LOCUS       NM_026902               1065 bp    mRNA    linear   ROD 11-FEB-2025
DEFINITION  Mus musculus malignant T cell amplified sequence 1 (Mcts1),
            transcript variant 1, mRNA.
ACCESSION   NM_026902
VERSION     NM_026902.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1065)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1065)
  AUTHORS   Nakano,T., Aochi,H., Hirasaki,M., Takenaka,Y., Fujita,K.,
            Tamura,M., Soma,H., Kamezawa,H., Koizumi,T., Shibuya,H.,
            Inomata,R., Okuda,A., Murakoshi,T., Shimada,A. and Inoue,I.
  TITLE     Effects of Ppargamma1 deletion on late-stage murine embryogenesis
            and cells that undergo endocycle
  JOURNAL   Dev Biol 478, 222-235 (2021)
   PUBMED   34246625
REFERENCE   3  (bases 1 to 1065)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1065)
  AUTHORS   Pandey,S.K., Yadav,S., Goel,Y. and Singh,S.M.
  TITLE     Cytotoxic action of acetate on tumor cells of thymic origin: Role
            of MCT-1, pH homeostasis and altered cell survival regulation
  JOURNAL   Biochimie 157, 1-9 (2019)
   PUBMED   30391286
  REMARK    GeneRIF: Acetate treatment also modulated the expression of pH
            regulators MCT-1 and V-ATPase accompanied by altered pH
            homeostasis. Expression of MDR and lipid metabolism regulatory
            molecules was also inhibited in tumor cells upon acetate exposure.
REFERENCE   5  (bases 1 to 1065)
  AUTHORS   Kwon,S.H., Oh,S., Nacke,M., Mostov,K.E. and Lipschutz,J.H.
  TITLE     Adaptor Protein CD2AP and L-type Lectin LMAN2 Regulate Exosome
            Cargo Protein Trafficking through the Golgi Complex
  JOURNAL   J Biol Chem 291 (49), 25462-25475 (2016)
   PUBMED   27765817
  REMARK    Erratum:[J Biol Chem. 2017 Oct 6;292(40):16523. doi:
            10.1074/jbc.A116.729202.. PMID: 28986432]
REFERENCE   6  (bases 1 to 1065)
  AUTHORS   Gendrel,A.V., Tang,Y.A., Suzuki,M., Godwin,J., Nesterova,T.B.,
            Greally,J.M., Heard,E. and Brockdorff,N.
  TITLE     Epigenetic functions of smchd1 repress gene clusters on the
            inactive X chromosome and on autosomes
  JOURNAL   Mol Cell Biol 33 (16), 3150-3165 (2013)
   PUBMED   23754746
REFERENCE   7  (bases 1 to 1065)
  AUTHORS   Blewitt,M.E., Gendrel,A.V., Pang,Z., Sparrow,D.B., Whitelaw,N.,
            Craig,J.M., Apedaile,A., Hilton,D.J., Dunwoodie,S.L.,
            Brockdorff,N., Kay,G.F. and Whitelaw,E.
  TITLE     SmcHD1, containing a structural-maintenance-of-chromosomes hinge
            domain, has a critical role in X inactivation
  JOURNAL   Nat Genet 40 (5), 663-669 (2008)
   PUBMED   18425126
REFERENCE   8  (bases 1 to 1065)
  AUTHORS   Wood,A.J., Roberts,R.G., Monk,D., Moore,G.E., Schulz,R. and
            Oakey,R.J.
  TITLE     A screen for retrotransposed imprinted genes reveals an association
            between X chromosome homology and maternal germ-line methylation
  JOURNAL   PLoS Genet 3 (2), e20 (2007)
   PUBMED   17291163
REFERENCE   9  (bases 1 to 1065)
  AUTHORS   Oda,M., Yamagiwa,A., Yamamoto,S., Nakayama,T., Tsumura,A.,
            Sasaki,H., Nakao,K., Li,E. and Okano,M.
  TITLE     DNA methylation regulates long-range gene silencing of an X-linked
            homeobox gene cluster in a lineage-specific manner
  JOURNAL   Genes Dev 20 (24), 3382-3394 (2006)
   PUBMED   17182866
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL513356.8 and AL845279.4.
            
            On Mar 19, 2018 this sequence version replaced NM_026902.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CF551108.1, AK005292.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849379
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-308               AL513356.8         213735-214042
            309-461             AL513356.8         215193-215345
            462-559             AL513356.8         215840-215937
            560-693             AL845279.4         4965-5098
            694-761             AL845279.4         10792-10859
            762-1065            AL845279.4         12247-12550
FEATURES             Location/Qualifiers
     source          1..1065
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 22.88 cM"
     gene            1..1065
                     /gene="Mcts1"
                     /gene_synonym="1500019M23Rik; MCT-1"
                     /note="malignant T cell amplified sequence 1"
                     /db_xref="GeneID:68995"
                     /db_xref="MGI:MGI:1916245"
     exon            1..308
                     /gene="Mcts1"
                     /gene_synonym="1500019M23Rik; MCT-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             298..843
                     /gene="Mcts1"
                     /gene_synonym="1500019M23Rik; MCT-1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     multiple copies T-cell malignancies 1"
                     /codon_start=1
                     /product="malignant T-cell-amplified sequence 1 isoform 1"
                     /protein_id="NP_081178.1"
                     /db_xref="CCDS:CCDS30094.1"
                     /db_xref="GeneID:68995"
                     /db_xref="MGI:MGI:1916245"
                     /translation="MFKKFDEKENVSNCIQLKTSVIKGIKNQLLEQFPGIEPWLNQIM
                     PKKDPVKIVRCHEHIEILTVNGELLFFRQREGPFYPTLRLLHKYPFILPHQQVDKGAI
                     KFVLSGANIMCPGLTSPGAKLYPAAVDTIVAIMAEGKQHALCVGVMKMSAEDIEKVNK
                     GIGIENIHYLNDGLWHMKTYK"
     exon            309..461
                     /gene="Mcts1"
                     /gene_synonym="1500019M23Rik; MCT-1"
                     /inference="alignment:Splign:2.1.0"
     exon            462..559
                     /gene="Mcts1"
                     /gene_synonym="1500019M23Rik; MCT-1"
                     /inference="alignment:Splign:2.1.0"
     exon            560..693
                     /gene="Mcts1"
                     /gene_synonym="1500019M23Rik; MCT-1"
                     /inference="alignment:Splign:2.1.0"
     exon            694..761
                     /gene="Mcts1"
                     /gene_synonym="1500019M23Rik; MCT-1"
                     /inference="alignment:Splign:2.1.0"
     exon            762..1065
                     /gene="Mcts1"
                     /gene_synonym="1500019M23Rik; MCT-1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      944..949
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mcts1"
                     /gene_synonym="1500019M23Rik; MCT-1"
                     /note="hexamer: AATAAA"
     polyA_site      967
                     /gene="Mcts1"
                     /gene_synonym="1500019M23Rik; MCT-1"
                     /note="major polyA site"
     regulatory      1038..1043
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mcts1"
                     /gene_synonym="1500019M23Rik; MCT-1"
                     /note="hexamer: ATTAAA"
     polyA_site      1065
                     /gene="Mcts1"
                     /gene_synonym="1500019M23Rik; MCT-1"
                     /note="major polyA site"
ORIGIN      
        1 aaccagaaag aattgcttga tcacttcttc cttctgaagt cccgcccttt cggctacccc
       61 caatggagac taagctgtta ctgaaaagga gccgacaaaa gcgtcaacgt ggagtcgaga
      121 ggagcggaag tagtcagatt tcgctaaggg ccgtaaagcg gatagtgttt tcgccttccg
      181 gattaacgac agcagctccg actgtcagtg caggccttcc tcgtgctgga cccttcctaa
      241 ttcaatttcc ttcccattcc gggcccttcc ctatcgtcgc ccctttcacc ttggatcatg
      301 ttcaagaaat ttgatgaaaa agaaaatgtg tccaactgca tccagttgaa aacctcggtt
      361 attaagggta ttaaaaatca attgctagag caatttccag gtattgaacc atggcttaat
      421 caaatcatgc ctaagaaaga ccctgtgaaa attgtccgat gccatgaaca catagaaatc
      481 cttacagtaa atggagaatt actgtttttt agacaaagag aagggccttt ttatccaact
      541 ttaagattac ttcataaata tccttttatc ttgccacatc agcaggttga taaaggagcc
      601 atcaaatttg tactcagtgg agcaaatatc atgtgtcctg gcttaacttc tcccggagct
      661 aagctttatc ctgctgcagt agatactatt gttgcaatca tggcagaagg aaaacaacat
      721 gctttatgtg tgggtgtcat gaagatgtct gcagaagata ttgagaaagt aaacaaagga
      781 attggcattg aaaatatcca ttatctaaat gatggtctgt ggcatatgaa gacatataaa
      841 tgagcctcaa aaggaatgtg catgggctaa ctatggatac tgtgctgtat ctgtgtctgt
      901 gtctgtgtga cagcatgaag acaaagcctc tatgattatg ctgaataaaa attccgcgga
      961 tgcttaattt ctgttagttt cagaaattat tttaactttt cttaaacaaa aattataatg
     1021 tggtagcaaa cttggctatt aaaaggtata tggtaaataa ctcaa
//
