LOCUS       NM_030174               6585 bp    mRNA    linear   ROD 12-FEB-2025
DEFINITION  Mus musculus multiple C2 domains, transmembrane 1 (Mctp1),
            transcript variant 1, mRNA.
ACCESSION   NM_030174 XM_017315642 XM_127419
VERSION     NM_030174.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6585)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 6585)
  AUTHORS   Tarchini,B., Longo-Guess,C., Tian,C., Tadenev,A.L.D., Devanney,N.
            and Johnson,K.R.
  TITLE     A spontaneous mouse deletion in Mctp1 uncovers a long-range
            cis-regulatory region crucial for NR2F1 function during inner ear
            development
  JOURNAL   Dev Biol 443 (2), 153-164 (2018)
   PUBMED   30217595
  REMARK    GeneRIF: we found that the Mctp1(dwnd) deletion affects the Nr2f1
            gene located 1.4Mb away, downregulating transcription and protein
            expression in the embryonic cochlea. Remarkably, the Mctp1(dwnd)
            allele failed to complement a targeted inactivation allele of
            Nr2f1, and transheterozygotes or Mctp1(dwnd) homozygotes exhibit
            the same morphological defects observed in inner ears of Nr2f1
            mutants
REFERENCE   3  (bases 1 to 6585)
  AUTHORS   Ashbrook,D.G., Williams,R.W., Lu,L. and Hager,R.
  TITLE     A cross-species genetic analysis identifies candidate genes for
            mouse anxiety and human bipolar disorder
  JOURNAL   Front Behav Neurosci 9, 171 (2015)
   PUBMED   26190982
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC154788.2, AC112671.25, AC124362.3, AC140345.3 and AC161266.2.
            
            On or before Dec 13, 2019 this sequence version replaced
            XM_017315642.2, NM_030174.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK047562.1, SRR1660813.43266.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164133
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1113              AC154788.2         105430-106542       c
            1114-1228           AC112671.25        48378-48492         c
            1229-1371           AC112671.25        1574-1716           c
            1372-1451           AC124362.3         63088-63167         c
            1452-1563           AC124362.3         51468-51579         c
            1564-1602           AC124362.3         43438-43476         c
            1603-1773           AC124362.3         18091-18261         c
            1774-1904           AC124362.3         15427-15557         c
            1905-2091           AC140345.3         82771-82957
            2092-2185           AC140345.3         87581-87674
            2186-2288           AC140345.3         104385-104487
            2289-2391           AC140345.3         106184-106286
            2392-2493           AC140345.3         106618-106719
            2494-2568           AC140345.3         107135-107209
            2569-2688           AC140345.3         109094-109213
            2689-2808           AC140345.3         172907-173026
            2809-2862           AC140345.3         206884-206937
            2863-2972           AC161266.2         151777-151886
            2973-3082           AC161266.2         155808-155917
            3083-3180           AC161266.2         159647-159744
            3181-6585           AC161266.2         160905-164309
FEATURES             Location/Qualifiers
     source          1..6585
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 40.98 cM"
     gene            1..6585
                     /gene="Mctp1"
                     /gene_synonym="2810465F10Rik"
                     /note="multiple C2 domains, transmembrane 1"
                     /db_xref="GeneID:78771"
                     /db_xref="MGI:MGI:1926021"
     exon            1..1113
                     /gene="Mctp1"
                     /gene_synonym="2810465F10Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             397..3252
                     /gene="Mctp1"
                     /gene_synonym="2810465F10Rik"
                     /note="isoform 1 is encoded by transcript variant 1;
                     multiple C2 and transmembrane domain-containing protein 1"
                     /codon_start=1
                     /product="multiple C2 and transmembrane domain-containing
                     protein 1 isoform 1"
                     /protein_id="NP_084450.3"
                     /db_xref="CCDS:CCDS26656.1"
                     /db_xref="GeneID:78771"
                     /db_xref="MGI:MGI:1926021"
                     /translation="MEPRAATTGELVRAASPSFQARLWKNLQLGVGKGKGGGGGRAGG
                     PEHRTAATPTPSPPPPGTTQDALAGVGSTGSRWSGFKKRKQVLDRVFSSSQPNLCCSS
                     PEPLEPGGAGRAEQGSTLRRRLREHLLPVAKGSSTATGTGGVTPPGGRSPDSAPSSSS
                     ASSSLSSSPQPPPRGDRVRDESTRRGGPGVHLCHQKSSSLPGTACLEQLLEPAPPPAE
                     PARGPAEPQALQKDIERDCSQKISTVGNSNADVPLADPGMYQLDITLRRGQSLAARDR
                     GGTSDPYVKFKIGRKEVFRSKIIHKNLNPVWEEKACVLIDHLREPLYIKVFDYDFGLQ
                     DDFMGSAFLDLTQLELNRSTDVTLTLKDPHYPDHDLGIILLSVILTPKEGEHRDVTML
                     MRKSWKRSSKFQTQSLRLSDQHRKSHLWRGIVSITLIEGRDLKAMDSNGLSDPYVKFR
                     LGHQKYKSKIMPKTLNPQWREQFDFHLYEERGGIMDITAWDKDAGKRDDFIGRCQVDL
                     SSLSREQTHKLELHLEEGEGHLVLLVTLTASATVCISDLSVNSMEDQKEREEILKRYS
                     PLRIFNNLKDVGFLQVKVIRAEGLMAADVTGKSDPFCVVELNNDRLLTHTVYKNLNPE
                     WNKVFTFNIKDIHSVLEVTVYDEDRDRSADFLGRVAIPLLSIQNGEQKAYVLKNKQLT
                     GPTKGVIYLEIDVIFNAVKASLRTLIPKERKYIEEENRLSKQLLLRNFIRTKRCVIVL
                     VNAAYYVNSCFDWDSPPRSLAAFVLFLLIVWNFELYMIPLLLLLLLTWNYFLIISGKD
                     NRQRDTVVEDMLEDEEEEDDRDDKDGEKKGFINKIYAIQEVCVSVQNILDEVASLGER
                     IKNTFNWTVPFLSWLAIVALCVFTAILYFIPLRYIVLVWGINKFTKKLRSPYAIDNNE
                     LLDFLSRVPSDVQVVQYQELKPDHSHSPYKRKKNNLG"
     exon            1114..1228
                     /gene="Mctp1"
                     /gene_synonym="2810465F10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1229..1371
                     /gene="Mctp1"
                     /gene_synonym="2810465F10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1372..1451
                     /gene="Mctp1"
                     /gene_synonym="2810465F10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1452..1563
                     /gene="Mctp1"
                     /gene_synonym="2810465F10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1564..1602
                     /gene="Mctp1"
                     /gene_synonym="2810465F10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1603..1773
                     /gene="Mctp1"
                     /gene_synonym="2810465F10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1774..1904
                     /gene="Mctp1"
                     /gene_synonym="2810465F10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1905..2091
                     /gene="Mctp1"
                     /gene_synonym="2810465F10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2092..2185
                     /gene="Mctp1"
                     /gene_synonym="2810465F10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2186..2288
                     /gene="Mctp1"
                     /gene_synonym="2810465F10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2289..2391
                     /gene="Mctp1"
                     /gene_synonym="2810465F10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2392..2493
                     /gene="Mctp1"
                     /gene_synonym="2810465F10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2494..2568
                     /gene="Mctp1"
                     /gene_synonym="2810465F10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2569..2688
                     /gene="Mctp1"
                     /gene_synonym="2810465F10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2689..2808
                     /gene="Mctp1"
                     /gene_synonym="2810465F10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2809..2862
                     /gene="Mctp1"
                     /gene_synonym="2810465F10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2863..2972
                     /gene="Mctp1"
                     /gene_synonym="2810465F10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2973..3082
                     /gene="Mctp1"
                     /gene_synonym="2810465F10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3083..3180
                     /gene="Mctp1"
                     /gene_synonym="2810465F10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3181..6585
                     /gene="Mctp1"
                     /gene_synonym="2810465F10Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5101..5106
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mctp1"
                     /gene_synonym="2810465F10Rik"
                     /note="hexamer: AATACA"
     polyA_site      5117
                     /gene="Mctp1"
                     /gene_synonym="2810465F10Rik"
                     /note="major polyA site"
     regulatory      6517..6522
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mctp1"
                     /gene_synonym="2810465F10Rik"
                     /note="hexamer: ATTAAA"
     polyA_site      6535
                     /gene="Mctp1"
                     /gene_synonym="2810465F10Rik"
     regulatory      6561..6566
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mctp1"
                     /gene_synonym="2810465F10Rik"
                     /note="hexamer: ATTAAA"
     polyA_site      6585
                     /gene="Mctp1"
                     /gene_synonym="2810465F10Rik"
ORIGIN      
        1 agtttggaga cggccgcctc tgctgctgac aggtgctggc ctgagggcgc gggtgtggtt
       61 cccagtgcag ctggaagccc gagccggccg cttgcagctt tccgagctcc cgcgggcgcc
      121 gaggggagtc agggtgcggc ctgggggcgc tcagtggtct ggagcagcgg agttccctgc
      181 tagaaacttt gcaggacggc cgcgccccgc ggcgggaggg cctcggccgc agccgttttg
      241 ctccgagctg gcctgaagcc gctggacgct ccgggcttgt gctgctgcgc tggccgccgc
      301 cgccgccgcc gccgcctcca cgctcccgga ggaggcgcag cccgagaggg aggaggaaag
      361 gcaataggag gggagacaag gtgcctgggt tggaggatgg agccccgggc tgccacgact
      421 ggcgagctcg tgcgggccgc gtccccctcc ttccaggccc ggctctggaa gaacctgcag
      481 ctgggggtgg gcaagggcaa gggcggcgga ggcgggcgcg ctgggggccc cgagcaccgc
      541 actgcggcca ctccgacccc gtccccgccg cccccgggga ccacgcagga cgccctggcc
      601 ggtgtgggaa gtactggcag caggtggagc ggcttcaaga agcggaagca agtgctggac
      661 cgagtgttct cctcctcaca gcccaacctg tgctgctcct caccagagcc cctggagcca
      721 ggcggagcag gcagagccga gcaagggtcc acgctgcgcc gccgcctacg cgaacatctg
      781 ctgcccgtgg ctaaggggtc ctcgacagcc acagggacag gcggagtgac gcctcctggc
      841 ggacgctctc cggactcagc tccttcttcg tcttccgcct catcttccct gtcctcttct
      901 ccccaaccgc ccccgagggg ggaccgcgtc cgtgatgaga gtacacggcg tgggggccct
      961 ggggtgcacc tgtgccacca aaagagctcc tctctgcccg gaaccgcgtg cctggagcag
     1021 ttgctggaac cggcgccacc ccccgcagaa ccggcccggg gtcccgccga accccaggct
     1081 ctgcagaagg acatagagcg cgactgcagc cagaaaataa gtacagttgg aaacagtaat
     1141 gcagatgtcc ctttggctga tcccggaatg taccagttgg atatcacact aagaaggggt
     1201 caaagtttag ctgcccgtga tcgaggaggg acaagcgatc cgtatgtgaa gtttaaaatt
     1261 ggaagaaaag aagtttttag aagcaaaatt atccacaaga acctaaatcc tgtgtgggag
     1321 gaaaaggctt gcgtgctcat tgaccatctt agagagccac tatatatcaa ggtatttgac
     1381 tatgattttg gactgcaaga tgactttatg ggctcagcct ttcttgatct cactcagttg
     1441 gagttaaaca ggtccacaga tgttacccta actctgaaag acccccatta tcctgaccat
     1501 gaccttggaa tcattttgct gtcagtcatc cttacgccta aggaaggtga acacagggat
     1561 gtgacaatgc taatgaggaa gagttggaaa agatccagta agtttcagac ccaaagttta
     1621 cgcctgtccg accagcacag gaaatcacac ctttggagag gaatagtcag catcaccttg
     1681 attgagggtc gagatctcaa agcaatggat tccaatgggt tgagtgatcc atatgtgaag
     1741 ttccggcttg gccatcagaa gtacaagagc aagattatgc ccaaaacttt gaaccctcag
     1801 tggagggagc aatttgattt ccatctctat gaagaaagag gtgggatcat ggacatcact
     1861 gcctgggaca aagatgctgg gaaaagagat gactttattg gaaggtgcca ggttgacctg
     1921 tcttccctca gtagggagca aactcacaag ctggagttac atctggaaga gggtgagggc
     1981 cacctggttc tgcttgtcac tctgacagcc tcggccacag tctgtatctc tgacctctct
     2041 gtcaattcca tggaggacca gaaggagcgg gaagagatat taaagagata tagcccactg
     2101 aggatattta acaacctaaa agacgtggga tttctccagg tgaaagtcat cagagcagaa
     2161 ggtttgatgg ctgcagatgt cacaggtaaa agtgatccat tttgtgtagt agaactgaac
     2221 aatgataggc tgctaacaca cactgtgtac aaaaacctca atcctgagtg gaacaaagtg
     2281 ttcacattta acattaaaga cattcattca gttcttgaag tgacagttta tgatgaagat
     2341 cgtgaccgga gtgccgactt tctgggcaga gtcgctatac cattgctgtc tattcaaaat
     2401 ggtgaacaga aagcctacgt cttgaaaaac aagcagctga cagggccaac aaagggggtc
     2461 atctatcttg aaatagatgt gatttttaat gctgtgaaag ccagcttacg aacattaata
     2521 cccaaagaac ggaagtacat tgaagaggaa aacagactct ctaaacagct gcttctaaga
     2581 aactttatca gaacaaaacg ttgtgtcata gtgcttgtaa acgctgcata ctacgttaat
     2641 agttgctttg attgggattc gcccccaagg agtcttgctg cttttgtgct ctttctcctc
     2701 attgtctgga actttgagct ctacatgata ccactgctgc tgttgttact attgacatgg
     2761 aactacttcc tgataatatc cgggaaagac aacaggcaac gggacacagt agtggaggac
     2821 atgctggagg acgaagagga agaagatgac agagatgaca aggatggtga aaagaaagga
     2881 tttataaata aaatctatgc gatccaggaa gtctgtgtca gtgtgcagaa catcctagat
     2941 gaagtggctt cccttggtga aaggataaag aatactttca actggactgt ccccttctta
     3001 agctggctgg ccattgtagc cctgtgtgtg ttcaccgcca ttctgtactt catcccactg
     3061 agatacattg ttcttgtttg gggaattaat aaatttacaa aaaagcttcg gagtccatat
     3121 gcaattgata acaatgaact acttgacttc ctttccagag ttccttcaga tgtacaagtg
     3181 gtgcagtacc aagaactgaa accagatcat tctcatagcc catacaaaag gaagaaaaac
     3241 aaccttggct agccagctcc gaggaaagca gcatgtttgg gaagataaaa gaaaaactcc
     3301 tccgcagcct ccgcagccct tcctctcttt ctgcttttta tttatccccc cccccctttt
     3361 taaatcatgg tcgagaacat ttgtaaatag tgtacaaaaa gcatacgtct ttgaaaagat
     3421 acttctactg tatacagact caacttgata agggatttta gctagtggag tgtgaaagcc
     3481 ttgttagcta tagataaaat aacaaagtga aataaaataa tggttataaa actggaagat
     3541 atacattttt ccaatcacaa gggaaagaac cgaactatca gataaaatgc tcaattatgc
     3601 tctggttcac tttccataaa acgtaaatgg cgattgatct ttagtttttt ttgtaatgta
     3661 actatttctt atctgaaaag taattcatta gcgccttttt cctgtttata cattcaaacg
     3721 ggggaaaccc caaagcttga ataatagaaa tgttgcactt caacttaaca tacatcacga
     3781 cttccactcc tgtgtaaata aattatgtat ggctaaggct gattttaagc tacaggtaca
     3841 ttcctatctt ttcctgtctg catacacaca taatccctta agagaatctg agagtctatg
     3901 aataagactt ttaagccttc tatcattcca tctaaaacct taaaatctct tcagaactat
     3961 attaaataaa tactgccagg tttataaatg attaccagga tttttatata taccactgtg
     4021 tttagcaaat tatcaagcca attgtcaaga aaaaaaaata ctagcaaacg aaatccctac
     4081 cacatttggt gtcaaattat gctcttgtgc attaaaacaa aaacaaaaca aacaaacaaa
     4141 aaacccatgt attgtttaag tgtcctctac tgatatactt caatgcataa tatgagtttt
     4201 tttcattagt gagttttaat ggagagtgca gttggctaag tgaaaggcca gtgttttcat
     4261 tataccactt ataaaggaag atcattgata acgcatgaaa acctgttttg taaaataaac
     4321 tgcttgtaag gcagtttcca ttaaaaaggt ttcactaacc acactctata cttcaacttg
     4381 cattcctaaa actaattcca gggtctatca agggaatata cctctgcaga ggtcatgtgg
     4441 gtggtgagga tgtcttcact gacttgttag tggaatcaca ctcaatgata attgctgcag
     4501 acaatgtttt gcactatttt attaattgct attaataaac aactggggtg aggtgaaggt
     4561 ggggattgtg ctggaaaatg tagaaaagca gaaatatata tttcacttta aagattcttt
     4621 aaatctcatc agaactgatt ttttaaagta tttttatttt agaaatatgt tgttaaatac
     4681 tatttcttac aataaaacta ttttgatgtt tatacactat gcttggaaga atgtcaacta
     4741 aattcccttt ctacagaaag actttgacct caatatgttc tagtgtatca tgtttaaaat
     4801 gacatgtgta catctgcatt ccattactgt ttgttgcaaa tacatacttt atgaagctga
     4861 tgtaatacat agtttattga tgagatcatt agtttggtat aaattctgat tatacctgtg
     4921 agatttatta ggttctgtgc agacaatgtc tattcaaatg tcgataagcc tgacaatcta
     4981 taacctcaga tatacctagt ggatgcaacc attaacagat gactgatttt gtttatttca
     5041 ttgtgtaaga tttcagatgt ttaattcaat agaaatgctg actacatatt cactgcatta
     5101 aatacacaag gaaataatct ttttatgtat aatcttttct tctgagttaa gaggtacatg
     5161 gtggggtcct gggtgcatat actcattaat gacacttcac ttggagagtg tgtgtgtgtg
     5221 tgtgtgtgtg tgtataaaca gggctattca tgaaacccta actatggtac aaactcagta
     5281 ccatgatgaa catccaatga agcagagaaa actagctgga gtcatgaaag ttaccttaag
     5341 tctttattgt ttttagaaat caatatattt ataggcccca aaagacaatg tcaagtagga
     5401 ttttaacttt cttgtataga agcattttta gtgtatgcct tggtttttct gatatttctg
     5461 aagcaaatat tccaagttat ctgaaaagac agaatttagt tcaacagcta tttgcactgc
     5521 taaatataac agatactata tttatggact atatttatat ttacattcta aattacagcc
     5581 attgttgaat gctgtcctct gggcaaaaga actgccatct tccttagatc atctatctgt
     5641 gcctgcttgt aagtgaccat cacagtcatg cttgcaatcg acatcccttc atgaagagaa
     5701 atgggtggag atggactcaa ggcttgctat tctagcaatt ccgatgtaat tccgcgctaa
     5761 gtacacatgg ccttaaagaa gtactagagt atataggagg gtgcagttgg cttgaaaagg
     5821 atctgtatct atgcagcaat ggaccatcat ttagactggt gaagacttcc cagtacagtt
     5881 gctatggagt catccatgct ctgtaaggaa gcctaattgg ttcatcaggc tgaacttcgt
     5941 tggctatttt agtttgttat tgagatcata tatgagggag tagatgagtt ttaatttctt
     6001 cctcaagaat aatgaattct gccacaccat taaccgggat aaatcagaca tctattttgt
     6061 aacattttgt ttacccacat gaacaatgaa catgctgtta atagtttatt ttgctactgt
     6121 ttcagactca aactgagagg ttcttgacag gtggggttaa gtgctgaaat gaagcagaga
     6181 aaacttttta tccagggacc acaggaagtt tccactttga tttcaaaatc catagatatc
     6241 caataccaaa accaaactat aacaagcctt attcaaaggc tatctttaag tttataagct
     6301 tgttaagtaa gcttaaatgc ttacaatgtt tttgtaatag tgctttggta ctcagcttaa
     6361 aaaactaaag gtataaggtg actggtagtt tcaaaataca agacagcttg tatgatacct
     6421 gtaaaaaaga cttagctatt attaaattaa tgcatgttca agttttgggg ttcagaatgt
     6481 tgcttttgta tgtacagatg ttcagtcaca agtctaatta aagtatctag agtcagcctt
     6541 tttaacgact gttcaattga attaaaaaca gcactgtagt caaaa
//
