LOCUS       NM_001276391            1483 bp    mRNA    linear   ROD 05-JUN-2024
DEFINITION  Mus musculus MyoD family inhibitor (Mdfi), transcript variant 4,
            mRNA.
ACCESSION   NM_001276391
VERSION     NM_001276391.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1483)
  AUTHORS   Houser,J.S., Patel,M., Wright,K., Onopiuk,M., Tsiokas,L. and
            Humphrey,M.B.
  TITLE     The inhibitor of MyoD Family A (I-MFA) regulates megakaryocyte
            lineage commitment and terminal differentiation
  JOURNAL   Blood Cells Mol Dis 102, 102760 (2023)
   PUBMED   37267696
  REMARK    GeneRIF: The inhibitor of MyoD Family A (I-MFA) regulates
            megakaryocyte lineage commitment and terminal differentiation.
REFERENCE   2  (bases 1 to 1483)
  AUTHORS   Kurz,J., Weiss,A.C., Thiesler,H., Qasrawi,F., Deuper,L., Kaur,J.,
            Rudat,C., Ludtke,T.H., Wojahn,I., Hildebrandt,H., Trowe,M.O. and
            Kispert,A.
  TITLE     Notch signaling is a novel regulator of visceral smooth muscle cell
            differentiation in the murine ureter
  JOURNAL   Development 149 (4) (2022)
   PUBMED   35103284
REFERENCE   3  (bases 1 to 1483)
  AUTHORS   Shotorbani,P.Y., Chaudhari,S., Tao,Y., Tsiokas,L. and Ma,R.
  TITLE     Inhibitor of myogenic differentiation family isoform a, a new
            positive regulator of fibronectin production by glomerular
            mesangial cells
  JOURNAL   Am J Physiol Renal Physiol 318 (3), F673-F682 (2020)
   PUBMED   31984795
  REMARK    GeneRIF: These results suggest that I-mfa, increased by high
            glucose/diabetes through the production of reactive oxygen species,
            stimulates fibronectin production by mesangial cells.
REFERENCE   4  (bases 1 to 1483)
  AUTHORS   Tian,C. and Johnson,K.R.
  TITLE     TBX1 is required for normal stria vascularis and semicircular canal
            development
  JOURNAL   Dev Biol 457 (1), 91-103 (2020)
   PUBMED   31550482
REFERENCE   5  (bases 1 to 1483)
  AUTHORS   Nair,R.R., Keratar,J.M., Autio,K.J., Masud,A.J., Finnila,M.A.J.,
            Autio-Harmainen,H.I., Miinalainen,I.J., Nieminen,P.A.,
            Hiltunen,J.K. and Kastaniotis,A.J.
  TITLE     Genetic modifications of Mecr reveal a role for mitochondrial
            2-enoyl-CoA/ACP reductase in placental development in mice
  JOURNAL   Hum Mol Genet 26 (11), 2104-2117 (2017)
   PUBMED   28369354
REFERENCE   6  (bases 1 to 1483)
  AUTHORS   Liao,W., Hong,S.H., Chan,B.H., Rudolph,F.B., Clark,S.C. and Chan,L.
  TITLE     APOBEC-2, a cardiac- and skeletal muscle-specific member of the
            cytidine deaminase supergene family
  JOURNAL   Biochem Biophys Res Commun 260 (2), 398-404 (1999)
   PUBMED   10403781
REFERENCE   7  (bases 1 to 1483)
  AUTHORS   Liu,Z. and Huang,C.H.
  TITLE     The mouse Rhl1 and Rhag genes: sequence, organization, expression,
            and chromosomal mapping
  JOURNAL   Biochem Genet 37 (3-4), 119-138 (1999)
   PUBMED   10495887
REFERENCE   8  (bases 1 to 1483)
  AUTHORS   Kraut,N., Snider,L., Chen,C.M., Tapscott,S.J. and Groudine,M.
  TITLE     Requirement of the mouse I-mfa gene for placental development and
            skeletal patterning
  JOURNAL   EMBO J 17 (21), 6276-6288 (1998)
   PUBMED   9799236
REFERENCE   9  (bases 1 to 1483)
  AUTHORS   Kraut,N.
  TITLE     The gene encoding I-mf (Mdfi) maps to human chromosome 6p21 and
            mouse chromosome 17
  JOURNAL   Mamm Genome 8 (8), 618-619 (1997)
   PUBMED   9250874
REFERENCE   10 (bases 1 to 1483)
  AUTHORS   Chen,C.M., Kraut,N., Groudine,M. and Weintraub,H.
  TITLE     I-mf, a novel myogenic repressor, interacts with members of the
            MyoD family
  JOURNAL   Cell 86 (5), 731-741 (1996)
   PUBMED   8797820
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC113536.10, CX564914.1, AA049446.1, W65565.1, W54345.1 and
            AI325040.1.
            
            [WARNING] On Jul 27, 2024 this sequence was replaced by
            NM_001276391.2.
            
            Transcript Variant: This variant (4) uses an alternate 5' exon
            structure, differs in the 5' UTR, contains an alternate exon in the
            5' coding region and uses a downstream start codon compared to
            variant 2. It encodes isoform 2 which is longer and has a distinct
            N-terminus, compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CX564914.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164134, SAMN01164137
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-33                AC113536.10        83667-83699
            34-811              CX564914.1         1-778
            812-817             AA049446.1         120-125
            818-890             CX564914.1         785-857
            891-957             W65565.1           5-71
            958-967             AC113536.10        101105-101114
            968-1053            W54345.1           228-313
            1054-1054           AC113536.10        101201-101201
            1055-1304           W65565.1           168-417
            1305-1361           AI325040.1         132-188             c
            1362-1362           AC113536.10        101509-101509
            1363-1481           AI325040.1         12-130              c
            1482-1483           AC113536.10        101629-101630
FEATURES             Location/Qualifiers
     source          1..1483
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 23.99 cM"
     gene            1..1483
                     /gene="Mdfi"
                     /gene_synonym="I-mf; I-mfa"
                     /note="MyoD family inhibitor"
                     /db_xref="GeneID:17240"
                     /db_xref="MGI:MGI:107687"
     exon            1..47
                     /gene="Mdfi"
                     /gene_synonym="I-mf; I-mfa"
                     /inference="alignment:Splign:2.1.0"
     exon            48..134
                     /gene="Mdfi"
                     /gene_synonym="I-mf; I-mfa"
                     /inference="alignment:Splign:2.1.0"
     exon            135..238
                     /gene="Mdfi"
                     /gene_synonym="I-mf; I-mfa"
                     /inference="alignment:Splign:2.1.0"
     CDS             148..903
                     /gene="Mdfi"
                     /gene_synonym="I-mf; I-mfa"
                     /note="isoform 2 precursor is encoded by transcript
                     variant 4; myogenic repressor I-mf"
                     /codon_start=1
                     /product="myoD family inhibitor isoform 2 precursor"
                     /protein_id="NP_001263320.1"
                     /db_xref="GeneID:17240"
                     /db_xref="MGI:MGI:107687"
                     /translation="MPPLVLDVVPFLLSLIWGILSTNTQSQTCRAQTMSLLPGLEVAR
                     STHPVEASSEEGFPEEAAPSMPHDSGLRAQQALNSIDLDVPTEAVTCQPQGNPQGCTP
                     LLPNGSSHDHLSEPGSAGHAGNGALGGSKAHRKLQTHPSLGSQAGRKSRGSARSASQV
                     PLQAQEDCCVHCILSCLFCEFLTLCNILLDCATCGSCSSEDSCLCCCCCGSGECADCD
                     LPCDLDCGIVDACCESADCLEICMECCGLCFSS"
     exon            239..418
                     /gene="Mdfi"
                     /gene_synonym="I-mf; I-mfa"
                     /inference="alignment:Splign:2.1.0"
     exon            419..646
                     /gene="Mdfi"
                     /gene_synonym="I-mf; I-mfa"
                     /inference="alignment:Splign:2.1.0"
     exon            647..1483
                     /gene="Mdfi"
                     /gene_synonym="I-mf; I-mfa"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1457..1462
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mdfi"
                     /gene_synonym="I-mf; I-mfa"
                     /note="hexamer: AATAAA"
     polyA_site      1481
                     /gene="Mdfi"
                     /gene_synonym="I-mf; I-mfa"
                     /note="major polyA site"
ORIGIN      
        1 ggagcgaggg ggctggaacg agagaaggaa gaaggaaggg gcgatcggtc ccaggccgat
       61 gtcccaggtg agcggtcagt gcccttctcg ctgcgacgcg cctcatggag tccccagcgc
      121 tgccctggac ccagggttca aagccagatg ccacccctag tccttgatgt ggtccctttt
      181 ctcctttccc ttatctgggg tattctgagt accaacactc agtcacagac gtgcagagcc
      241 cagaccatgt ccctcctccc tgggctggag gtagcaagat ccactcaccc tgtagaggca
      301 tcttctgaag agggcttccc ggaggaggcg gcaccctcca tgccccatga cagtggtctc
      361 cgggctcagc aggctctgaa cagcattgac ctcgatgtcc ccacagaagc tgtgacgtgc
      421 cagcctcaag ggaaccccca aggctgcacc ccactactgc caaatggctc cagccacgac
      481 cacctctcag aaccgggcag tgcagggcat gcggggaacg gtgctctggg cgggtccaag
      541 gcccaccgga agttgcagac gcatccatct ctgggcagcc aggctggaag gaaaagcaga
      601 ggcagcgccc ggtcagcctc acaggtccct ctccaggcac aggaagattg ctgcgtccac
      661 tgcatactgt cctgtctatt ctgtgagttc ctgacgctct gtaacatcct cctggactgc
      721 gccacctgtg gctcctgcag ctctgaggac tcctgcctct gctgctgctg ctgtgggtcc
      781 ggcgagtgcg cggactgtga cctgccctgc gacctggact gcggcatcgt ggatgcctgc
      841 tgcgagtccg cagactgctt ggagatatgc atggagtgct gtggactctg tttctcctcc
      901 tgatgccatg gggtggcccc agagctaccg cacaaagctt gacgcctccc ctgaccccgg
      961 gccgccccct cagaatccca acccagatgt gagaaggtgg gacgctcaga ggggccacct
     1021 cagccaccga acaggtctgc tttcagacgc gtagcctggt cccctccacg ggtgaccagg
     1081 aacacggcat ctagagcctg gtaggacaga accagttagc tgccataact cagaacactg
     1141 tgaacggtag gggaggggcc aggagtggga ggggccagga atgggaggcc cgtgtccttc
     1201 tctacctctg ctccaggtgc ctgcctccct cagcgcttac cccagctttg aggacagaaa
     1261 atgtgaaaag gcctctgccc cgcccactgc caggccccca ctctcctccc cagctcattt
     1321 cctgggctct tgtggggggc ctaacccata gagtgaccca agaggatggg gtttcgggtg
     1381 ggggtgggtg ggaggggcgc aatatggaaa agactggaag ggggtagagg gagggtctgt
     1441 tcgattcatt actgtaaata aagacatccg ttcaagctcc atc
//
