRNA-183/96/182 cluster results in
            syndromic retinal degeneration
  JOURNAL   Proc Natl Acad Sci U S A 110 (6), E507-E516 (2013)
   PUBMED   23341629
REFERENCE   4  (bases 1 to 3435)
  AUTHORS   Martindill,D.M., Risebro,C.A., Smart,N., Franco-Viseras Mdel,M.,
            Rosario,C.O., Swallow,C.J., Dennis,J.W. and Riley,P.R.
  TITLE     Nucleolar release of Hand1 acts as a molecular switch to determine
            cell fate
  JOURNAL   Nat Cell Biol 9 (10), 1131-1141 (2007)
   PUBMED   17891141
REFERENCE   5  (bases 1 to 3435)
  AUTHORS   Ishiguro,A., Inoue,T., Mikoshiba,K. and Aruga,J.
  TITLE     Molecular properties of Zic4 and Zic5 proteins: functional
            diversity within Zic family
  JOURNAL   Biochem Biophys Res Commun 324 (1), 302-307 (2004)
   PUBMED   15465018
REFERENCE   6  (bases 1 to 3435)
  AUTHORS   Mizugishi,K., Hatayama,M., Tohmonda,T., Ogawa,M., Inoue,T.,
            Mikoshiba,K. and Aruga,J.
  TITLE     Myogenic repressor I-mfa interferes with the function of Zic family
            proteins
  JOURNAL   Biochem Biophys Res Commun 320 (1), 233-240 (2004)
   PUBMED   15207726
REFERENCE   7  (bases 1 to 3435)
  AUTHORS   Thebault,S., Gachon,F., Lemasson,I., Devaux,C. and Mesnard,J.M.
  TITLE     Molecular cloning of a novel human I-mfa domain-containing protein
            that differently regulates human T-cell leukemia virus type I and
            HIV-1 expression
  JOURNAL   J Biol Chem 275 (7), 4848-4857 (2000)
   PUBMED   10671520
REFERENCE   8  (bases 1 to 3435)
  AUTHORS   Thompson,H.A., Burson,J.M., Lang,J.A., Gross,K.W. and Sigmund,C.D.
  TITLE     Tissue-specific expression of novel messenger ribonucleic acids
            cloned from a renin-expressing kidney tumor cell line (As4.1)
  JOURNAL   Endocrinology 136 (7), 3037-3045 (1995)
   PUBMED   7789330
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK165016.1, BB603899.2,
            BG083307.2, AK087298.1, CO043232.1 and BY509244.1.
            
            On Apr 9, 2008 this sequence version replaced NM_175088.4.
            
            Summary: This gene product is a member of a family of proteins
            characterized by a specific cysteine-rich C-terminal domain, which
            is involved in transcriptional regulation of viral genome
            expression. Alternative translation initiation from an upstream
            non-AUG (GUG), and an in-frame, downstream AUG codon, results in
            the production of two isoforms, which in human have been shown to
            have different subcellular localization. [provided by RefSeq, Jul
            2008].
            
            Sequence Note: An AUG translation start codon is selected for this
            RefSeq based on its conservation with the homologous human isoform,
            p32. Studies in PMID:10671520 demonstrate the existence of a longer
            human isoform, p40, which can initiate translation from an upstream
            non-AUG (GUG) start codon. Possible in-frame, upstream GUG start
            codons are also present in mouse, which could extend the protein
            N-terminal by 82, 106 or 117 aa; however, these extensions are not
            conserved with the human p40 N-terminal.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660821.50847.1, AK165016.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-134               AK165016.1         2-135
            135-279             BB603899.2         102-246
            280-2184            AK165016.1         281-2185
            2185-2481           BG083307.2         234-530
            2482-2873           AK087298.1         246-637
            2874-3430           CO043232.1         18-574              c
            3431-3435           BY509244.1         411-415
FEATURES             Location/Qualifiers
     source          1..3435
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 6.85 cM"
     gene            1..3435
                     /gene="Mdfic"
                     /gene_synonym="Kdt1; Mdfid"
                     /note="MyoD family inhibitor domain containing"
                     /db_xref="GeneID:16543"
                     /db_xref="MGI:MGI:104611"
     exon            1..303
                     /gene="Mdfic"
                     /gene_synonym="Kdt1; Mdfid"
                     /inference="alignment:Splign:2.1.0"
     exon            304..481
                     /gene="Mdfic"
                     /gene_synonym="Kdt1; Mdfid"
                     /inference="alignment:Splign:2.1.0"
     CDS             388..1131
                     /gene="Mdfic"
                     /gene_synonym="Kdt1; Mdfid"
                     /note="kidney cell line-derived transcript 1; I-mfa
                     domain-containing protein"
                     /codon_start=1
                     /product="myoD family inhibitor domain-containing protein"
                     /protein_id="NP_780297.3"
                     /db_xref="CCDS:CCDS19919.1"
                     /db_xref="GeneID:16543"
                     /db_xref="MGI:MGI:104611"
                     /translation="MSCAGEALAPGPAEQQCPVEAGGGRLGSPAHEACNEDNTEKDKR
                     PATSGHTRCGLMRDQSIWPNPSAGELVRTQPERLPQLQTSAQEPGKEETGKIKNGGHT
                     RMSNGNGIPHGAKHVSVENHKISAPVSQKMHRKIQSSLSVNNDISKKSKVNAVFSPKA
                     ASSPEDCCVHCILACLFCEFLTLCNIVLGQASCGICTSEACCCCCGDEMGDDCSCPCD
                     MDCGIMDACCESSDCLEICMECCGICFPS"
     exon            482..604
                     /gene="Mdfic"
                     /gene_synonym="Kdt1; Mdfid"
                     /inference="alignment:Splign:2.1.0"
     exon            605..883
                     /gene="Mdfic"
                     /gene_synonym="Kdt1; Mdfid"
                     /inference="alignment:Splign:2.1.0"
     exon            884..3435
                     /gene="Mdfic"
                     /gene_synonym="Kdt1; Mdfid"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3411..3416
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mdfic"
                     /gene_synonym="Kdt1; Mdfid"
                     /note="hexamer: ATTAAA"
     polyA_site      3434
                     /gene="Mdfic"
                     /gene_synonym="Kdt1; Mdfid"
                     /note="major polyA site"
ORIGIN      
        1 atccggatat gatgaaaggg agccacagag agagaagtgt ttgaagagtg taggagtggc
       61 agcgcgaggg tgaaagagac gcacaagtgg atcctaaagt ccttcccgga ggagaggggc
      121 tgcccggagg gaagggacgg agtgcgcgga gtcagcgcgg gcggctgcca ctgtcgctgc
      181 cactcccggg gccggaggga cgtggtcagg ctgccagggc gtgatggggc cgcggccaga
      241 gcctcgctga ctaccggtgg cgggaggaag ggacccggaa cagcccacgg gggggatgcc
      301 aagaggcagg ccgtttcctg cacccagcac ctaagcagct ggggtccgtg caccccgcgg
      361 ggacggctct ggctcggagc gtggcccatg tcctgcgcgg gtgaagccct cgctcccggg
      421 cccgcggagc agcagtgccc ggtcgaggcg ggcggcggcc ggctgggctc cccggcccac
      481 gaagcatgta atgaggacaa tacggagaaa gataaaaggc cagctaccag tggccatacc
      541 aggtgtgggc tgatgcggga ccagtccatt tggccaaatc cttcagctgg tgaacttgtc
      601 agaacccaac ctgaacgtct gcctcaactc cagacatcag cacaggaacc cggcaaggag
      661 gaaacaggca agataaagaa tggcggccac acaaggatga gcaatgggaa tggaattcct
      721 cacggagcca aacatgtgtc cgtggagaat cacaagatat cagcccccgt ttctcagaag
      781 atgcacagaa aaatccagtc cagcttgtct gtaaacaatg acatcagtaa gaagagtaaa
      841 gtaaatgctg tcttttcccc aaaagcagcc tcctcacccg aagactgctg tgtccactgt
      901 atcctggcat gcttgttctg tgaattcctg accctctgca acattgtcct gggacaagct
      961 tcgtgtggca tctgcacctc cgaagcctgc tgctgttgct gtggcgatga gatgggtgat
     1021 gactgtagct gcccctgtga catggactgc ggcatcatgg atgcctgttg tgaatcgtca
     1081 gactgtctag aaatctgcat ggaatgctgt ggcatctgtt ttccttcata aaagatttat
     1141 ctcttgtttt tactaaaact ggagacaact ttacaatatt tcttgtaggg gaaagaaagg
     1201 cgcatggtaa gactcccatg aaacaactca gtatttgcac tgttttttgt agacccattc
     1261 cttctaagta agctctgaaa ttcttccttt cgccggatgt atgtggttta atatgtgaag
     1321 ttttgactgt ctaattggtt ttttgaaact tcttcataga tgacaataat tggaagacat
     1381 tttgacacac acagcctaaa atgttaaatg tcttctttct cttgacatgt ctgttttcgc
     1441 taaccattct gagcagctct ttgctctaaa cacaacattg ctcagtatgt atttaagcca
     1501 gatcactttg atgtttatct attggaggtt aaaagcaaac ttttttttaa ttctaagtaa
     1561 gcacaaacat tgggcagagc cgtaaacaga tgtgggactc tccgtgttgg tctcctctgg
     1621 gcttttcagc tctcttgttc tgccagagtg ctctgaagaa gatcacattg ctctcatcca
     1681 gagcggcagg aagtgtaatg gaagcaagca ggatgggagc tgtaaaggat gaaccaggtt
     1741 tcaaagcatg ctggcttcaa gactgtaaag gcaagaggcc ataggaacat acagaagtga
     1801 ataacaggtt acagaagaag gcctggagga agatatggca ctgtggatgc tctaggacca
     1861 gctacttgaa tttaaggaaa tgttgaaggt acacagccta gactgtcagt gctttggaca
     1921 agtgaaaagg atttgccttg tatatcgcag caacacagct ttcttagaac tgtaaaatct
     1981 caactaatgc aaatacgcac tttcctacat gtaatttaag tgttataaat tttaatgaaa
     2041 acataatacc ttgttaacat aactatattt taccaaaaaa tgtagaacac tttttaacaa
     2101 cgttcattta aatgagctgg ttttttttcc ttttttttaa gattaaaaaa atcccagtat
     2161 tccttggggt ttttccaaag ctgccttata tttggaaaga ctcggttctt tatcatgcag
     2221 gggtgggggg gggcggggtt ctatttattt tcattggctt gtagtcctag ccatgttgtc
     2281 tttcataagg aggtgagttt tggatccact acaggaggac ttccgacgtc caacaccatc
     2341 caccaggtat caggattcca actgtgtgtg aaattatgcc aagtgacagg ttataaagat
     2401 actaaagtac gaagaagagg ggctgcaatg agactaattc tacagtgatg gagtcagctc
     2461 atgtggaggg gagagtttgg attcacacac accctcccgt gggcgttttc cctttctctc
     2521 cagattttaa aatttggtta tattgactga ttccttgtag gctcttgaga gtatgttgtt
     2581 gttagtggtt ctttctagtt ccagatgaat attagattgt tagaaataat gcaatcttaa
     2641 gaagccatta gccagcctag gcctttagga gacttaaact ttttttcttt ttcatgaaga
     2701 atggcgacat caccagtgtc tttcctttga aagttagctt agcttataat taaattatta
     2761 ttttaaatat tctttgaaaa agaaaagcta atccgtctcc tttctagtgc aatttccacg
     2821 tgcatacact ttaaatacga tgctaatgta cagctgcctt cctcctcgtc tttgaaacag
     2881 aagctttgat tcgctgcgtc aaatataatg gcaaccttag tatttccaca tacccaatgc
     2941 tagtgtgtgc ttatatcata ggatgaagaa gtgccatctg tttatggata agcctcctaa
     3001 tgattgttaa aatatttgcc tcattatcct gtaaaactgt ttaaccaaga ggcttgtctg
     3061 atgcttgaat atatcttgct atgatttgca atgaaaatgt tagtgcattc gacatgtttt
     3121 tctgtaatag agagcattag tgaacaccag aatttaattt ccatacttgt acaggtagga
     3181 ctattcttca gctctctact ccaggcaagc cattccttaa ggcatcttgt ataattcaaa
     3241 agaaaaatag gcaaatgtga aaacagtttt agcatatttt agaattttgg catgtaaagt
     3301 gttttgttga accttatggc cgtcaagact aattgctata gtttacacct agatattcca
     3361 tctcttttta aacgtggcat attttcaaac tggatcctga ctattttaaa attaaaaaga
     3421 attatgatga ctgac
//
