LOCUS       NM_001276390            1593 bp    mRNA    linear   ROD 05-JUN-2024
DEFINITION  Mus musculus MyoD family inhibitor (Mdfi), transcript variant 3,
            mRNA.
ACCESSION   NM_001276390
VERSION     NM_001276390.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1593)
  AUTHORS   Houser,J.S., Patel,M., Wright,K., Onopiuk,M., Tsiokas,L. and
            Humphrey,M.B.
  TITLE     The inhibitor of MyoD Family A (I-MFA) regulates megakaryocyte
            lineage commitment and terminal differentiation
  JOURNAL   Blood Cells Mol Dis 102, 102760 (2023)
   PUBMED   37267696
  REMARK    GeneRIF: The inhibitor of MyoD Family A (I-MFA) regulates
            megakaryocyte lineage commitment and terminal differentiation.
REFERENCE   2  (bases 1 to 1593)
  AUTHORS   Kurz,J., Weiss,A.C., Thiesler,H., Qasrawi,F., Deuper,L., Kaur,J.,
            Rudat,C., Ludtke,T.H., Wojahn,I., Hildebrandt,H., Trowe,M.O. and
            Kispert,A.
  TITLE     Notch signaling is a novel regulator of visceral smooth muscle cell
            differentiation in the murine ureter
  JOURNAL   Development 149 (4) (2022)
   PUBMED   35103284
REFERENCE   3  (bases 1 to 1593)
  AUTHORS   Shotorbani,P.Y., Chaudhari,S., Tao,Y., Tsiokas,L. and Ma,R.
  TITLE     Inhibitor of myogenic differentiation family isoform a, a new
            positive regulator of fibronectin production by glomerular
            mesangial cells
  JOURNAL   Am J Physiol Renal Physiol 318 (3), F673-F682 (2020)
   PUBMED   31984795
  REMARK    GeneRIF: These results suggest that I-mfa, increased by high
            glucose/diabetes through the production of reactive oxygen species,
            stimulates fibronectin production by mesangial cells.
REFERENCE   4  (bases 1 to 1593)
  AUTHORS   Tian,C. and Johnson,K.R.
  TITLE     TBX1 is required for normal stria vascularis and semicircular canal
            development
  JOURNAL   Dev Biol 457 (1), 91-103 (2020)
   PUBMED   31550482
REFERENCE   5  (bases 1 to 1593)
  AUTHORS   Nair,R.R., Keratar,J.M., Autio,K.J., Masud,A.J., Finnila,M.A.J.,
            Autio-Harmainen,H.I., Miinalainen,I.J., Nieminen,P.A.,
            Hiltunen,J.K. and Kastaniotis,A.J.
  TITLE     Genetic modifications of Mecr reveal a role for mitochondrial
            2-enoyl-CoA/ACP reductase in placental development in mice
  JOURNAL   Hum Mol Genet 26 (11), 2104-2117 (2017)
   PUBMED   28369354
REFERENCE   6  (bases 1 to 1593)
  AUTHORS   Liao,W., Hong,S.H., Chan,B.H., Rudolph,F.B., Clark,S.C. and Chan,L.
  TITLE     APOBEC-2, a cardiac- and skeletal muscle-specific member of the
            cytidine deaminase supergene family
  JOURNAL   Biochem Biophys Res Commun 260 (2), 398-404 (1999)
   PUBMED   10403781
REFERENCE   7  (bases 1 to 1593)
  AUTHORS   Liu,Z. and Huang,C.H.
  TITLE     The mouse Rhl1 and Rhag genes: sequence, organization, expression,
            and chromosomal mapping
  JOURNAL   Biochem Genet 37 (3-4), 119-138 (1999)
   PUBMED   10495887
REFERENCE   8  (bases 1 to 1593)
  AUTHORS   Kraut,N., Snider,L., Chen,C.M., Tapscott,S.J. and Groudine,M.
  TITLE     Requirement of the mouse I-mfa gene for placental development and
            skeletal patterning
  JOURNAL   EMBO J 17 (21), 6276-6288 (1998)
   PUBMED   9799236
REFERENCE   9  (bases 1 to 1593)
  AUTHORS   Kraut,N.
  TITLE     The gene encoding I-mf (Mdfi) maps to human chromosome 6p21 and
            mouse chromosome 17
  JOURNAL   Mamm Genome 8 (8), 618-619 (1997)
   PUBMED   9250874
REFERENCE   10 (bases 1 to 1593)
  AUTHORS   Chen,C.M., Kraut,N., Groudine,M. and Weintraub,H.
  TITLE     I-mf, a novel myogenic repressor, interacts with members of the
            MyoD family
  JOURNAL   Cell 86 (5), 731-741 (1996)
   PUBMED   8797820
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC113536.10, BQ832230.1, CX564914.1, AA049446.1, W54345.1, W65565.1
            and AI325040.1.
            
            [WARNING] On Jul 27, 2024 this sequence was replaced by
            NM_001276390.2.
            
            Transcript Variant: This variant (3) uses an alternate 5' exon
            structure and differs in the 5' UTR compared to variant 2. Variants
            1, 2 and 3 encode the same isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U57820.1, CB195291.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164134, SAMN01164137
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-33                AC113536.10        83667-83699
            34-499              BQ832230.1         1-466
            500-921             CX564914.1         357-778
            922-927             AA049446.1         120-125
            928-1000            CX564914.1         785-857
            1001-1057           AA049446.1         198-254
            1058-1077           AC113536.10        101095-101114
            1078-1163           W54345.1           228-313
            1164-1164           AC113536.10        101201-101201
            1165-1414           W65565.1           168-417
            1415-1471           AI325040.1         132-188             c
            1472-1472           AC113536.10        101509-101509
            1473-1591           AI325040.1         12-130              c
            1592-1593           AC113536.10        101629-101630
FEATURES             Location/Qualifiers
     source          1..1593
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 23.99 cM"
     gene            1..1593
                     /gene="Mdfi"
                     /gene_synonym="I-mf; I-mfa"
                     /note="MyoD family inhibitor"
                     /db_xref="GeneID:17240"
                     /db_xref="MGI:MGI:107687"
     exon            1..348
                     /gene="Mdfi"
                     /gene_synonym="I-mf; I-mfa"
                     /inference="alignment:Splign:2.1.0"
     CDS             273..1013
                     /gene="Mdfi"
                     /gene_synonym="I-mf; I-mfa"
                     /note="isoform 1 is encoded by transcript variant 3;
                     myogenic repressor I-mf"
                     /codon_start=1
                     /product="myoD family inhibitor isoform 1"
                     /protein_id="NP_001263319.1"
                     /db_xref="CCDS:CCDS50134.1"
                     /db_xref="GeneID:17240"
                     /db_xref="MGI:MGI:107687"
                     /translation="MSQVSGQCPSRCDAPHGVPSAALDPAQTMSLLPGLEVARSTHPV
                     EASSEEGFPEEAAPSMPHDSGLRAQQALNSIDLDVPTEAVTCQPQGNPQGCTPLLPNG
                     SSHDHLSEPGSAGHAGNGALGGSKAHRKLQTHPSLGSQAGRKSRGSARSASQVPLQAQ
                     EDCCVHCILSCLFCEFLTLCNILLDCATCGSCSSEDSCLCCCCCGSGECADCDLPCDL
                     DCGIVDACCESADCLEICMECCGLCFSS"
     exon            349..528
                     /gene="Mdfi"
                     /gene_synonym="I-mf; I-mfa"
                     /inference="alignment:Splign:2.1.0"
     exon            529..756
                     /gene="Mdfi"
                     /gene_synonym="I-mf; I-mfa"
                     /inference="alignment:Splign:2.1.0"
     exon            757..1593
                     /gene="Mdfi"
                     /gene_synonym="I-mf; I-mfa"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1567..1572
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mdfi"
                     /gene_synonym="I-mf; I-mfa"
                     /note="hexamer: AATAAA"
     polyA_site      1591
                     /gene="Mdfi"
                     /gene_synonym="I-mf; I-mfa"
                     /note="major polyA site"
ORIGIN      
        1 ggagcgaggg ggctggaacg agagaaggaa gaaggaaggg gcgatcggtg ggtgcgagct
       61 ggcgctggaa tgggagccaa gagcgagtga gcggggaggg ggcgcgggcg acacccaggt
      121 gtcgcatggc ggggtccacg aggtgacctg cctaggccag cagcgcgcag cttgcacgag
      181 tatgcgctag ggcacccact ccgtttcccc acgcacacgc gagggaggcc tgccccgccc
      241 gctgagcgct gttttctcca ggtcccaggc cgatgtccca ggtgagcggt cagtgccctt
      301 ctcgctgcga cgcgcctcat ggagtcccca gcgctgccct ggacccagcc cagaccatgt
      361 ccctcctccc tgggctggag gtagcaagat ccactcaccc tgtagaggca tcttctgaag
      421 agggcttccc ggaggaggcg gcaccctcca tgccccatga cagtggtctc cgggctcagc
      481 aggctctgaa cagcattgac ctcgatgtcc ccacagaagc tgtgacgtgc cagcctcaag
      541 ggaaccccca aggctgcacc ccactactgc caaatggctc cagccacgac cacctctcag
      601 aaccgggcag tgcagggcat gcggggaacg gtgctctggg cgggtccaag gcccaccgga
      661 agttgcagac gcatccatct ctgggcagcc aggctggaag gaaaagcaga ggcagcgccc
      721 ggtcagcctc acaggtccct ctccaggcac aggaagattg ctgcgtccac tgcatactgt
      781 cctgtctatt ctgtgagttc ctgacgctct gtaacatcct cctggactgc gccacctgtg
      841 gctcctgcag ctctgaggac tcctgcctct gctgctgctg ctgtgggtcc ggcgagtgcg
      901 cggactgtga cctgccctgc gacctggact gcggcatcgt ggatgcctgc tgcgagtccg
      961 cagactgctt ggagatatgc atggagtgct gtggactctg tttctcctcc tgatgccatg
     1021 gggtggcccc agagctaccg cacaaagctt gacgcctccc ctgaccccgg gccgccccct
     1081 cagaatccca acccagatgt gagaaggtgg gacgctcaga ggggccacct cagccaccga
     1141 acaggtctgc tttcagacgc gtagcctggt cccctccacg ggtgaccagg aacacggcat
     1201 ctagagcctg gtaggacaga accagttagc tgccataact cagaacactg tgaacggtag
     1261 gggaggggcc aggagtggga ggggccagga atgggaggcc cgtgtccttc tctacctctg
     1321 ctccaggtgc ctgcctccct cagcgcttac cccagctttg aggacagaaa atgtgaaaag
     1381 gcctctgccc cgcccactgc caggccccca ctctcctccc cagctcattt cctgggctct
     1441 tgtggggggc ctaacccata gagtgaccca agaggatggg gtttcgggtg ggggtgggtg
     1501 ggaggggcgc aatatggaaa agactggaag ggggtagagg gagggtctgt tcgattcatt
     1561 actgtaaata aagacatccg ttcaagctcc atc
//
