LOCUS       NM_001081059            4368 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus mitochondrial calcium uniporter regulator 1 (Mcur1),
            mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_001081059 XM_127325
VERSION     NM_001081059.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4368)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4368)
  AUTHORS   Shanmughapriya,S., Tomar,D., Dong,Z., Slovik,K.J., Nemani,N.,
            Natarajaseenivasan,K., Carvalho,E., Lu,C., Corrigan,K.,
            Garikipati,V.N.S., Ibetti,J., Rajan,S., Barrero,C., Chuprun,K.,
            Kishore,R., Merali,S., Tian,Y., Yang,W. and Madesh,M.
  TITLE     FOXD1-dependent MICU1 expression regulates mitochondrial activity
            and cell differentiation
  JOURNAL   Nat Commun 9 (1), 3449 (2018)
   PUBMED   30158529
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4368)
  AUTHORS   Tomar,D., Dong,Z., Shanmughapriya,S., Koch,D.A., Thomas,T.,
            Hoffman,N.E., Timbalia,S.A., Goldman,S.J., Breves,S.L.,
            Corbally,D.P., Nemani,N., Fairweather,J.P., Cutri,A.R., Zhang,X.,
            Song,J., Jana,F., Huang,J., Barrero,C., Rabinowitz,J.E.,
            Luongo,T.S., Schumacher,S.M., Rockman,M.E., Dietrich,A., Merali,S.,
            Caplan,J., Stathopulos,P., Ahima,R.S., Cheung,J.Y., Houser,S.R.,
            Koch,W.J., Patel,V., Gohil,V.M., Elrod,J.W., Rajan,S. and Madesh,M.
  TITLE     MCUR1 Is a Scaffold Factor for the MCU Complex Function and
            Promotes Mitochondrial Bioenergetics
  JOURNAL   Cell Rep 15 (8), 1673-1685 (2016)
   PUBMED   27184846
  REMARK    GeneRIF: MCUR1 binds to MCU and EMRE and function as a scaffold
            factor.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK041849.1, AK018089.1, AC124171.3 and BQ174175.1.
            
            On Dec 18, 2010 this sequence version replaced NM_001081059.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR13948564.2987317.1,
                                           SRR13422600.982951.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-30                AK041849.1         2-31
            31-1203             AK018089.1         2-1174
            1204-4338           AC124171.3         78839-81973         c
            4339-4368           BQ174175.1         1-30                c
FEATURES             Location/Qualifiers
     source          1..4368
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 21.6 cM"
     gene            1..4368
                     /gene="Mcur1"
                     /gene_synonym="6230416A05Rik; Ccdc90a"
                     /note="mitochondrial calcium uniporter regulator 1"
                     /db_xref="GeneID:76137"
                     /db_xref="MGI:MGI:1923387"
     exon            1..423
                     /gene="Mcur1"
                     /gene_synonym="6230416A05Rik; Ccdc90a"
                     /inference="alignment:Splign:2.1.0"
     CDS             66..1088
                     /gene="Mcur1"
                     /gene_synonym="6230416A05Rik; Ccdc90a"
                     /EC_number="1.1.1.41"
                     /note="coiled-coil domain-containing protein 90A,
                     mitochondrial; coiled-coil domain containing 90A; MCU
                     regulator 1"
                     /codon_start=1
                     /product="mitochondrial calcium uniporter regulator 1"
                     /protein_id="NP_001074528.1"
                     /db_xref="CCDS:CCDS36645.1"
                     /db_xref="GeneID:76137"
                     /db_xref="MGI:MGI:1923387"
                     /translation="MDSGSVAAERPRRTPSRQRLPSSGCGVPARPGVSTLPGGRSWLR
                     PRGRAARASPLLFLLLVPSPRLAATATATAPRRTLAERSRPGLVLPAAALGAGRNALG
                     RLRLGARRVAALASSRRELSLSAKCHQLEHRKENLPLSVSRQLYFDTHALVCLLEANG
                     FTIQQAEIIVSALVKITETNMNIIYKDMVSKMQQEIALQQVLSKIANVKKDMVILEKS
                     EFSALRAENEKIKLELHQLKQQVMDEVTKVRTDTKLNFNLEKSRVKELYSLNEKKMLE
                     LRTEIVSLHAQQDRALTQTDRKIETEVAGLKTMLEAHKLDTIKYLAGSVFTCLTVALG
                     FYRLWI"
     exon            424..543
                     /gene="Mcur1"
                     /gene_synonym="6230416A05Rik; Ccdc90a"
                     /inference="alignment:Splign:2.1.0"
     exon            544..647
                     /gene="Mcur1"
                     /gene_synonym="6230416A05Rik; Ccdc90a"
                     /inference="alignment:Splign:2.1.0"
     exon            648..749
                     /gene="Mcur1"
                     /gene_synonym="6230416A05Rik; Ccdc90a"
                     /inference="alignment:Splign:2.1.0"
     exon            750..791
                     /gene="Mcur1"
                     /gene_synonym="6230416A05Rik; Ccdc90a"
                     /inference="alignment:Splign:2.1.0"
     exon            792..863
                     /gene="Mcur1"
                     /gene_synonym="6230416A05Rik; Ccdc90a"
                     /inference="alignment:Splign:2.1.0"
     exon            864..917
                     /gene="Mcur1"
                     /gene_synonym="6230416A05Rik; Ccdc90a"
                     /inference="alignment:Splign:2.1.0"
     exon            918..1032
                     /gene="Mcur1"
                     /gene_synonym="6230416A05Rik; Ccdc90a"
                     /inference="alignment:Splign:2.1.0"
     exon            1033..4356
                     /gene="Mcur1"
                     /gene_synonym="6230416A05Rik; Ccdc90a"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1087..1092
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mcur1"
                     /gene_synonym="6230416A05Rik; Ccdc90a"
                     /note="hexamer: AATAAA"
     polyA_site      1107
                     /gene="Mcur1"
                     /gene_synonym="6230416A05Rik; Ccdc90a"
                     /note="major polyA site"
     regulatory      4336..4341
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mcur1"
                     /gene_synonym="6230416A05Rik; Ccdc90a"
                     /note="hexamer: AATAAA"
     polyA_site      4356
                     /gene="Mcur1"
                     /gene_synonym="6230416A05Rik; Ccdc90a"
                     /note="major polyA site"
ORIGIN      
        1 gactcggagt cggggccgcg cgggagcgac ctgcgtgcgc gctcgggcct gtgacccgct
       61 cggggatgga cagcggctcc gtggcggccg agcggccgag gcgcacaccg agtcgccagc
      121 ggctcccgtc ctccggctgc ggagttccgg cgcgcccggg cgtctccacg ctgcccggtg
      181 gacgaagctg gctgaggcct cgcggacggg cggcccgcgc gtctccgctg ttgttcctcc
      241 tgctcgtgcc ctccccgcgc ctggccgcca ccgccactgc caccgccccg cgtaggacgc
      301 tggctgagcg ctcgcgcccg gggctcgttc tccccgcggc cgcgctcggc gccggcagga
      361 acgcgctggg ccgtctgcgg ctgggcgccc ggcgtgtggc cgcgcttgcg agcagccgga
      421 gagagctcag cctgtctgct aagtgccatc agctggagca cagaaaagag aacttgcccc
      481 tctctgtgag ccggcagctc tactttgaca cccacgctct ggtgtgctta cttgaagcaa
      541 atgggtttac cattcaacaa gcagaaatca ttgtgtctgc actggtcaag atcacagaga
      601 ccaacatgaa catcatctac aaagacatgg tcagcaagat gcagcaggaa atcgctctcc
      661 agcaggtatt atctaagatt gctaacgtga aaaaagatat ggtcatcttg gagaagagtg
      721 agttttcagc cctcagagca gaaaatgaga aaataaaact tgaactgcac cagttaaagc
      781 aacaagtgat ggatgaagtg accaaagtcc ggacagatac caaattaaac ttcaatctag
      841 aaaaaagcag agtaaaagaa ctgtactcgc tgaacgagaa gaagatgctg gaactgagga
      901 ctgaaatagt gtcgctgcat gcccagcaag acagagccct gactcagaca gaccggaaga
      961 tagagacgga ggtggctggc ctcaagacga tgctggaggc gcacaagctt gatacaatca
     1021 aatacttagc ggggtctgtg tttacgtgcc taacagtggc tctgggattt tatcgcctgt
     1081 ggatataata aagtgtctat ttaaagacat tttcattgtt ttgccataag agtaccagat
     1141 tgttatacca cccacccaac tccccccttt tttattcttg tttcaagttt taatcctaat
     1201 tcgacttcat gcatattatt tatttctgtg caaactgtgg atccgtaacc aaggtgaaga
     1261 aagttgggat ttctgtgatc gttctccgga gcagctctgt ttagttggct ttttggctga
     1321 gccgtgtgga tggaccacac tttcaagact cctttcaggc gaacctgcag catttgacaa
     1381 gaaataaatg tactctctac agctttaagc agtttgtaag gtggagagcg tgggaaggca
     1441 tgtggaaaac aaggtagctt taagtctaaa gaatccttgg catcagccca gagcccttct
     1501 gtgcctgacc agcagccgtt ccccacgcag tcttgcctct gctgcagcag ctgcagtgtt
     1561 aatgatgcag gactcgccac accttagggg cctttgtctc tgggttccca ttgtcttagt
     1621 aacattgtta atgtgccttg caactgggag tctaggtacc taatgaaact ttgtgacttt
     1681 agcacaagtt ctcttactgc tgccacacct gcctttctgg ttttgagaca aggtcttgct
     1741 ttgtaggcca ggttggcttt gaactcacta tccggcttca acaccaccgt gcccagcctc
     1801 tacctttccg aatgctagcc ttccctctcc ctcttcttcc tcttccttcc cttcctgatg
     1861 tgggagtcta acaccacact cctggcatta tctacctaga aatcttgtaa ttcttggaat
     1921 gaaaccctgc ttcagtgtgt ggtttggagt gaacttcctt ctggtgtcca cctgctttgc
     1981 ctaagatgac acgcggcact tcgctcctat gggctatcta gacagtgtgc acgcatttag
     2041 aataagtaca cttttccctg tgagcggctc aggttgtcac ttgcccagtg agagagcccc
     2101 agtgcttggc agtgcccccc tgtgcattga cttcttctgt ggtagcagac acccccacag
     2161 ccgcctcagc tctccatcgg aaacagatag gtcctggagc agctgcagtt attttggaga
     2221 agtgcgttct cttttcctct ttaaattgct ggcactcgga tgagagtgag catttgggaa
     2281 gcagtgacac tgggggaccc ttcctggctt gccccacaca ggcacaaatg cacaagctgg
     2341 tgcacatagt gcagaaacca caagagaccg cgccatcgga ttggtggaat aaatcagccc
     2401 ttgtcactgt tccaagcaca ctgctaaaaa taaaagctac cttttgttcc ttggctgtaa
     2461 tttccaagtt tgagaaacca ttaagttctt gcctcattag aaaacatttg cgtaaaaaga
     2521 ttctgagccc cacatattat ggaaatcgag tgcttttgta ttagaacagt atcacggtga
     2581 aacagaagtt tatcctttcc aagaagacaa aaaaaaaaaa aaaaagtctt aaccacagtt
     2641 gactgcttga tgtcagagaa agggctcaaa gcccacatac tcttaataaa gaccaactcc
     2701 tgggaggaaa gagcgccgtg tgcagttatg ttttacaata agggctaacc tgggtaggtt
     2761 aaaaacaggg gatacctttc accgtgtcct gataagtatt ctttaagaaa cacatcctta
     2821 tgtctgcttg aagtgctcta caccacagca ggctatgtgt gattttgttc tagcattctt
     2881 tgtagcaccc taatcgtgtt tggccttaga aaacgatgtc actgagggtg tgggtggtgt
     2941 gcatatctga agtttaagag agtctaagac tctgtcccct ttatttccta ataaagttgg
     3001 aaagaattga tctataaatg tacatgtccc cgctgtcgct gccatagaca tacatgaatg
     3061 gtgaggatag tgtgaccaga cactgtactg aacctccatg aagctgcgga gctcttagga
     3121 gggacctggc aggtttccag gcagcagcct tgagtccagc ctgtggggac ctttgcaata
     3181 gctgtacagg gtaagagtcc agtgggtgga cttccttcac tgtcatcata cctaaactgt
     3241 tcctctgcct tcctgctagg cattgcattt tctgtcccct cttttttttc ttgtggtact
     3301 tgctggggat caaacccact ggcacaaatg ttctgtcatc ttgcctcagc ctcccaagtg
     3361 ctgggattac aagcattagc acggcagcac aaagctccct ctggcttttt taaaagagcc
     3421 ttaagcccag tttcactcct tgcctgcata cttttgctaa actcctttgg ggctttttac
     3481 tggagacact tgctttgatt ttcggtattg cttttagtct cctggctgct tttcttgctt
     3541 agtatctggc aacacgattt tcccttcaag tatgccaagc aagtcagtta gaacgccaca
     3601 gtcaagaaga aaggcctgac tcgaggcggg tgtcttgctg gagtctgtct ctgaacgctt
     3661 taagcaccaa gattctgggg gcagcaagcc tggcctgggt gggcctgtgc tgtgccttgg
     3721 taccatcttc cctcgatttt ccttgaccct ccttcccaag ctgatacggc aagtactttg
     3781 cttccccagc cctgtgtgct gtgtgccagg actggcagag cctaccctag agaacttggg
     3841 acttcaaggt gaccaagttg ttacagcttt tatagcacta aagaataaaa gcgggttaac
     3901 caggaataat ttattctata tgtatgtaag atctttgaga atgtttagcc cggttgaaat
     3961 tgtattcagg aaatatcttt ttacagattt gtacttaaca ttccttcagt gataatccag
     4021 ataattttgt aatcctttta ttgcttcagc aagtatgcag ttgtatttta tcattgtata
     4081 gagtgaatct attttattat ctaagataac agattcgtgt ttgtgtggct aatgcgcctt
     4141 tcctgtggtt caggaggaat gtatgaagct agaccatacc ttctatcttg aacaacagta
     4201 ttgaagctgt taattctacc cattgtaaaa tgataccatt ctattgcctc gggtaaatga
     4261 caaataaatt taatacctaa aaaaaatttg tatttacaga gaaaatatat ttgaaaatga
     4321 atgtctgatt ttcaaaataa attttatttg aaagaaaaaa aaaaaaaa
//
